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SOPHIA Y TSAI

TitleProfessor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular & Cellular Biology
AddressOne Baylor Plaza
Houston TX 77030
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    Other Positions
    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Medicine
    DivisionMedicine-Endocrinology


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    COUP-TFs
    Nuclear Receptors
    Development
    Cancer
    Cardiovascular Diseases


    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Xie X, Tsai SY, Tsai MJ. COUP-TFII regulates satellite cell function and muscular dystrophy. J Clin Invest. 2016 Oct 3; 126(10):3929-3941. PMID: 27617862.
      View in: PubMed
    2. Lin SC, Kao CY, Lee HJ, Creighton CJ, Ittmann MM, Tsai SJ, Tsai SY, Tsai MJ. Dysregulation of miRNAs-COUP-TFII-FOXM1-CENPF axis contributes to the metastasis of prostate cancer. Nat Commun. 2016; 7:11418. PMID: 27108958; PMCID: PMC4848536.
    3. Vasquez YM, Wu SP, Anderson ML, Hawkins SM, Creighton CJ, Ray M, Tsai SY, Tsai MJ, Lydon JP, DeMayo FJ. Endometrial Expression of Steroidogenic Factor 1 Promotes Cystic Glandular Morphogenesis. Mol Endocrinol. 2016 May; 30(5):518-32. PMID: 27018534; PMCID: PMC4853565 [Available on 05/01/17].
    4. Wang L, Xu M, Qin J, Lin SC, Lee HJ, Tsai SY, Tsai MJ. MPC1, a key gene in cancer metabolism, is regulated by COUPTFII in human prostate cancer. Oncotarget. 2016 Mar 22; 7(12):14673-83. PMID: 26895100.
      View in: PubMed
    5. Wu SP, Yu CT, Tsai SY, Tsai MJ. Choose your destiny: Make a cell fate decision with COUP-TFII. J Steroid Biochem Mol Biol. 2016 Mar; 157:7-12. PMID: 26658017.
      View in: PubMed
    6. Szwarc MM, Kommagani R, Jeong JW, Wu SP, Tsai SY, Tsai MJ, O'Malley BW, DeMayo FJ, Lydon JP. Correction: Perturbing the Cellular Levels of Steroid Receptor Coactivator-2 Impairs Murine Endometrial Function. PLoS One. 2015; 10(11):e0143652. PMID: 26580555; PMCID: PMC4651323.
    7. Han SJ, Jung SY, Wu SP, Hawkins SM, Park MJ, Kyo S, Qin J, Lydon JP, Tsai SY, Tsai MJ, DeMayo FJ, O'Malley BW. Estrogen Receptor ß Modulates Apoptosis Complexes and the Inflammasome to Drive the Pathogenesis of Endometriosis. Cell. 2015 Nov 5; 163(4):960-74. PMID: 26544941.
      View in: PubMed
    8. Wu SP, Kao CY, Wang L, Creighton CJ, Yang J, Donti TR, Harmancey R, Vasquez HG, Graham BH, Bellen HJ, Taegtmeyer H, Chang CP, Tsai MJ, Tsai SY. Increased COUP-TFII expression in adult hearts induces mitochondrial dysfunction resulting in heart failure. Nat Commun. 2015; 6:8245. PMID: 26356605.
      View in: PubMed
    9. Xu P, Cao X, He Y, Zhu L, Yang Y, Saito K, Wang C, Yan X, Hinton AO, Zou F, Ding H, Xia Y, Yan C, Shu G, Wu SP, Yang B, Feng Y, Clegg DJ, DeMarchi R, Khan SA, Tsai SY, DeMayo FJ, Wu Q, Tong Q, Xu Y. Estrogen receptor-? in medial amygdala neurons regulates body weight. J Clin Invest. 2015 Jul 1; 125(7):2861-76. PMID: 26098212.
