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MING ZHOU

TitleProfessor
InstitutionBaylor College of Medicine
DepartmentDepartment of Biochemistry & Molecular Biology
AddressOne Baylor Plaza
Houston TX 77030
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    Lipid bilayer membranes form water-impermeable barriers that define the boundaries of biological cells and of specialized compartments within cells. Membrane proteins are embedded in lipid bilayers and serve a wide range of essential cellular functions, such as mediating signal transduction through the membrane, facilitating uptake of nutrients and excretion of wastes, and metabolizing of lipids and fatty acids. The main impetus behind my research program is the desire to understand how membrane proteins work at the molecular level, both to improve our understanding of biological mechanisms and to provide information on protein-ligand interactions of physiological and pharmacological significance. In particular, our focus is on two families of proteins, membrane transport proteins that facilitate transmembrane flux of ions and small molecules, and membrane-embedded enzymes that are involved in synthesis and modification of lipids, fatty acids, and cholesterol.

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    membrane proteins, x-ray crystallography, enzymology, ion channels, transporters, membrane embedded enzymes.


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. McCoy JG, Ren Z, Stanevich V, Lee J, Mitra S, Levin EJ, Poget S, Quick M, Im W, Zhou M. The Structure of a Sugar Transporter of the Glucose EIIC Superfamily Provides Insight into the Elevator Mechanism of Membrane Transport. Structure. 2016 Jun 7; 24(6):956-64. PMID: 27161976; PMCID: PMC4899283 [Available on 06/07/17].
    2. Zhou M, Zhao J, Tian M, Song S, Zhang R, Gupta S, Tan D, Shen H, Ferrari M, Li C. Radio-photothermal therapy mediated by a single compartment nanoplatform depletes tumor initiating cells and reduces lung metastasis in the orthotopic 4T1 breast tumor model. Nanoscale. 2015 Dec 14; 7(46):19438-47. PMID: 26376843.
      View in: PubMed
    3. Zhou M, Song S, Zhao J, Tian M, Li C. Theranostic CuS Nanoparticles Targeting Folate Receptors for PET Image-Guided Photothermal Therapy. J Mater Chem B Mater Biol Med. 2015 Dec 14; 3(46):8939-8948. PMID: 27725882.
      View in: PubMed
    4. Bai Y, McCoy JG, Levin EJ, Sobrado P, Rajashankar KR, Fox BG, Zhou M. X-ray structure of a mammalian stearoyl-CoA desaturase. Nature. 2015 Aug 13; 524(7564):252-6. PMID: 26098370.
      View in: PubMed
    5. Zhao J, Melancon M, Zhou M. Nanoparticle Formulation to Improve the Efficacy of Radiation Therapy Against Radiation-resistant Leukemia. EBioMedicine. 2015 Jun; 2(6):486. PMID: 26288809.
      View in: PubMed
    6. Zhou M, Chen Y, Adachi M, Wen X, Erwin B, Mawlawi O, Lai SY, Li C. Single agent nanoparticle for radiotherapy and radio-photothermal therapy in anaplastic thyroid cancer. Biomaterials. 2015 Jul; 57:41-9. PMID: 25913249; PMCID: PMC4426239 [Available on 07/01/16].
    7. Zhou M, Ku G, Pageon L, Li C. Theranostic probe for simultaneous in vivo photoacoustic imaging and confined photothermolysis by pulsed laser at 1064 nm in 4T1 breast cancer model. Nanoscale. 2014 Dec 21; 6(24):15228-35. PMID: 25379880; PMCID: PMC4389689.
    8. Huang H, Levin EJ, Liu S, Bai Y, Lockless SW, Zhou M. Structure of a membrane-embedded prenyltransferase homologous to UBIAD1. PLoS Biol. 2014 Jul; 12(7):e1001911. PMID: 25051182; PMCID: PMC4106721.
    9. Levin EJ, Zhou M. Recent progress on the structure and function of the TrkH/KtrB ion channel. Curr Opin Struct Biol. 2014 Aug; 27:95-101. PMID: 25011047; PMCID: PMC4182332.
    10. McCoy JG, Levin EJ, Zhou M. Structural insight into the PTS sugar transporter EIIC. Biochim Biophys Acta. 2015 Mar; 1850(3):577-85. PMID: 24657490; PMCID: PMC4169766.
