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GRETCHEN J DARLINGTON

TitleDistinguished Emeritus Professor
InstitutionBaylor College of Medicine
DepartmentHuffington Center on Aging
AddressOne Baylor Plaza, MS230
Houston TX 77030
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    Other Positions
    TitleDistinguished Emeritus Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Pathology & Immunology
    DivisionPathology

    TitleDistinguished Emeritus Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular & Cellular Biology
    DivisionMolecular & Cellular Biology

    TitleDistinguished Emeritus Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular & Human Genetics
    DivisionMolecular & Human Genetics

    TitleDistinguished Emeritus Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Pediatrics
    DivisionPediatrics-Administration


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Luo M, Jeong M, Sun D, Park HJ, Rodriguez BA, Xia Z, Yang L, Zhang X, Sheng K, Darlington GJ, Li W, Goodell MA. Long non-coding RNAs control hematopoietic stem cell function. Cell Stem Cell. 2015 Apr 2; 16(4):426-38. PMID: 25772072; PMCID: PMC4388783.
    2. Challen GA, Sun D, Mayle A, Jeong M, Luo M, Rodriguez B, Mallaney C, Celik H, Yang L, Xia Z, Cullen S, Berg J, Zheng Y, Darlington GJ, Li W, Goodell MA. Dnmt3a and Dnmt3b have overlapping and distinct functions in hematopoietic stem cells. Cell Stem Cell. 2014 Sep 4; 15(3):350-64. PMID: 25130491; PMCID: PMC4163922.
    3. Sun D, Luo M, Jeong M, Rodriguez B, Xia Z, Hannah R, Wang H, Le T, Faull KF, Chen R, Gu H, Bock C, Meissner A, Göttgens B, Darlington GJ, Li W, Goodell MA. Epigenomic profiling of young and aged HSCs reveals concerted changes during aging that reinforce self-renewal. Cell Stem Cell. 2014 May 1; 14(5):673-88. PMID: 24792119; PMCID: PMC4070311.
    4. McClellan AJ, Volpe EA, Zhang X, Darlington GJ, Li DQ, Pflugfelder SC, de Paiva CS. Ocular surface disease and dacryoadenitis in aging C57BL/6 mice. Am J Pathol. 2014 Mar; 184(3):631-43. PMID: 24389165; PMCID: PMC3936306.
    5. Jeong M, Sun D, Luo M, Huang Y, Challen GA, Rodriguez B, Zhang X, Chavez L, Wang H, Hannah R, Kim SB, Yang L, Ko M, Chen R, Göttgens B, Lee JS, Gunaratne P, Godley LA, Darlington GJ, Rao A, Li W, Goodell MA. Large conserved domains of low DNA methylation maintained by Dnmt3a. Nat Genet. 2014 Jan; 46(1):17-23. PMID: 24270360; PMCID: PMC3920905.
    6. Jiang Y, Jin J, Iakova P, Hernandez JC, Jawanmardi N, Sullivan E, Guo GL, Timchenko NA, Darlington GJ. Farnesoid X receptor directly regulates xenobiotic detoxification genes in the long-lived Little mice. Mech Ageing Dev. 2013 Sep; 134(9):407-15. PMID: 24007921; PMCID: PMC3845407.
    7. Reddy AK, Hartley CJ, Pham TT, Darlington G, Entman ML, Taffet GE. Young little mice express a premature cardiovascular aging phenotype. J Gerontol A Biol Sci Med Sci. 2014 Feb; 69(2):152-9. PMID: 23682160; PMCID: PMC4038241.
    8. Jiang Y, Iakova P, Jin J, Sullivan E, Sharin V, Hong IH, Anakk S, Mayor A, Darlington G, Finegold M, Moore D, Timchenko NA. Farnesoid X receptor inhibits gankyrin in mouse livers and prevents development of liver cancer. Hepatology. 2013 Mar; 57(3):1098-106. PMID: 23172628; PMCID: PMC3649861.
    9. Lee JS, Ward WO, Ren H, Vallanat B, Darlington GJ, Han ES, Laguna JC, DeFord JH, Papaconstantinou J, Selman C, Corton JC. Meta-analysis of gene expression in the mouse liver reveals biomarkers associated with inflammation increased early during aging. Mech Ageing Dev. 2012 Jul; 133(7):467-78. PMID: 22704917.
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    10. Challen GA, Sun D, Jeong M, Luo M, Jelinek J, Berg JS, Bock C, Vasanthakumar A, Gu H, Xi Y, Liang S, Lu Y, Darlington GJ, Meissner A, Issa JP, Godley LA, Li W, Goodell MA. Dnmt3a is essential for hematopoietic stem cell differentiation. Nat Genet. 2012 Jan; 44(1):23-31. PMID: 22138693; PMCID: PMC3637952.
    11. Qiu Q, Hernandez JC, Dean AM, Rao PH, Darlington GJ. CD24-positive cells from normal adult mouse liver are hepatocyte progenitor cells. Stem Cells Dev. 2011 Dec; 20(12):2177-88. PMID: 21361791; PMCID: PMC3225069.
    12. Singh P, Goode T, Dean A, Awad SS, Darlington GJ. Elevated interferon gamma signaling contributes to impaired regeneration in the aged liver. J Gerontol A Biol Sci Med Sci. 2011 Sep; 66(9):944-56. PMID: 21719609; PMCID: PMC3156631.
    13. Kurinna S, Stratton SA, Tsai WW, Akdemir KC, Gu W, Singh P, Goode T, Darlington GJ, Barton MC. Direct activation of forkhead box O3 by tumor suppressors p53 and p73 is disrupted during liver regeneration in mice. Hepatology. 2010 Sep; 52(3):1023-32. PMID: 20564353; PMCID: PMC3741038.
