Keywords
Last Name
Institution

TSZ-KWONG MAN

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pediatrics
AddressONE BAYLOR PLAZA
HOUSTON TX 77030
vCardDownload vCard

    Collapse Additional Tools and Researcher Information 
    Collapse Websites
    Collapse Faculty Mentor
    Collapse Aliases
    Collapse Verify Publications

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Davis CF, Ritter DI, Wheeler DA, Wang H, Ding Y, Dugan SP, Bainbridge MN, Muzny DM, Rao PH, Man TK, Plon SE, Gibbs RA, Lau CC. SV-STAT accurately detects structural variation via alignment to reference-based assemblies. Source Code Biol Med. 2016; 11:8. PMID: 27330550; PMCID: PMC4913042.
    2. Li Y, Nakka M, Kelly AJ, Lau CC, Krailo M, Barkauskas DA, Hicks JM, Man TK. p27 is a Candidate Prognostic Biomarker and Metastatic Promoter in Osteosarcoma. Cancer Res. 2016 Apr 19. PMID: 27197201.
      View in: PubMed
    3. Rao PH, Zhao S, Zhao YJ, Yu A, Rainusso N, Trucco M, Allen-Rhoades W, Satterfield L, Fuja D, Borra VJ, Man TK, Donehower LA, Yustein JT. Coamplification of Myc/Pvt1 and homozygous deletion of Nlrp1 locus are frequent genetics changes in mouse osteosarcoma. Genes Chromosomes Cancer. 2015 Dec; 54(12):796-808. PMID: 26355645.
      View in: PubMed
    4. Long X, Yu Y, Perlaky L, Man TK, Redell MS. Stromal CYR61 Confers Resistance to Mitoxantrone via Spleen Tyrosine Kinase Activation in Human Acute Myeloid Leukaemia. Br J Haematol. 2015 May 14. PMID: 25974135.
      View in: PubMed
    5. Zhao S, Kurenbekova L, Gao Y, Roos A, Creighton CJ, Rao P, Hicks J, Man TK, Lau C, Brown AM, Jones SN, Lazar AJ, Ingram D, Lev D, Donehower LA, Yustein JT. NKD2, a negative regulator of Wnt signaling, suppresses tumor growth and metastasis in osteosarcoma. Oncogene. 2015 Sep 24; 34(39):5069-79. PMID: 25579177; PMCID: PMC4802362.
    6. Baxter PA, Lin Q, Mao H, Kogiso M, Zhao X, Liu Z, Huang Y, Voicu H, Gurusiddappa S, Su JM, Adesina AM, Perlaky L, Dauser RC, Leung HC, Muraszko KM, Heth JA, Fan X, Lau CC, Man TK, Chintagumpala M, Li XN. Silencing BMI1 eliminates tumor formation of pediatric glioma CD133+ cells not by affecting known targets but by down-regulating a novel set of core genes. Acta Neuropathol Commun. 2014; 2:160. PMID: 25526772; PMCID: PMC4289398.
    7. Teo WY, Elghetany MT, Shen J, Man TK, Li X, Chintagumpala M, Su JM, Dauser R, Whitehead W, Adesina AM, Lau CC. Therapeutic implications of CD1d expression and tumor-infiltrating macrophages in pediatric medulloblastomas. J Neurooncol. 2014 Nov; 120(2):293-301. PMID: 25115738.
      View in: PubMed
    8. Liu Z, Zhao X, Wang Y, Mao H, Huang Y, Kogiso M, Qi L, Baxter PA, Man TK, Adesina A, Su JM, Picard D, Ching Ho K, Huang A, Perlaky L, Lau CC, Chintagumpala M, Li XN. A patient tumor-derived orthotopic xenograft mouse model replicating the group 3 supratentorial primitive neuroectodermal tumor in children. Neuro Oncol. 2014 Jun; 16(6):787-99. PMID: 24470556; PMCID: PMC4022216.
    9. Barbieri E, De Preter K, Capasso M, Johansson P, Man TK, Chen Z, Stowers P, Tonini GP, Speleman F, Shohet JM. A p53 drug response signature identifies prognostic genes in high-risk neuroblastoma. PLoS One. 2013; 8(11):e79843. PMID: 24348903; PMCID: PMC3865347.