      View in: PubMed
    10. Julian LM, Liu Y, Pakenham CA, Dugal-Tessier D, Ruzhynsky V, Bae S, Tsai SY, Leone G, Slack RS, Blais A. Tissue-specific targeting of cell fate regulatory genes by E2f factors. Cell Death Differ. 2016 Apr; 23(4):565-75. PMID: 25909886.
      View in: PubMed
    11. Kang YK, Putluri N, Maity S, Tsimelzon A, Ilkayeva O, Mo Q, Lonard D, Michailidis G, Sreekumar A, Newgard CB, Wang M, Tsai SY, Tsai MJ, O'Malley BW. CAPER is vital for energy and redox homeostasis by integrating glucose-induced mitochondrial functions via ERR-?-Gabpa and stress-induced adaptive responses via NF-?B-cMYC. PLoS Genet. 2015 Apr; 11(4):e1005116. PMID: 25830341; PMCID: PMC4382186.
    12. Qin J, Lee HJ, Wu SP, Lin SC, Lanz RB, Creighton CJ, DeMayo FJ, Tsai SY, Tsai MJ. Androgen deprivation-induced NCoA2 promotes metastatic and castration-resistant prostate cancer. J Clin Invest. 2014 Nov; 124(11):5013-26. PMID: 25295534; PMCID: PMC4347241.
    13. Xu M, Qin J, Tsai SY, Tsai MJ. The role of the orphan nuclear receptor COUP-TFII in tumorigenesis. Acta Pharmacol Sin. 2015 Jan; 36(1):32-6. PMID: 25283503; PMCID: PMC4571324.
    14. Qin J, Tsai SY, Tsai MJ. The critical roles of COUP-TFII in tumor progression and metastasis. Cell Biosci. 2014; 4(1):58. PMID: 25328664; PMCID: PMC4201699.
    15. Szwarc MM, Kommagani R, Jeong JW, Wu SP, Tsai SY, Tsai MJ, O'Malley BW, DeMayo FJ, Lydon JP. Perturbing the cellular levels of steroid receptor coactivator-2 impairs murine endometrial function. PLoS One. 2014; 9(6):e98664. PMID: 24905738; PMCID: PMC4048228.
    16. Tang K, Tsai SY, Tsai MJ. COUP-TFs and eye development. Biochim Biophys Acta. 2015 Feb; 1849(2):201-9. PMID: 24878540; PMCID: PMC4246046.
    17. Kang YK, Jung SY, Qin J, Li C, Tsai SY, Tsai MJ, O'Malley BW. E2/Estrogen receptor/sjogren syndrome-associated autoantigen relieves coactivator activator-induced G1/S arrest to promote breast tumorigenicity. Mol Cell Biol. 2014 May; 34(9):1670-81. PMID: 24567374; PMCID: PMC3993604.
    18. Bosch DG, Boonstra FN, Gonzaga-Jauregui C, Xu M, de Ligt J, Jhangiani S, Wiszniewski W, Muzny DM, Yntema HG, Pfundt R, Vissers LE, Spruijt L, Blokland EA, Chen CA. NR2F1 mutations cause optic atrophy with intellectual disability. Am J Hum Genet. 2014 Feb 6; 94(2):303-9. PMID: 24462372; PMCID: PMC3928641.
    19. Lin SC, Li YH, Wu MH, Chang YF, Lee DK, Tsai SY, Tsai MJ, Tsai SJ. Suppression of COUP-TFII by proinflammatory cytokines contributes to the pathogenesis of endometriosis. J Clin Endocrinol Metab. 2014 Mar; 99(3):E427-37. PMID: 24423359.
      View in: PubMed
    20. Li X, Large MJ, Creighton CJ, Lanz RB, Jeong JW, Young SL, Lessey BA, Palomino WA, Tsai SY, Demayo FJ. COUP-TFII regulates human endometrial stromal genes involved in inflammation. Mol Endocrinol. 2013 Dec; 27(12):2041-54. PMID: 24176914; PMCID: PMC3857200.
