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KENNETH L MCCLAIN

TitleProfessor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pediatrics
AddressOne Baylor Plaza
Houston TX 77030
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    Collapse Overview 
    Collapse keywords
    Langerhans cell histiocytosis
    Hemophagocytic lymphohistiocytosis
    Rosai Dorfman Disease
    Juvenile xanthogranuloma
    Erdheim Chester Disease
    Multifocal Reticulohistiocytosis
    Post-transplant lymphoprolifertive disease
    Hodgkin Lymphoma
    Non-Hodgkin Lymphoma


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Peckham-Gregory EC, Danysh HE, Brown AL, Eckstein O, Grimes A, Chakraborty R, Lubega J, McClain KL, Allen CE, Scheurer ME, Lupo PJ. Evaluation of maternal and perinatal characteristics on childhood lymphoma risk: A population-based case-control study. Pediatr Blood Cancer. 2016 Nov 28. PMID: 27896915.
      View in: PubMed
    2. Chakraborty R, Burke TM, Hampton OA, Zinn DJ, Lim KP, Abhyankar H, Scull B, Kumar V, Kakkar N, Wheeler DA, Roy A, Poulikakos PI, Merad M, McClain KL, Parsons DW, Allen CE. Alternative genetic mechanisms of BRAF activation in Langerhans cell histiocytosis. Blood. 2016 Oct 11. PMID: 27729324.
      View in: PubMed
    3. Tamamyan GN, Kantarjian HM, Ning J, Jain P, Sasaki K, McClain KL, Allen CE, Pierce SA, Cortes JE, Ravandi F, Konopleva MY, Garcia-Manero G, Benton CB, Chihara D, Rytting ME, Wang S, Abdelall W, Konoplev SN, Daver NG. Malignancy-associated hemophagocytic lymphohistiocytosis in adults: Relation to hemophagocytosis, characteristics, and outcomes. Cancer. 2016; 2016 doi: 10.1002/cncr.30084. .
    4. Tamamyan GN, Kantarjian HM, Ning J, Jain P, Sasaki K, McClain KL, Allen CE, Pierce SA, Cortes JE, Ravandi F, Konopleva MY, Garcia-Manero G, Benton CB, Chihara D, Rytting ME, Wang S, Abdelall W, Konoplev SN, Daver NG. Malignancy-associated hemophagocytic lymphohistiocytosis in adults: Relation to hemophagocytosis, characteristics, and outcomes. Cancer. 2016 Sep 15; 122(18):2857-66. PMID: 27244347; PMCID: PMC5014667 [Available on 09/15/17].
    5. Allen CE, McClain KL. Pathophysiology and epidemiology of hemophagocytic lymphohistiocytosis. Hematology Am Soc Hematol Educ Program. 2015 Dec 5; 2015(1):177-82. PMID: 26637718.
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    6. Collin M, Bigley V, McClain KL, Allen CE. Cell(s) of Origin of Langerhans Cell Histiocytosis. Hematol Oncol Clin North Am. 2015 Oct; 29(5):825-38. PMID: 26461145.
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    7. Darby JB, Liddell L, DeGuzman M, McClain KL, Rubenstein J, Chase L, Marquez L. A 2-year-old with 4 weeks of daily Fever. Pediatrics. 2015 May; 135(5):902-8. PMID: 25917994.
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    8. Allen CE, Ladisch S, McClain KL. How We Treat Langerhans Cell Histiocytosis. Blood. 2015 Mar 31. PMID: 25827831.
      View in: PubMed
    9. Allen CE, McClain KL. Treatment of Langerhans cell histiocytosis: it is time to learn from the past: response to Minkov and Rodriguez-Galindo. Br J Haematol. 2015 Mar 30. PMID: 25817049.
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    10. Ehrhardt MJ, Karst J, Donohoue PA, Maheshwari M, McClain KL, Bingen K, Kelly ME. Recognition and treatment of concurrent active and neurodegenerative langerhans cell histiocytosis: a case report. J Pediatr Hematol Oncol. 2015 Jan; 37(1):e37-40. PMID: 24322503.
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    11. Aricò M, Astigarraga I, Braier J, Donadieu J, Gadner H, Glogova E, Grois N, Henter JI, Janka G, McClain KL, Ladisch S, Pötschger U, Rosso D, Thiem E, Weitzman S, Windebank K, Minkov M. Lack of bone lesions at diagnosis is associated with inferior outcome in multisystem langerhans cell histiocytosis of childhood. Br J Haematol. 2015 Apr; 169(2):241-8. PMID: 25522229.
      View in: PubMed
    12. Simko SJ, McClain KL, Allen CE. Up-front therapy for LCH: is it time to test an alternative to vinblastine/prednisone? Br J Haematol. 2015 Apr; 169(2):299-301. PMID: 25400231; PMCID: PMC4791956.
    13. Milner JD, Vogel TP, Forbes L, Ma CA, Stray-Pedersen A, Niemela JE, Lyons JJ, Engelhardt KR, Zhang Y, Topcagic N, Roberson ED, Matthews H, Verbsky JW, Dasu T, Vargas-Hernandez A, Varghese N, McClain KL, Karam LB, Nahmod K, Makedonas G, Mace EM, Sorte HS, Perminow G, Rao VK, O'Connell MP, Price S, Su HC, Butrick M, McElwee J, Hughes JD, Willet J, Swan D, Xu Y, Santibanez-Koref M, Slowik V, Dinwiddie DL, Ciaccio CE, Saunders CJ, Septer S, Kingsmore SF, White AJ, Cant AJ, Hambleton S, Cooper MA. Early-onset lymphoproliferation and autoimmunity caused by germline STAT3 gain-of-function mutations. Blood. 2015 Jan 22; 125(4):591-9. PMID: 25359994; PMCID: PMC4304103.