    14. Jin J, Wang GL, Shi X, Darlington GJ, Timchenko NA. The age-associated decline of glycogen synthase kinase 3beta plays a critical role in the inhibition of liver regeneration. Mol Cell Biol. 2009 Jul; 29(14):3867-80. PMID: 19398579; PMCID: PMC2704742.
    15. El-Serag HB, Nurgalieva ZZ, Mistretta TA, Finegold MJ, Souza R, Hilsenbeck S, Shaw C, Darlington G. Gene expression in Barrett's esophagus: laser capture versus whole tissue. Scand J Gastroenterol. 2009; 44(7):787-95. PMID: 19391063; PMCID: PMC2822542.
    16. Darlington GJ. Inoculation and passaging of Mammalian monolayer cell cultures. CSH Protoc. 2008; 2008:pdb.prot4347. PMID: 21356879.
      View in: PubMed
    17. Singh P, Coskun ZZ, Goode C, Dean A, Thompson-Snipes L, Darlington G. Lymphoid neogenesis and immune infiltration in aged liver. Hepatology. 2008 May; 47(5):1680-90. PMID: 18395842; PMCID: PMC2859446.
    18. Reddy AK, Amador-Noguez D, Darlington GJ, Scholz BA, Michael LH, Hartley CJ, Entman ML, Taffet GE. Cardiac function in young and old Little mice. J Gerontol A Biol Sci Med Sci. 2007 Dec; 62(12):1319-25. PMID: 18166681; PMCID: PMC2771398.
    19. Ochsner SA, Strick-Marchand H, Qiu Q, Venable S, Dean A, Wilde M, Weiss MC, Darlington GJ. Transcriptional profiling of bipotential embryonic liver cells to identify liver progenitor cell surface markers. Stem Cells. 2007 Oct; 25(10):2476-87. PMID: 17641245; PMCID: PMC2853184.
    20. Darlington GJ. Inoculation and passaging of Mammalian cell suspension cultures. CSH Protoc. 2007; 2007:pdb.prot4346. PMID: 21357091.
      View in: PubMed
    21. Darlington GJ. Viability staining of Mammalian cell cultures. CSH Protoc. 2007; 2007:pdb.prot4769. PMID: 21357107.
      View in: PubMed
    22. Amador-Noguez D, Dean A, Huang W, Setchell K, Moore D, Darlington G. Alterations in xenobiotic metabolism in the long-lived Little mice. Aging Cell. 2007 Aug; 6(4):453-70. PMID: 17521389; PMCID: PMC2859448.
    23. Darlington GJ. Lymphocyte isolation and culture. CSH Protoc. 2006; 2006(2). PMID: 22485827.
      View in: PubMed
    24. Darlington GJ. Epstein-barr virus transformation of lymphoblasts. CSH Protoc. 2006; 2006(2). PMID: 22485828.
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    25. El-Serag HB, Nurgalieva Z, Souza RF, Shaw C, Darlington G. Is genomic evaluation feasible in endoscopic studies of Barrett's esophagus? A pilot study. Gastrointest Endosc. 2006 Jul; 64(1):17-26. PMID: 16813797.
      View in: PubMed
    26. Darlington GJ. Serum testing for Mammalian cell culture. CSH Protoc. 2006; 2006(1). PMID: 22485722.
      View in: PubMed
    27. Darlington GJ. Cryopreservation of Mammalian culture cells: preparation and recovery of samples. CSH Protoc. 2006; 2006(1). PMID: 22485724.
      View in: PubMed
    28. Darlington GJ. Detection of Mycoplasma in Mammalian cell cultures using fluorescence microscopy. CSH Protoc. 2006; 2006(1). PMID: 22485725.
      View in: PubMed
    29. Darlington GJ. Trypsinization of cells grown in monolayer. CSH Protoc. 2006; 2006(1). PMID: 22485723.
      View in: PubMed
    30. Yoshida Y, Hughes DE, Rausa FM, Kim IM, Tan Y, Darlington GJ, Costa RH. C/EBPalpha and HNF6 protein complex formation stimulates HNF6-dependent transcription by CBP coactivator recruitment in HepG2 cells. Hepatology. 2006 Feb; 43(2):276-86. PMID: 16440369; PMCID: PMC1360165.
    31. Bowman TV, McCooey AJ, Merchant AA, Ramos CA, Fonseca P, Poindexter A, Bradfute SB, Oliveira DM, Green R, Zheng Y, Jackson KA, Chambers SM, McKinney-Freeman SL, Norwood KG, Darlington G, Gunaratne PH, Steffen D, Goodell MA. Differential mRNA processing in hematopoietic stem cells. Stem Cells. 2006 Mar; 24(3):662-70. PMID: 16373690.
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    32. Yang J, Croniger CM, Lekstrom-Himes J, Zhang P, Fenyus M, Tenen DG, Darlington GJ, Hanson RW. Metabolic response of mice to a postnatal ablation of CCAAT/enhancer-binding protein alpha. J Biol Chem. 2005 Nov 18; 280(46):38689-99. PMID: 16166091.
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    33. Abrams SA, Griffin IJ, Hawthorne KM, Liang L, Gunn SK, Darlington G, Ellis KJ. A combination of prebiotic short- and long-chain inulin-type fructans enhances calcium absorption and bone mineralization in young adolescents. Am J Clin Nutr. 2005 Aug; 82(2):471-6. PMID: 16087995.
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    34. Amador-Noguez D, Zimmerman J, Venable S, Darlington G. Gender-specific alterations in gene expression and loss of liver sexual dimorphism in the long-lived Ames dwarf mice. Biochem Biophys Res Commun. 2005 Jul 15; 332(4):1086-100. PMID: 15925325.
