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HAROLD SHINE

TitleProfessor Emeritus
InstitutionBaylor College of Medicine
DepartmentDepartment of Neuroscience
AddressOne Baylor Plaza
Houston, TX 77030
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    Other Positions
    TitleProfessor Emeritus
    InstitutionBaylor College of Medicine
    DepartmentCenter for Cell & Gene Therapy
    DivisionCenter for Cell & Gene Therapy

    TitleProfessor Emeritus
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular & Cellular Biology
    DivisionMolecular & Cellular Biology


    Collapse Research 
    Collapse research activities and funding
    R01NS084919     (SHINE, HAROLD DAVID)Jul 1, 2015 - Jun 30, 2020
    NIH
    Neuroimmune Processes and Neuroplasticity in Chronic Spinal Cord Injury
    Role: Principal Investigator
    I01RX000241     (SHINE, HAROLD DAVID)Jul 1, 2010 - Jun 30, 2013
    NIH
    Neuroimmune Processes and Neuroplasticity in Chronic Spinal Cord Injury
    Role: Principal Investigator
    R01NS039198     (SHINE, HAROLD DAVID)Sep 15, 1999 - May 31, 2006
    NIH
    GENE DELIVERY FOR SPIRAL CORD INJURY REPAIR
    Role: Principal Investigator
    R01NS035280     (SHINE, HAROLD DAVID)Jul 15, 1997 - Jun 30, 2001
    NIH
    MECHANISMS OF BRAIN TUMOR CELL DEATH AFTER GENE TRANSFER
    Role: Principal Investigator
    R23NS022223     (SHINE, HAROLD DAVID)Apr 1, 1985 - Mar 31, 1988
    NIH
    IMPLANTS CONTAINING CELLS SUPPORT PNS AXON REGENERATION
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Duricki DA, Drndarski S, Bernanos M, Wood T, Bosch K, Chen Q, Shine HD, Simmons C, Williams SCR, McMahon SB, Begley DJ, Cash D, Moon LDF. Stroke Recovery in Rats after 24-Hour-Delayed Intramuscular Neurotrophin-3 Infusion. Ann Neurol. 2019 01; 85(1):32-46. PMID: 30525223; PMCID: PMC6492080.
      Citations: 6     Fields:    Translation:Animals
    2. Duricki DA, Hutson TH, Kathe C, Soleman S, Gonzalez-Carter D, Petruska JC, Shine HD, Chen Q, Wood TC, Bernanos M, Cash D, Williams SC, Gage FH, Moon LD. Delayed intramuscular human neurotrophin-3 improves recovery in adult and elderly rats after stroke. Brain. 2016 Jan; 139(Pt 1):259-75. PMID: 26614754; PMCID: PMC4785394.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    3. Kathe C, Hutson TH, Chen Q, Shine HD, McMahon SB, Moon LD. Unilateral pyramidotomy of the corticospinal tract in rats for assessment of neuroplasticity-inducing therapies. J Vis Exp. 2014 Dec 15; (94). PMID: 25549050; PMCID: PMC4396919.
      Citations: 11     Fields:    Translation:Animals
    4. Chen Q, Shine HD. Neuroimmune processes associated with Wallerian degeneration support neurotrophin-3-induced axonal sprouting in the injured spinal cord. J Neurosci Res. 2013 Oct; 91(10):1280-91. PMID: 23907999.
      Citations: 8     Fields:    Translation:AnimalsCells
    5. Mulherkar S, Liu F, Chen Q, Narayanan A, Couvillon AD, Shine HD, Tolias KF. The small GTPase RhoA is required for proper locomotor circuit assembly. PLoS One. 2013; 8(6):e67015. PMID: 23825607; PMCID: PMC3692541.
      Citations: 10     Fields:    Translation:AnimalsCells
    6. Grider MH, Park D, Spencer DM, Shine HD. Lipid raft-targeted Akt promotes axonal branching and growth cone expansion via mTOR and Rac1, respectively. J Neurosci Res. 2009 Nov 01; 87(14):3033-42. PMID: 19530170; PMCID: PMC6561343.
      Citations: 37     Fields:    Translation:AnimalsCells
    7. Qi H, Shine HD, Li DQ, de Paiva CS, Farley WJ, Jones DB, Pflugfelder SC. Glial cell-derived neurotrophic factor gene delivery enhances survival of human corneal epithelium in culture and the overexpression of GDNF in bioengineered constructs. Exp Eye Res. 2008 Dec; 87(6):580-6. PMID: 18938159; PMCID: PMC4529993.
      Citations: 8     Fields:    Translation:HumansCells
    8. Chen Q, Smith GM, Shine HD. Immune activation is required for NT-3-induced axonal plasticity in chronic spinal cord injury. Exp Neurol. 2008 Feb; 209(2):497-509. PMID: 18191837; PMCID: PMC2706784.