    14. Simko SJ, Garmezy B, Abhyankar H, Lupo PJ, Chakraborty R, Lim KP, Shih A, Hicks MJ, Wright TS, Levy ML, McClain KL, Allen CE. Differentiating skin-limited and multisystem Langerhans cell histiocytosis. J Pediatr. 2014 Nov; 165(5):990-6. PMID: 25441388; PMCID: PMC4254414.
    15. Chakraborty R, Hampton OA, Shen X, Simko SJ, Shih A, Abhyankar H, Lim KP, Covington KR, Trevino L, Dewal N, Muzny DM, Doddapaneni H, Hu J, Wang L, Lupo PJ, Hicks MJ, Bonilla DL, Dwyer KC, Berres ML, Poulikakos PI, Merad M, McClain KL, Wheeler DA, Allen CE, Parsons DW. Mutually exclusive recurrent somatic mutations in MAP2K1 and BRAF support a central role for ERK activation in LCH pathogenesis. Blood. 2014 Nov 6; 124(19):3007-15. PMID: 25202140; PMCID: PMC4224195.
    16. Allen CE, McClain KL. fHLH: becoming a blended family. Blood. 2014 Aug 21; 124(8):1210-1. PMID: 25147377; PMCID: PMC4141507.
    17. Gaikwad AS, Donohue RE, Elghetany MT, Sheehan AM, Lu XY, Gramatges MM, McClain KL, Mistretta TA, Punia JN, Moore TJ, Goltsova T, Cubbage M, Curry CV. Expression of CD25 is a specific and relatively sensitive marker for the Philadelphia chromosome (BCR-ABL1) translocation in pediatric B acute lymphoblastic leukemia. Int J Clin Exp Pathol. 2014; 7(9):6225-30. PMID: 25337274; PMCID: PMC4203245.
    18. Diamond EL, Dagna L, Hyman DM, Cavalli G, Janku F, Estrada-Veras J, Ferrarini M, Abdel-Wahab O, Heaney ML, Scheel PJ, Feeley NK, Ferrero E, McClain KL, Vaglio A, Colby T, Arnaud L, Haroche J. Consensus guidelines for the diagnosis and clinical management of Erdheim-Chester disease. Blood. 2014 Jul 24; 124(4):483-92. PMID: 24850756; PMCID: PMC4110656.
    19. Lehmberg K, McClain KL, Janka GE, Allen CE. Determination of an appropriate cut-off value for ferritin in the diagnosis of hemophagocytic lymphohistiocytosis. Pediatr Blood Cancer. 2014 Nov; 61(11):2101-3. PMID: 24753034.
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    20. McClain KL. Why do T cells cause so much trouble? Blood. 2014 Mar 27; 123(13):1978. PMID: 24677399.
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    21. Berres ML, Lim KP, Peters T, Price J, Takizawa H, Salmon H, Idoyaga J, Ruzo A, Lupo PJ, Hicks MJ, Shih A, Simko SJ, Abhyankar H, Chakraborty R, Leboeuf M, Beltrão M, Lira SA, Heym KM, Bigley V, Collin M, Manz MG, McClain K, Merad M, Allen CE. BRAF-V600E expression in precursor versus differentiated dendritic cells defines clinically distinct LCH risk groups. J Exp Med. 2014 Apr 7; 211(4):669-83. PMID: 24638167; PMCID: PMC3978272.
    22. Eissa HM, Allen CE, Kamdar K, Simko S, Goradia P, Dreyer Z, Steuber P, McClain KL, Guillerman RP, Bollard CM. Pediatric Burkitt's lymphoma and diffuse B-cell lymphoma: are surveillance scans required? Pediatr Hematol Oncol. 2014 Apr; 31(3):253-7. PMID: 24087880; PMCID: PMC4133356.
    23. Simko SJ, Tran HD, Jones J, Bilgi M, Beaupin LK, Coulter D, Garrington T, McCavit TL, Moore C, Rivera-Ortegón F, Shaffer L, Stork L, Turcotte L, Welsh EC, Hicks MJ, McClain KL, Allen CE. Clofarabine salvage therapy in refractory multifocal histiocytic disorders, including Langerhans cell histiocytosis, juvenile xanthogranuloma and Rosai-Dorfman disease. Pediatr Blood Cancer. 2014 Mar; 61(3):479-87. PMID: 24106153; PMCID: PMC4474604.
    24. Girschikofsky M, Arico M, Castillo D, Chu A, Doberauer C, Fichter J, Haroche J, Kaltsas GA, Makras P, Marzano AV, de Menthon M, Micke O, Passoni E, Seegenschmiedt HM, Tazi A, McClain KL. Management of adult patients with Langerhans cell histiocytosis: recommendations from an expert panel on behalf of Euro-Histio-Net. Orphanet J Rare Dis. 2013; 8:72. PMID: 23672541; PMCID: PMC3667012.
    25. Gadner H, Minkov M, Grois N, Pötschger U, Thiem E, Aricò M, Astigarraga I, Braier J, Donadieu J, Henter JI, Janka-Schaub G, McClain KL, Weitzman S, Windebank K, Ladisch S. Therapy prolongation improves outcome in multisystem Langerhans cell histiocytosis. Blood. 2013 Jun 20; 121(25):5006-14. PMID: 23589673.
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    26. Cantu MA, Lupo PJ, Bilgi M, Hicks MJ, Allen CE, McClain KL. Optimal therapy for adults with Langerhans cell histiocytosis bone lesions. PLoS One. 2012; 7(8):e43257. PMID: 22916233; PMCID: PMC3419729.