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    35. Abrams SA, Griffin IJ, Hawthorne KM, Chen Z, Gunn SK, Wilde M, Darlington G, Shypailo RJ, Ellis KJ. Vitamin D receptor Fok1 polymorphisms affect calcium absorption, kinetics, and bone mineralization rates during puberty. J Bone Miner Res. 2005 Jun; 20(6):945-53. PMID: 15883634.
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    36. Amador-Noguez D, Yagi K, Venable S, Darlington G. Gene expression profile of long-lived Ames dwarf mice and Little mice. Aging Cell. 2004 Dec; 3(6):423-41. PMID: 15569359.
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    37. Mackey SL, Darlington GJ. CCAAT enhancer-binding protein alpha is required for interleukin-6 receptor alpha signaling in newborn hepatocytes. J Biol Chem. 2004 Apr 16; 279(16):16206-13. PMID: 14960573.
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    38. Bruder C, Hagleitner M, Darlington G, Mohsenipour I, Würzner R, Höllmüller I, Stoiber H, Lass-Flörl C, Dierich MP, Speth C. HIV-1 induces complement factor C3 synthesis in astrocytes and neurons by modulation of promoter activity. Mol Immunol. 2004 Feb; 40(13):949-61. PMID: 14725791.
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    39. Mackey S, Singh P, Darlington GJ. Making the liver young again. Hepatology. 2003 Dec; 38(6):1349-52. PMID: 14647042.
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    40. Ramsay PL, Luo Z, Major A, Park MS, Finegold M, Welty SE, Kwak I, Darlington G, Demayo FJ. Multiple mechanisms for oxygen-induced regulation of the Clara cell secretory protein gene. FASEB J. 2003 Nov; 17(14):2142-4. PMID: 14500549.
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    41. Akiba T, Kuroiwa N, Shimizu-Yabe A, Iwase K, Hiwasa T, Yokoe H, Kubosawa H, Kageyama R, Darlington GJ, Mori M, Tanzawa H, Takiguchi M, Dahrington GJ. Expression and regulation of the gene for arginase I in mouse salivary glands: requirement of CCAAT/enhancer-binding protein alpha for the expression in the parotid gland. J Biochem. 2002 Oct; 132(4):621-7. PMID: 12359078.
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    42. Welm AL, Timchenko NA, Ono Y, Sorimachi H, Radomska HS, Tenen DG, Lekstrom-Himes J, Darlington GJ. C/EBPalpha is required for proteolytic cleavage of cyclin A by calpain 3 in myeloid precursor cells. J Biol Chem. 2002 Sep 13; 277(37):33848-56. PMID: 12105198.
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    43. Carmona MC, Iglesias R, Obregón MJ, Darlington GJ, Villarroya F, Giralt M. Mitochondrial biogenesis and thyroid status maturation in brown fat require CCAAT/enhancer-binding protein alpha. J Biol Chem. 2002 Jun 14; 277(24):21489-98. PMID: 11940593.
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    44. Linhart HG, Ishimura-Oka K, DeMayo F, Kibe T, Repka D, Poindexter B, Bick RJ, Darlington GJ. C/EBPalpha is required for differentiation of white, but not brown, adipose tissue. Proc Natl Acad Sci U S A. 2001 Oct 23; 98(22):12532-7. PMID: 11606718; PMCID: PMC60088.
    45. Collins SJ, Ulmer J, Purton LE, Darlington G. Multipotent hematopoietic cell lines derived from C/EBPalpha(-/-) knockout mice display granulocyte macrophage-colony-stimulating factor, granulocyte- colony-stimulating factor, and retinoic acid-induced granulocytic differentiation. Blood. 2001 Oct 15; 98(8):2382-8. PMID: 11588034.
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    46. Sugahara K, Iyama KI, Kimura T, Sano K, Darlington GJ, Akiba T, Takiguchi M. Mice lacking CCAAt/enhancer-binding protein-alpha show hyperproliferation of alveolar type II cells and increased surfactant protein mRNAs. Cell Tissue Res. 2001 Oct; 306(1):57-63. PMID: 11683182.
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    47. Harris TE, Albrecht JH, Nakanishi M, Darlington GJ. CCAAT/enhancer-binding protein-alpha cooperates with p21 to inhibit cyclin-dependent kinase-2 activity and induces growth arrest independent of DNA binding. J Biol Chem. 2001 Aug 3; 276(31):29200-9. PMID: 11369759.
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    48. Williams LJ, Lyons V, MacLeod I, Rajan V, Darlington GJ, Poli V, Seckl JR, Chapman KE. C/EBP regulates hepatic transcription of 11beta -hydroxysteroid dehydrogenase type 1. A novel mechanism for cross-talk between the C/EBP and glucocorticoid signaling pathways. J Biol Chem. 2000 Sep 29; 275(39):30232-9. PMID: 10906322.
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    49. Park JS, Qiao L, Gilfor D, Yang MY, Hylemon PB, Benz C, Darlington G, Firestone G, Fisher PB, Dent P. A role for both Ets and C/EBP transcription factors and mRNA stabilization in the MAPK-dependent increase in p21 (Cip-1/WAF1/mda6) protein levels in primary hepatocytes. Mol Biol Cell. 2000 Sep; 11(9):2915-32. PMID: 10982390; PMCID: PMC14965.
    50. Welm AL, Mackey SL, Timchenko LT, Darlington GJ, Timchenko NA. Translational induction of liver-enriched transcriptional inhibitory protein during acute phase response leads to repression of CCAAT/enhancer binding protein alpha mRNA. J Biol Chem. 2000 Sep 1; 275(35):27406-13. PMID: 10854425.