    21. Xie X, Tang K, Yu CT, Tsai SY, Tsai MJ. Regulatory potential of COUP-TFs in development: stem/progenitor cells. Semin Cell Dev Biol. 2013 Dec; 24(10-12):687-93. PMID: 23978678; PMCID: PMC3849206.
    22. Foulds CE, Feng Q, Ding C, Bailey S, Hunsaker TL, Malovannaya A, Hamilton RA, Gates LA, Zhang Z, Li C, Chan D, Bajaj A, Callaway CG, Edwards DP, Lonard DM, Tsai SY, Tsai MJ, Qin J, O'Malley BW. Proteomic analysis of coregulators bound to ER? on DNA and nucleosomes reveals coregulator dynamics. Mol Cell. 2013 Jul 25; 51(2):185-99. PMID: 23850489; PMCID: PMC3900250.
    23. Wu SP, Cheng CM, Lanz RB, Wang T, Respress JL, Ather S, Chen W, Tsai SJ, Wehrens XH, Tsai MJ, Tsai SY. Atrial identity is determined by a COUP-TFII regulatory network. Dev Cell. 2013 May 28; 25(4):417-26. PMID: 23725765; PMCID: PMC3687546.
    24. Qin J, Tsai S, Tsai MJ. COUP-TFII, a prognostic marker and therapeutic target for prostate cancer. Asian J Androl. 2013 May; 15(3):360-1. PMID: 23435470; PMCID: PMC3739656.
    25. Qin J, Wu SP, Creighton CJ, Dai F, Xie X, Cheng CM, Frolov A, Ayala G, Lin X, Feng XH, Ittmann MM, Tsai SJ, Tsai MJ, Tsai SY. COUP-TFII inhibits TGF-?-induced growth barrier to promote prostate tumorigenesis. Nature. 2013 Jan 10; 493(7431):236-40. PMID: 23201680; PMCID: PMC4022346.
    26. Lin FJ, You LR, Yu CT, Hsu WH, Tsai MJ, Tsai SY. Endocardial cushion morphogenesis and coronary vessel development require chicken ovalbumin upstream promoter-transcription factor II. Arterioscler Thromb Vasc Biol. 2012 Nov; 32(11):e135-46. PMID: 22962329; PMCID: PMC3598627.
    27. Yu CT, Tang K, Suh JM, Jiang R, Tsai SY, Tsai MJ. COUP-TFII is essential for metanephric mesenchyme formation and kidney precursor cell survival. Development. 2012 Jul; 139(13):2330-9. PMID: 22669823; PMCID: PMC3367443.
    28. Chen X, Qin J, Cheng CM, Tsai MJ, Tsai SY. COUP-TFII is a major regulator of cell cycle and Notch signaling pathways. Mol Endocrinol. 2012 Aug; 26(8):1268-77. PMID: 22734039; PMCID: PMC3404301.
    29. Mayer S, Roeser M, Lachmann P, Ishii S, Suh JM, Harlander S, Desch M, Brunssen C, Morawietz H, Tsai SY, Tsai MJ, Hohenstein B, Hugo C, Todorov VT. Chicken ovalbumin upstream promoter transcription factor II regulates renin gene expression. J Biol Chem. 2012 Jul 13; 287(29):24483-91. PMID: 22645148; PMCID: PMC3397873.
    30. Tang K, Rubenstein JL, Tsai SY, Tsai MJ. COUP-TFII controls amygdala patterning by regulating neuropilin expression. Development. 2012 May; 139(9):1630-9. PMID: 22492355; PMCID: PMC3317968.
    31. Long W, Foulds CE, Qin J, Liu J, Ding C, Lonard DM, Solis LM, Wistuba II, Qin J, Tsai SY, Tsai MJ, O'Malley BW. ERK3 signals through SRC-3 coactivator to promote human lung cancer cell invasion. J Clin Invest. 2012 May; 122(5):1869-80. PMID: 22505454; PMCID: PMC3336992.
