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MARK W MAJESKY

TitleAdjunct Associate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pathology & Immunology
AddressSeattle Children's Hospital
1900 Ninth Avenue, M/S C95-5
Seattle WA 981011309
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Kuang SQ, Medina-Martinez O, Guo DC, Gong L, Regalado ES, Reynolds CL, Boileau C, Jondeau G, Prakash SK, Kwartler CS, Zhu LY, Peters AM, Duan XY, Bamshad MJ, Shendure J, Nickerson DA, Santos-Cortez RL, Dong X, Leal SM, Majesky MW, Swindell EC, Jamrich M, Milewicz DM. FOXE3 mutations predispose to thoracic aortic aneurysms and dissections. J Clin Invest. 2016 Mar 1; 126(3):948-61. PMID: 26854927; PMCID: PMC4767350.
    2. Wu J, Montaniel KR, Saleh MA, Xiao L, Chen W, Owens GK, Humphrey JD, Majesky MW, Paik DT, Hatzopoulos AK, Madhur MS, Harrison DG. Origin of Matrix-Producing Cells That Contribute to Aortic Fibrosis in Hypertension. Hypertension. 2016 Feb; 67(2):461-8. PMID: 26693821.
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    3. Majesky MW. Adventitia and perivascular cells. Arterioscler Thromb Vasc Biol. 2015 Aug; 35(8):e31-5. PMID: 26203160.
      View in: PubMed
    4. Majesky MW. Choosing Smads: smooth muscle origin-specific transforming growth factor-? signaling. Circ Res. 2013 Sep 27; 113(8):946-8. PMID: 24071452.
      View in: PubMed
    5. Wu SP, Dong XR, Regan JN, Su C, Majesky MW. Tbx18 regulates development of the epicardium and coronary vessels. Dev Biol. 2013 Nov 15; 383(2):307-20. PMID: 24016759; PMCID: PMC4172450.
    6. Boucek RJ, Kirsh AL, Majesky MW, Perkins JA. Propranolol responsiveness in vascular tumors is not determined by qualitative differences in adrenergic receptors. Otolaryngol Head Neck Surg. 2013 Nov; 149(5):772-6. PMID: 24009211.
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    7. Ieronimakis N, Hays AL, Janebodin K, Mahoney WM, Duffield JS, Majesky MW, Reyes M. Coronary adventitial cells are linked to perivascular cardiac fibrosis via TGF?1 signaling in the mdx mouse model of Duchenne muscular dystrophy. J Mol Cell Cardiol. 2013 Oct; 63:122-34. PMID: 23911435; PMCID: PMC3834000.
    8. Awgulewitsch A, Majesky MW. Interpreting inflammation: smooth muscle positional identity and nuclear factor-?B signaling. Arterioscler Thromb Vasc Biol. 2013 Jun; 33(6):1113-5. PMID: 23677878; PMCID: PMC3748817.
    9. Mahoney WM, Gunaje J, Daum G, Dong XR, Majesky MW. Regulator of G-protein signaling - 5 (RGS5) is a novel repressor of hedgehog signaling. PLoS One. 2013; 8(4):e61421. PMID: 23637832; PMCID: PMC3630190.
    10. Pruett ND, Hajdu Z, Zhang J, Visconti RP, Kern MJ, Wellik DM, Majesky MW, Awgulewitsch A. Changing topographic Hox expression in blood vessels results in regionally distinct vessel wall remodeling. Biol Open. 2012 May 15; 1(5):430-5. PMID: 23213434; PMCID: PMC3507213.
    11. Dong XR, Majesky MW. Restoring elastin with microRNA-29. Arterioscler Thromb Vasc Biol. 2012 Mar; 32(3):548-51. PMID: 22345590; PMCID: PMC3390171.
    12. Majesky MW, Mummery CL. Smooth muscle diversity from human pluripotent cells. Nat Biotechnol. 2012 Feb; 30(2):152-4. PMID: 22318032; PMCID: PMC3690307.