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    51. Park JS, Boyer S, Mitchell K, Gilfor D, Birrer M, Darlington G, El Deiry W, Firestone GL, Munger K, Band V, Fisher PB, Dent P. Expression of human papilloma virus E7 protein causes apoptosis and inhibits DNA synthesis in primary hepatocytes via increased expression of p21(Cip-1/WAF1/MDA6). J Biol Chem. 2000 Jan 7; 275(1):18-28. PMID: 10617580.
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    52. Darlington GJ. Molecular mechanisms of liver development and differentiation. Curr Opin Cell Biol. 1999 Dec; 11(6):678-82. PMID: 10600708.
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    53. Khaoustov VI, Darlington GJ, Soriano HE, Krishnan B, Risin D, Pellis NR, Yoffe B. Induction of three-dimensional assembly of human liver cells by simulated microgravity. In Vitro Cell Dev Biol Anim. 1999 Oct; 35(9):501-9. PMID: 10548431.
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    54. Timchenko NA, Wilde M, Iakova P, Albrecht JH, Darlington GJ. E2F/p107 and E2F/p130 complexes are regulated by C/EBPalpha in 3T3-L1 adipocytes. Nucleic Acids Res. 1999 Sep 1; 27(17):3621-30. PMID: 10446255; PMCID: PMC148609.
    55. Timchenko NA, Wilde M, Darlington GJ. C/EBPalpha regulates formation of S-phase-specific E2F-p107 complexes in livers of newborn mice. Mol Cell Biol. 1999 Apr; 19(4):2936-45. PMID: 10082561; PMCID: PMC84088.
    56. Welm AL, Timchenko NA, Darlington GJ. C/EBPalpha regulates generation of C/EBPbeta isoforms through activation of specific proteolytic cleavage. Mol Cell Biol. 1999 Mar; 19(3):1695-704. PMID: 10022857; PMCID: PMC83963.
    57. Wu Z, Rosen ED, Brun R, Hauser S, Adelmant G, Troy AE, McKeon C, Darlington GJ, Spiegelman BM. Cross-regulation of C/EBP alpha and PPAR gamma controls the transcriptional pathway of adipogenesis and insulin sensitivity. Mol Cell. 1999 Feb; 3(2):151-8. PMID: 10078198.
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    58. Burgess-Beusse BL, Timchenko NA, Darlington GJ. CCAAT/enhancer binding protein alpha (C/EBPalpha) is an important mediator of mouse C/EBPbeta protein isoform production. Hepatology. 1999 Feb; 29(2):597-601. PMID: 9918941.
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    59. Yoffe B, Darlington GJ, Soriano HE, Krishnan B, Risin D, Pellis NR, Khaoustov VI. Cultures of human liver cells in simulated microgravity environment. Adv Space Res. 1999; 24(6):829-36. PMID: 11542629.
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    60. Auer KL, Park JS, Seth P, Coffey RJ, Darlington G, Abo A, McMahon M, Depinho RA, Fisher PB, Dent P. Prolonged activation of the mitogen-activated protein kinase pathway promotes DNA synthesis in primary hepatocytes from p21Cip-1/WAF1-null mice, but not in hepatocytes from p16INK4a-null mice. Biochem J. 1998 Dec 15; 336 ( Pt 3):551-60. PMID: 9841865; PMCID: PMC1219904.
    61. Burgess-Beusse BL, Darlington GJ. C/EBPalpha is critical for the neonatal acute-phase response to inflammation. Mol Cell Biol. 1998 Dec; 18(12):7269-77. PMID: 9819413; PMCID: PMC109308.
    62. Darlington GJ, Ross SE, MacDougald OA. The role of C/EBP genes in adipocyte differentiation. J Biol Chem. 1998 Nov 13; 273(46):30057-60. PMID: 9804754.
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    63. Christoffels VM, Grange T, Kaestner KH, Cole TJ, Darlington GJ, Croniger CM, Lamers WH. Glucocorticoid receptor, C/EBP, HNF3, and protein kinase A coordinately activate the glucocorticoid response unit of the carbamoylphosphate synthetase I gene. Mol Cell Biol. 1998 Nov; 18(11):6305-15. PMID: 9774647; PMCID: PMC109217.
    64. Kimura T, Christoffels VM, Chowdhury S, Iwase K, Matsuzaki H, Mori M, Lamers WH, Darlington GJ, Takiguchi M. Hypoglycemia-associated hyperammonemia caused by impaired expression of ornithine cycle enzyme genes in C/EBPalpha knockout mice. J Biol Chem. 1998 Oct 16; 273(42):27505-10. PMID: 9765281.
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    65. Zhang P, Iwama A, Datta MW, Darlington GJ, Link DC, Tenen DG. Upregulation of interleukin 6 and granulocyte colony-stimulating factor receptors by transcription factor CCAAT enhancer binding protein alpha (C/EBP alpha) is critical for granulopoiesis. J Exp Med. 1998 Sep 21; 188(6):1173-84. PMID: 9743535; PMCID: PMC2212540.
    66. Timchenko NA, Wilde M, Kosai KI, Heydari A, Bilyeu TA, Finegold MJ, Mohamedali K, Richardson A, Darlington GJ. Regenerating livers of old rats contain high levels of C/EBPalpha that correlate with altered expression of cell cycle associated proteins. Nucleic Acids Res. 1998 Jul 1; 26(13):3293-9. PMID: 9628932; PMCID: PMC147695.
    67. Iwama A, Zhang P, Darlington GJ, McKercher SR, Maki R, Tenen DG. Use of RDA analysis of knockout mice to identify myeloid genes regulated in vivo by PU.1 and C/EBPalpha. Nucleic Acids Res. 1998 Jun 15; 26(12):3034-43. PMID: 9611252; PMCID: PMC147647.
