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RONALD T JAVIER

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular Virology & Microbiology
AddressONE BAYLOR PLAZA
HOUSTON TX 77030
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Kong K, Kumar M, Taruishi M, Javier RT. Adenovirus E4-ORF1 Dysregulates Epidermal Growth Factor and Insulin/Insulin-Like Growth Factor Receptors To Mediate Constitutive Myc Expression. J Virol. 2015 Nov; 89(21):10774-85. PMID: 26269183.
      View in: PubMed
    2. Kumar M, Kong K, Javier RT. Hijacking Dlg1 for oncogenic phosphatidylinositol 3-kinase activation in human epithelial cells is a conserved mechanism of human adenovirus E4-ORF1 proteins. J Virol. 2014 Dec; 88(24):14268-77. PMID: 25253337; PMCID: PMC4249130.
    3. Kong K, Kumar M, Taruishi M, Javier RT. The human adenovirus E4-ORF1 protein subverts discs large 1 to mediate membrane recruitment and dysregulation of phosphatidylinositol 3-kinase. PLoS Pathog. 2014 May; 10(5):e1004102. PMID: 24788832; PMCID: PMC4006922.
    4. Irvin-Wilson CV, Newberg JY, Kong K, Javier RT, Marriott SJ. High throughput method to quantify anterior-posterior polarity of T-cells and epithelial cells. Viruses. 2011 Dec; 3(12):2396-411. PMID: 22355445; PMCID: PMC3280515.
    5. Golebiewski L, Liu H, Javier RT, Rice AP. The avian influenza virus NS1 ESEV PDZ binding motif associates with Dlg1 and Scribble to disrupt cellular tight junctions. J Virol. 2011 Oct; 85(20):10639-48. PMID: 21849460; PMCID: PMC3187509.
    6. Javier RT, Rice AP. Emerging theme: cellular PDZ proteins as common targets of pathogenic viruses. J Virol. 2011 Nov; 85(22):11544-56. PMID: 21775458; PMCID: PMC3209276.
    7. Ivanova S, Gregorc U, Vidergar N, Javier R, Bredt DS, Vandenabeele P, Pardo J, Simon MM, Turk V, Banks L, Turk B. MAGUKs, scaffolding proteins at cell junctions, are substrates of different proteases during apoptosis. Cell Death Dis. 2011; 2:e116. PMID: 21368887; PMCID: PMC3077288.
    8. Liu H, Golebiewski L, Dow EC, Krug RM, Javier RT, Rice AP. The ESEV PDZ-binding motif of the avian influenza A virus NS1 protein protects infected cells from apoptosis by directly targeting Scribble. J Virol. 2010 Nov; 84(21):11164-74. PMID: 20702615; PMCID: PMC2953166.
    9. Javier RT. Cell polarity proteins: common targets for tumorigenic human viruses. Oncogene. 2008 Nov 24; 27(55):7031-46. PMID: 19029943; PMCID: PMC3501650.
    10. Javier RT, Butel JS. The history of tumor virology. Cancer Res. 2008 Oct 1; 68(19):7693-706. PMID: 18829521; PMCID: PMC3501656.
    11. Chung SH, Weiss RS, Frese KK, Prasad BV, Javier RT. Functionally distinct monomers and trimers produced by a viral oncoprotein. Oncogene. 2008 Feb 28; 27(10):1412-20. PMID: 17828302; PMCID: PMC3471668.
    12. Chung SH, Frese KK, Weiss RS, Prasad BV, Javier RT. A new crucial protein interaction element that targets the adenovirus E4-ORF1 oncoprotein to membrane vesicles. J Virol. 2007 May; 81(9):4787-97. PMID: 17314165; PMCID: PMC1900153.
    13. Gregorc U, Ivanova S, Thomas M, Guccione E, Glaunsinger B, Javier R, Turk V, Banks L, Turk B. Cleavage of MAGI-1, a tight junction PDZ protein, by caspases is an important step for cell-cell detachment in apoptosis. Apoptosis. 2007 Feb; 12(2):343-54. PMID: 17191119; PMCID: PMC3501654.
