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RICHARD LOUIS HURWITZ

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pediatrics
AddressOne Baylor Plaza
Houston TX 77030
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    Other Positions
    TitleAssociate Professor
    InstitutionBaylor College of Medicine
    DepartmentCenter for Cell & Gene Therapy
    DivisionCenter for Cell & Gene Therapy

    TitleAssociate Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular & Cellular Biology
    DivisionMolecular & Cellular Biology

    TitleAssociate Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Ophthalmology
    DivisionOphthalmology


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Bond WS, Akinfenwa PY, Perlaky L, Hurwitz MY, Hurwitz RL, Chévez-Barrios P. Tumorspheres but not adherent cells derived from retinoblastoma tumors are of malignant origin. PLoS One. 2013; 8(6):e63519. PMID: 23826078; PMCID: PMC3691222.
    2. Liu Z, Zhao X, Mao H, Baxter PA, Huang Y, Yu L, Wadhwa L, Su JM, Adesina A, Perlaky L, Hurwitz M, Idamakanti N, Police SR, Hallenbeck PL, Hurwitz RL, Lau CC, Chintagumpala M, Blaney SM, Li XN. Intravenous injection of oncolytic picornavirus SVV-001 prolongs animal survival in a panel of primary tumor-based orthotopic xenograft mouse models of pediatric glioma. Neuro Oncol. 2013 Sep; 15(9):1173-85. PMID: 23658322; PMCID: PMC3748915.
    3. Hurwitz RL. A new vision of mesenchymal stromal cells. Mol Ther. 2012 Nov; 20(11):2017-8. PMID: 23131854; PMCID: PMC3498812.
    4. Ildefonso CJ, Bond WS, Al-Tawashi AR, Hurwitz MY, Hurwitz RL. The liberation of CD44 intracellular domain modulates adenoviral vector transgene expression. J Biol Chem. 2012 Sep 21; 287(39):32697-707. PMID: 22865879; PMCID: PMC3463356.
    5. Wadhwa L, Bond WS, Perlaky L, Overbeek PA, Hurwitz MY, Chévez-Barrios P, Hurwitz RL. Embryonic retinal tumors in SV40 T-Ag transgenic mice contain CD133+ tumor-initiating cells. Invest Ophthalmol Vis Sci. 2012 Jun; 53(7):3454-62. PMID: 22562503; PMCID: PMC4022423.
    6. Bond WS, Wadhwa L, Perlaky L, Penland RL, Hurwitz MY, Hurwitz RL, Chèvez-Barrios P. Establishment and propagation of human retinoblastoma tumors in immune deficient mice. J Vis Exp. 2011; (54). PMID: 21847079; PMCID: PMC3211116.
    7. Yu L, Baxter PA, Zhao X, Liu Z, Wadhwa L, Zhang Y, Su JM, Tan X, Yang J, Adesina A, Perlaky L, Hurwitz M, Idamakanti N, Police SR, Hallenbeck PL, Blaney SM, Chintagumpala M, Hurwitz RL, Li XN. A single intravenous injection of oncolytic picornavirus SVV-001 eliminates medulloblastomas in primary tumor-based orthotopic xenograft mouse models. Neuro Oncol. 2011 Jan; 13(1):14-27. PMID: 21075780; PMCID: PMC3018906.
    8. Ildefonso CJ, Kong L, Leen A, Chai SJ, Petrochelli V, Chintagumpala M, Hurwitz MY, Chévez-Barrios P, Hurwitz RL. Absence of systemic immune response to adenovectors after intraocular administration to children with retinoblastoma. Mol Ther. 2010 Oct; 18(10):1885-90. PMID: 20606647; PMCID: PMC2951557.
    9. Wadhwa L, Hurwitz MY, Chévez-Barrios P, Hurwitz RL. Treatment of invasive retinoblastoma in a murine model using an oncolytic picornavirus. Cancer Res. 2007 Nov 15; 67(22):10653-6. PMID: 18006805.
      View in: PubMed
    10. Chintagumpala M, Chevez-Barrios P, Paysse EA, Plon SE, Hurwitz R. Retinoblastoma: review of current management. Oncologist. 2007 Oct; 12(10):1237-46. PMID: 17962617.