      Citations: 21     Fields:    Translation:AnimalsCells
    9. Qi H, Chuang EY, Yoon KC, de Paiva CS, Shine HD, Jones DB, Pflugfelder SC, Li DQ. Patterned expression of neurotrophic factors and receptors in human limbal and corneal regions. Mol Vis. 2007 Oct 16; 13:1934-41. PMID: 17982417; PMCID: PMC2185513.
      Citations: 29     Fields:    Translation:Humans
    10. Qi H, Li DQ, Shine HD, Chen Z, Yoon KC, Jones DB, Pflugfelder SC. Nerve growth factor and its receptor TrkA serve as potential markers for human corneal epithelial progenitor cells. Exp Eye Res. 2008 Jan; 86(1):34-40. PMID: 17980361; PMCID: PMC2198932.
      Citations: 37     Fields:    Translation:HumansCells
    11. Ahmed N, Ratnayake M, Savoldo B, Perlaky L, Dotti G, Wels WS, Bhattacharjee MB, Gilbertson RJ, Shine HD, Weiss HL, Rooney CM, Heslop HE, Gottschalk S. Regression of experimental medulloblastoma following transfer of HER2-specific T cells. Cancer Res. 2007 Jun 15; 67(12):5957-64. PMID: 17575166.
      Citations: 85     Fields:    Translation:HumansAnimalsCells
    12. Chen Q, Zhou L, Shine HD. Expression of neurotrophin-3 promotes axonal plasticity in the acute but not chronic injured spinal cord. J Neurotrauma. 2006 Aug; 23(8):1254-60. PMID: 16928183.
      Citations: 24     Fields:    Translation:AnimalsCells
    13. Grider MH, Chen Q, Shine HD. Semi-automated quantification of axonal densities in labeled CNS tissue. J Neurosci Methods. 2006 Sep 15; 155(2):172-9. PMID: 16469388.
      Citations: 34     Fields:    Translation:AnimalsCells
    14. Grider MH, Mamounas LA, Le W, Shine HD. In situ expression of brain-derived neurotrophic factor or neurotrophin-3 promotes sprouting of cortical serotonergic axons following a neurotoxic lesion. J Neurosci Res. 2005 Nov 01; 82(3):404-12. PMID: 16206279.
      Citations: 14     Fields:    Translation:AnimalsCells
    15. Olmsted-Davis EA, Gugala Z, Camargo F, Gannon FH, Jackson K, Kienstra KA, Shine HD, Lindsey RW, Hirschi KK, Goodell MA, Brenner MK, Davis AR. Primitive adult hematopoietic stem cells can function as osteoblast precursors. Proc Natl Acad Sci U S A. 2003 Dec 23; 100(26):15877-82. PMID: 14673088; PMCID: PMC307661.
      Citations: 55     Fields:    Translation:AnimalsCells
    16. Zhou L, Shine HD. Neurotrophic factors expressed in both cortex and spinal cord induce axonal plasticity after spinal cord injury. J Neurosci Res. 2003 Oct 15; 74(2):221-6. PMID: 14515351.
      Citations: 42     Fields:    Translation:AnimalsCells
    17. Zhou L, Baumgartner BJ, Hill-Felberg SJ, McGowen LR, Shine HD. Neurotrophin-3 expressed in situ induces axonal plasticity in the adult injured spinal cord. J Neurosci. 2003 Feb 15; 23(4):1424-31. PMID: 12598631; PMCID: PMC6742279.
      Citations: 47     Fields:    Translation:HumansAnimalsCells
    18. Zou L, Yuan X, Long Y, Shine HD, Yang K. Improvement of spatial learning and memory after adenovirus-mediated transfer of the nerve growth factor gene to aged rat brain. Hum Gene Ther. 2002 Dec 10; 13(18):2173-84. PMID: 12542848.
      Citations: 5     Fields:    Translation:AnimalsCells
    19. Sivaraman L, Gay J, Hilsenbeck SG, Shine HD, Conneely OM, Medina D, O'Malley BW. Effect of selective ablation of proliferating mammary epithelial cells on MNU induced rat mammary tumorigenesis. Breast Cancer Res Treat. 2002 May; 73(1):75-83. PMID: 12083633.
      Citations: 7     Fields:    Translation:AnimalsCells
    20. Ayala GE, Wheeler TM, Shine HD, Schmelz M, Frolov A, Chakraborty S, Rowley D. In vitro dorsal root ganglia and human prostate cell line interaction: redefining perineural invasion in prostate cancer. Prostate. 2001 Nov 01; 49(3):213-23. PMID: 11746267.
      Citations: 101     Fields:    Translation:HumansAnimalsCells
    21. Trask TW, Trask RP, Aguilar-Cordova E, Shine HD, Wyde PR, Goodman JC, Hamilton WJ, Rojas-Martinez A, Chen SH, Woo SL, Grossman RG. Phase I study of adenoviral delivery of the HSV-tk gene and ganciclovir administration in patients with current malignant brain tumors. Mol Ther. 2000 Feb; 1(2):195-203. PMID: 10933931.