    13. Hoglund VJ, Majesky MW. Patterning the artery wall by lateral induction of Notch signaling. Circulation. 2012 Jan 17; 125(2):212-5. PMID: 22147908; PMCID: PMC3392127.
    14. Duan J, Gherghe C, Liu D, Hamlett E, Srikantha L, Rodgers L, Regan JN, Rojas M, Willis M, Leask A, Majesky M, Deb A. Wnt1/?catenin injury response activates the epicardium and cardiac fibroblasts to promote cardiac repair. EMBO J. 2012 Jan 18; 31(2):429-42. PMID: 22085926; PMCID: PMC3261567.
    15. Majesky MW, Dong XR, Hoglund V, Daum G, Mahoney WM. The adventitia: a progenitor cell niche for the vessel wall. Cells Tissues Organs. 2012; 195(1-2):73-81. PMID: 22005572; PMCID: PMC3257816.
    16. Cheng Z, Sundberg-Smith LJ, Mangiante LE, Sayers RL, Hakim ZS, Musunuri S, Maguire CT, Majesky MW, Zhou Z, Mack CP, Taylor JM. Focal adhesion kinase regulates smooth muscle cell recruitment to the developing vasculature. Arterioscler Thromb Vasc Biol. 2011 Oct; 31(10):2193-202. PMID: 21757658; PMCID: PMC3182406.
    17. Majesky MW, Dong XR, Hoglund V, Mahoney WM, Daum G. The adventitia: a dynamic interface containing resident progenitor cells. Arterioscler Thromb Vasc Biol. 2011 Jul; 31(7):1530-9. PMID: 21677296; PMCID: PMC3382115.
    18. Majesky MW, Dong XR, Hoglund VJ. Parsing aortic aneurysms: more surprises. Circ Res. 2011 Mar 4; 108(5):528-30. PMID: 21372288; PMCID: PMC3390159.
    19. Gherghe CM, Duan J, Gong J, Rojas M, Klauber-Demore N, Majesky M, Deb A. Wnt1 is a proangiogenic molecule, enhances human endothelial progenitor function, and increases blood flow to ischemic limbs in a HGF-dependent manner. FASEB J. 2011 Jun; 25(6):1836-43. PMID: 21321190; PMCID: PMC3219217.
    20. Majesky MW, Dong XR, Regan JN, Hoglund VJ. Vascular smooth muscle progenitor cells: building and repairing blood vessels. Circ Res. 2011 Feb 4; 108(3):365-77. PMID: 21293008; PMCID: PMC3382110.
    21. Balakrishnan K, Majesky M, Perkins JA. Head and neck lymphatic tumors and bony abnormalities: a clinical and molecular review. Lymphat Res Biol. 2011; 9(4):205-12. PMID: 22196287; PMCID: PMC3391938.
    22. Hoglund VJ, Dong XR, Majesky MW. Neointima formation: a local affair. Arterioscler Thromb Vasc Biol. 2010 Oct; 30(10):1877-9. PMID: 20844267; PMCID: PMC3049730.
    23. Huang ZP, Chen JF, Regan JN, Maguire CT, Tang RH, Dong XR, Majesky MW, Wang DZ. Loss of microRNAs in neural crest leads to cardiovascular syndromes resembling human congenital heart defects. Arterioscler Thromb Vasc Biol. 2010 Dec; 30(12):2575-86. PMID: 20884876; PMCID: PMC2988089.
    24. Yoshida T, Gan Q, Franke AS, Ho R, Zhang J, Chen YE, Hayashi M, Majesky MW, Somlyo AV, Owens GK. Smooth and cardiac muscle-selective knock-out of Kruppel-like factor 4 causes postnatal death and growth retardation. J Biol Chem. 2010 Jul 2; 285(27):21175-84. PMID: 20439457; PMCID: PMC2898332.
