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O FRAZIER

TitleProfessor
InstitutionBaylor College of Medicine
DepartmentDepartment of Surgery
Address6720 BERTNER
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    Collapse Overview 
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    For more than 30 years, Dr. O. H. Frazier has been a pioneer in the treatment of severe heart failure and in the fields of heart transplantation and artificial devices that may be used either to substitute for or assist the pumping action of the human heart. As a result of his work, the Texas Heart Institute has become one of the top transplantation and mechanical circulatory support programs in the world. Dr. Frazier has performed over 1,200 heart transplants and implanted more than 900 left ventricular assist devices, more than any other surgeon in the world.

    Dr. Frazier’s interest in mechanical circulatory support began in 1969, when, as a student at Baylor College of Medicine, he wrote a research paper about the experimental total artificial heart, which was first implanted in 1969 by Dr. Denton Cooley. Throughout the 1970s and 1980s, Dr. Frazier continued experimental work toward developing an implantable left ventricular assist device (LVAD) to aid the failing heart. He implanted the first LVAD in 1986 with the HeartMate I; since then this device has become the most widely used implantable LVAD in the world. In 2011, Dr. Frazier implanted the first successful continuous-flow total artificial heart using two second generation HeartMate II LVADs to replace a patient’s failing heart.

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Scioscia JP, Murrieta-Alvarez I, Li S, Xu Z, Zheng G, Uwaeze J, Walther CP, Gray Z, Nordick KV, Braverman V, Shafii AE, Loor G, Hochman-Mendez C, Ghanta RK, Chatterjee S, Frazier OH, Rosengart TK, Liao KK, Mondal NK. Machine Learning Assisted Stroke Prediction in Mechanical Circulatory Support: Predictive Role of Systemic Mitochondrial Dysfunction. ASAIO J. 2024 Oct 23. PMID: 39437251.
      Citations:    Fields:    
    2. Devich R, Neuendorff NR, Frazier OH, Eisen HJ, Dowling R, Freundt M. Hematopoietic Stimulation During Impella 5.5 Support to Avoid Transfusions in a Jehovah's Witness. ASAIO J. 2023 08 01; 69(8):e384-e387. PMID: 37084256.
      Citations:    Fields:    Translation:Humans
    3. Broda CR, Frankel WC, Nair AP, Dreyer WJ, Tunuguntla HP, Frazier OH, Dolgner SJ, Qureshi AM, Parekh DR, Hickey EJ, Adachi I, Civitello AB, Anders MM, Tume SC. Continuous-Flow Ventricular Assist Device Support in Adult Congenital Heart Disease: A 15-Year, Multicenter Experience of Temporary and Durable Support. ASAIO J. 2023 05 01; 69(5):429-437. PMID: 36730653.
      Citations:    Fields:    Translation:Humans
    4. Selzman CH, Feller ED, Walker JC, Sheridan BC, Silvestry SC, Daly RC, Anyanwu AC, Madigan D, Liu PY, Frazier OH, Jorde UP, Griffith BP. The Jarvik 2000 Left Ventricular Assist Device: Results of the United States Bridge to Transplant Trial. ASAIO J. 2023 02 01; 69(2):174-182. PMID: 35421002.
      Citations:    Fields:    
    5. Demirozu ZT, Critsinelis A, Cohn WE, Radovancevic R, Ho J, Hernandez R, Morgan JA, Frazier OH. Experience with the HeartMate II Left Ventricular Assist Device in Patients Older than 60 Years. Heart Surg Forum. 2019 03 08; 22(2):E124-E130. PMID: 31013222.
      Citations:    Fields:    Translation:Humans
    6. Taylor DA, Frazier OH, Elgalad A, Hochman-Mendez C, Sampaio LC. Building a Total Bioartificial Heart: Harnessing Nature to Overcome the Current Hurdles. Artif Organs. 2018 Oct; 42(10):970-982. PMID: 30044011.
      Citations: 9     Fields:    Translation:AnimalsCells
    7. Frazier OH, Morgan JA, Beaupr? RA. Total artificial heart implantation as a bridge to transplantation: a viable model for the future? Expert Rev Med Devices. 2018 Oct; 15(10):701-706. PMID: 30221561.
      Citations: 1     Fields:    Translation:Humans
    8. Chan CHH, Diab S, Moody K, Frazier OH, Sampaio LC, Fraser CD, Teruya J, Adachi I. In Vitro Hemocompatibility Evaluation of Ventricular Assist Devices in Pediatric Flow Conditions: A Benchmark Study. Artif Organs. 2018 Nov; 42(11):1028-1034. PMID: 30101559.