    32. Xie X, Qin J, Lin SH, Tsai SY, Tsai MJ. Nuclear receptor chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII) modulates mesenchymal cell commitment and differentiation. Proc Natl Acad Sci U S A. 2011 Sep 6; 108(36):14843-8. PMID: 21873211; PMCID: PMC3169151.
    33. Lin FJ, Qin J, Tang K, Tsai SY, Tsai MJ. Coup d'Etat: an orphan takes control. Endocr Rev. 2011 Jun; 32(3):404-21. PMID: 21257780; PMCID: PMC3365794.
    34. Qin J, Chen X, Yu-Lee LY, Tsai MJ, Tsai SY. Nuclear receptor COUP-TFII controls pancreatic islet tumor angiogenesis by regulating vascular endothelial growth factor/vascular endothelial growth factor receptor-2 signaling. Cancer Res. 2010 Nov 1; 70(21):8812-21. PMID: 20978203; PMCID: PMC2970665.
    35. Wu SP, Lee DK, Demayo FJ, Tsai SY, Tsai MJ. Generation of ES cells for conditional expression of nuclear receptors and coregulators in vivo. Mol Endocrinol. 2010 Jun; 24(6):1297-304. PMID: 20382891; PMCID: PMC2875802.
    36. Lin FJ, Chen X, Qin J, Hong YK, Tsai MJ, Tsai SY. Direct transcriptional regulation of neuropilin-2 by COUP-TFII modulates multiple steps in murine lymphatic vessel development. J Clin Invest. 2010 May; 120(5):1694-707. PMID: 20364082; PMCID: PMC2860940.
    37. Foulds CE, Tsimelzon A, Long W, Le A, Tsai SY, Tsai MJ, O'Malley BW. Research resource: expression profiling reveals unexpected targets and functions of the human steroid receptor RNA activator (SRA) gene. Mol Endocrinol. 2010 May; 24(5):1090-105. PMID: 20219889; PMCID: PMC2870939.
    38. Lee DK, Kurihara I, Jeong JW, Lydon JP, DeMayo FJ, Tsai MJ, Tsai SY. Suppression of ERalpha activity by COUP-TFII is essential for successful implantation and decidualization. Mol Endocrinol. 2010 May; 24(5):930-40. PMID: 20219888; PMCID: PMC2870934.
    39. Tang K, Xie X, Park JI, Jamrich M, Tsai S, Tsai MJ. COUP-TFs regulate eye development by controlling factors essential for optic vesicle morphogenesis. Development. 2010 Mar; 137(5):725-34. PMID: 20147377; PMCID: PMC2827684.
    40. Long W, Yi P, Amazit L, LaMarca HL, Ashcroft F, Kumar R, Mancini MA, Tsai SY, Tsai MJ, O'Malley BW. SRC-3Delta4 mediates the interaction of EGFR with FAK to promote cell migration. Mol Cell. 2010 Feb 12; 37(3):321-32. PMID: 20159552; PMCID: PMC2824333.
    41. Qin J, Chen X, Xie X, Tsai MJ, Tsai SY. COUP-TFII regulates tumor growth and metastasis by modulating tumor angiogenesis. Proc Natl Acad Sci U S A. 2010 Feb 23; 107(8):3687-92. PMID: 20133706; PMCID: PMC2840495.
    42. Rubel CA, Jeong JW, Tsai SY, Lydon JP, Demayo FJ. Epithelial-stromal interaction and progesterone receptors in the mouse uterus. Semin Reprod Med. 2010 Jan; 28(1):27-35. PMID: 20104426.
      View in: PubMed
    43. Feng Q, He B, Jung SY, Song Y, Qin J, Tsai SY, Tsai MJ, O'Malley BW. Biochemical control of CARM1 enzymatic activity by phosphorylation. J Biol Chem. 2009 Dec 25; 284(52):36167-74. PMID: 19843527; PMCID: PMC2794732.
