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NIKOLAI A TIMCHENKO

TitleProfessor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pathology & Immunology
AddressOne Baylor Plaza, M320
Houston TX 77030
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    Other Positions
    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentHuffington Center on Aging
    DivisionHuffington Ctr on Aging

    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular & Cellular Biology
    DivisionMolecular & Cellular Biology


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Tiao G, Geller J, Timchenko NA. Generation of pediatric liver cancer patient-derived xenograft platforms for pediatric liver cancer: A critical stage in the development of anticancer treatments. Hepatology. 2016 Oct; 64(4):1017-9. PMID: 27359258.
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    2. Jin J, Valanejad L, Nguyen TP, Lewis K, Wright M, Cast A, Stock L, Timchenko L, Timchenko NA. Activation of CDK4 Triggers Development of Non-alcoholic Fatty Liver Disease. Cell Rep. 2016 Jul 19; 16(3):744-56. PMID: 27373160.
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    3. Valanejad L, Timchenko N. Akt-FoxO1 axis controls liver regeneration. Hepatology. 2016 May; 63(5):1424-6. PMID: 27100144.
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    4. Miller NJ, Schick K, Timchenko N, Harrison E, Roesler WJ. The Glutamine-Alanine Repeat Domain of TCERG1 is Required for the Inhibition of the Growth Arrest Activity of C/EBP?. J Cell Biochem. 2016 Mar; 117(3):612-20. PMID: 26264132.
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    5. Fleet T, Zhang B, Lin F, Zhu B, Dasgupta S, Stashi E, Tackett B, Thevananther S, Rajapakshe KI, Gonzales N, Dean A, Mao J, Timchenko N, Malovannaya A, Qin J, Coarfa C, DeMayo F, Dacso CC, Foulds CE, O'Malley BW, York B. SRC-2 orchestrates polygenic inputs for fine-tuning glucose homeostasis. Proc Natl Acad Sci U S A. 2015 Nov 3; 112(44):E6068-77. PMID: 26487680.
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    6. Breaux M, Lewis K, Valanejad L, Iakova P, Chen F, Mo Q, Medrano E, Timchenko L, Timchenko N. p300 Regulates Liver Functions by Controlling p53 and C/EBP Family Proteins through Multiple Signaling Pathways. Mol Cell Biol. 2015 Sep 1; 35(17):3005-16. PMID: 26100016.
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    7. Jones K, Wei C, Schoser B, Meola G, Timchenko N, Timchenko L. Reduction of toxic RNAs in myotonic dystrophies type 1 and type 2 by the RNA helicase p68/DDX5. Proc Natl Acad Sci U S A. 2015 Jun 30; 112(26):8041-5. PMID: 26080402.
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    8. Jin J, Hong IH, Lewis K, Iakova P, Breaux M, Jiang Y, Sullivan E, Jawanmardi N, Timchenko L, Timchenko NA. Cooperation of C/EBP family proteins and chromatin remodeling proteins is essential for termination of liver regeneration. Hepatology. 2015 Jan; 61(1):315-25. PMID: 25043739; PMCID: PMC4280321.
    9. Hong IH, Lewis K, Iakova P, Jin J, Sullivan E, Jawanmardi N, Timchenko L, Timchenko N. Age-associated change of C/EBP family proteins causes severe liver injury and acceleration of liver proliferation after CCl4 treatments. J Biol Chem. 2014 Jan 10; 289(2):1106-18. PMID: 24273171; PMCID: PMC3887178.
    10. Wei C, Jones K, Timchenko NA, Timchenko L. GSK3? is a new therapeutic target for myotonic dystrophy type 1. Rare Dis. 2013; 1:e26555. PMID: 25003008; PMCID: PMC3927489.
    11. Jiang Y, Jin J, Iakova P, Hernandez JC, Jawanmardi N, Sullivan E, Guo GL, Timchenko NA, Darlington GJ. Farnesoid X receptor directly regulates xenobiotic detoxification genes in the long-lived Little mice. Mech Ageing Dev. 2013 Sep; 134(9):407-15. PMID: 24007921; PMCID: PMC3845407.