    68. Seagroves TN, Krnacik S, Raught B, Gay J, Burgess-Beusse B, Darlington GJ, Rosen JM. C/EBPbeta, but not C/EBPalpha, is essential for ductal morphogenesis, lobuloalveolar proliferation, and functional differentiation in the mouse mammary gland. Genes Dev. 1998 Jun 15; 12(12):1917-28. PMID: 9637692; PMCID: PMC316914.
    69. Kosai KI, Finegold MJ, Thi-Huynh BT, Tewson M, Ou CN, Bowles N, Woo SL, Schwall RH, Darlington GJ. Retrovirus-mediated in vivo gene transfer in the replicating liver using recombinant hepatocyte growth factor without liver injury or partial hepatectomy. Hum Gene Ther. 1998 Jun 10; 9(9):1293-301. PMID: 9650614.
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    70. Oesterreicher TJ, Leeper LL, Finegold MJ, Darlington GJ, Henning SJ. Intestinal maturation in mice lacking CCAAT/enhancer-binding protein alpha (C/EPBalpha). Biochem J. 1998 Mar 15; 330 ( Pt 3):1165-71. PMID: 9494081; PMCID: PMC1219257.
    71. Soriano HE, Kang DC, Finegold MJ, Hicks MJ, Wang ND, Harrison W, Darlington GJ. Lack of C/EBP alpha gene expression results in increased DNA synthesis and an increased frequency of immortalization of freshly isolated mice [correction of rat] hepatocytes. Hepatology. 1998 Feb; 27(2):392-401. PMID: 9462636.
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    72. Timchenko NA, Harris TE, Wilde M, Bilyeu TA, Burgess-Beusse BL, Finegold MJ, Darlington GJ. CCAAT/enhancer binding protein alpha regulates p21 protein and hepatocyte proliferation in newborn mice. Mol Cell Biol. 1997 Dec; 17(12):7353-61. PMID: 9372966; PMCID: PMC232591.
    73. Davies N, Austen DE, Wilde MD, Darlington GJ, Brownlee GG. Clotting factor IX levels in C/EBP alpha knockout mice. Br J Haematol. 1997 Dec; 99(3):578-9. PMID: 9401069.
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    74. Croniger C, Trus M, Lysek-Stupp K, Cohen H, Liu Y, Darlington GJ, Poli V, Hanson RW, Reshef L. Role of the isoforms of CCAAT/enhancer-binding protein in the initiation of phosphoenolpyruvate carboxykinase (GTP) gene transcription at birth. J Biol Chem. 1997 Oct 17; 272(42):26306-12. PMID: 9334201.
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    75. Rubelj I, Venable SF, Lednicky J, Butel JS, Bilyeu T, Darlington G, Surmacz E, Campisi J, Pereira-Smith OM. Loss of T-antigen sequences allows SV40-transformed human cells in crisis to acquire a senescent-like phenotype. J Gerontol A Biol Sci Med Sci. 1997 Sep; 52(5):B229-34. PMID: 9310070.
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    76. Ozçelik H, Schmocker B, Di Nicola N, Shi XH, Langer B, Moore M, Taylor BR, Narod SA, Darlington G, Andrulis IL, Gallinger S, Redston M. Germline BRCA2 6174delT mutations in Ashkenazi Jewish pancreatic cancer patients. Nat Genet. 1997 May; 16(1):17-8. PMID: 9140390.
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    77. Zhang DE, Zhang P, Wang ND, Hetherington CJ, Darlington GJ, Tenen DG. Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT enhancer binding protein alpha-deficient mice. Proc Natl Acad Sci U S A. 1997 Jan 21; 94(2):569-74. PMID: 9012825; PMCID: PMC19554.
    78. Nizielski SE, Lechner PS, Croniger CM, Wang ND, Darlington GJ, Hanson RW. Animal models for studying the genetic basis of metabolic regulation. J Nutr. 1996 Nov; 126(11):2697-708. PMID: 8914939.
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    79. Ozer A, Khaoustov VI, Mearns M, Lewis DE, Genta RM, Darlington GJ, Yoffe B. Effect of hepatocyte proliferation and cellular DNA synthesis on hepatitis B virus replication. Gastroenterology. 1996 May; 110(5):1519-28. PMID: 8613059.
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    80. Timchenko NA, Wilde M, Nakanishi M, Smith JR, Darlington GJ. CCAAT/enhancer-binding protein alpha (C/EBP alpha) inhibits cell proliferation through the p21 (WAF-1/CIP-1/SDI-1) protein. Genes Dev. 1996 Apr 1; 10(7):804-15. PMID: 8846917.
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    81. Hendricks-Taylor LR, Darlington GJ. Inhibition of cell proliferation by C/EBP alpha occurs in many cell types, does not require the presence of p53 or Rb, and is not affected by large T-antigen. Nucleic Acids Res. 1995 Nov 25; 23(22):4726-33. PMID: 8524667; PMCID: PMC307450.
    82. Adams RM, Wang M, Crane AM, Brown B, Darlington GJ, Ledley FD. Effective cryopreservation and long-term storage of primary human hepatocytes with recovery of viability, differentiation, and replicative potential. Cell Transplant. 1995 Nov-Dec; 4(6):579-86. PMID: 8714779.
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    83. Darlington GJ, Wang N, Hanson RW. C/EBP alpha: a critical regulator of genes governing integrative metabolic processes. Curr Opin Genet Dev. 1995 Oct; 5(5):565-70. PMID: 8664543.
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    84. Soriano HE, Bilyeu TA, Juan TS, Zhao W, Darlington GJ. DNA binding by C/EBP proteins correlates with hepatocyte proliferation. In Vitro Cell Dev Biol Anim. 1995 Oct; 31(9):703-9. PMID: 8564082.