    27. McClain KL. Are all mutant SNARES equal? Blood. 2012 Jun 21; 119(25):5944-5. PMID: 22730520.
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    28. Rathore N, Eissa HM, Margolin JF, Liu H, Wu MF, Horton T, Kamdar K, Dreyer Z, Steuber P, Rabin KR, Redell M, Allen CE, McClain KL, Guillerman RP, Bollard CM. Pediatric Hodgkin lymphoma: are we over-scanning our patients? Pediatr Hematol Oncol. 2012 Aug; 29(5):415-23. PMID: 22632168; PMCID: PMC3685486.
    29. Marsh RA, Allen CE, McClain KL, Weinstein JL, Kanter J, Skiles J, Lee ND, Khan SP, Lawrence J, Mo JQ, Bleesing JJ, Filipovich AH, Jordan MB. Salvage therapy of refractory hemophagocytic lymphohistiocytosis with alemtuzumab. Pediatr Blood Cancer. 2013 Jan; 60(1):101-9. PMID: 22522603; PMCID: PMC3410971.
    30. Jordan MB, Allen CE, Weitzman S, Filipovich AH, McClain KL. How I treat hemophagocytic lymphohistiocytosis. Blood. 2011 Oct 13; 118(15):4041-52. PMID: 21828139; PMCID: PMC3204727.
    31. Peters TL, McClain KL, Allen CE. Neither IL-17A mRNA nor IL-17A protein are detectable in Langerhans cell histiocytosis lesions. Mol Ther. 2011 Aug; 19(8):1433-9. PMID: 21654633; PMCID: PMC3149162.
    32. Allen CE, McClain KL. Erdheim-Chester: beyond the lesion. Blood. 2011 Mar 10; 117(10):2745-6. PMID: 21393495.
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    33. Lin TF, Ferlic-Stark LL, Allen CE, Kozinetz CA, McClain KL. Rate of decline of ferritin in patients with hemophagocytic lymphohistiocytosis as a prognostic variable for mortality. Pediatr Blood Cancer. 2011 Jan; 56(1):154-5. PMID: 20842751; PMCID: PMC3444147.
    34. Kelly C, Salvi S, McClain K, Hayani A. Hemophagocytic lymphohistiocytosis associated with precursor B acute lymphoblastic leukemia. Pediatr Blood Cancer. 2011 Apr; 56(4):658-60. PMID: 21298755.
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    35. Grois N, Fahrner B, Arceci RJ, Henter JI, McClain K, Lassmann H, Nanduri V, Prosch H, Prayer D. Central nervous system disease in Langerhans cell histiocytosis. J Pediatr. 2010 Jun; 156(6):873-81, 881.e1. PMID: 20434166.
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    36. Venkataraman G, McClain KL, Pittaluga S, Rao VK, Jaffe ES. Development of disseminated histiocytic sarcoma in a patient with autoimmune lymphoproliferative syndrome and associated Rosai-Dorfman disease. Am J Surg Pathol. 2010 Apr; 34(4):589-94. PMID: 20216376; PMCID: PMC2861546.
    37. Allen CE, Li L, Peters TL, Leung HC, Yu A, Man TK, Gurusiddappa S, Phillips MT, Hicks MJ, Gaikwad A, Merad M, McClain KL. Cell-specific gene expression in Langerhans cell histiocytosis lesions reveals a distinct profile compared with epidermal Langerhans cells. J Immunol. 2010 Apr 15; 184(8):4557-67. PMID: 20220088; PMCID: PMC3142675.
    38. Allen CE, Flores R, Rauch R, Dauser R, Murray JC, Puccetti D, Hsu DA, Sondel P, Hetherington M, Goldman S, McClain KL. Neurodegenerative central nervous system Langerhans cell histiocytosis and coincident hydrocephalus treated with vincristine/cytosine arabinoside. Pediatr Blood Cancer. 2010 Mar; 54(3):416-23. PMID: 19908293; PMCID: PMC3444163.
    39. Niece JA, Rogers ZR, Ahmad N, Langevin AM, McClain KL. Hemophagocytic lymphohistiocytosis in Texas: observations on ethnicity and race. Pediatr Blood Cancer. 2010 Mar; 54(3):424-8. PMID: 19953651.
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    40. Filipovich A, McClain K, Grom A. Histiocytic disorders: recent insights into pathophysiology and practical guidelines. Biol Blood Marrow Transplant. 2010 Jan; 16(1 Suppl):S82-9. PMID: 19932759.
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    41. Bird JA, McClain KL, Rosenblatt HM, Abramson SL, Hanson IC. Hemophagocytic lymphohistiocytosis in a patient with x-linked lymphoproliferative disease. Allergy Asthma Proc. 2009 Jul-Aug; 30(4):458-62. PMID: 19772767.
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    42. Allen CE, McClain KL. Interleukin-17A is not expressed by CD207(+) cells in Langerhans cell histiocytosis lesions. Nat Med. 2009 May; 15(5):483-4; author reply 484-5. PMID: 19424201; PMCID: PMC2820828.
    43. Abla O, Weitzman S, Minkov M, McClain KL, Visser J, Filipovich A, Grois N. Diabetes insipidus in Langerhans cell histiocytosis: When is treatment indicated? Pediatr Blood Cancer. 2009 May; 52(5):555-6. PMID: 19142995.
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    44. Thompson PA, Allen CE, Horton T, Jones JY, Vinks AA, McClain KL. Severe neurologic side effects in patients being treated for hemophagocytic lymphohistiocytosis. Pediatr Blood Cancer. 2009 May; 52(5):621-5. PMID: 19137570; PMCID: PMC3660724.