    12. Jin J, Iakova P, Jiang Y, Lewis K, Sullivan E, Jawanmardi N, Donehower L, Timchenko L, Timchenko NA. Transcriptional and translational regulation of C/EBP?-HDAC1 protein complexes controls different levels of p53, SIRT1, and PGC1? proteins at the early and late stages of liver cancer. J Biol Chem. 2013 May 17; 288(20):14451-62. PMID: 23564453; PMCID: PMC3656300.
    13. Jin J, Iakova P, Breaux M, Sullivan E, Jawanmardi N, Chen D, Jiang Y, Medrano EM, Timchenko NA. Increased expression of enzymes of triglyceride synthesis is essential for the development of hepatic steatosis. Cell Rep. 2013 Mar 28; 3(3):831-43. PMID: 23499441; PMCID: PMC3615099.
    14. Jiang Y, Iakova P, Jin J, Sullivan E, Sharin V, Hong IH, Anakk S, Mayor A, Darlington G, Finegold M, Moore D, Timchenko NA. Farnesoid X receptor inhibits gankyrin in mouse livers and prevents development of liver cancer. Hepatology. 2013 Mar; 57(3):1098-106. PMID: 23172628; PMCID: PMC3649861.
    15. Jones K, Wei C, Iakova P, Bugiardini E, Schneider-Gold C, Meola G, Woodgett J, Killian J, Timchenko NA, Timchenko LT. GSK3? mediates muscle pathology in myotonic dystrophy. J Clin Invest. 2012 Dec; 122(12):4461-72. PMID: 23160194; PMCID: PMC3533547.
    16. Jones K, Timchenko L, Timchenko NA. The role of CUGBP1 in age-dependent changes of liver functions. Ageing Res Rev. 2012 Sep; 11(4):442-9. PMID: 22446383; PMCID: PMC3610417.
    17. Jones K, Jin B, Iakova P, Huichalaf C, Sarkar P, Schneider-Gold C, Schoser B, Meola G, Shyu AB, Timchenko N, Timchenko L. RNA Foci, CUGBP1, and ZNF9 are the primary targets of the mutant CUG and CCUG repeats expanded in myotonic dystrophies type 1 and type 2. Am J Pathol. 2011 Nov; 179(5):2475-89. PMID: 21889481; PMCID: PMC3204036.
    18. Jin J, Iakova P, Jiang Y, Medrano EE, Timchenko NA. The reduction of SIRT1 in livers of old mice leads to impaired body homeostasis and to inhibition of liver proliferation. Hepatology. 2011 Sep 2; 54(3):989-98. PMID: 21638299; PMCID: PMC3242815.
    19. Haefliger S, Klebig C, Schaubitzer K, Schardt J, Timchenko N, Mueller BU, Pabst T. Protein disulfide isomerase blocks CEBPA translation and is up-regulated during the unfolded protein response in AML. Blood. 2011 Jun 2; 117(22):5931-40. PMID: 21471526; PMCID: PMC3293752.
    20. Jin J, Wang GL, Iakova P, Shi X, Haefliger S, Finegold M, Timchenko NA. Epigenetic changes play critical role in age-associated dysfunctions of the liver. Aging Cell. 2010 Oct; 9(5):895-910. PMID: 20698834; PMCID: PMC3046424.
    21. Iakova P, Timchenko L, Timchenko NA. Intracellular signaling and hepatocellular carcinoma. Semin Cancer Biol. 2011 Feb; 21(1):28-34. PMID: 20850540; PMCID: PMC3228644.
    22. Wang GL, Shi X, Haefliger S, Jin J, Major A, Iakova P, Finegold M, Timchenko NA. Elimination of C/EBPalpha through the ubiquitin-proteasome system promotes the development of liver cancer in mice. J Clin Invest. 2010 Jul; 120(7):2549-62. PMID: 20516642; PMCID: PMC2898600.
    23. Orellana D, Liu X, Wang GL, Jin J, Iakova P, Timchenko NA. Calmodulin controls liver proliferation via interactions with C/EBPbeta-LAP and C/EBPbeta-LIP. J Biol Chem. 2010 Jul 23; 285(30):23444-56. PMID: 20498378; PMCID: PMC2906335.
