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Institution

O HOWARD FRAZIER

TitleProfessor
InstitutionBaylor College of Medicine
DepartmentDepartment of Surgery
AddressTexas Heart Institute/St. Luke's Episcopal Hospital
P.O. Box 20345, MC 2-114A
Houston TX 772250345
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    For more than 30 years, Dr. O. H. Frazier has been a pioneer in the treatment of severe heart failure and in the fields of heart transplantation and artificial devices that may be used either to substitute for or assist the pumping action of the human heart. As a result of his work, the Texas Heart Institute has become one of the top transplantation and mechanical circulatory support programs in the world. Dr. Frazier has performed over 1,200 heart transplants and implanted more than 900 left ventricular assist devices, more than any other surgeon in the world.

    Dr. Frazier’s interest in mechanical circulatory support began in 1969, when, as a student at Baylor College of Medicine, he wrote a research paper about the experimental total artificial heart, which was first implanted in 1969 by Dr. Denton Cooley. Throughout the 1970s and 1980s, Dr. Frazier continued experimental work toward developing an implantable left ventricular assist device (LVAD) to aid the failing heart. He implanted the first LVAD in 1986 with the HeartMate I; since then this device has become the most widely used implantable LVAD in the world. In 2011, Dr. Frazier implanted the first successful continuous-flow total artificial heart using two second generation HeartMate II LVADs to replace a patient’s failing heart.