    14. Frese KK, Latorre IJ, Chung SH, Caruana G, Bernstein A, Jones SN, Donehower LA, Justice MJ, Garner CC, Javier RT. Oncogenic function for the Dlg1 mammalian homolog of the Drosophila discs-large tumor suppressor. EMBO J. 2006 Mar 22; 25(6):1406-17. PMID: 16511562; PMCID: PMC1422156.
    15. Singh D, Solan JL, Taffet SM, Javier R, Lampe PD. Connexin 43 interacts with zona occludens-1 and -2 proteins in a cell cycle stage-specific manner. J Biol Chem. 2005 Aug 26; 280(34):30416-21. PMID: 15980428; PMCID: PMC3501655.
    16. Lee OK, Frese KK, James JS, Chadda D, Chen ZH, Javier RT, Cho KO. Discs-Large and Strabismus are functionally linked to plasma membrane formation. Nat Cell Biol. 2003 Nov; 5(11):987-93. PMID: 14562058; PMCID: PMC3471657.
    17. Frese KK, Lee SS, Thomas DL, Latorre IJ, Weiss RS, Glaunsinger BA, Javier RT. Selective PDZ protein-dependent stimulation of phosphatidylinositol 3-kinase by the adenovirus E4-ORF1 oncoprotein. Oncogene. 2003 Feb 6; 22(5):710-21. PMID: 12569363; PMCID: PMC3501958.
    18. Kimber WA, Trinkle-Mulcahy L, Cheung PC, Deak M, Marsden LJ, Kieloch A, Watt S, Javier RT, Gray A, Downes CP, Lucocq JM, Alessi DR. Evidence that the tandem-pleckstrin-homology-domain-containing protein TAPP1 interacts with Ptd(3,4)P2 and the multi-PDZ-domain-containing protein MUPP1 in vivo. Biochem J. 2002 Feb 1; 361(Pt 3):525-36. PMID: 11802782; PMCID: PMC1222335.
    19. Glaunsinger BA, Weiss RS, Lee SS, Javier R. Link of the unique oncogenic properties of adenovirus type 9 E4-ORF1 to a select interaction with the candidate tumor suppressor protein ZO-2. EMBO J. 2001 Oct 15; 20(20):5578-86. PMID: 11598001; PMCID: PMC125668.
    20. Thomas M, Glaunsinger B, Pim D, Javier R, Banks L. HPV E6 and MAGUK protein interactions: determination of the molecular basis for specific protein recognition and degradation. Oncogene. 2001 Sep 6; 20(39):5431-9. PMID: 11571640; PMCID: PMC3072467.
    21. Thomas DL, Schaack J, Vogel H, Javier R. Several E4 region functions influence mammary tumorigenesis by human adenovirus type 9. J Virol. 2001 Jan; 75(2):557-68. PMID: 11134268; PMCID: PMC113951.
    22. Glaunsinger BA, Lee SS, Thomas M, Banks L, Javier R. Interactions of the PDZ-protein MAGI-1 with adenovirus E4-ORF1 and high-risk papillomavirus E6 oncoproteins. Oncogene. 2000 Nov 2; 19(46):5270-80. PMID: 11077444; PMCID: PMC3072458.
    23. Lee SS, Glaunsinger B, Mantovani F, Banks L, Javier RT. Multi-PDZ domain protein MUPP1 is a cellular target for both adenovirus E4-ORF1 and high-risk papillomavirus type 18 E6 oncoproteins. J Virol. 2000 Oct; 74(20):9680-93. PMID: 11000240; PMCID: PMC112400.
    24. Barritt DS, Pearn MT, Zisch AH, Lee SS, Javier RT, Pasquale EB, Stallcup WB. The multi-PDZ domain protein MUPP1 is a cytoplasmic ligand for the membrane-spanning proteoglycan NG2. J Cell Biochem. 2000 Aug 2; 79(2):213-24. PMID: 10967549; PMCID: PMC3501957.
    25. Pim D, Thomas M, Javier R, Gardiol D, Banks L. HPV E6 targeted degradation of the discs large protein: evidence for the involvement of a novel ubiquitin ligase. Oncogene. 2000 Feb 10; 19(6):719-25. PMID: 10698489.