    24. Lin Q, Chen D, Timchenko NA, Medrano EE. SKI promotes Smad3 linker phosphorylations associated with the tumor-promoting trait of TGFbeta. Cell Cycle. 2010 May; 9(9):1684-9. PMID: 20404506; PMCID: PMC3235508.
    25. Huichalaf C, Sakai K, Jin B, Jones K, Wang GL, Schoser B, Schneider-Gold C, Sarkar P, Pereira-Smith OM, Timchenko N, Timchenko L. Expansion of CUG RNA repeats causes stress and inhibition of translation in myotonic dystrophy 1 (DM1) cells. FASEB J. 2010 Oct; 24(10):3706-19. PMID: 20479119; PMCID: PMC2996918.
    26. Chen D, Lin Q, Box N, Roop D, Ishii S, Matsuzaki K, Fan T, Hornyak TJ, Reed JA, Stavnezer E, Timchenko NA, Medrano EE. SKI knockdown inhibits human melanoma tumor growth in vivo. Pigment Cell Melanoma Res. 2009 Dec; 22(6):761-72. PMID: 19845874.
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    27. Willis-Martinez D, Richards HW, Timchenko NA, Medrano EE. Role of HDAC1 in senescence, aging, and cancer. Exp Gerontol. 2010 Apr; 45(4):279-85. PMID: 19818845; PMCID: PMC2838962.
    28. Jin J, Wang GL, Salisbury E, Timchenko L, Timchenko NA. GSK3beta-cyclin D3-CUGBP1-eIF2 pathway in aging and in myotonic dystrophy. Cell Cycle. 2009 Aug; 8(15):2356-9. PMID: 19571675.
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    29. Schardt JA, Eyholzer M, Timchenko NA, Mueller BU, Pabst T. Unfolded protein response suppresses CEBPA by induction of calreticulin in acute myeloid leukaemia. J Cell Mol Med. 2010 Jun; 14(6B):1509-19. PMID: 19659458; PMCID: PMC3829017.
    30. Salisbury E, Schoser B, Schneider-Gold C, Wang GL, Huichalaf C, Jin B, Sirito M, Sarkar P, Krahe R, Timchenko NA, Timchenko LT. Expression of RNA CCUG repeats dysregulates translation and degradation of proteins in myotonic dystrophy 2 patients. Am J Pathol. 2009 Aug; 175(2):748-62. PMID: 19590039; PMCID: PMC2716970.
    31. Jin J, Wang GL, Timchenko L, Timchenko NA. GSK3beta and aging liver. Aging (Albany NY). 2009 Jun; 1(6):582-5. PMID: 20157540; PMCID: PMC2806031.
    32. Jin J, Wang GL, Shi X, Darlington GJ, Timchenko NA. The age-associated decline of glycogen synthase kinase 3beta plays a critical role in the inhibition of liver regeneration. Mol Cell Biol. 2009 Jul; 29(14):3867-80. PMID: 19398579; PMCID: PMC2704742.
    33. Timchenko NA. Aging and liver regeneration. Trends Endocrinol Metab. 2009 May; 20(4):171-6. PMID: 19359195.
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    34. Wang GL, Salisbury E, Shi X, Timchenko L, Medrano EE, Timchenko NA. HDAC1 promotes liver proliferation in young mice via interactions with C/EBPbeta. J Biol Chem. 2008 Sep 19; 283(38):26179-87. PMID: 18622014; PMCID: PMC2533797.
    35. Wang GL, Salisbury E, Shi X, Timchenko L, Medrano EE, Timchenko NA. HDAC1 cooperates with C/EBPalpha in the inhibition of liver proliferation in old mice. J Biol Chem. 2008 Sep 19; 283(38):26169-78. PMID: 18622015; PMCID: PMC2533775.
    36. Wang GL, Shi X, Salisbury E, Timchenko NA. Regulation of apoptotic and growth inhibitory activities of C/EBPalpha in different cell lines. Exp Cell Res. 2008 Apr 15; 314(7):1626-39. PMID: 18313667; PMCID: PMC3228643.