    45. Phillips M, Allen C, Gerson P, McClain K. Comparison of FDG-PET scans to conventional radiography and bone scans in management of Langerhans cell histiocytosis. Pediatr Blood Cancer. 2009 Jan; 52(1):97-101. PMID: 18951435.
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    46. Minkov M, Steiner M, Pötschger U, Aricò M, Braier J, Donadieu J, Grois N, Henter JI, Janka G, McClain K, Weitzman S, Windebank K, Ladisch S, Gadner H. Reactivations in multisystem Langerhans cell histiocytosis: data of the international LCH registry. J Pediatr. 2008 Nov; 153(5):700-5, 705.e1-2. PMID: 18589441.
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    47. Allen CE, Yu X, Kozinetz CA, McClain KL. Highly elevated ferritin levels and the diagnosis of hemophagocytic lymphohistiocytosis. Pediatr Blood Cancer. 2008 Jun; 50(6):1227-35. PMID: 18085676.
      View in: PubMed
    48. Fung EB, Harmatz PR, Milet M, Balasa V, Ballas SK, Casella JF, Hilliard L, Kutlar A, McClain KL, Olivieri NF, Porter JB, Vichinsky EP. Disparity in the management of iron overload between patients with sickle cell disease and thalassemia who received transfusions. Transfusion. 2008 Sep; 48(9):1971-80. PMID: 18513257; PMCID: PMC4613769.
    49. Lee DA, Tatevian N, Herring RA, McClain KL. EBV+ lymphoproliferative disease following prolonged chemotherapy for refractory LCH. Pediatr Blood Cancer. 2008 Mar; 50(3):728-30. PMID: 17243127.
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    50. O'Brien MM, Lee-Kim Y, George TI, McClain KL, Twist CJ, Jeng M. Precursor B-cell acute lymphoblastic leukemia presenting with hemophagocytic lymphohistiocytosis. Pediatr Blood Cancer. 2008 Feb; 50(2):381-3. PMID: 16856156.
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    51. Steiner QG, Otten LA, Hicks MJ, Kaya G, Grosjean F, Saeuberli E, Lavanchy C, Beermann F, McClain KL, Acha-Orbea H. In vivo transformation of mouse conventional CD8alpha+ dendritic cells leads to progressive multisystem histiocytosis. Blood. 2008 Feb 15; 111(4):2073-82. PMID: 18029555.
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    52. Allen CE, McClain KL. Langerhans cell histiocytosis: a review of past, current and future therapies. Drugs Today (Barc). 2007 Sep; 43(9):627-43. PMID: 17940639.
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    53. Henter JI, Horne A, Aricó M, Egeler RM, Filipovich AH, Imashuku S, Ladisch S, McClain K, Webb D, Winiarski J, Janka G. HLH-2004: Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis. Pediatr Blood Cancer. 2007 Feb; 48(2):124-31. PMID: 16937360.
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    54. McClain KL, Kozinetz CA. A phase II trial using thalidomide for Langerhans cell histiocytosis. Pediatr Blood Cancer. 2007 Jan; 48(1):44-9. PMID: 16333818.
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    55. McClain KL. Drug therapy for the treatment of Langerhans cell histiocytosis. Expert Opin Pharmacother. 2005 Nov; 6(14):2435-41. PMID: 16259575.
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    56. Shah MD, McClain KL. Intracranial plasma cell granuloma: case report and treatment of recurrence with methotrexate and 6-mercaptopurine. J Pediatr Hematol Oncol. 2005 Nov; 27(11):599-603. PMID: 16282891.
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    57. McClain KL, Cai YH, Hicks J, Peterson LE, Yan XT, Che S, Ginsberg SD. Expression profiling using human tissues in combination with RNA amplification and microarray analysis: assessment of Langerhans cell histiocytosis. Amino Acids. 2005 May; 28(3):279-90. PMID: 15791395.
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    58. Jordan MB, McClain KL, Yan X, Hicks J, Jaffe R. Anti-CD52 antibody, alemtuzumab, binds to Langerhans cells in Langerhans cell histiocytosis. Pediatr Blood Cancer. 2005 Mar; 44(3):251-4. PMID: 15390358.
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    59. Rolland A, Guyon L, Gill M, Cai YH, Banchereau J, McClain K, Palucka AK. Increased blood myeloid dendritic cells and dendritic cell-poietins in Langerhans cell histiocytosis. J Immunol. 2005 Mar 1; 174(5):3067-71. PMID: 15728521.
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    60. Stine KC, Saylors RL, Saccente S, McClain KL, Becton DL. Efficacy of continuous infusion 2-CDA (cladribine) in pediatric patients with Langerhans cell histiocytosis. Pediatr Blood Cancer. 2004 Jul; 43(1):81-4. PMID: 15170896.
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    61. Haupt R, Nanduri V, Calevo MG, Bernstrand C, Braier JL, Broadbent V, Rey G, McClain KL, Janka-Schaub G, Egeler RM. Permanent consequences in Langerhans cell histiocytosis patients: a pilot study from the Histiocyte Society-Late Effects Study Group. Pediatr Blood Cancer. 2004 May; 42(5):438-44. PMID: 15049016.
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    62. McClain KL, Natkunam Y, Swerdlow SH. Atypical cellular disorders. Hematology Am Soc Hematol Educ Program. 2004; 283-96. PMID: 15561688.
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    63. McClain KL, Laud P, Wu WS, Pollack MS. Langerhans cell histiocytosis patients have HLA Cw7 and DR4 types associated with specific clinical presentations and no increased frequency in polymorphisms of the tumor necrosis factor alpha promoter. Med Pediatr Oncol. 2003 Dec; 41(6):502-7. PMID: 14595706.