    11. Levin EJ, Zhou M. Structure of urea transporters. Subcell Biochem. 2014; 73:65-78. PMID: 25298339; PMCID: PMC4422644.
    12. Zhou X, Levin EJ, Pan Y, McCoy JG, Sharma R, Kloss B, Bruni R, Quick M, Zhou M. Structural basis of the alternating-access mechanism in a bile acid transporter. Nature. 2014 Jan 23; 505(7484):569-73. PMID: 24317697; PMCID: PMC4142352.
    13. Cao Y, Pan Y, Huang H, Jin X, Levin EJ, Kloss B, Zhou M. Gating of the TrkH ion channel by its associated RCK protein TrkA. Nature. 2013 Apr 18; 496(7445):317-22. PMID: 23598339; PMCID: PMC3726529.
    14. Pan Y, Levin EJ, Quick M, Zhou M. Potentiation of the Kv1 family K(+) channel by cortisone analogues. ACS Chem Biol. 2012 Oct 19; 7(10):1641-6. PMID: 22803826; PMCID: PMC3567311.
    15. Levin EJ, Cao Y, Enkavi G, Quick M, Pan Y, Tajkhorshid E, Zhou M. Structure and permeation mechanism of a mammalian urea transporter. Proc Natl Acad Sci U S A. 2012 Jul 10; 109(28):11194-9. PMID: 22733730; PMCID: PMC3396522.
    16. Cao Y, Jin X, Levin EJ, Huang H, Zong Y, Quick M, Weng J, Pan Y, Love J, Punta M, Rost B, Hendrickson WA, Javitch JA, Rajashankar KR, Zhou M. Crystal structure of a phosphorylation-coupled saccharide transporter. Nature. 2011 May 5; 473(7345):50-4. PMID: 21471968; PMCID: PMC3201810.
    17. Pan Y, Weng J, Levin EJ, Zhou M. Oxidation of NADPH on Kvbeta1 inhibits ball-and-chain type inactivation by restraining the chain. Proc Natl Acad Sci U S A. 2011 Apr 5; 108(14):5885-90. PMID: 21436029; PMCID: PMC3078402.
    18. Cao Y, Jin X, Huang H, Derebe MG, Levin EJ, Kabaleeswaran V, Pan Y, Punta M, Love J, Weng J, Quick M, Ye S, Kloss B, Bruni R, Martinez-Hackert E, Hendrickson WA, Rost B, Javitch JA, Rajashankar KR, Jiang Y, Zhou M. Crystal structure of a potassium ion transporter, TrkH. Nature. 2011 Mar 17; 471(7338):336-40. PMID: 21317882; PMCID: PMC3077569.
    19. Levin EJ, Quick M, Zhou M. Crystal structure of a bacterial homologue of the kidney urea transporter. Nature. 2009 Dec 10; 462(7274):757-61. PMID: 19865084; PMCID: PMC2871279.
    20. Pan Y, Weng J, Kabaleeswaran V, Li H, Cao Y, Bhosle RC, Zhou M. Cortisone dissociates the Shaker family K+ channels from their beta subunits. Nat Chem Biol. 2008 Nov; 4(11):708-14. PMID: 18806782; PMCID: PMC2633621.
    21. Pan Y, Weng J, Cao Y, Bhosle RC, Zhou M. Functional coupling between the Kv1.1 channel and aldoketoreductase Kvbeta1. J Biol Chem. 2008 Mar 28; 283(13):8634-42. PMID: 18222921; PMCID: PMC2417172.
    22. Lockless SW, Zhou M, MacKinnon R. Structural and thermodynamic properties of selective ion binding in a K+ channel. PLoS Biol. 2007 May; 5(5):e121. PMID: 17472437; PMCID: PMC1858713.
    23. Weng J, Cao Y, Moss N, Zhou M. Modulation of voltage-dependent Shaker family potassium channels by an aldo-keto reductase. J Biol Chem. 2006 Jun 2; 281(22):15194-200. PMID: 16569641; PMCID: PMC2862575.
    24. Zhou M, MacKinnon R. A mutant KcsA K(+) channel with altered conduction properties and selectivity filter ion distribution. J Mol Biol. 2004 May 7; 338(4):839-46. PMID: 15099749.
      View in: PubMed
    25. Zhou M, Morais-Cabral JH, Mann S, MacKinnon R. Potassium channel receptor site for the inactivation gate and quaternary amine inhibitors. Nature. 2001 Jun 7; 411(6838):657-61. PMID: 11395760.
      View in: PubMed
    26. Gulbis JM, Zhou M, Mann S, MacKinnon R. Structure of the cytoplasmic beta subunit-T1 assembly of voltage-dependent K+ channels. Science. 2000 Jul 7; 289(5476):123-7. PMID: 10884227.
      View in: PubMed
    27. Grosman C, Zhou M, Auerbach A. Mapping the conformational wave of acetylcholine receptor channel gating. Nature. 2000 Feb 17; 403(6771):773-6. PMID: 10693806.
      View in: PubMed
    28. Zhou M, Engel AG, Auerbach A. Serum choline activates mutant acetylcholine receptors that cause slow channel congenital myasthenic syndromes. Proc Natl Acad Sci U S A. 1999 Aug 31; 96(18):10466-71. PMID: 10468632; PMCID: PMC17912.
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