    37. Harrison-Findik DD, Klein E, Crist C, Evans J, Timchenko N, Gollan J. Iron-mediated regulation of liver hepcidin expression in rats and mice is abolished by alcohol. Hepatology. 2007 Dec; 46(6):1979-85. PMID: 17763462.
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    38. Smith RG, Sun Y, Jiang H, Albarran-Zeckler R, Timchenko N. Ghrelin receptor (GHS-R1A) agonists show potential as interventive agents during aging. Ann N Y Acad Sci. 2007 Nov; 1119:147-64. PMID: 18056963.
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    39. Choi WT, Folsom MR, Azim MF, Meyer C, Kowarz E, Marschalek R, Timchenko NA, Naeem RC, Lee DA. C/EBPbeta suppression by interruption of CUGBP1 resulting from a complex rearrangement of MLL. Cancer Genet Cytogenet. 2007 Sep; 177(2):108-14. PMID: 17854664; PMCID: PMC3311538.
    40. Bandyopadhyay D, Curry JL, Lin Q, Richards HW, Chen D, Hornsby PJ, Timchenko NA, Medrano EE. Dynamic assembly of chromatin complexes during cellular senescence: implications for the growth arrest of human melanocytic nevi. Aging Cell. 2007 Aug; 6(4):577-91. PMID: 17578512; PMCID: PMC1974778.
    41. Huichalaf CH, Sakai K, Wang GL, Timchenko NA, Timchenko L. Regulation of the promoter of CUG triplet repeat binding protein, Cugbp1, during myogenesis. Gene. 2007 Jul 15; 396(2):391-402. PMID: 17531403.
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    42. Wang GL, Shi X, Salisbury E, Sun Y, Albrecht JH, Smith RG, Timchenko NA. Growth hormone corrects proliferation and transcription of phosphoenolpyruvate carboxykinase in livers of old mice via elimination of CCAAT/enhancer-binding protein alpha-Brm complex. J Biol Chem. 2007 Jan 12; 282(2):1468-78. PMID: 17107955.
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    43. Timchenko LT, Salisbury E, Wang GL, Nguyen H, Albrecht JH, Hershey JW, Timchenko NA. Age-specific CUGBP1-eIF2 complex increases translation of CCAAT/enhancer-binding protein beta in old liver. J Biol Chem. 2006 Oct 27; 281(43):32806-19. PMID: 16931514.
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    44. Lee YJ, Jones LC, Timchenko NA, Perrotti D, Tenen DG, Kogan SC. CCAAT/enhancer binding proteins alpha and epsilon cooperate with all-trans retinoic acid in therapy but differ in their antileukemic activities. Blood. 2006 Oct 1; 108(7):2416-9. PMID: 16788101; PMCID: PMC1895555.
    45. Karagiannides I, Thomou T, Tchkonia T, Pirtskhalava T, Kypreos KE, Cartwright A, Dalagiorgou G, Lash TL, Farmer SR, Timchenko NA, Kirkland JL. Increased CUG triplet repeat-binding protein-1 predisposes to impaired adipogenesis with aging. J Biol Chem. 2006 Aug 11; 281(32):23025-33. PMID: 16754681.
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    46. Harrison-Findik DD, Schafer D, Klein E, Timchenko NA, Kulaksiz H, Clemens D, Fein E, Andriopoulos B, Pantopoulos K, Gollan J. Alcohol metabolism-mediated oxidative stress down-regulates hepcidin transcription and leads to increased duodenal iron transporter expression. J Biol Chem. 2006 Aug 11; 281(32):22974-82. PMID: 16737972.
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    47. McFie PJ, Wang GL, Timchenko NA, Wilson HL, Hu X, Roesler WJ. Identification of a co-repressor that inhibits the transcriptional and growth-arrest activities of CCAAT/enhancer-binding protein alpha. J Biol Chem. 2006 Jun 30; 281(26):18069-80. PMID: 16644732.
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    48. Wang GL, Shi X, Salisbury E, Sun Y, Albrecht JH, Smith RG, Timchenko NA. Cyclin D3 maintains growth-inhibitory activity of C/EBPalpha by stabilizing C/EBPalpha-cdk2 and C/EBPalpha-Brm complexes. Mol Cell Biol. 2006 Apr; 26(7):2570-82. PMID: 16537903; PMCID: PMC1430318.