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    64. Aricò M, Girschikofsky M, Généreau T, Klersy C, McClain K, Grois N, Emile JF, Lukina E, De Juli E, Danesino C. Langerhans cell histiocytosis in adults. Report from the International Registry of the Histiocyte Society. Eur J Cancer. 2003 Nov; 39(16):2341-8. PMID: 14556926.
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    65. Palazzi DL, McClain KL, Kaplan SL. Hemophagocytic syndrome after Kawasaki disease. Pediatr Infect Dis J. 2003 Jul; 22(7):663-6. PMID: 12886898.
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    66. Pollock BH, Jenson HB, Leach CT, McClain KL, Hutchison RE, Garzarella L, Joshi VV, Parmley RT, Murphy SB. Risk factors for pediatric human immunodeficiency virus-related malignancy. JAMA. 2003 May 14; 289(18):2393-9. PMID: 12746363.
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    67. Rooms L, Fitzgerald N, McClain KL. Hemophagocytic lymphohistiocytosis masquerading as child abuse: presentation of three cases and review of central nervous system findings in hemophagocytic lymphohistiocytosis. Pediatrics. 2003 May; 111(5 Pt 1):e636-40. PMID: 12728123.
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    68. Palazzi DL, McClain KL, Kaplan SL. Hemophagocytic syndrome in children: an important diagnostic consideration in fever of unknown origin. Clin Infect Dis. 2003 Feb 1; 36(3):306-12. PMID: 12539072.
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    69. Singh A, Prieto VG, Czelusta A, McClain KL, Duvic M. Adult Langerhans cell histiocytosis limited to the skin. Dermatology. 2003; 207(2):157-61. PMID: 12920365.
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    70. Cabalo E, Wilkinson R, Lu NT, Shimizu S, Melish M, McClain KL, Jenson HB, Shiramizu B. Molecular analysis and pathology of a second pediatric HIV-associated Burkitt lymphoma. Pediatr Pathol Mol Med. 2002 Nov-Dec; 21(6):525-30. PMID: 12537769.
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    71. McClain KL, Gonzalez JM, Jonkers R, De Juli E, Egeler M. Need for a cooperative study: Pulmonary Langerhans cell histiocytosis and its management in adults. Med Pediatr Oncol. 2002 Jul; 39(1):35-9. PMID: 12116077.
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    72. Leach CT, Pollock BH, McClain KL, Parmley RT, Murphy SB, Jenson HB. Human herpesvirus 6 and cytomegalovirus infections in children with human immunodeficiency virus infection and cancer. Pediatr Infect Dis J. 2002 Feb; 21(2):125-32. PMID: 11840079.
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    73. McClain KL. Epstein-Barr virus and HIV-AIDS-associated diseases. Biomed Pharmacother. 2001 Sep; 55(7):348-52. PMID: 11669495.
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    74. Winter H, Hu HM, McClain K, Urba WJ, Fox BA. Immunotherapy of melanoma: a dichotomy in the requirement for IFN-gamma in vaccine-induced antitumor immunity versus adoptive immunotherapy. J Immunol. 2001 Jun 15; 166(12):7370-80. PMID: 11390488.
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    75. Pease CL, Horton TM, McClain KL, Kaplan SL. Aseptic meningitis in a child after systemic treatment with high dose cytarabine. Pediatr Infect Dis J. 2001 Jan; 20(1):87-9. PMID: 11176579.
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    76. Jenson HB, McClain KL, Leach CT, Deng JH, Gao SJ. Evaluation of human herpesvirus type 8 infection in childhood langerhans cell histiocytosis. Am J Hematol. 2000 Aug; 64(4):237-41. PMID: 10911374.
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    77. McClain KL, Leach CT, Jenson HB, Joshi VV, Pollock BH, Hutchison RE, Murphy SB. Molecular and virologic characteristics of lymphoid malignancies in children with AIDS. J Acquir Immune Defic Syndr. 2000 Feb 1; 23(2):152-9. PMID: 10737430.
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    78. Kavan P, Kabickova E, Gajdos P, Koutecky J, Kodet R, McClain KL. Treatment of pediatric B-cell non-Hodgkin's lymphomas at the Motol Hospital in Prague, Czech Republic: results based on the NHL BFM 90 protocols. Pediatr Hematol Oncol. 1999 May-Jun; 16(3):201-12. PMID: 10326218.
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    79. Leach CT, Frantz C, Head DR, Gao SJ, McClain KL, Cohen M, Campbell AB, Pollock BH, Murphy SB, Jenson HB. Human herpesvirus-8 (HHV-8) associated with small non-cleaved cell lymphoma in a child with AIDS. Am J Hematol. 1999 Mar; 60(3):215-21. PMID: 10072113.
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    80. Kavan P, Kabickova E, Koutecky J, McClain K, Gajdos P, Kodet R, Slavik Z, Tousovska K. Treatment of Hodgkin's disease in children with VAMP (vinblastine, adriamycin, methotrexate, prednisone) and VEPA (vinblastine, etoposide, prednisone, adriamycin). Pediatr Hematol Oncol. 1999 Mar-Apr; 16(2):141-8. PMID: 10100274.
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    81. Jenson HB, Montalvo EA, McClain KL, Ench Y, Heard P, Christy BA, Dewalt-Hagan PJ, Moyer MP. Characterization of natural Epstein-Barr virus infection and replication in smooth muscle cells from a leiomyosarcoma. J Med Virol. 1999 Jan; 57(1):36-46. PMID: 9890420.