      View in: PubMed
    11. Chaudhuri SR, Mallam JN, Chévez-Barrios P, Wadhwa L, Ng P, Hurwitz MY, Hurwitz RL. Modulation of adenoviral transduction in vitro and in vivo by hyaluronan and its receptor CD44. Mol Ther. 2007 Mar; 15(3):566-70. PMID: 17180120.
      View in: PubMed
    12. Chong EM, Coffee RE, Chintagumpala M, Hurwitz RL, Hurwitz MY, Chévez-Barrios P. Extensively necrotic retinoblastoma is associated with high-risk prognostic factors. Arch Pathol Lab Med. 2006 Nov; 130(11):1669-72. PMID: 17076529.
      View in: PubMed
    13. Chévez-Barrios P, Chintagumpala M, Mieler W, Paysse E, Boniuk M, Kozinetz C, Hurwitz MY, Hurwitz RL. Response of retinoblastoma with vitreous tumor seeding to adenovirus-mediated delivery of thymidine kinase followed by ganciclovir. J Clin Oncol. 2005 Nov 1; 23(31):7927-35. PMID: 16258092.
      View in: PubMed
    14. Mallam JN, Hurwitz MY, Mahoney T, Chévez-Barrios P, Hurwitz RL. Efficient gene transfer into retinal cells using adenoviral vectors: dependence on receptor expression. Invest Ophthalmol Vis Sci. 2004 Jun; 45(6):1680-7. PMID: 15161826.
      View in: PubMed
    15. Hurwitz RL, Chévez-Barrios P, Boniuk M, Chintagumpala M, Hurwitz MY. Retinoblastoma: from bench to bedside. Expert Rev Mol Med. 2003 Jan; 5(1):1-14. PMID: 14987394.
      View in: PubMed
    16. Hurwitz RL. Re.:"A Death in the Laboratory". Mol Ther. 2001 Jul; 4(1):4. PMID: 11472099.
      View in: PubMed
    17. Suber ML, Hurwitz MY, Chévez-Barrios P, Hurwitz RL. Immune consequences of intraocular administration of modified adenoviral vectors. Hum Gene Ther. 2001 May 1; 12(7):833-8. PMID: 11339899.
      View in: PubMed
    18. Takahashi S, Rousseau RF, Yotnda P, Mei Z, Dotti G, Rill D, Hurwitz R, Marini F, Andreeff M, Brenner MK. Autologous antileukemic immune response induced by chronic lymphocytic leukemia B cells expressing the CD40 ligand and interleukin 2 transgenes. Hum Gene Ther. 2001 Apr 10; 12(6):659-70. PMID: 11426465.
      View in: PubMed
    19. Chévez-Barrios P, Hurwitz MY, Louie K, Marcus KT, Holcombe VN, Schafer P, Aguilar-Cordova CE, Hurwitz RL. Metastatic and nonmetastatic models of retinoblastoma. Am J Pathol. 2000 Oct; 157(4):1405-12. PMID: 11021842; PMCID: PMC1850157.
    20. Hurwitz RL, Brenner MK, Poplack DG, Horowitz MC. Retinoblastoma treatment. Science. 1999 Jul 30; 285(5428):663-4. PMID: 10454919.
      View in: PubMed
    21. Hurwitz MY, Marcus KT, Chévez-Barrios P, Louie K, Aguilar-Cordova E, Hurwitz RL. Suicide gene therapy for treatment of retinoblastoma in a murine model. Hum Gene Ther. 1999 Feb 10; 10(3):441-8. PMID: 10048396.
      View in: PubMed
    22. Kylmä T, Paulin L, Hurwitz MY, Hurwitz RL, Kommonen B. Cloning and analysis of the cDNA encoding the rod G-protein transduction alpha, beta1 and gamma1 subunits from the canine retina. Gene. 1997 Jul 1; 193(1):1-4. PMID: 9249060.
      View in: PubMed
    23. Kylmä T, Paulin L, Hurwitz MY, Hurwitz RL, Kommonen B. Cloning of the cDNA encoding rod photoreceptor cGMP-phosphodiesterase alpha and gamma subunits from the retinal degenerate Labrador retriever dog. Res Vet Sci. 1997 May-Jun; 62(3):293-6. PMID: 9300552.