    49. Schwahn DJ, Timchenko NA, Shibahara S, Medrano EE. Dynamic regulation of the human dopachrome tautomerase promoter by MITF, ER-alpha and chromatin remodelers during proliferation and senescence of human melanocytes. Pigment Cell Res. 2005 Jun; 18(3):203-13. PMID: 15892717.
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    50. Helbling D, Mueller BU, Timchenko NA, Schardt J, Eyer M, Betts DR, Jotterand M, Meyer-Monard S, Fey MF, Pabst T. CBFB-SMMHC is correlated with increased calreticulin expression and suppresses the granulocytic differentiation factor CEBPA in AML with inv(16). Blood. 2005 Aug 15; 106(4):1369-75. PMID: 15855281.
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    51. Timchenko NA, Wang GL, Timchenko LT. RNA CUG-binding protein 1 increases translation of 20-kDa isoform of CCAAT/enhancer-binding protein beta by interacting with the alpha and beta subunits of eukaryotic initiation translation factor 2. J Biol Chem. 2005 May 27; 280(21):20549-57. PMID: 15788409.
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    52. Bales E, Mills L, Milam N, McGahren-Murray M, Bandyopadhyay D, Chen D, Reed JA, Timchenko N, van den Oord JJ, Bar-Eli M, Keyomarsi K, Medrano EE. The low molecular weight cyclin E isoforms augment angiogenesis and metastasis of human melanoma cells in vivo. Cancer Res. 2005 Feb 1; 65(3):692-7. PMID: 15705861.
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    53. Wang GL, Timchenko NA. Dephosphorylated C/EBPalpha accelerates cell proliferation through sequestering retinoblastoma protein. Mol Cell Biol. 2005 Feb; 25(4):1325-38. PMID: 15684384; PMCID: PMC548025.
    54. Helbling D, Mueller BU, Timchenko NA, Hagemeijer A, Jotterand M, Meyer-Monard S, Lister A, Rowley JD, Huegli B, Fey MF, Pabst T. The leukemic fusion gene AML1-MDS1-EVI1 suppresses CEBPA in acute myeloid leukemia by activation of Calreticulin. Proc Natl Acad Sci U S A. 2004 Sep 7; 101(36):13312-7. PMID: 15326310; PMCID: PMC516564.
    55. Baldwin BR, Timchenko NA, Zahnow CA. Epidermal growth factor receptor stimulation activates the RNA binding protein CUG-BP1 and increases expression of C/EBPbeta-LIP in mammary epithelial cells. Mol Cell Biol. 2004 May; 24(9):3682-91. PMID: 15082764; PMCID: PMC387752.
    56. Wang GL, Iakova P, Wilde M, Awad S, Timchenko NA. Liver tumors escape negative control of proliferation via PI3K/Akt-mediated block of C/EBP alpha growth inhibitory activity. Genes Dev. 2004 Apr 15; 18(8):912-25. PMID: 15107404; PMCID: PMC395850.
    57. Iakova P, Wang GL, Timchenko L, Michalak M, Pereira-Smith OM, Smith JR, Timchenko NA. Competition of CUGBP1 and calreticulin for the regulation of p21 translation determines cell fate. EMBO J. 2004 Jan 28; 23(2):406-17. PMID: 14726956; PMCID: PMC1271759.
    58. Timchenko NA, Patel R, Iakova P, Cai ZJ, Quan L, Timchenko LT. Overexpression of CUG triplet repeat-binding protein, CUGBP1, in mice inhibits myogenesis. J Biol Chem. 2004 Mar 26; 279(13):13129-39. PMID: 14722059.
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    59. Yan Y, Phan L, Yang F, Talpaz M, Yang Y, Xiong Z, Ng B, Timchenko NA, Wu CJ, Ritz J, Wang H, Yang XF. A novel mechanism of alternative promoter and splicing regulates the epitope generation of tumor antigen CML66-L. J Immunol. 2004 Jan 1; 172(1):651-60. PMID: 14688378; PMCID: PMC3901998.