    25. Majesky MW. Developmental biology in the vasculature--review series. Arterioscler Thromb Vasc Biol. 2009 May; 29(5):622. PMID: 19369655.
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    26. Regan JN, Majesky MW. Building a vessel wall with notch signaling. Circ Res. 2009 Feb 27; 104(4):419-21. PMID: 19246684; PMCID: PMC2727662.
    27. Passman JN, Dong XR, Wu SP, Maguire CT, Hogan KA, Bautch VL, Majesky MW. A sonic hedgehog signaling domain in the arterial adventitia supports resident Sca1+ smooth muscle progenitor cells. Proc Natl Acad Sci U S A. 2008 Jul 8; 105(27):9349-54. PMID: 18591670; PMCID: PMC2453724.
    28. Dong XR, Maguire CT, Wu SP, Majesky MW. Chapter 9. Development of coronary vessels. Methods Enzymol. 2008; 445:209-28. PMID: 19022061.
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    29. Majesky MW. Developmental basis of vascular smooth muscle diversity. Arterioscler Thromb Vasc Biol. 2007 Jun; 27(6):1248-58. PMID: 17379839.
      View in: PubMed
    30. Majesky MW. Organizing motility: LIM domains, LPP, and smooth muscle migration. Circ Res. 2006 Feb 17; 98(3):306-8. PMID: 16484626.
      View in: PubMed
    31. Somlyo AV, Wang H, Choudhury N, Khromov AS, Majesky M, Owens GK, Somlyo AP. Myosin light chain kinase knockout. J Muscle Res Cell Motil. 2004; 25(3):241-2. PMID: 15467390.
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    32. Hirschi KK, Majesky MW. Smooth muscle stem cells. Anat Rec A Discov Mol Cell Evol Biol. 2004 Jan; 276(1):22-33. PMID: 14699631.
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    33. Majesky MW. Development of coronary vessels. Curr Top Dev Biol. 2004; 62:225-59. PMID: 15522744.
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    34. Majesky MW. Decisions, decisions...SRF coactivators and smooth muscle myogenesis. Circ Res. 2003 May 2; 92(8):824-6. PMID: 12730127.
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    35. Majesky MW. Vascular smooth muscle diversity: insights from developmental biology. Curr Atheroscler Rep. 2003 May; 5(3):208-13. PMID: 12667434.
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    36. Majka SM, Jackson KA, Kienstra KA, Majesky MW, Goodell MA, Hirschi KK. Distinct progenitor populations in skeletal muscle are bone marrow derived and exhibit different cell fates during vascular regeneration. J Clin Invest. 2003 Jan; 111(1):71-9. PMID: 12511590; PMCID: PMC151835.
    37. Chang DF, Belaguli NS, Iyer D, Roberts WB, Wu SP, Dong XR, Marx JG, Moore MS, Beckerle MC, Majesky MW, Schwartz RJ. Cysteine-rich LIM-only proteins CRP1 and CRP2 are potent smooth muscle differentiation cofactors. Dev Cell. 2003 Jan; 4(1):107-18. PMID: 12530967.
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    38. Majesky MW. Mouse model for atherosclerotic plaque rupture. Circulation. 2002 Apr 30; 105(17):2010-1. PMID: 11980677.
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    39. Majesky MW. Smooth muscle-specific transcription without a CArG box element. Circ Res. 2002 Apr 5; 90(6):628-30. PMID: 11934827.
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    40. Lu J, Landerholm TE, Wei JS, Dong XR, Wu SP, Liu X, Nagata K, Inagaki M, Majesky MW. Coronary smooth muscle differentiation from proepicardial cells requires rhoA-mediated actin reorganization and p160 rho-kinase activity. Dev Biol. 2001 Dec 15; 240(2):404-18. PMID: 11784072.