      Citations: 4     Fields:    Translation:HumansAnimals
    9. Kawabori M, Kurihara C, Sugiura T, Cohn WE, Civitello AB, Frazier OH, Morgan JA. Continuous-Flow Left Ventricular Assist Device Implantation in Patients With a Small Left Ventricle. Ann Thorac Surg. 2018 03; 105(3):799-806. PMID: 29290308.
      Citations: 4     Fields:    Translation:Humans
    10. Kleinheyer M, Timms DL, Tansley GD, Nestler F, Greatrex NA, Frazier OH, Cohn WE. Rapid Speed Modulation of a Rotary Total Artificial Heart Impeller. Artif Organs. 2016 Sep; 40(9):824-33. PMID: 27645393.
      Citations: 3     Fields:    Translation:Humans
    11. Feng J, Cohn WE, Parnis SM, Sodha NR, Clements RT, Sellke N, Frazier OH, Sellke FW. New continuous-flow total artificial heart and vascular permeability. J Surg Res. 2015 Dec; 199(2):296-305. PMID: 26188957; PMCID: PMC4636951.
      Citations: 4     Fields:    Translation:AnimalsCells
    12. Nestler F, Bradley AP, Wilson SJ, Timms DL, Frazier OH, Cohn WE. A hybrid mock circulation loop for a total artificial heart. Artif Organs. 2014 Sep; 38(9):775-82. PMID: 25234760.
      Citations: 3     Fields:    Translation:Humans
    13. El-Sayed Ahmed MM, Aftab M, Singh SK, Mallidi HR, Frazier OH. Left ventricular assist device outflow graft: alternative sites. Ann Cardiothorac Surg. 2014 Sep; 3(5):541-5. PMID: 25452918; PMCID: PMC4229468.
      Citations: 9     
    14. Frazier OH. Increase in left ventricular assist device thrombosis. N Engl J Med. 2014 04 10; 370(15):1464-5. PMID: 24716697.
      Citations:    Fields:    Translation:Humans
    15. Baskin KK, Rodriguez MR, Kansara S, Chen W, Carranza S, Frazier OH, Glass DJ, Taegtmeyer H. MAFbx/Atrogin-1 is required for atrophic remodeling of the unloaded heart. J Mol Cell Cardiol. 2014 Jul; 72:168-76. PMID: 24650875; PMCID: PMC4037330.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    16. Kleinheyer M, Timms DL, Greatrex NA, Masuzawa T, Frazier OH, Cohn WE. Pulsatile operation of the BiVACOR TAH - Motor design, control and hemodynamics. Annu Int Conf IEEE Eng Med Biol Soc. 2014; 2014:5659-62. PMID: 25571279.
      Citations: 3     Fields:    Translation:HumansAnimals
    17. Boyle AJ, Jorde UP, Sun B, Park SJ, Milano CA, Frazier OH, Sundareswaran KS, Farrar DJ, Russell SD, HeartMate II Clinical Investigators. Pre-operative risk factors of bleeding and stroke during left ventricular assist device support: an analysis of more than 900 HeartMate II outpatients. J Am Coll Cardiol. 2014 Mar 11; 63(9):880-8. PMID: 24316083.
      Citations: 46     Fields:    Translation:Humans
    18. Cabrera AG, Sundareswaran KS, Samayoa AX, Jeewa A, McKenzie ED, Rossano JW, Farrar DJ, Frazier OH, Morales DL. Outcomes of pediatric patients supported by the HeartMate II left ventricular assist device in the United States. J Heart Lung Transplant. 2013 Nov; 32(11):1107-13. PMID: 24002006.
      Citations: 21     Fields:    Translation:Humans
    19. Moazami N, Milano CA, John R, Sun B, Adamson RM, Pagani FD, Smedira N, Slaughter MS, Farrar DJ, Frazier OH, HeartMate II Investigators. Pump replacement for left ventricular assist device failure can be done safely and is associated with low mortality. Ann Thorac Surg. 2013 Feb; 95(2):500-5. PMID: 23261114.
      Citations: 25     Fields:    Translation:Humans
    20. Goldstein DJ, Maybaum S, MacGillivray TE, Moore SA, Bogaev R, Farrar DJ, Frazier OH, HeartMate II Clinical Investigators. Young patients with nonischemic cardiomyopathy have higher likelihood of left ventricular recovery during left ventricular assist device support. J Card Fail. 2012 May; 18(5):392-5. PMID: 22555270.
      Citations: 23     Fields:    Translation:Humans
    21. Agusala K, Bogaev R, Frazier OH, Franklin WJ. Ventricular assist device placement in an adult with D-transposition of the great arteries with prior Mustard operation. Congenit Heart Dis. 2010 Nov-Dec; 5(6):635-7. PMID: 21106027.