    60. Timchenko NA. Old livers--C/EBPalpha meets new partners. Cell Cycle. 2003 Sep-Oct; 2(5):445-6. PMID: 12963839.
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    61. Iakova P, Awad SS, Timchenko NA. Aging reduces proliferative capacities of liver by switching pathways of C/EBPalpha growth arrest. Cell. 2003 May 16; 113(4):495-506. PMID: 12757710.
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    62. Timchenko LT, Iakova P, Welm AL, Cai ZJ, Timchenko NA. Calreticulin interacts with C/EBPalpha and C/EBPbeta mRNAs and represses translation of C/EBP proteins. Mol Cell Biol. 2002 Oct; 22(20):7242-57. PMID: 12242300; PMCID: PMC139801.
    63. Welm AL, Timchenko NA, Ono Y, Sorimachi H, Radomska HS, Tenen DG, Lekstrom-Himes J, Darlington GJ. C/EBPalpha is required for proteolytic cleavage of cyclin A by calpain 3 in myeloid precursor cells. J Biol Chem. 2002 Sep 13; 277(37):33848-56. PMID: 12105198.
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    64. Rickheim DG, Nelsen CJ, Fassett JT, Timchenko NA, Hansen LK, Albrecht JH. Differential regulation of cyclins D1 and D3 in hepatocyte proliferation. Hepatology. 2002 Jul; 36(1):30-8. PMID: 12085346.
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    65. Wang H, Goode T, Iakova P, Albrecht JH, Timchenko NA. C/EBPalpha triggers proteasome-dependent degradation of cdk4 during growth arrest. EMBO J. 2002 Mar 1; 21(5):930-41. PMID: 11867521; PMCID: PMC125893.
    66. Nelsen CJ, Rickheim DG, Timchenko NA, Stanley MW, Albrecht JH. Transient expression of cyclin D1 is sufficient to promote hepatocyte replication and liver growth in vivo. Cancer Res. 2001 Dec 1; 61(23):8564-8. PMID: 11731443.
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    67. Wang H, Iakova P, Wilde M, Welm A, Goode T, Roesler WJ, Timchenko NA. C/EBPalpha arrests cell proliferation through direct inhibition of Cdk2 and Cdk4. Mol Cell. 2001 Oct; 8(4):817-28. PMID: 11684017.
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    68. Timchenko NA, Iakova P, Cai ZJ, Smith JR, Timchenko LT. Molecular basis for impaired muscle differentiation in myotonic dystrophy. Mol Cell Biol. 2001 Oct; 21(20):6927-38. PMID: 11564876; PMCID: PMC99869.
    69. Leung JK, Berube N, Venable S, Ahmed S, Timchenko N, Pereira-Smith OM. MRG15 activates the B-myb promoter through formation of a nuclear complex with the retinoblastoma protein and the novel protein PAM14. J Biol Chem. 2001 Oct 19; 276(42):39171-8. PMID: 11500496.
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    70. Bandyopadhyay D, Timchenko N, Suwa T, Hornsby PJ, Campisi J, Medrano EE. The human melanocyte: a model system to study the complexity of cellular aging and transformation in non-fibroblastic cells. Exp Gerontol. 2001 Aug; 36(8):1265-75. PMID: 11602203.
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    71. Timchenko NA, Cai ZJ, Welm AL, Reddy S, Ashizawa T, Timchenko LT. RNA CUG repeats sequester CUGBP1 and alter protein levels and activity of CUGBP1. J Biol Chem. 2001 Mar 16; 276(11):7820-6. PMID: 11124939.
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    72. Welm AL, Mackey SL, Timchenko LT, Darlington GJ, Timchenko NA. Translational induction of liver-enriched transcriptional inhibitory protein during acute phase response leads to repression of CCAAT/enhancer binding protein alpha mRNA. J Biol Chem. 2000 Sep 1; 275(35):27406-13. PMID: 10854425.
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    73. Timchenko NA, Welm AL, Lu X, Timchenko LT. CUG repeat binding protein (CUGBP1) interacts with the 5' region of C/EBPbeta mRNA and regulates translation of C/EBPbeta isoforms. Nucleic Acids Res. 1999 Nov 15; 27(22):4517-25. PMID: 10536163; PMCID: PMC148737.