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    85. Wang ND, Finegold MJ, Bradley A, Ou CN, Abdelsayed SV, Wilde MD, Taylor LR, Wilson DR, Darlington GJ. Impaired energy homeostasis in C/EBP alpha knockout mice. Science. 1995 Aug 25; 269(5227):1108-12. PMID: 7652557.
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    86. Timchenko N, Wilson DR, Taylor LR, Abdelsayed S, Wilde M, Sawadogo M, Darlington GJ. Autoregulation of the human C/EBP alpha gene by stimulation of upstream stimulatory factor binding. Mol Cell Biol. 1995 Mar; 15(3):1192-202. PMID: 7862113; PMCID: PMC230342.
    87. Maraia RJ, Sasaki-Tozawa N, Driscoll CT, Green ED, Darlington GJ. The human Y4 small cytoplasmic RNA gene is controlled by upstream elements and resides on chromosome 7 with all other hY scRNA genes. Nucleic Acids Res. 1994 Aug 11; 22(15):3045-52. PMID: 7520568; PMCID: PMC310274.
    88. Chang DY, Nelson B, Bilyeu T, Hsu K, Darlington GJ, Maraia RJ. A human Alu RNA-binding protein whose expression is associated with accumulation of small cytoplasmic Alu RNA. Mol Cell Biol. 1994 Jun; 14(6):3949-59. PMID: 8196634; PMCID: PMC358761.
    89. Driscoll CT, Darlington GJ, Maraia RJ. The conserved 7SK snRNA gene localizes to human chromosome 6 by homolog exclusion probing of somatic cell hybrid RNA. Nucleic Acids Res. 1994 Mar 11; 22(5):722-5. PMID: 8139910; PMCID: PMC307874.
    90. Wu KJ, Wilson DR, Shih C, Darlington GJ. The transcription factor HNF1 acts with C/EBP alpha to synergistically activate the human albumin promoter through a novel domain. J Biol Chem. 1994 Jan 14; 269(2):1177-82. PMID: 8288579.
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    91. Soriano HE, Gest AL, Bair DK, Vander Straten M, Lewis DE, Darlington GJ, Finegold MJ, Ledley FD. Feasibility of hepatocellular transplantation via the umbilical vein in prenatal and perinatal lambs. Fetal Diagn Ther. 1993 Sep-Oct; 8(5):293-304. PMID: 8267863.
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    92. Maraia RJ, Driscoll CT, Bilyeu T, Hsu K, Darlington GJ. Multiple dispersed loci produce small cytoplasmic Alu RNA. Mol Cell Biol. 1993 Jul; 13(7):4233-41. PMID: 7686619; PMCID: PMC359973.
    93. Ledley FD, Adams RM, Soriano HE, Darlington G, Finegold M, Lanford R, Carey D, Lewis D, Baley PA, Rothenberg S, et al. Development of a clinical protocol for hepatic gene transfer: lessons learned in preclinical studies. Pediatr Res. 1993 Apr; 33(4 Pt 1):313-20. PMID: 8386832.
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    94. Juan TS, Wilson DR, Wilde MD, Darlington GJ. Participation of the transcription factor C/EBP delta in the acute-phase regulation of the human gene for complement component C3. Proc Natl Acad Sci U S A. 1993 Apr 1; 90(7):2584-8. PMID: 8385337; PMCID: PMC46139.
    95. Soriano HE, Adams RM, Darlington G, Finegold M, Steffen DL, Ledley FD. Retroviral transduction of human hepatocytes and orthotopic engraftment in SCID mice after hepatocellular transplantation. Transplant Proc. 1992 Dec; 24(6):3020-1. PMID: 1466040.
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    96. Ledley FD, Soriano HE, O'Malley BW, Lewis D, Darlington GJ, Finegold M. DiI as a marker for cellular transplantation into solid organs. Biotechniques. 1992 Oct; 13(4):580, 582, 584-7. PMID: 1282342.
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    97. Adams RM, Soriano HE, Wang M, Darlington G, Steffen D, Ledley FD. Transduction of primary human hepatocytes with amphotropic and xenotropic retroviral vectors. Proc Natl Acad Sci U S A. 1992 Oct 1; 89(19):8981-5. PMID: 1329086; PMCID: PMC50048.
    98. Soriano HE, Lewis D, Legner M, Brandt M, Baley P, Darlington G, Finegold M, Ledley FD. The use of DiI-marked hepatocytes to demonstrate orthotopic, intrahepatic engraftment following hepatocellular transplantation. Transplantation. 1992 Oct; 54(4):717-23. PMID: 1412764.
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    99. Hendricks-Taylor LR, Bachinski LL, Siciliano MJ, Fertitta A, Trask B, de Jong PJ, Ledbetter DH, Darlington GJ. The CCAAT/enhancer binding protein (C/EBP alpha) gene (CEBPA) maps to human chromosome 19q13.1 and the related nuclear factor NF-IL6 (C/EBP beta) gene (CEBPB) maps to human chromosome 20q13.1. Genomics. 1992 Sep; 14(1):12-7. PMID: 1427819.
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    100. Heffelfinger SC, Hawkins HH, Barrish J, Taylor L, Darlington GJ. SK HEP-1: a human cell line of endothelial origin. In Vitro Cell Dev Biol. 1992 Feb; 28A(2):136-42. PMID: 1371504.
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    101. Kay MA, Baley P, Rothenberg S, Leland F, Fleming L, Ponder KP, Liu T, Finegold M, Darlington G, Pokorny W, et al. Expression of human alpha 1-antitrypsin in dogs after autologous transplantation of retroviral transduced hepatocytes. Proc Natl Acad Sci U S A. 1992 Jan 1; 89(1):89-93. PMID: 1729724; PMCID: PMC48181.