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    41. Jackson KA, Majka SM, Wang H, Pocius J, Hartley CJ, Majesky MW, Entman ML, Michael LH, Hirschi KK, Goodell MA. Regeneration of ischemic cardiac muscle and vascular endothelium by adult stem cells. J Clin Invest. 2001 Jun; 107(11):1395-402. PMID: 11390421; PMCID: PMC209322.
    42. Goodell MA, Jackson KA, Majka SM, Mi T, Wang H, Pocius J, Hartley CJ, Majesky MW, Entman ML, Michael LH, Hirschi KK. Stem cell plasticity in muscle and bone marrow. Ann N Y Acad Sci. 2001 Jun; 938:208-18; discussion 218-20. PMID: 11458510.
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    43. Majesky MW. Novel genes for mitogen-independent smooth muscle replication. Circ Res. 2000 Sep 29; 87(7):532-4. PMID: 11009554.
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    44. Belaguli NS, Zhou W, Trinh TH, Majesky MW, Schwartz RJ. Dominant negative murine serum response factor: alternative splicing within the activation domain inhibits transactivation of serum response factor binding targets. Mol Cell Biol. 1999 Jul; 19(7):4582-91. PMID: 10373507; PMCID: PMC84256.
    45. Landerholm TE, Dong XR, Lu J, Belaguli NS, Schwartz RJ, Majesky MW. A role for serum response factor in coronary smooth muscle differentiation from proepicardial cells. Development. 1999 May; 126(10):2053-62. PMID: 10207131.
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    46. MacLellan WR, Majesky MW. Cell cycle regulators in vascular disease. Circulation. 1997 Sep 16; 96(6):1717-9. PMID: 9323050.
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    47. Majesky MW, Schwartz SM. An origin for smooth muscle cells from endothelium? Circ Res. 1997 Apr; 80(4):601-3. PMID: 9118492.
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    48. Majesky MW. A little VEGF goes a long way. Therapeutic angiogenesis by direct injection of vascular endothelial growth factor-encoding plasmid DNA. Circulation. 1996 Dec 15; 94(12):3062-4. PMID: 8989106.
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    49. Winkles JA, Alberts GF, Peifley KA, Nomoto K, Liau G, Majesky MW. Postnatal regulation of fibroblast growth factor ligand and receptor gene expression in rat thoracic aorta. Am J Pathol. 1996 Dec; 149(6):2119-31. PMID: 8952544; PMCID: PMC1865367.
    50. Topouzis S, Majesky MW. Smooth muscle lineage diversity in the chick embryo. Two types of aortic smooth muscle cell differ in growth and receptor-mediated transcriptional responses to transforming growth factor-beta. Dev Biol. 1996 Sep 15; 178(2):430-45. PMID: 8830742.
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    51. Majesky MW, Dong XR, Topouzis S. Smooth muscle cell diversity and the extracellular matrix in a rat model of restenosis. P R Health Sci J. 1996 Sep; 15(3):187-91. PMID: 8994283.
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    52. Lipke DL, Aziz SM, Fagerland JA, Majesky M, Arcot SS. Tenascin synthesis, deposition, and isoforms in monocrotaline-induced pulmonary hypertensive rat lungs. Am J Physiol. 1996 Aug; 271(2 Pt 1):L208-15. PMID: 8770058.
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    53. Miano JM, Topouzis S, Majesky MW, Olson EN. Retinoid receptor expression and all-trans retinoic acid-mediated growth inhibition in vascular smooth muscle cells. Circulation. 1996 May 15; 93(10):1886-95. PMID: 8635268.
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    54. Truong LD, Pindur J, Foster S, Majesky M, Suki WN. Tenascin expression in nephrogenesis and in normal or pathologic glomerulus morphologic features and functional implications. Nephron. 1996; 72(4):499-506. PMID: 8730411.
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    55. Chen CY, Croissant J, Majesky M, Topouzis S, McQuinn T, Frankovsky MJ, Schwartz RJ. Activation of the cardiac alpha-actin promoter depends upon serum response factor, Tinman homologue, Nkx-2.5, and intact serum response elements. Dev Genet. 1996; 19(2):119-30. PMID: 8900044.