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    82. Roskrow MA, Rooney CM, Heslop HE, Brenner MK, Krance RA, Gresik MV, McClain K, Aguilar LK, Grilley B, Rob E, Carrum G. Administration of neomycin resistance gene marked EBV specific cytotoxic T-lymphocytes to patients with relapsed EBV-positive Hodgkin disease. Hum Gene Ther. 1998 May 20; 9(8):1237-50. PMID: 9625264.
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    83. Willman CL, McClain KL. An update on clonality, cytokines, and viral etiology in Langerhans cell histiocytosis. Hematol Oncol Clin North Am. 1998 Apr; 12(2):407-16. PMID: 9561909.
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    84. Mahoney DH, Schreuders LC, Gresik MV, McClain KL. Role of staging bone marrow examination in children with Hodgkin disease. Med Pediatr Oncol. 1998 Mar; 30(3):175-7. PMID: 9434827.
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    85. Vogel H, Kornman M, Ledet SC, Rajagopalan L, Taber L, McClain K. Congenital parvovirus infection. Pediatr Pathol Lab Med. 1997 Nov-Dec; 17(6):903-12. PMID: 9353830.
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    86. Wu WS, McClain KL. DNA polymorphisms and mutations of the tumor necrosis factor-alpha (TNF-alpha) promoter in Langerhans cell histiocytosis (LCH). J Interferon Cytokine Res. 1997 Oct; 17(10):631-5. PMID: 9355965.
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    87. Jenson HB, Leach CT, McClain KL, Joshi VV, Pollock BH, Parmley RT, Chadwick EG, Murphy SB. Benign and malignant smooth muscle tumors containing Epstein-Barr virus in children with AIDS. Leuk Lymphoma. 1997 Oct; 27(3-4):303-14. PMID: 9402327.
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    88. Kavan P, Smelhaus V, Stary J, McClain K, Koutecky J. History of pediatric hematology-oncology in the Czech Republic. Pediatr Hematol Oncol. 1997 Jul-Aug; 14(4):307-13. PMID: 9211535.
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    89. Joshi VV, Gagnon GA, Chadwick EG, Berard CW, McClain KL, Leach CT, Jenson HB, Murphy SB. The spectrum of mucosa-associated lymphoid tissue lesions in pediatric patients infected with HIV: A clinicopathologic study of six cases. Am J Clin Pathol. 1997 May; 107(5):592-600. PMID: 9128273.
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    90. Wright-Browne V, McClain KL, Talpaz M, Ordonez N, Estrov Z. Physiology and pathophysiology of dendritic cells. Hum Pathol. 1997 May; 28(5):563-79. PMID: 9158705.
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    91. Roberts WM, Estrov Z, Ouspenskaia MV, Johnston DA, McClain KL, Zipf TF. Measurement of residual leukemia during remission in childhood acute lymphoblastic leukemia. N Engl J Med. 1997 Jan 30; 336(5):317-23. PMID: 9011783.
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    92. McClain K, Estrov Z, Raju U, Kelley PK, Aggarwal BB. Epstein-Barr Virus EBNA-2 gene expression enhances lymphotoxin production by B lymphocytes. Methods. 1997 Jan; 11(1):83-7. PMID: 8990093.
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    93. McClain KL. Immunodeficiency states and related malignancies. Cancer Treat Res. 1997; 92:39-61. PMID: 9494757.
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    94. McClain KL, Joshi VV, Murphy SB. Cancers in children with HIV infection. Hematol Oncol Clin North Am. 1996 Oct; 10(5):1189-201. PMID: 8880205.
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    95. Weiss NS, Katz JA, Frankel LS, Lloyd LE, McClain KL, Torges K, Thomas PJ, Bleyer WA. Incidence of childhood and adolescent cancer in Texas. Tex Med. 1996 Jul; 92(7):54-60. PMID: 8763250.
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    96. Mustafa MM, McClain KL. Diverse hematologic effects of parvovirus B19 infection. Pediatr Clin North Am. 1996 Jun; 43(3):809-21. PMID: 8649911.
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    97. Murray JC, Paul ME, Rosenblatt HM, McClain KL. Recurrent human parvovirus B19-induced anemia: initial manifestation of humoral immunodeficiency. J Pediatr Hematol Oncol. 1996 Feb; 18(1):97-8. PMID: 8556382.
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    98. McClain KL, Leach CT, Jenson HB, Joshi VV, Pollock BH, Parmley RT, DiCarlo FJ, Chadwick EG, Murphy SB. Association of Epstein-Barr virus with leiomyosarcomas in children with AIDS. N Engl J Med. 1995 Jan 5; 332(1):12-8. PMID: 7990860.
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    99. Kelley PK, McClain KL. Respiratory contamination of polymerase chain reactions by human herpesvirus 6. Am J Hematol. 1994 Dec; 47(4):325-7. PMID: 7977307.
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    100. Murray JC, Kelley PK, Hogrefe WR, McClain KL. Childhood idiopathic thrombocytopenic purpura: association with human parvovirus B19 infection. Am J Pediatr Hematol Oncol. 1994 Nov; 16(4):314-9. PMID: 7978048.
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    101. Murray JC, Stein F, McGlothlin JC, McClain KL. Prolongation of the prothrombin time after organophosphate poisoning. Pediatr Emerg Care. 1994 Oct; 10(5):289-90. PMID: 7845858.
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    102. McClain K, Jin H, Gresik V, Favara B. Langerhans cell histiocytosis: lack of a viral etiology. Am J Hematol. 1994 Sep; 47(1):16-20. PMID: 8042610.
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    103. Murray JC, Kelley PK, McClain KL. Adenovirus and childhood immune thrombocytopenic purpura. Am J Hematol. 1994 Sep; 47(1):65. PMID: 8042623.