    102. Liu TJ, Kay MA, Darlington GJ, Woo SL. Reconstitution of enzymatic activity in hepatocytes of phenylalanine hydroxylase-deficient mice. Somat Cell Mol Genet. 1992 Jan; 18(1):89-96. PMID: 1312261.
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    103. Wu KJ, Samuelson LC, Howard G, Meisler MH, Darlington GJ. Transactivation of pancreas-specific gene sequences in somatic cell hybrids. Mol Cell Biol. 1991 Sep; 11(9):4423-30. PMID: 1715019; PMCID: PMC361305.
    104. Ponder KP, Gupta S, Leland F, Darlington G, Finegold M, DeMayo J, Ledley FD, Chowdhury JR, Woo SL. Mouse hepatocytes migrate to liver parenchyma and function indefinitely after intrasplenic transplantation. Proc Natl Acad Sci U S A. 1991 Feb 15; 88(4):1217-21. PMID: 1899924; PMCID: PMC50988.
    105. Ponder KP, Dunbar RP, Wilson DR, Darlington GJ, Woo SL. Evaluation of relative promoter strength in primary hepatocytes using optimized lipofection. Hum Gene Ther. 1991; 2(1):41-52. PMID: 1863638.
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    106. Ledley FD, Woo SL, Ferry GD, Whisennand HH, Brandt ML, Darlington GJ, Demmler GJ, Finegold MJ, Pokorny WJ, Rosenblatt H, et al. Hepatocellular transplantation in acute hepatic failure and targeting genetic markers to hepatic cells. Hum Gene Ther. 1991; 2(4):331-58. PMID: 1665349.
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    107. Wilson DR, Juan TS, Wilde MD, Fey GH, Darlington GJ. A 58-base-pair region of the human C3 gene confers synergistic inducibility by interleukin-1 and interleukin-6. Mol Cell Biol. 1990 Dec; 10(12):6181-91. PMID: 2247055; PMCID: PMC362893.
    108. Armentano D, Thompson AR, Darlington G, Woo SL. Expression of human factor IX in rabbit hepatocytes by retrovirus-mediated gene transfer: potential for gene therapy of hemophilia B. Proc Natl Acad Sci U S A. 1990 Aug; 87(16):6141-5. PMID: 2385589; PMCID: PMC54488.
    109. Schäfer BW, Blakely BT, Darlington GJ, Blau HM. Effect of cell history on response to helix-loop-helix family of myogenic regulators. Nature. 1990 Mar 29; 344(6265):454-8. PMID: 2157160.
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    110. Chin KV, Tanaka S, Darlington G, Pastan I, Gottesman MM. Heat shock and arsenite increase expression of the multidrug resistance (MDR1) gene in human renal carcinoma cells. J Biol Chem. 1990 Jan 5; 265(1):221-6. PMID: 1967174.
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    111. Rouah E, Wilson DR, Armstrong DL, Darlington GJ. N-myc amplification and neuronal differentiation in human primitive neuroectodermal tumors of the central nervous system. Cancer Res. 1989 Apr 1; 49(7):1797-801. PMID: 2924321.
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    112. Kelly JH, Darlington GJ. Modulation of the liver specific phenotype in the human hepatoblastoma line Hep G2. In Vitro Cell Dev Biol. 1989 Feb; 25(2):217-22. PMID: 2466032.
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    113. Donehower LA, Slagle BL, Wilde M, Darlington G, Butel JS. Identification of a conserved sequence in the non-coding regions of many human genes. Nucleic Acids Res. 1989 Jan 25; 17(2):699-710. PMID: 2536922; PMCID: PMC331613.
    114. Darlington GJ, Wilson DR, Revel M, Kelly JH. Response of liver genes to acute phase mediators. Ann N Y Acad Sci. 1989; 557:310-5; discussion 315-6. PMID: 2472091.
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    115. Peng H, Armentano D, MacKenzie-Graham L, Shen RF, Darlington G, Ledley FD, Woo SL. Retroviral-mediated gene transfer and expression of human phenylalanine hydroxylase in primary mouse hepatocytes. Proc Natl Acad Sci U S A. 1988 Nov; 85(21):8146-50. PMID: 3186716; PMCID: PMC282383.
    116. Samuelson LC, Keller PR, Darlington GJ, Meisler MH. Glucocorticoid and developmental regulation of amylase mRNAs in mouse liver cells. Mol Cell Biol. 1988 Sep; 8(9):3857-63. PMID: 2464743; PMCID: PMC365444.
    117. Ledley FD, Darlington GJ, Hahn T, Woo SL. Retroviral gene transfer into primary hepatocytes: implications for genetic therapy of liver-specific functions. Proc Natl Acad Sci U S A. 1987 Aug; 84(15):5335-9. PMID: 3474659; PMCID: PMC298850.
    118. Darlington GJ, Kelly JH, Buffone GJ. Growth and hepatospecific gene expression of human hepatoma cells in a defined medium. In Vitro Cell Dev Biol. 1987 May; 23(5):349-54. PMID: 3034851.
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    119. Darlington GJ. Liver cell lines. Methods Enzymol. 1987; 151:19-38. PMID: 3431441.
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    120. Darlington GJ, Wilson DR, Lachman LB. Monocyte-conditioned medium, interleukin-1, and tumor necrosis factor stimulate the acute phase response in human hepatoma cells in vitro. J Cell Biol. 1986 Sep; 103(3):787-93. PMID: 3017995; PMCID: PMC2114283.
    121. Buffone GJ, Schimbor CM, Demmler GJ, Wilson DR, Darlington GJ. Detection of cytomegalovirus in urine by nonisotopic DNA hybridization. J Infect Dis. 1986 Jul; 154(1):163-6. PMID: 3011920.