      View in: PubMed
    24. Murray JC, Hill RM, Hegemier S, Hurwitz RL. Lymphoblastic lymphoma following prenatal exposure to phenytoin. J Pediatr Hematol Oncol. 1996 May; 18(2):241-3. PMID: 8846150.
      View in: PubMed
    25. Kommonen B, Kylma T, Cohen RJ, Penn JS, Paulin L, Hurwitz M, Hurwitz RL. Elevation of cGMP with normal expression and activity of rod cGMP-PDE in photoreceptor degenerate labrador retrievers. Ophthalmic Res. 1996; 28(1):19-28. PMID: 8726673.
      View in: PubMed
    26. Carcamo B, Hurwitz MY, Craft CM, Hurwitz RL. The mammalian pineal expresses the cone but not the rod cyclic GMP phosphodiesterase. J Neurochem. 1995 Sep; 65(3):1085-92. PMID: 7643086.
      View in: PubMed
    27. Srivastava D, Hurwitz RL, Fox DA. Lead- and calcium-mediated inhibition of bovine rod cGMP phosphodiesterase: interactions with magnesium. Toxicol Appl Pharmacol. 1995 Sep; 134(1):43-52. PMID: 7676457.
      View in: PubMed
    28. Srivastava D, Fox DA, Hurwitz RL. Effects of magnesium on cyclic GMP hydrolysis by the bovine retinal rod cyclic GMP phosphodiesterase. Biochem J. 1995 Jun 1; 308 ( Pt 2):653-8. PMID: 7772055; PMCID: PMC1136976.
    29. Fox DA, Srivastava D, Hurwitz RL. Lead-induced alterations in rod-mediated visual functions and cGMP metabolism: new insights. Neurotoxicology. 1994; 15(3):503-12. PMID: 7854584.
      View in: PubMed
    30. Suber ML, Pittler SJ, Qin N, Wright GC, Holcombe V, Lee RH, Craft CM, Lolley RN, Baehr W, Hurwitz RL. Irish setter dogs affected with rod/cone dysplasia contain a nonsense mutation in the rod cGMP phosphodiesterase beta-subunit gene. Proc Natl Acad Sci U S A. 1993 May 1; 90(9):3968-72. PMID: 8387203; PMCID: PMC46427.
    31. Morad AB, Steuber CP, Mahoney DH, Hurwitz RL. Hypoplastic anemia in an infant with human immunodeficiency virus (HIV) infection. Am J Hematol. 1993 Feb; 42(2):236. PMID: 8438892.
      View in: PubMed
    32. Kazazian HH, Dowling CE, Hurwitz RL, Coleman M, Stopeck A, Adams JG. Dominant thalassemia-like phenotypes associated with mutations in exon 3 of the beta-globin gene. Blood. 1992 Jun 1; 79(11):3014-8. PMID: 1586746.
      View in: PubMed
    33. Pittler SJ, Lee AK, Altherr MR, Howard TA, Seldin MF, Hurwitz RL, Wasmuth JJ, Baehr W. Primary structure and chromosomal localization of human and mouse rod photoreceptor cGMP-gated cation channel. J Biol Chem. 1992 Mar 25; 267(9):6257-62. PMID: 1372902.
      View in: PubMed
    34. Hayani A, Mahoney DH, Hawkins HK, Steuber CP, Hurwitz R, Fernbach DJ. Soft-tissue sarcomas other than rhabdomyosarcoma in children. Med Pediatr Oncol. 1992; 20(2):114-8. PMID: 1734215.
      View in: PubMed
    35. Chintagumpala MM, Hurwitz RL, Moake JL, Mahoney DH, Steuber CP. Chronic relapsing thrombotic thrombocytopenic purpura in infants with large von Willebrand factor multimers during remission. J Pediatr. 1992 Jan; 120(1):49-53. PMID: 1731024.
      View in: PubMed
    36. Booth DP, Hurwitz RL, Lolley RN. Phosphodiesterase of cone photoreceptors from the lizard, Anolis carolinensis. J Neurochem. 1991 Jun; 56(6):1949-56. PMID: 1851207.
      View in: PubMed
    37. Hurwitz R, Holcombe V. Affinity purification of the photoreceptor cGMP-gated cation channel. J Biol Chem. 1991 May 5; 266(13):7975-7. PMID: 1850731.