    74. Timchenko NA, Wilde M, Iakova P, Albrecht JH, Darlington GJ. E2F/p107 and E2F/p130 complexes are regulated by C/EBPalpha in 3T3-L1 adipocytes. Nucleic Acids Res. 1999 Sep 1; 27(17):3621-30. PMID: 10446255; PMCID: PMC148609.
    75. Timchenko NA, Wilde M, Darlington GJ. C/EBPalpha regulates formation of S-phase-specific E2F-p107 complexes in livers of newborn mice. Mol Cell Biol. 1999 Apr; 19(4):2936-45. PMID: 10082561; PMCID: PMC84088.
    76. Welm AL, Timchenko NA, Darlington GJ. C/EBPalpha regulates generation of C/EBPbeta isoforms through activation of specific proteolytic cleavage. Mol Cell Biol. 1999 Mar; 19(3):1695-704. PMID: 10022857; PMCID: PMC83963.
    77. Burgess-Beusse BL, Timchenko NA, Darlington GJ. CCAAT/enhancer binding protein alpha (C/EBPalpha) is an important mediator of mouse C/EBPbeta protein isoform production. Hepatology. 1999 Feb; 29(2):597-601. PMID: 9918941.
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    78. Lu X, Timchenko NA, Timchenko LT. Cardiac elav-type RNA-binding protein (ETR-3) binds to RNA CUG repeats expanded in myotonic dystrophy. Hum Mol Genet. 1999 Jan; 8(1):53-60. PMID: 9887331.
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    79. Timchenko NA, Wilde M, Kosai KI, Heydari A, Bilyeu TA, Finegold MJ, Mohamedali K, Richardson A, Darlington GJ. Regenerating livers of old rats contain high levels of C/EBPalpha that correlate with altered expression of cell cycle associated proteins. Nucleic Acids Res. 1998 Jul 1; 26(13):3293-9. PMID: 9628932; PMCID: PMC147695.
    80. Timchenko NA, Harris TE, Wilde M, Bilyeu TA, Burgess-Beusse BL, Finegold MJ, Darlington GJ. CCAAT/enhancer binding protein alpha regulates p21 protein and hepatocyte proliferation in newborn mice. Mol Cell Biol. 1997 Dec; 17(12):7353-61. PMID: 9372966; PMCID: PMC232591.
    81. Roberts R, Timchenko NA, Miller JW, Reddy S, Caskey CT, Swanson MS, Timchenko LT. Altered phosphorylation and intracellular distribution of a (CUG)n triplet repeat RNA-binding protein in patients with myotonic dystrophy and in myotonin protein kinase knockout mice. Proc Natl Acad Sci U S A. 1997 Nov 25; 94(24):13221-6. PMID: 9371827; PMCID: PMC24290.
    82. Timchenko LT, Miller JW, Timchenko NA, DeVore DR, Datar KV, Lin L, Roberts R, Caskey CT, Swanson MS. Identification of a (CUG)n triplet repeat RNA-binding protein and its expression in myotonic dystrophy. Nucleic Acids Res. 1996 Nov 15; 24(22):4407-14. PMID: 8948631; PMCID: PMC146274.
    83. Timchenko NA, Wilde M, Nakanishi M, Smith JR, Darlington GJ. CCAAT/enhancer-binding protein alpha (C/EBP alpha) inhibits cell proliferation through the p21 (WAF-1/CIP-1/SDI-1) protein. Genes Dev. 1996 Apr 1; 10(7):804-15. PMID: 8846917.
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    84. Timchenko LT, Timchenko NA, Caskey CT, Roberts R. Novel proteins with binding specificity for DNA CTG repeats and RNA CUG repeats: implications for myotonic dystrophy. Hum Mol Genet. 1996 Jan; 5(1):115-21. PMID: 8789448.
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    85. Timchenko N, Wilson DR, Taylor LR, Abdelsayed S, Wilde M, Sawadogo M, Darlington GJ. Autoregulation of the human C/EBP alpha gene by stimulation of upstream stimulatory factor binding. Mol Cell Biol. 1995 Mar; 15(3):1192-202. PMID: 7862113; PMCID: PMC230342.