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    56. Schwartz SM, Majesky MW, Murry CE. The intima: development and monoclonal responses to injury. Atherosclerosis. 1995 Dec; 118 Suppl:S125-40. PMID: 8821472.
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    57. Truong LD, Majesky MW, Pindur J. Tenascin is synthesized and secreted by rat mesangial cells in culture and is present in extracellular matrix in human glomerular diseases. J Am Soc Nephrol. 1994 Apr; 4(10):1771-7. PMID: 7520763.
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    58. Truong LD, Pindur J, Barrios R, D'Agati V, Lechago J, Suki W, Majesky M. Tenascin is an important component of the glomerular extracellular matrix in normal and pathologic conditions. Kidney Int. 1994 Jan; 45(1):201-10. PMID: 7510349.
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    59. Majesky MW. Neointima formation after acute vascular injury. Role of counteradhesive extracellular matrix proteins. Tex Heart Inst J. 1994; 21(1):78-85. PMID: 7514061; PMCID: PMC325135.
    60. Kapur V, Topouzis S, Majesky MW, Li LL, Hamrick MR, Hamill RJ, Patti JM, Musser JM. A conserved Streptococcus pyogenes extracellular cysteine protease cleaves human fibronectin and degrades vitronectin. Microb Pathog. 1993 Nov; 15(5):327-46. PMID: 7516997.
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    61. Kapur V, Majesky MW, Li LL, Black RA, Musser JM. Cleavage of interleukin 1 beta (IL-1 beta) precursor to produce active IL-1 beta by a conserved extracellular cysteine protease from Streptococcus pyogenes. Proc Natl Acad Sci U S A. 1993 Aug 15; 90(16):7676-80. PMID: 7689226; PMCID: PMC47205.
    62. Okazaki H, Majesky MW, Harker LA, Schwartz SM. Regulation of platelet-derived growth factor ligand and receptor gene expression by alpha-thrombin in vascular smooth muscle cells. Circ Res. 1992 Dec; 71(6):1285-93. PMID: 1423927.
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    63. Majesky MW, Giachelli CM, Reidy MA, Schwartz SM. Rat carotid neointimal smooth muscle cells reexpress a developmentally regulated mRNA phenotype during repair of arterial injury. Circ Res. 1992 Oct; 71(4):759-68. PMID: 1516153.
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    64. Majesky MW, Lindner V, Twardzik DR, Schwartz SM, Reidy MA. Production of transforming growth factor beta 1 during repair of arterial injury. J Clin Invest. 1991 Sep; 88(3):904-10. PMID: 1832175; PMCID: PMC295478.
    65. Giachelli C, Bae N, Lombardi D, Majesky M, Schwartz S. Molecular cloning and characterization of 2B7, a rat mRNA which distinguishes smooth muscle cell phenotypes in vitro and is identical to osteopontin (secreted phosphoprotein I, 2aR). Biochem Biophys Res Commun. 1991 Jun 14; 177(2):867-73. PMID: 1828666.
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    66. Johnson RJ, Iida H, Alpers CE, Majesky MW, Schwartz SM, Pritzi P, Gordon K, Gown AM. Expression of smooth muscle cell phenotype by rat mesangial cells in immune complex nephritis. Alpha-smooth muscle actin is a marker of mesangial cell proliferation. J Clin Invest. 1991 Mar; 87(3):847-58. PMID: 1671868; PMCID: PMC329873.
    67. Giachelli CM, Majesky MW, Schwartz SM. Developmentally regulated cytochrome P-450IA1 expression in cultured rat vascular smooth muscle cells. J Biol Chem. 1991 Feb 25; 266(6):3981-6. PMID: 1995646.