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    122. Darlington GJ, Tsai CC, Samuelson LC, Gumucio DL, Meisler MH. Simultaneous expression of salivary and pancreatic amylase genes in cultured mouse hepatoma cells. Mol Cell Biol. 1986 Apr; 6(4):969-75. PMID: 2431276; PMCID: PMC367604.
    123. Dracopoli NC, Rettig WJ, Whitfield GK, Darlington GJ, Spengler BA, Biedler JL, Old LJ, Kourides IA. Assignment of the gene for the beta subunit of thyroid-stimulating hormone to the short arm of human chromosome 1. Proc Natl Acad Sci U S A. 1986 Mar; 83(6):1822-6. PMID: 3006075; PMCID: PMC323176.
    124. Kochersperger LM, Parker EL, Siciliano M, Darlington GJ, Denney RM. Assignment of genes for human monoamine oxidases A and B to the X chromosome. J Neurosci Res. 1986; 16(4):601-16. PMID: 3540317.
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    125. Buffone GJ, Darlington GJ, Wilson DR, Schimbor CM. Suitability of SP6 RNA polymerase transcripts for in vitro viral diagnosis. Clin Chem. 1985 Dec; 31(12):2043-4. PMID: 4064299.
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    126. Kelly JH, Darlington GJ. Hybrid genes: molecular approaches to tissue-specific gene regulation. Annu Rev Genet. 1985; 19:273-96. PMID: 3909944.
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    127. Esterman AL, Baum H, Javitt NB, Darlington GJ. 26-hydroxycholesterol: regulation of hydroxymethylglutaryl-CoA reductase activity in Chinese hamster ovary cell culture. J Lipid Res. 1983 Oct; 24(10):1304-9. PMID: 6644180.
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    128. Darlington GJ, Papaconstantinou J, Sammons DW, Brown PC, Wong EY, Esterman AL, Kang J. Generation and chracterization of variants of mouse hepatoma cells with defects in hepato-specific gene expression. I. Albumin synthesis variants. Somatic Cell Genet. 1982 Jul; 8(4):451-64. PMID: 6181572.
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    129. Darlington GJ, Rankin JK, Schlanger G. Expression of human hepatic genes in somatic cell hybrids. Somatic Cell Genet. 1982 May; 8(3):403-12. PMID: 6180490.
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    130. Darlington GJ, Astrin KH, Muirhead SP, Desnick RJ, Smith M. Assignment of human alpha 1-antitrypsin to chromosome 14 by somatic cell hybrid analysis. Proc Natl Acad Sci U S A. 1982 Feb; 79(3):870-3. PMID: 6801664; PMCID: PMC345854.
    131. Darlington GJ. Application of cell-fusion techniques to induce amniotic fluid cells to express special functions and for complementation analysis. Methods Cell Biol. 1982; 26:297-310. PMID: 7132785.
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    132. Brown WT, Dutkowski R, Darlington GJ. Localization and quantitation of human superoxide dismutase using computerized 2-D gel electrophoresis. Biochem Biophys Res Commun. 1981 Sep 30; 102(2):675-81. PMID: 7306178.
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    133. Sammons DW, Sanchez E, Darlington GJ. Immuno-overlay: a method for identification of hepatoma cell colonies that secrete albumin. In Vitro. 1980 Nov; 16(11):918-24. PMID: 7005077.
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    134. Hefton JM, Darlington GJ, Casazza BA, Weksler ME. Immunologic studies of aging. V. Impaired proliferation of PHA responsive human lymphocytes in culture. J Immunol. 1980 Sep; 125(3):1007-10. PMID: 7410824.
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    135. Darlington GJ, Bernhard HP, Miller RA, Ruddle FH. Expression of liver phenotypes in cultured mouse hepatoma cells. J Natl Cancer Inst. 1980 Apr; 64(4):809-19. PMID: 6102619.
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    136. Nelson-Rees WA, Hunter L, Darlington GJ, O'Brien SJ. Characteristics of HeLa strains: permanent vs. variable features. Cytogenet Cell Genet. 1980; 27(4):216-31. PMID: 7002488.
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    137. Rankin JK, Darlington GJ. Expression of human hepatic genes in mouse hepatoma--human amniocyte hybrids. Somatic Cell Genet. 1979 Jan; 5(1):1-10. PMID: 107601.
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    138. Conscience JF, Ruddle FH, Skoultchi A, Darlington GJ. Somatic cell hybrids between Friend erythroleukemia cells and mouse hepatoma cells. Somatic Cell Genet. 1977 Mar; 3(2):157-72. PMID: 204066.
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    139. Darlington GJ, Bernard HP, Ruddle FH. Human serum albumin phenotype activation in mouse hepatoma--human leukocyte cell hybrids. Science. 1974 Sep 6; 185(4154):859-62. PMID: 4367319.
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    140. Darlington GJ, Bernhard HP, Ruddle FH. Proceedings: The expression of hepatic functions in mouse hepatoma x human leukocyte hybrids. Cytogenet Cell Genet. 1974; 13(1):86-8. PMID: 4363871.
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    141. Bernhard HP, Darlington GJ, Ruddle FH. Expression of liver phenotypes in cultured mouse hepatoma cells: synthesis and secretion of serum albumin. Dev Biol. 1973 Nov; 35(1):83-96. PMID: 4362668.
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    142. Ruddle F, Ricciuti F, McMorris FA, Darlington G, Chen T. Somatic cell genetic assignment of peptidase C and the Rh linkage group to chromosome A-1 in man. Science. 1972 Jun 30; 176(4042):1429-31. PMID: 4113665.
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