      Citations: 8     Fields:    Translation:Humans
    22. John R, Long JW, Massey HT, Griffith BP, Sun BC, Tector AJ, Frazier OH, Joyce LD. Outcomes of a multicenter trial of the Levitronix CentriMag ventricular assist system for short-term circulatory support. J Thorac Cardiovasc Surg. 2011 Apr; 141(4):932-9. PMID: 20605026.
      Citations: 33     Fields:    Translation:HumansCTClinical Trials
    23. John R, Pagani FD, Naka Y, Boyle A, Conte JV, Russell SD, Klodell CT, Milano CA, Rogers J, Farrar DJ, Frazier OH. Post-cardiac transplant survival after support with a continuous-flow left ventricular assist device: impact of duration of left ventricular assist device support and other variables. J Thorac Cardiovasc Surg. 2010 Jul; 140(1):174-81. PMID: 20447659.
      Citations: 29     Fields:    Translation:Humans
    24. Slaughter MS, Rogers JG, Milano CA, Russell SD, Conte JV, Feldman D, Sun B, Tatooles AJ, Delgado RM, Long JW, Wozniak TC, Ghumman W, Farrar DJ, Frazier OH, HeartMate II Investigators. Advanced heart failure treated with continuous-flow left ventricular assist device. N Engl J Med. 2009 Dec 03; 361(23):2241-51. PMID: 19920051.
      Citations: 626     Fields:    Translation:Humans
    25. Boyle AJ, Russell SD, Teuteberg JJ, Slaughter MS, Moazami N, Pagani FD, Frazier OH, Heatley G, Farrar DJ, John R. Low thromboembolism and pump thrombosis with the HeartMate II left ventricular assist device: analysis of outpatient anti-coagulation. J Heart Lung Transplant. 2009 Sep; 28(9):881-7. PMID: 19716039.
      Citations: 72     Fields:    Translation:Humans
    26. Pagani FD, Miller LW, Russell SD, Aaronson KD, John R, Boyle AJ, Conte JV, Bogaev RC, MacGillivray TE, Naka Y, Mancini D, Massey HT, Chen L, Klodell CT, Aranda JM, Moazami N, Ewald GA, Farrar DJ, Frazier OH, HeartMate II Investigators. Extended mechanical circulatory support with a continuous-flow rotary left ventricular assist device. J Am Coll Cardiol. 2009 Jul 21; 54(4):312-21. PMID: 19608028.
      Citations: 133     Fields:    Translation:HumansCTClinical Trials
    27. Westaby S, Siegenthaler M, Beyersdorf F, Massetti M, Pepper J, Khayat A, Hetzer R, Frazier OH. Destination therapy with a rotary blood pump and novel power delivery. Eur J Cardiothorac Surg. 2010 Feb; 37(2):350-6. PMID: 19589689.
      Citations: 11     Fields:    Translation:Humans
    28. Westaby S, Banning A, Neil D, Poole-Wilson P, Frazier OH. Optimism derived from 7.5 years of continuous-flow circulatory support. J Thorac Cardiovasc Surg. 2010 Mar; 139(3):e45-7. PMID: 19660322.
      Citations: 3     Fields:    Translation:Humans
    29. Schnee PM, Shah N, Bergheim M, Poindexter BJ, Buja LM, Gemmato C, Radovancevic B, Letsou GV, Frazier OH, Bick RJ. Location and density of alpha- and beta-adrenoreceptor sub-types in myocardium after mechanical left ventricular unloading. J Heart Lung Transplant. 2008 Jul; 27(7):710-7. PMID: 18582798.
      Citations: 5     Fields:    Translation:Humans
    30. Radovancevic R, Bracey AW, Radovancevic B, Elayda M, Gregoric ID, Frazier OH. Plasma exchange before surgery for left ventricular assist device implantation. Artif Organs. 2008 Jun; 32(6):427-32. PMID: 18422799.
      Citations: 1     Fields:    Translation:Humans
    31. Bourque K, Dague C, Farrar D, Harms K, Tamez D, Cohn W, Tuzun E, Poirier V, Frazier OH. In vivo assessment of a rotary left ventricular assist device-induced artificial pulse in the proximal and distal aorta. Artif Organs. 2006 Aug; 30(8):638-42. PMID: 16911321.