      View in: PubMed
    38. Hurwitz RL, Bogenmann E, Font RL, Holcombe V, Clark D. Expression of the functional cone phototransduction cascade in retinoblastoma. J Clin Invest. 1990 Jun; 85(6):1872-8. PMID: 2161431; PMCID: PMC296653.
    39. Hurwitz RL, Hirsch KM, Clark DJ, Holcombe VN, Hurwitz MY. Induction of a calcium/calmodulin-dependent phosphodiesterase during phytohemagglutinin-stimulated lymphocyte mitogenesis. J Biol Chem. 1990 May 25; 265(15):8901-7. PMID: 2160471.
      View in: PubMed
    40. Hurwitz RL, Mahoney DH, Armstrong DL, Browder TM. Reversible encephalopathy and seizures as a result of conventional vincristine administration. Med Pediatr Oncol. 1988; 16(3):216-9. PMID: 3164090.
      View in: PubMed
    41. Lee RH, Lieberman BS, Hurwitz RL, Lolley RN. Phosphodiesterase-probes show distinct defects in rd mice and Irish setter dog disorders. Invest Ophthalmol Vis Sci. 1985 Nov; 26(11):1569-79. PMID: 2997075.
      View in: PubMed
    42. Hurwitz RL, Bunt-Milam AH, Chang ML, Beavo JA. cGMP phosphodiesterase in rod and cone outer segments of the retina. J Biol Chem. 1985 Jan 10; 260(1):568-73. PMID: 2981219.
      View in: PubMed
    43. Hurwitz RL, Bunt-Milam AH, Beavo JA. Immunologic characterization of the photoreceptor outer segment cyclic GMP phosphodiesterase. J Biol Chem. 1984 Jul 10; 259(13):8612-8. PMID: 6330115.
      View in: PubMed
    44. Hurwitz RL, Beavo JA. Immunotitration analysis of the rod outer segment phosphodiesterase. Adv Cyclic Nucleotide Protein Phosphorylation Res. 1984; 17:239-48. PMID: 6203341.
      View in: PubMed
    45. Hurwitz RL, Hansen RS, Harrison SA, Martins TJ, Mumby MC, Beavo JA. Immunologic approaches to the study of cyclic nucleotide phosphodiesterases. Adv Cyclic Nucleotide Protein Phosphorylation Res. 1984; 16:89-106. PMID: 6326539.
      View in: PubMed
    46. Beavo JA, Hansen RS, Harrison SA, Hurwitz RL, Martins TJ, Mumby MC. Identification and properties of cyclic nucleotide phosphodiesterases. Mol Cell Endocrinol. 1982 Nov-Dec; 28(3):387-410. PMID: 6185373.
      View in: PubMed
    47. Hozier J, Lindquist L, Hurwitz R, LeBien T, Kersey J. Evolution of cultured leukemic cell lines monitored by chromosomal and immunologic analysis. Int J Cancer. 1980 Sep 15; 26(3):281-4. PMID: 6945291.
      View in: PubMed
    48. Kersey JH, LeBien TW, Hurwitz R, Nesbit ME, Gajl-Peczalska KJ, Hammond D, Miller DR, Coccia PF, Leikin S. Childhood leukemia-lymphoma. Heterogeneity of phenotypes and prognoses. Am J Clin Pathol. 1979 Oct; 72(4 Suppl):746-52. PMID: 291337.
      View in: PubMed
    49. Hurwitz RL, Schreinemachers D, Kersey JH. Elimination of platelets from mononuclear cell preparations using heat-killed yeast. Exp Hematol. 1979 Feb; 7(2):81-6. PMID: 371975.
      View in: PubMed
    50. Hurwitz R, Hozier J, LeBien T, Minowada J, Gajl-Peczalska K, Kubonishi I, Kersey J. Characterization of a leukemic cell line of the pre-B phenotype. Int J Cancer. 1979 Feb; 23(2):174-80. PMID: 83966.
      View in: PubMed
    51. LeBien TW, Hurwitz RL, Kersey JH. Characterization of a xenoantiserum produced against three molar KCl-solubilized antigens obtained from a non-T, non-B (pre-B) acute lymphoblastic leukemia cell line. J Immunol. 1979 Jan; 122(1):82-8. PMID: 310838.
      View in: PubMed
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