    10. Terashima K, Yu A, Chow WY, Hsu WC, Chen P, Wong S, Hung YS, Suzuki T, Nishikawa R, Matsutani M, Nakamura H, Ng HK, Allen JC, Aldape KD, Su JM, Adesina AM, Leung HC, Man TK, Lau CC. Genome-wide analysis of DNA copy number alterations and loss of heterozygosity in intracranial germ cell tumors. Pediatr Blood Cancer. 2014 Apr; 61(4):593-600. PMID: 24249158.
      View in: PubMed
    11. Chen P, Fan Y, Man TK, Hung YS, Lau CC, Wong ST. A gene signature based method for identifying subtypes and subtype-specific drivers in cancer with an application to medulloblastoma. BMC Bioinformatics. 2013; 14 Suppl 18:S1. PMID: 24564171; PMCID: PMC3820164.
    12. Teo WY, Shen J, Su JM, Yu A, Wang J, Chow WY, Li X, Jones J, Dauser R, Whitehead W, Adesina AM, Chintagumpala M, Man TK, Lau CC. Implications of tumor location on subtypes of medulloblastoma. Pediatr Blood Cancer. 2013 Sep; 60(9):1408-10. PMID: 23512859.
      View in: PubMed
    13. Flores RJ, Li Y, Yu A, Shen J, Rao PH, Lau SS, Vannucci M, Lau CC, Man TK. A systems biology approach reveals common metastatic pathways in osteosarcoma. BMC Syst Biol. 2012; 6:50. PMID: 22640921; PMCID: PMC3431263.
    14. Li Y, Dang TA, Man TK. Plasma proteomic profiling of pediatric osteosarcoma. Methods Mol Biol. 2012; 818:81-96. PMID: 22083817.
      View in: PubMed
    15. Egler RA, Li Y, Dang TA, Peters TL, Leung E, Huang S, Russell HV, Liu H, Man TK. An integrated proteomic approach to identifying circulating biomarkers in high-risk neuroblastoma and their potential in relapse monitoring. Proteomics Clin Appl. 2011 Oct; 5(9-10):532-41. PMID: 21833997; PMCID: PMC3685293.
    16. Rainusso N, Man TK, Lau CC, Hicks J, Shen JJ, Yu A, Wang LL, Rosen JM. Identification and gene expression profiling of tumor-initiating cells isolated from human osteosarcoma cell lines in an orthotopic mouse model. Cancer Biol Ther. 2011 Aug 15; 12(4):278-87. PMID: 21617384; PMCID: PMC3173730.
    17. Daves MH, Hilsenbeck SG, Lau CC, Man TK. Meta-analysis of multiple microarray datasets reveals a common gene signature of metastasis in solid tumors. BMC Med Genomics. 2011; 4:56. PMID: 21736749; PMCID: PMC3212952.
    18. Guo B, Villagran A, Vannucci M, Wang J, Davis C, Man TK, Lau C, Guerra R. Bayesian estimation of genomic copy number with single nucleotide polymorphism genotyping arrays. BMC Res Notes. 2010; 3:350. PMID: 21192799; PMCID: PMC3023756.
    19. Li Y, Dang TA, Shen J, Hicks J, Chintagumpala M, Lau CC, Man TK. Plasma proteome predicts chemotherapy response in osteosarcoma patients. Oncol Rep. 2011 Feb; 25(2):303-14. PMID: 21165584.
      View in: PubMed
    20. Li Y, Flores R, Yu A, Okcu MF, Murray J, Chintagumpala M, Hicks J, Lau CC, Man TK. Elevated expression of CXC chemokines in pediatric osteosarcoma patients. Cancer. 2011 Jan 1; 117(1):207-17. PMID: 20806347; PMCID: PMC2997117.
    21. Allen CE, Li L, Peters TL, Leung HC, Yu A, Man TK, Gurusiddappa S, Phillips MT, Hicks MJ, Gaikwad A, Merad M, McClain KL. Cell-specific gene expression in Langerhans cell histiocytosis lesions reveals a distinct profile compared with epidermal Langerhans cells. J Immunol. 2010 Apr 15; 184(8):4557-67. PMID: 20220088; PMCID: PMC3142675.