      Citations: 9     Fields:    Translation:Animals
    32. Takach TJ, Reul GJ, Duncan JM, Krajcer Z, Livesay JJ, Gregoric ID, Cervera RD, Ott DA, Frazier OH, Cooley DA. Concomitant brachiocephalic and coronary artery disease: outcome and decision analysis. Ann Thorac Surg. 2005 Aug; 80(2):564-9. PMID: 16039206.
      Citations: 6     Fields:    Translation:Humans
    33. Bick RJ, Grigore AM, Poindexter BJ, Schnee PM, Nussmeier NA, Gregoric ID, Shah NA, Myers TJ, Buja LM, Frazier OH. Left ventricular unloading with an assist device results in receptor relocalization as well as increased beta-adrenergic receptor numbers: are these changes indications for outcome? J Card Surg. 2005 Jul-Aug; 20(4):332-6. PMID: 15985133.
      Citations: 5     Fields:    Translation:Humans
    34. Bick RJ, Bagwell SH, Jones CE, Poindexter BJ, Buja LM, Youker KA, Grigore A, Clubb F, Radovancevic B, Frazier OH. Fluorescence imaging microscopy of cellular markers in ischemic vs non-ischemic cardiomyopathy after left ventricular unloading. J Heart Lung Transplant. 2005 Apr; 24(4):454-61. PMID: 15797748.
      Citations:    Fields:    Translation:Humans
    35. Park SJ, Tector A, Piccioni W, Raines E, Gelijns A, Moskowitz A, Rose E, Holman W, Furukawa S, Frazier OH, Dembitsky W. Left ventricular assist devices as destination therapy: a new look at survival. J Thorac Cardiovasc Surg. 2005 Jan; 129(1):9-17. PMID: 15632819.
      Citations: 39     Fields:    Translation:HumansCTClinical Trials
    36. Connelly JH, Frazier OH, Taegtmeyer H, Davies PJ, Uray IP. Mechanical unloading increases caveolin expression in the failing human heart. Cardiovasc Res. 2003 Jul 01; 59(1):57-66. PMID: 12829176.
      Citations: 9     Fields:    Translation:Humans
    37. Rose AG, Connelly JH, Park SJ, Frazier OH, Miller LW, Ormaza S. Total left ventricular outflow tract obstruction due to left ventricular assist device-induced sub-aortic thrombosis in 2 patients with aortic valve bioprosthesis. J Heart Lung Transplant. 2003 May; 22(5):594-9. PMID: 12742425.
      Citations: 4     Fields:    Translation:Humans
    38. Connelly JH, Shipley GL, Vaughn WK, Frazier OH, Taegtmeyer H, Davies PJ, Uray IP, Thom?zy V. Left ventricular unloading alters receptor tyrosine kinase expression in the failing human heart. J Heart Lung Transplant. 2002 Jul; 21(7):771-82. PMID: 12100903.
      Citations: 17     Fields:    Translation:HumansCells
    39. Flamm SD, Walmsley R, Frazier OH. 3D-magnetic resonance angiogram of heterotopic heart transplant. Circulation. 2002 Feb 05; 105(5):E36-6. PMID: 11827937.
      Citations:    Fields:    Translation:Humans
    40. Walker WE, Duncan JM, Frazier OH, Livesay JJ, Ott DA, Reul GJ, Cooley DA. Early experience with the ionescu-shiley pericardial xenograft valve. Accelerated calcification in children. J Thorac Cardiovasc Surg. 1983 Oct; 86(4):570-5. PMID: 6621085.
      Citations: 7     Fields:    Translation:Humans
    41. Cooley DA, Akutsu T, Norman JC, Serrato MA, Frazier OH. Total artificial heart in two-staged cardiac transplantation. Cardiovasc Dis. 1981 Sep; 8(3):305-319. PMID: 15216188; PMCID: PMC287945.
      Citations: 11     
    42. Gregg FP, Frazier OH. Radiologic case presentation. Cardiovasc Dis. 1981 Sep; 8(3):455-459. PMID: 15216203; PMCID: PMC287975.
      Citations:    
    43. Cooley DA, Frazier OH, Norman JC. MITRAL LEAFLET PROLAPSE: SURGICAL TREATMENT USING A POSTERIOR ANNULAR COLLAR PROSTHESIS. Cardiovasc Dis. 1976; 3(4):438-443. PMID: 15216146; PMCID: PMC287627.
      Citations: 10     
    44. Oglietti J, Frazier OH, Reul GJ, Cooley DA. CORRECTION OF ANOMALOUS VENOUS RETURN FROM THE RIGHT LUNG TO THE INFERIOR VENA CAVA (SCIMITAR DEFORMITY). Cardiovasc Dis. 1976; 3(2):210-219. PMID: 15216167; PMCID: PMC287598.
      Citations: 1     
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