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    68. Majesky MW, Reidy MA, Bowen-Pope DF, Hart CE, Wilcox JN, Schwartz SM. PDGF ligand and receptor gene expression during repair of arterial injury. J Cell Biol. 1990 Nov; 111(5 Pt 1):2149-58. PMID: 2172262; PMCID: PMC2116329.
    69. Schwartz SM, Heimark RL, Majesky MW. Developmental mechanisms underlying pathology of arteries. Physiol Rev. 1990 Oct; 70(4):1177-209. PMID: 2217558.
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    70. Majack RA, Majesky MW, Goodman LV. Role of PDGF-A expression in the control of vascular smooth muscle cell growth by transforming growth factor-beta. J Cell Biol. 1990 Jul; 111(1):239-47. PMID: 1694856; PMCID: PMC2116160.
    71. Majesky MW, Daemen MJ, Schwartz SM. Alpha 1-adrenergic stimulation of platelet-derived growth factor A-chain gene expression in rat aorta. J Biol Chem. 1990 Jan 15; 265(2):1082-8. PMID: 1688551.
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    72. Majesky MW, Schwartz SM. Smooth muscle diversity in arterial wound repair. Toxicol Pathol. 1990; 18(4 Pt 1):554-9. PMID: 2091234.
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    73. Fingerle J, Johnson R, Clowes AW, Majesky MW, Reidy MA. Role of platelets in smooth muscle cell proliferation and migration after vascular injury in rat carotid artery. Proc Natl Acad Sci U S A. 1989 Nov; 86(21):8412-6. PMID: 2813399; PMCID: PMC298292.
    74. Majesky MW, Benditt EP, Schwartz SM. Expression and developmental control of platelet-derived growth factor A-chain and B-chain/Sis genes in rat aortic smooth muscle cells. Proc Natl Acad Sci U S A. 1988 Mar; 85(5):1524-8. PMID: 3278316; PMCID: PMC279805.
    75. Majesky MW, Schwartz SM, Clowes MM, Clowes AW. Heparin regulates smooth muscle S phase entry in the injured rat carotid artery. Circ Res. 1987 Aug; 61(2):296-300. PMID: 3621492.
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    76. Yang HY, Majesky MW, Namkung MJ, Juchau MR. Phase II biotransformation of carcinogens/atherogens in cultured aortic tissues and cells. II. Glucuronidation of 3-hydroxy-benzo(a)pyrene. Drug Metab Dispos. 1986 May-Jun; 14(3):293-8. PMID: 2872027.
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    77. Majesky MW, Reidy MA, Benditt EP, Juchau MR. Focal smooth muscle proliferation in the aortic intima produced by an initiation-promotion sequence. Proc Natl Acad Sci U S A. 1985 May; 82(10):3450-4. PMID: 3923478; PMCID: PMC397793.
    78. Majesky MW, Yang HY, Juchau MR. Interaction of alpha and beta adrenergic stimulation on aortic ornithine decarboxylase activity. Life Sci. 1985 Jan 14; 36(2):153-9. PMID: 2578206.
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    79. Majesky MW, Yang HY, Benditt EP, Juchau MR. Carcinogenesis and atherogenesis: differences in monooxygenase inducibility and bioactivation of benzo[a]pyrene in aortic and hepatic tissues of atherosclerosis-susceptible versus resistant pigeons. Carcinogenesis. 1983; 4(6):647-52. PMID: 6305525.
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    80. Majesky MW, Silver M, Yang HL, Reidy MA, Juchau MR. Elicitation of raised aortic smooth muscle lesions with an initiation-promotion regimen. Dev Toxicol Environ Sci. 1983; 11:367-70. PMID: 6428852.
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    81. Bond JA, Yang HY, Majesky MW, Benditt EP, Juchau MR. Metabolism of benzo[a]pyrene and 7,12-dimethylbenz[a]anthracene in chicken aortas: monooxygenation, bioactivation to mutagens, and covalent binding to DNA in vitro. Toxicol Appl Pharmacol. 1980 Feb; 52(2):323-35. PMID: 6244684.
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