      Citations: 77     Fields:    Translation:HumansCellsCTClinical Trials
    22. Baumgartner BJ, Shine HD. Permanent rescue of lesioned neonatal motoneurons and enhanced axonal regeneration by adenovirus-mediated expression of glial cell-line-derived neurotrophic factor. J Neurosci Res. 1998 Dec 15; 54(6):766-77. PMID: 9856860.
      Citations: 11     Fields:    Translation:AnimalsCells
    23. Baumgartner BJ, Shine HD. Neuroprotection of spinal motoneurons following targeted transduction with an adenoviral vector carrying the gene for glial cell line-derived neurotrophic factor. Exp Neurol. 1998 Sep; 153(1):102-12. PMID: 9743571.
      Citations: 25     Fields:    Translation:AnimalsCells
    24. Baumgartner BJ, Shine HD. Targeted transduction of CNS neurons with adenoviral vectors carrying neurotrophic factor genes confers neuroprotection that exceeds the transduced population. J Neurosci. 1997 Sep 01; 17(17):6504-11. PMID: 9254662; PMCID: PMC6573127.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    25. Shine HD, Wyde PR, Aguilar-Cordova E, Chen SH, Woo SL, Grossman RG, Goodman JC. Neurotoxicity of intracerebral injection of a replication-defective adenoviral vector in a semipermissive species (cotton rat). Gene Ther. 1997 Apr; 4(4):275-9. PMID: 9176511.
      Citations: 6     Fields:    Translation:AnimalsCells
    26. Goodman JC, Trask TW, Chen SH, Woo SL, Grossman RG, Carey KD, Hubbard GB, Carrier DA, Rajagopalan S, Aguilar-Cordova E, Shine HD. Adenoviral-mediated thymidine kinase gene transfer into the primate brain followed by systemic ganciclovir: pathologic, radiologic, and molecular studies. Hum Gene Ther. 1996 Jun 20; 7(10):1241-50. PMID: 8793548.
      Citations: 11     Fields:    Translation:AnimalsCells
    27. Colak A, Goodman JC, Chen SH, Woo SL, Grossman RG, Shine HD. Adenovirus-mediated gene therapy in an experimental model of breast cancer metastatic to the brain. Hum Gene Ther. 1995 Oct; 6(10):1317-22. PMID: 8590736.
      Citations: 2     Fields:    Translation:AnimalsCells
    28. Colak A, Goodman JC, Chen SH, Woo SL, Grossman RG, Shine HD. Adenovirus-mediated gene therapy for experimental spinal cord tumors: tumoricidal efficacy and functional outcome. Brain Res. 1995 Sep 11; 691(1-2):76-82. PMID: 8590067.
      Citations: 5     Fields:    Translation:AnimalsCells
    29. Perez-Cruet MJ, Trask TW, Chen SH, Goodman JC, Woo SL, Grossman RG, Shine HD. Adenovirus-mediated gene therapy of experimental gliomas. J Neurosci Res. 1994 Nov 01; 39(4):506-11. PMID: 7884826.
      Citations: 19     Fields:    Translation:AnimalsCells
    30. Chen SH, Shine HD, Goodman JC, Grossman RG, Woo SL. Gene therapy for brain tumors: regression of experimental gliomas by adenovirus-mediated gene transfer in vivo. Proc Natl Acad Sci U S A. 1994 Apr 12; 91(8):3054-7. PMID: 8159705; PMCID: PMC43513.
      Citations: 68     Fields:    Translation:AnimalsCells
    31. Smith GM, Rabinovsky ED, McManaman JL, Shine HD. Temporal and spatial expression of ciliary neurotrophic factor after peripheral nerve injury. Exp Neurol. 1993 Jun; 121(2):239-47. PMID: 8339774.
      Citations: 11     Fields:    Translation:AnimalsCells
    32. Smith GM, Shine HD. Immunofluorescent labeling of tight junctions in the rat brain and spinal cord. Int J Dev Neurosci. 1992 Oct; 10(5):387-92. PMID: 1492590.
      Citations: 3     Fields:    Translation:AnimalsCells
    33. Rabinovsky ED, Smith GM, Browder DP, Shine HD, McManaman JL. Peripheral nerve injury down-regulates CNTF expression in adult rat sciatic nerves. J Neurosci Res. 1992 Jan; 31(1):188-92. PMID: 1319503.
      Citations: 11     Fields:    Translation:AnimalsCells
    34. Shine HD, Readhead C, Popko B, Hood L, Sidman RL. Morphometric analysis of normal, mutant, and transgenic CNS: correlation of myelin basic protein expression to myelinogenesis. J Neurochem. 1992 Jan; 58(1):342-9. PMID: 1370079.
      Citations: 25     Fields:    Translation:AnimalsCells
    35. Shine HD, Readhead C, Popko B, Hood L, Sidman RL. Myelin basic protein and myelinogenesis: morphometric analysis of normal, mutant and transgenic central nervous system. Prog Clin Biol Res. 1990; 336:81-92. PMID: 1691511.
      Citations:    Fields:    Translation:AnimalsCells
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