      View in: PubMed
    26. Gardiol D, K├╝hne C, Glaunsinger B, Lee SS, Javier R, Banks L. Oncogenic human papillomavirus E6 proteins target the discs large tumour suppressor for proteasome-mediated degradation. Oncogene. 1999 Sep 30; 18(40):5487-96. PMID: 10523825.
      View in: PubMed
    27. Thomas DL, Shin S, Jiang BH, Vogel H, Ross MA, Kaplitt M, Shenk TE, Javier RT. Early region 1 transforming functions are dispensable for mammary tumorigenesis by human adenovirus type 9. J Virol. 1999 Apr; 73(4):3071-9. PMID: 10074157; PMCID: PMC104067.
    28. Weiss RS, Javier RT. A carboxy-terminal region required by the adenovirus type 9 E4 ORF1 oncoprotein for transformation mediates direct binding to cellular polypeptides. J Virol. 1997 Oct; 71(10):7873-80. PMID: 9311876; PMCID: PMC192143.
    29. Lee SS, Weiss RS, Javier RT. Binding of human virus oncoproteins to hDlg/SAP97, a mammalian homolog of the Drosophila discs large tumor suppressor protein. Proc Natl Acad Sci U S A. 1997 Jun 24; 94(13):6670-5. PMID: 9192623; PMCID: PMC21216.
    30. Weiss RS, Gold MO, Vogel H, Javier RT. Mutant adenovirus type 9 E4 ORF1 genes define three protein regions required for transformation of CREF cells. J Virol. 1997 Jun; 71(6):4385-94. PMID: 9151828; PMCID: PMC191656.
    31. Weiss RS, Lee SS, Prasad BV, Javier RT. Human adenovirus early region 4 open reading frame 1 genes encode growth-transforming proteins that may be distantly related to dUTP pyrophosphatase enzymes. J Virol. 1997 Mar; 71(3):1857-70. PMID: 9032316; PMCID: PMC191256.
    32. Weiss RS, McArthur MJ, Javier RT. Human adenovirus type 9 E4 open reading frame 1 encodes a cytoplasmic transforming protein capable of increasing the oncogenicity of CREF cells. J Virol. 1996 Feb; 70(2):862-72. PMID: 8551625; PMCID: PMC189889.
    33. Javier R, Shenk T. Mammary tumors induced by human adenovirus type 9: a role for the viral early region 4 gene. Breast Cancer Res Treat. 1996; 39(1):57-67. PMID: 8738606.
      View in: PubMed
    34. Javier RT. Adenovirus type 9 E4 open reading frame 1 encodes a transforming protein required for the production of mammary tumors in rats. J Virol. 1994 Jun; 68(6):3917-24. PMID: 8189528; PMCID: PMC236897.
    35. Javier R, Raska K, Shenk T. Requirement for the adenovirus type 9 E4 region in production of mammary tumors. Science. 1992 Aug 28; 257(5074):1267-71. PMID: 1519063.
      View in: PubMed
    36. Javier R, Raska K, Macdonald GJ, Shenk T. Human adenovirus type 9-induced rat mammary tumors. J Virol. 1991 Jun; 65(6):3192-202. PMID: 2033670; PMCID: PMC240976.
    37. Sedarati F, Javier RT, Stevens JG. Pathogenesis of a lethal mixed infection in mice with two nonneuroinvasive herpes simplex virus strains. J Virol. 1988 Aug; 62(8):3037-9. PMID: 2839719; PMCID: PMC253744.
    38. Javier RT, Izumi KM, Stevens JG. Localization of a herpes simplex virus neurovirulence gene dissociated from high-titer virus replication in the brain. J Virol. 1988 Apr; 62(4):1381-7. PMID: 2831400; PMCID: PMC253151.
    39. Javier RT, Thompson RL, Stevens JG. Genetic and biological analyses of a herpes simplex virus intertypic recombinant reduced specifically for neurovirulence. J Virol. 1987 Jun; 61(6):1978-84. PMID: 3033324; PMCID: PMC254206.
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