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    104. McClain K, Weiss RA. Viruses and Langerhans cell histiocytosis: is there a link? Br J Cancer Suppl. 1994 Sep; 23:S34-6. PMID: 8075003; PMCID: PMC2149698.
    105. Willman CL, Busque L, Griffith BB, Favara BE, McClain KL, Duncan MH, Gilliland DG. Langerhans'-cell histiocytosis (histiocytosis X)--a clonal proliferative disease. N Engl J Med. 1994 Jul 21; 331(3):154-60. PMID: 8008029.
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    106. Murray JC, McClain KL, Wearden ME. Using granulocyte colony-stimulating factor for neutropenia during neonatal sepsis. Arch Pediatr Adolesc Med. 1994 Jul; 148(7):764-6. PMID: 7517276.
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    107. Estrov Z, Ouspenskaia MV, Felix EA, McClain KL, Lee MS, Harris D, Pinkel DP, Zipf TF. Persistence of self-renewing leukemia cell progenitors during remission in children with B-precursor acute lymphoblastic leukemia. Leukemia. 1994 Jan; 8(1):46-52. PMID: 8289497.
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    108. Murray JC, Gresik MV, Leger F, McClain KL. B19 parvovirus-induced anemia in a normal child. Initial bone marrow erythroid hyperplasia and response to intravenous immunoglobulin. Am J Pediatr Hematol Oncol. 1993 Nov; 15(4):420-3. PMID: 8214365.
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    109. Furman WL, Strother D, McClain K, Bell B, Leventhal B, Pratt CB. Phase I clinical trial of recombinant human tumor necrosis factor in children with refractory solid tumors: a Pediatric Oncology Group study. J Clin Oncol. 1993 Nov; 11(11):2205-10. PMID: 8229135.
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    110. Morad AB, McClain KL, Ogden AK. The role of tranexamic acid in the treatment of giant hemangiomas in newborns. Am J Pediatr Hematol Oncol. 1993 Nov; 15(4):383-5. PMID: 7605400.
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    111. McClain K, Estrov Z, Chen H, Mahoney DH. Chronic neutropenia of childhood: frequent association with parvovirus infection and correlations with bone marrow culture studies. Br J Haematol. 1993 Sep; 85(1):57-62. PMID: 8251410.
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    112. Estrov Z, Talpaz M, Kantarjian HM, Zipf TF, McClain KL, Kurzrock R. Heterogeneity in lineage derivation of Philadelphia-positive acute lymphoblastic leukemia expressing p190BCR-ABL or p210BCR-ABL: determination by analysis of individual colonies with the polymerase chain reaction. Cancer Res. 1993 Jul 15; 53(14):3289-93. PMID: 8324740.
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    113. Chintagumpala MM, Mahoney DH, McClain K, Dreyer ZE, Fishman MA, Carrol CL, Steuber CP. Hodgkin's disease associated with central pontine myelinolysis. Med Pediatr Oncol. 1993; 21(4):311-4. PMID: 7682285.
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    114. Rogers BB, Browning I, Rosenblatt H, McClain K, Kemp J, Glasser LL, Gresik MV, Sumaya C, Wagner ML, Pollack MS, et al. A familial lymphoproliferative disorder presenting with primary pulmonary manifestations. Am Rev Respir Dis. 1992 Jan; 145(1):203-8. PMID: 1309966.
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    115. Dreyer ZE, Dowell BL, Chen H, Hawkins E, McClain KL. Infection-associated hemophagocytic syndrome. Evidence for Epstein-Barr virus gene expression. Am J Pediatr Hematol Oncol. 1991; 13(4):476-81. PMID: 1664662.
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    116. Hayani A, Venger BH, Rouah E, Laurent JP, Mahoney DH, McClain KL. Primary leptomeningeal B-cell lymphoma in a 8-year-old child. Cancer. 1990 Oct 15; 66(8):1856-60. PMID: 2170000.
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    117. Chadwick EG, Connor EJ, Hanson IC, Joshi VV, Abu-Farsakh H, Yogev R, McSherry G, McClain K, Murphy SB. Tumors of smooth-muscle origin in HIV-infected children. JAMA. 1990 Jun 20; 263(23):3182-4. PMID: 2348529.
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    118. Patton DF, Wilkowski CW, Hanson CA, Shapiro R, Gajl-Peczalska KJ, Filipovich AH, McClain KL. Epstein-Barr virus--determined clonality in posttransplant lymphoproliferative disease. Transplantation. 1990 Jun; 49(6):1080-4. PMID: 2163133.
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    119. McClain KL, Heise R, Day DL, Lee CK, Woods WG, Aeppli D. Hodgkin's disease in children: correlation of clinical characteristics, staging procedures, and treatment at the University of Minnesota. Am J Pediatr Hematol Oncol. 1990; 12(2):147-54. PMID: 1696073.
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    120. Schumacher HR, Desai SN, McClain KL, Domenico DR, Dizikes GJ, Bird ML. Acute lymphoblastic leukemia-hand mirror variant. Analysis for endogenous retroviral antibodies in bone marrow plasma. Am J Clin Pathol. 1989 Apr; 91(4):410-6. PMID: 2467550.
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    121. Mahoney DH, McClain KL, Hanson IC, Taylor LD, Steuber CP. Acquired immune deficiency, myelodysplasia, and acute nonlymphocytic leukemia associated with monosomy 7 and t(3;3) (q21;q26) in a child with Langerhans cell histiocytosis. Am J Pediatr Hematol Oncol. 1989; 11(2):153-7. PMID: 2546462.