    22. Yu L, Baxter PA, Voicu H, Gurusiddappa S, Zhao Y, Adesina A, Man TK, Shu Q, Zhang YJ, Zhao XM, Su JM, Perlaky L, Dauser R, Chintagumpala M, Lau CC, Blaney SM, Rao PH, Leung HC, Li XN. A clinically relevant orthotopic xenograft model of ependymoma that maintains the genomic signature of the primary tumor and preserves cancer stem cells in vivo. Neuro Oncol. 2010 Jun; 12(6):580-94. PMID: 20511191; PMCID: PMC2940646.
    23. Ma O, Cai WW, Zender L, Dayaram T, Shen J, Herron AJ, Lowe SW, Man TK, Lau CC, Donehower LA. MMP13, Birc2 (cIAP1), and Birc3 (cIAP2), amplified on chromosome 9, collaborate with p53 deficiency in mouse osteosarcoma progression. Cancer Res. 2009 Mar 15; 69(6):2559-67. PMID: 19276372; PMCID: PMC2663905.
    24. Cruz-Marcelo A, Guerra R, Vannucci M, Li Y, Lau CC, Man TK. Comparison of algorithms for pre-processing of SELDI-TOF mass spectrometry data. Bioinformatics. 2008 Oct 1; 24(19):2129-36. PMID: 18694894; PMCID: PMC2553436.
    25. Rabin KR, Man TK, Yu A, Folsom MR, Zhao YJ, Rao PH, Plon SE, Naeem RC. Clinical utility of array comparative genomic hybridization for detection of chromosomal abnormalities in pediatric acute lymphoblastic leukemia. Pediatr Blood Cancer. 2008 Aug; 51(2):171-7. PMID: 18253961; PMCID: PMC4063297.
    26. Rabin K, Man TK, Lau CC. Personalized care of pediatric cancer patients. Nestle Nutr Workshop Ser Pediatr Program. 2008; 62:173-85; discussion 185-8. PMID: 18626200.
      View in: PubMed
    27. Gu JX, Wei MY, Rao PH, Lau CC, Behl S, Man TK. CGI: Java software for mapping and visualizing data from array-based comparative genomic hybridization and expression profiling. Gene Regul Syst Bio. 2007; 1:131-6. PMID: 19936083; PMCID: PMC2759124.
    28. De Bortoli M, Castellino RC, Skapura DG, Shen JJ, Su JM, Russell HV, Hicks MJ, Man TK, Kim JY. Patched haploinsufficient mouse rhabdomyosarcoma overexpress secreted phosphoprotein 1 and matrix metalloproteinases. Eur J Cancer. 2007 May; 43(8):1308-17. PMID: 17467979.
      View in: PubMed
    29. Dang TA, Man TK. Classification of sarcomas using bioinformatics and molecular profiling. Curr Pharm Biotechnol. 2007 Apr; 8(2):83-91. PMID: 17430156.
      View in: PubMed
    30. De Bortoli M, Castellino RC, Lu XY, Deyo J, Sturla LM, Adesina AM, Perlaky L, Pomeroy SL, Lau CC, Man TK, Rao PH, Kim JY. Medulloblastoma outcome is adversely associated with overexpression of EEF1D, RPL30, and RPS20 on the long arm of chromosome 8. BMC Cancer. 2006; 6:223. PMID: 16968546; PMCID: PMC1578584.
    31. Li Y, Dang TA, Shen J, Perlaky L, Hicks J, Murray J, Meyer W, Chintagumpala M, Lau CC, Man TK. Identification of a plasma proteomic signature to distinguish pediatric osteosarcoma from benign osteochondroma. Proteomics. 2006 Jun; 6(11):3426-35. PMID: 16673437.
      View in: PubMed
    32. Man TK, Li Y, Dang TA, Shen J, Perlaky L, Lau CC. Optimising the use of TRIzol-extracted proteins in surface enhanced laser desorption/ ionization (SELDI) analysis. Proteome Sci. 2006; 4:3. PMID: 16556310; PMCID: PMC1440846.