    86. Timchenko NA, Zhuchenko OP, Timchenko LT, Iguchi-Ariga SM, Ariga H, Bozhkov VM, Tomilin NV. Rat DNA sequence associated with a complex form of DNA polymerase alpha in nonregenerating liver interacts with a ubiquitous transcription/replication factor Oct-1. Biomed Sci. 1991; 2(6):595-600. PMID: 1841628.
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    87. Zhuchenko OP, Timchenko LT, Timchenko NA. [Increased expression of genes coding for replication proteins during the period of DNA synthesis]. Mol Biol (Mosk). 1990 May-Jun; 24(3):824-31. PMID: 2402240.
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    88. Timchenko NA, Shcherbakov OG, Krutiakov VM, Filatov MV. [Autonomic replication of plasmids containing DNA fragments from rat liver alpha-polymerase complex]. Mol Biol (Mosk). 1990 May-Jun; 24(3):814-23. PMID: 2169584.
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    89. Timchenko NA, Beliakova NV, Timchenko LT, Krutiakov VM. [Characteristics of DNA isolated from a complex form of DNA-polymerase alpha from the rat liver]. Mol Biol (Mosk). 1989 Jul-Aug; 23(4):1171-6. PMID: 2586509.
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    90. Timchenko NA, Shevelev IV, Drobchenko SN, Zhuchenko OP, Krutiakov VM. [Isolation and characteristics of endonuclease tightly bound to alpha-polymerase from the rat liver]. Mol Biol (Mosk). 1988 Jul-Aug; 22(4):976-83. PMID: 2847024.
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    91. Timchenko LT, Timchenko NA, Giliano NV, Noskin LA. [Increase in gene expression in the rat liver following whole body x-irradiation]. Radiobiologiia. 1988 Mar-Apr; 28(2):166-71. PMID: 3283822.
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    92. Timchenko NA, Timchenko LT, Bilobrov SV, Zhuchenko OP, Krutiakov VM. [Identification and characteristics of mRNA's showing increased levels during DNA replication]. Mol Biol (Mosk). 1987 May-Jun; 21(3):640-6. PMID: 3657765.
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    93. Baranov VS, Schwartzman AL, Gorbunova VN, Gaitskhoki VS, Rubtsov NB, Timchenko NA, Neifakh SA. Chromosomal localization of ceruloplasmin and transferrin genes in laboratory rats, mice and in man by hybridization with specific DNA probes. Chromosoma. 1987; 96(1):60-6. PMID: 3436225.
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    94. Timchenko NA, Timchenko LT, Krutiakov VM. [Cloning of mRNA nucleotide sequences amplified during DNA replication in the regenerating liver]. Mol Gen Mikrobiol Virusol. 1986 Dec; (12):23-5. PMID: 3027553.
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    95. Baranov VS, Shvartsman AL, Gorbunova VN, Ryskov AP, Timchenko NA. [Mapping of the transferrin gene in laboratory rats, mice and man by direct in situ hybridization]. Genetika. 1984 Oct; 20(10):1584-93. PMID: 6548721.
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    96. Ryskov AP, Timchenko NA, Timchenko LT, Salikhov TA, Ga?tsokhi VS. [Cloning of double-stranded DNA--a transcript of rat transferrin mRNA]. Mol Biol (Mosk). 1984 Jan-Feb; 18(1):104-14. PMID: 6200763.
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    97. Timchenko NA, Timchenko LT, Shvartsman AL, Salikhov TA, Ga?tskhoki VS. [Transferrin mRNA from the rat liver]. Mol Biol (Mosk). 1983 Mar-Apr; 17(2):322-9. PMID: 6687919.
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    98. Gaitskhoki VS, Timchenko NA, Timchenko LT, Puchkova LV, Aslanov KhA. [Biosynthesis and post-translational maturation of transferrin in subcellular fractions of rat liver]. Biokhimiia. 1982 Jan; 47(1):13-8. PMID: 7066415.
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    99. Ga?tskhoki VS, Timchenko NA, Timchenko LT, Puchkova LV, Aslanov KhA. [Properties of rat liver polyribosomes synthesizing transferrin]. Biokhimiia. 1981 Aug; 46(8):1426-34. PMID: 7272363.
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