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Rees ML, Subramaniam J, Li Y, Hamilton DJ, Frazier OH, Taegtmeyer H. A PKM2 signature in the failing heart. Biochem Biophys Res Commun. 2015 Apr 10; 459(3):430-6. PMID: 25735978; PMCID: PMC4380635.
    2. Nestler F, Bradley AP, Wilson SJ, Timms DL, Frazier OH, Cohn WE. A hybrid mock circulation loop for a total artificial heart. Artif Organs. 2014 Sep; 38(9):775-82. PMID: 25234760.
      View in: PubMed
    3. El-Sayed Ahmed MM, Aftab M, Singh SK, Mallidi HR, Frazier OH. Left ventricular assist device outflow graft: alternative sites. Ann Cardiothorac Surg. 2014 Sep; 3(5):541-5. PMID: 25452918; PMCID: PMC4229468.
    4. Frazier OH. Increase in left ventricular assist device thrombosis. N Engl J Med. 2014 Apr 10; 370(15):1464-5. PMID: 24716697.
      View in: PubMed
    5. Baskin KK, Rodriguez MR, Kansara S, Chen W, Carranza S, Frazier OH, Glass DJ, Taegtmeyer H. MAFbx/Atrogin-1 is required for atrophic remodeling of the unloaded heart. J Mol Cell Cardiol. 2014 Jul; 72:168-76. PMID: 24650875; PMCID: PMC4037330.
    6. Boyle AJ, Jorde UP, Sun B, Park SJ, Milano CA, Frazier OH, Sundareswaran KS, Farrar DJ, Russell SD. Pre-operative risk factors of bleeding and stroke during left ventricular assist device support: an analysis of more than 900 HeartMate II outpatients. J Am Coll Cardiol. 2014 Mar 11; 63(9):880-8. PMID: 24316083.
      View in: PubMed
    7. Cabrera AG, Sundareswaran KS, Samayoa AX, Jeewa A, McKenzie ED, Rossano JW, Farrar DJ, Frazier OH, Morales DL. Outcomes of pediatric patients supported by the HeartMate II left ventricular assist device in the United States. J Heart Lung Transplant. 2013 Nov; 32(11):1107-13. PMID: 24002006.
      View in: PubMed
    8. Sen S, Kundu BK, Wu HC, Hashmi SS, Guthrie P, Locke LW, Roy RJ, Matherne GP, Berr SS, Terwelp M, Scott B, Carranza S, Frazier OH, Glover DK, Dillmann WH, Gambello MJ, Entman ML, Taegtmeyer H. Glucose regulation of load-induced mTOR signaling and ER stress in mammalian heart. J Am Heart Assoc. 2013 Jun; 2(3):e004796. PMID: 23686371; PMCID: PMC3698799.
    9. Moazami N, Milano CA, John R, Sun B, Adamson RM, Pagani FD, Smedira N, Slaughter MS, Farrar DJ, Frazier OH. Pump replacement for left ventricular assist device failure can be done safely and is associated with low mortality. Ann Thorac Surg. 2013 Feb; 95(2):500-5. PMID: 23261114.
      View in: PubMed
    10. Goldstein DJ, Maybaum S, MacGillivray TE, Moore SA, Bogaev R, Farrar DJ, Frazier OH. Young patients with nonischemic cardiomyopathy have higher likelihood of left ventricular recovery during left ventricular assist device support. J Card Fail. 2012 May; 18(5):392-5. PMID: 22555270.
      View in: PubMed
    11. Agusala K, Bogaev R, Frazier OH, Franklin WJ. Ventricular assist device placement in an adult with D-transposition of the great arteries with prior Mustard operation. Congenit Heart Dis. 2010 Nov-Dec; 5(6):635-7. PMID: 21106027.
      View in: PubMed
    12. John R, Long JW, Massey HT, Griffith BP, Sun BC, Tector AJ, Frazier OH, Joyce LD. Outcomes of a multicenter trial of the Levitronix CentriMag ventricular assist system for short-term circulatory support. J Thorac Cardiovasc Surg. 2011 Apr; 141(4):932-9. PMID: 20605026.
      View in: PubMed
    13. John R, Pagani FD, Naka Y, Boyle A, Conte JV, Russell SD, Klodell CT, Milano CA, Rogers J, Farrar DJ, Frazier OH. Post-cardiac transplant survival after support with a continuous-flow left ventricular assist device: impact of duration of left ventricular assist device support and other variables. J Thorac Cardiovasc Surg. 2010 Jul; 140(1):174-81. PMID: 20447659.
      View in: PubMed
    14. Slaughter MS, Rogers JG, Milano CA, Russell SD, Conte JV, Feldman D, Sun B, Tatooles AJ, Delgado RM, Long JW, Wozniak TC, Ghumman W, Farrar DJ, Frazier OH. Advanced heart failure treated with continuous-flow left ventricular assist device. N Engl J Med. 2009 Dec 3; 361(23):2241-51. PMID: 19920051.
      View in: PubMed
    15. Boyle AJ, Russell SD, Teuteberg JJ, Slaughter MS, Moazami N, Pagani FD, Frazier OH, Heatley G, Farrar DJ, John R. Low thromboembolism and pump thrombosis with the HeartMate II left ventricular assist device: analysis of outpatient anti-coagulation. J Heart Lung Transplant. 2009 Sep; 28(9):881-7. PMID: 19716039.
      View in: PubMed
    16. Pagani FD, Miller LW, Russell SD, Aaronson KD, John R, Boyle AJ, Conte JV, Bogaev RC, MacGillivray TE, Naka Y, Mancini D, Massey HT, Chen L, Klodell CT, Aranda JM, Moazami N, Ewald GA, Farrar DJ, Frazier OH. Extended mechanical circulatory support with a continuous-flow rotary left ventricular assist device. J Am Coll Cardiol. 2009 Jul 21; 54(4):312-21. PMID: 19608028.
      View in: PubMed
    17. Westaby S, Siegenthaler M, Beyersdorf F, Massetti M, Pepper J, Khayat A, Hetzer R, Frazier OH. Destination therapy with a rotary blood pump and novel power delivery. Eur J Cardiothorac Surg. 2010 Feb; 37(2):350-6. PMID: 19589689.
      View in: PubMed
    18. Schnee PM, Shah N, Bergheim M, Poindexter BJ, Buja LM, Gemmato C, Radovancevic B, Letsou GV, Frazier OH, Bick RJ. Location and density of alpha- and beta-adrenoreceptor sub-types in myocardium after mechanical left ventricular unloading. J Heart Lung Transplant. 2008 Jul; 27(7):710-7. PMID: 18582798.
      View in: PubMed
    19. Radovancevic R, Bracey AW, Radovancevic B, Elayda M, Gregoric ID, Frazier OH. Plasma exchange before surgery for left ventricular assist device implantation. Artif Organs. 2008 Jun; 32(6):427-32. PMID: 18422799.
      View in: PubMed
    20. Bourque K, Dague C, Farrar D, Harms K, Tamez D, Cohn W, Tuzun E, Poirier V, Frazier OH. In vivo assessment of a rotary left ventricular assist device-induced artificial pulse in the proximal and distal aorta. Artif Organs. 2006 Aug; 30(8):638-42. PMID: 16911321.
      View in: PubMed
    21. Takach TJ, Reul GJ, Duncan JM, Krajcer Z, Livesay JJ, Gregoric ID, Cervera RD, Ott DA, Frazier OH, Cooley DA. Concomitant brachiocephalic and coronary artery disease: outcome and decision analysis. Ann Thorac Surg. 2005 Aug; 80(2):564-9. PMID: 16039206.
      View in: PubMed
    22. Bick RJ, Grigore AM, Poindexter BJ, Schnee PM, Nussmeier NA, Gregoric ID, Shah NA, Myers TJ, Buja LM, Frazier OH. Left ventricular unloading with an assist device results in receptor relocalization as well as increased beta-adrenergic receptor numbers: are these changes indications for outcome? J Card Surg. 2005 Jul-Aug; 20(4):332-6. PMID: 15985133.
      View in: PubMed
    23. Bick RJ, Bagwell SH, Jones CE, Poindexter BJ, Buja LM, Youker KA, Grigore A, Clubb F, Radovancevic B, Frazier OH. Fluorescence imaging microscopy of cellular markers in ischemic vs non-ischemic cardiomyopathy after left ventricular unloading. J Heart Lung Transplant. 2005 Apr; 24(4):454-61. PMID: 15797748.
      View in: PubMed
    24. Park SJ, Tector A, Piccioni W, Raines E, Gelijns A, Moskowitz A, Rose E, Holman W, Furukawa S, Frazier OH, Dembitsky W. Left ventricular assist devices as destination therapy: a new look at survival. J Thorac Cardiovasc Surg. 2005 Jan; 129(1):9-17. PMID: 15632819.
      View in: PubMed
    25. Rose AG, Connelly JH, Park SJ, Frazier OH, Miller LW, Ormaza S. Total left ventricular outflow tract obstruction due to left ventricular assist device-induced sub-aortic thrombosis in 2 patients with aortic valve bioprosthesis. J Heart Lung Transplant. 2003 May; 22(5):594-9. PMID: 12742425.
      View in: PubMed
    26. Uray IP, Connelly JH, Thomázy V, Shipley GL, Vaughn WK, Frazier OH, Taegtmeyer H, Davies PJ. Left ventricular unloading alters receptor tyrosine kinase expression in the failing human heart. J Heart Lung Transplant. 2002 Jul; 21(7):771-82. PMID: 12100903.
      View in: PubMed
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