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    122. Patton DF, Wilkowski C, Hanson CA, Kersey JH, Bostrom B, McClain KL. Epstein-Barr-virus-related post-bone-marrow-transplant lymphoproliferative disease: association with cytomegalovirus infection and Down syndrome donor marrow. Am J Pediatr Hematol Oncol. 1989; 11(4):429-32. PMID: 2559622.
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    123. Grishaber JE, McClain KL, Mahoney DH, Fernbach DJ. Successful outcome of severe aplastic anemia following Epstein-Barr virus infection. Am J Hematol. 1988 Aug; 28(4):273-5. PMID: 2843043.
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    124. Bender AP, Robison LL, Kashmiri SV, McClain KL, Woods WG, Smithson WA, Heyn R, Finlay J, Schuman LM, Renier C, et al. No involvement of bovine leukemia virus in childhood acute lymphoblastic leukemia and non-Hodgkin's lymphoma. Cancer Res. 1988 May 15; 48(10):2919-22. PMID: 2834051.
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    125. Shapiro RS, McClain K, Frizzera G, Gajl-Peczalska KJ, Kersey JH, Blazar BR, Arthur DC, Patton DF, Greenberg JS, Burke B, et al. Epstein-Barr virus associated B cell lymphoproliferative disorders following bone marrow transplantation. Blood. 1988 May; 71(5):1234-43. PMID: 2833957.
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    126. Hanson CA, Frizzera G, Patton DF, Peterson BA, McClain KL, Gajl-Peczalska KJ, Kersey JH. Clonal rearrangement for immunoglobulin and T-cell receptor genes in systemic Castleman's disease. Association with Epstein-Barr virus. Am J Pathol. 1988 Apr; 131(1):84-91. PMID: 2833104; PMCID: PMC1880570.
    127. McClain K, Gehrz R, Grierson H, Purtilo D, Filipovich A. Virus-associated histiocytic proliferations in children. Frequent association with Epstein-Barr virus and congenital or acquired immunodeficiencies. Am J Pediatr Hematol Oncol. 1988; 10(3):196-205. PMID: 2845831.
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    128. Wirtschafter JD, Nesbit M, Anderson P, McClain K. Intralesional methylprednisolone for Langerhans' cell histiocytosis of the orbit and cranium. J Pediatr Ophthalmol Strabismus. 1987 Jul-Aug; 24(4):194-7. PMID: 3668768.
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    129. McClain K. Epstein-Barr virus DNA in lymphocytes of patients with the virus-associated hemophagocytic syndrome. Am J Pediatr Hematol Oncol. 1986; 8(2):121-7. PMID: 3017142.
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    130. Leonard AS, Alyono D, Fischel RJ, Nesbit ME, Nguyen DH, McClain KL. Role of the surgeon in the treatment of children's cancer. Surg Clin North Am. 1985 Dec; 65(6):1387-422. PMID: 3000008.
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    131. Rubin CM, Burke BA, McKenna RW, McClain KL, White JG, Nesbit ME, Filipovich AH. The accelerated phase of Chediak-Higashi syndrome. An expression of the virus-associated hemophagocytic syndrome? Cancer. 1985 Aug 1; 56(3):524-30. PMID: 2988747.
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    132. Loeffel S, Chang CH, Heyn R, Harada S, Lipscomb H, Sinangil F, Volsky DJ, McClain K, Ochs H, Purtilo DT. Necrotizing lymphoid vasculitis in X-linked lymphoproliferative syndrome. Arch Pathol Lab Med. 1985 Jun; 109(6):546-50. PMID: 2986573.
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    133. Rubin CM, Arthur DC, Meyers G, McClain KL, Kim TH, Woods WG. Leukemia cutis treated with total skin irradiation. Cancer. 1985 Jun 1; 55(11):2649-52. PMID: 3888368.
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    134. Petersen JM, Tubbs RR, Savage RA, Calabrese LC, Proffitt MR, Manolova Y, Manolov G, Shumaker A, Tatsumi E, McClain K, et al. Small noncleaved B cell Burkitt-like lymphoma with chromosome t(8;14) translocation and Epstein-Barr virus nuclear-associated antigen in a homosexual man with acquired immune deficiency syndrome. Am J Med. 1985 Jan; 78(1):141-8. PMID: 2981469.
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    135. McClain K, Warkentin P, Kay N. Spontaneous remission of Burkitt's lymphoma associated with herpes zoster infection. Am J Pediatr Hematol Oncol. 1985; 7(1):9-14. PMID: 3876039.
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    136. McClain KL. Expression of oncogenes in human leukemias. Cancer Res. 1984 Nov; 44(11):5382-9. PMID: 6593118.
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    137. Horwitz CA, McClain K, Henle W, Henle G, Anderson SJ. Fatal illness in a 2-week-old infant: diagnosis by detection of Epstein-Barr virus genomes from a lymph node biopsy. J Pediatr. 1983 Nov; 103(5):752-5. PMID: 6313890.
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    138. Hanto DW, Gajl-Peczalska KJ, Frizzera G, Arthur DC, Balfour HH, McClain K, Simmons RL, Najarian JS. Epstein-Barr virus (EBV) induced polyclonal and monoclonal B-cell lymphoproliferative diseases occurring after renal transplantation. Clinical, pathologic, and virologic findings and implications for therapy. Ann Surg. 1983 Sep; 198(3):356-69. PMID: 6311121; PMCID: PMC1353308.
    139. McClain K, Ramsay NK, Robison L, Sundberg RD, Nesbit M. Bone marrow involvement in histiocytosis X. Med Pediatr Oncol. 1983; 11(3):167-71. PMID: 6602270.
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    140. Fusner JE, McClain KL. Disseminated lymphonodular cryptococcosis treated with 5-fluorocytosine. J Pediatr. 1979 Apr; 94(4):599-601. PMID: 430297.
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