    33. Man TK, Chintagumpala M, Visvanathan J, Shen J, Perlaky L, Hicks J, Johnson M, Davino N, Murray J, Helman L, Meyer W, Triche T, Wong KK, Lau CC. Expression profiles of osteosarcoma that can predict response to chemotherapy. Cancer Res. 2005 Sep 15; 65(18):8142-50. PMID: 16166288.
      View in: PubMed
    34. Man TK, Lu XY, Jaeweon K, Perlaky L, Harris CP, Shah S, Ladanyi M, Gorlick R, Lau CC, Rao PH. Genome-wide array comparative genomic hybridization analysis reveals distinct amplifications in osteosarcoma. BMC Cancer. 2004 Aug 7; 4:45. PMID: 15298715; PMCID: PMC514550.
    35. Man TK, Yang JS, Stormo GD. Quantitative modeling of DNA-protein interactions: effects of amino acid substitutions on binding specificity of the Mnt repressor. Nucleic Acids Res. 2004; 32(13):4026-32. PMID: 15289576; PMCID: PMC506813.
    36. Wong KK, Tsang YT, Shen J, Cheng RS, Chang YM, Man TK, Lau CC. Allelic imbalance analysis by high-density single-nucleotide polymorphic allele (SNP) array with whole genome amplified DNA. Nucleic Acids Res. 2004; 32(9):e69. PMID: 15148342; PMCID: PMC419627.
    37. Man TK, Stormo GD. Non-independence of Mnt repressor-operator interaction determined by a new quantitative multiple fluorescence relative affinity (QuMFRA) assay. Nucleic Acids Res. 2001 Jun 15; 29(12):2471-8. PMID: 11410653; PMCID: PMC55749.
    38. Harris ZL, Durley AP, Man TK, Gitlin JD. Targeted gene disruption reveals an essential role for ceruloplasmin in cellular iron efflux. Proc Natl Acad Sci U S A. 1999 Sep 14; 96(19):10812-7. PMID: 10485908; PMCID: PMC17965.
    39. Yang Y, Zhao G, Man TK, Winkler ME. Involvement of the gapA- and epd (gapB)-encoded dehydrogenases in pyridoxal 5'-phosphate coenzyme biosynthesis in Escherichia coli K-12. J Bacteriol. 1998 Aug; 180(16):4294-9. PMID: 9696782; PMCID: PMC107430.
    40. Yang Y, Tsui HC, Man TK, Winkler ME. Identification and function of the pdxY gene, which encodes a novel pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate biosynthesis in Escherichia coli K-12. J Bacteriol. 1998 Apr; 180(7):1814-21. PMID: 9537380; PMCID: PMC107095.
    41. Man TK, Pease AJ, Winkler ME. Maximization of transcription of the serC (pdxF)-aroA multifunctional operon by antagonistic effects of the cyclic AMP (cAMP) receptor protein-cAMP complex and Lrp global regulators of Escherichia coli K-12. J Bacteriol. 1997 Jun; 179(11):3458-69. PMID: 9171388; PMCID: PMC179136.
    42. Man TK, Zhao G, Winkler ME. Isolation of a pdxJ point mutation that bypasses the requirement for the PdxH oxidase in pyridoxal 5' -phosphate coenzyme biosynthesis in Escherichia coli K-12. J Bacteriol. 1996 Apr; 178(8):2445-9. PMID: 8636054; PMCID: PMC177961.
    43. Cheung AN, Srivastava G, Chung LP, Ngan HY, Man TK, Liu YT, Chen WZ, Collins RJ, Wong LC, Ma HK. Expression of the p53 gene in trophoblastic cells in hydatidiform moles and normal human placentas. J Reprod Med. 1994 Mar; 39(3):223-7. PMID: 8035377.
      View in: PubMed
    44. Cheung AN, Srivastava G, Pittaluga S, Man TK, Ngan H, Collins RJ. Expression of c-myc and c-fms oncogenes in trophoblastic cells in hydatidiform mole and normal human placenta. J Clin Pathol. 1993 Mar; 46(3):204-7. PMID: 8463412; PMCID: PMC501170.
    MAN's Networks
    Click the "See All" links for more information and interactive visualizations!
    Concepts Expand Description
    _
    Co-Authors Expand Description
    _
    Similar People Expand Description
    _
    Same Department Expand Description
    Physical Neighbors Expand Description
    _