    44. Satoh S, Tang K, Iida A, Inoue M, Kodama T, Tsai SY, Tsai MJ, Furuta Y, Watanabe S. The spatial patterning of mouse cone opsin expression is regulated by bone morphogenetic protein signaling through downstream effector COUP-TF nuclear receptors. J Neurosci. 2009 Oct 7; 29(40):12401-11. PMID: 19812316; PMCID: PMC2791207.
    45. Jeong JW, Lee HS, Lee KY, White LD, Broaddus RR, Zhang YW, Vande Woude GF, Giudice LC, Young SL, Lessey BA, Tsai SY, Lydon JP, DeMayo FJ. Mig-6 modulates uterine steroid hormone responsiveness and exhibits altered expression in endometrial disease. Proc Natl Acad Sci U S A. 2009 May 26; 106(21):8677-82. PMID: 19439667; PMCID: PMC2681319.
    46. McKenna NJ, Cooney AJ, DeMayo FJ, Downes M, Glass CK, Lanz RB, Lazar MA, Mangelsdorf DJ, Moore DD, Qin J, Steffen DL, Tsai MJ, Tsai SY, Yu R, Margolis RN, Evans RM, O'Malley BW. Minireview: Evolution of NURSA, the Nuclear Receptor Signaling Atlas. Mol Endocrinol. 2009 Jun; 23(6):740-6. PMID: 19423650; PMCID: PMC2691684.
    47. Ngan ES, Lang BH, Liu T, Shum CK, So MT, Lau DK, Leon TY, Cherny SS, Tsai SY, Lo CY, Khoo US, Tam PK, Garcia-Barceló MM. A germline mutation (A339V) in thyroid transcription factor-1 (TITF-1/NKX2.1) in patients with multinodular goiter and papillary thyroid carcinoma. J Natl Cancer Inst. 2009 Feb 4; 101(3):162-75. PMID: 19176457.
      View in: PubMed
    48. Li L, Xie X, Qin J, Jeha GS, Saha PK, Yan J, Haueter CM, Chan L, Tsai SY, Tsai MJ. The nuclear orphan receptor COUP-TFII plays an essential role in adipogenesis, glucose homeostasis, and energy metabolism. Cell Metab. 2009 Jan 7; 9(1):77-87. PMID: 19117548; PMCID: PMC2630393.
    49. Kim BJ, Takamoto N, Yan J, Tsai SY, Tsai MJ. Chicken Ovalbumin Upstream Promoter-Transcription Factor II (COUP-TFII) regulates growth and patterning of the postnatal mouse cerebellum. Dev Biol. 2009 Feb 15; 326(2):378-91. PMID: 19041640; PMCID: PMC2654226.
    50. Kang YK, Schiff R, Ko L, Wang T, Tsai SY, Tsai MJ, O'Malley BW. Dual roles for coactivator activator and its counterbalancing isoform coactivator modulator in human kidney cell tumorigenesis. Cancer Res. 2008 Oct 1; 68(19):7887-96. PMID: 18829545; PMCID: PMC2597518.
    51. Qin J, Tsai MJ, Tsai SY. Essential roles of COUP-TFII in Leydig cell differentiation and male fertility. PLoS One. 2008; 3(9):e3285. PMID: 18818749; PMCID: PMC2553269.
    52. Li C, Liang YY, Feng XH, Tsai SY, Tsai MJ, O'Malley BW. Essential phosphatases and a phospho-degron are critical for regulation of SRC-3/AIB1 coactivator function and turnover. Mol Cell. 2008 Sep 26; 31(6):835-49. PMID: 18922467; PMCID: PMC2597059.
    53. Jeong JW, Lee HS, Franco HL, Broaddus RR, Taketo MM, Tsai SY, Lydon JP, DeMayo FJ. beta-catenin mediates glandular formation and dysregulation of beta-catenin induces hyperplasia formation in the murine uterus. Oncogene. 2009 Jan 8; 28(1):31-40. PMID: 18806829; PMCID: PMC2646831.
    54. Kruse SW, Suino-Powell K, Zhou XE, Kretschman JE, Reynolds R, Vonrhein C, Xu Y, Wang L, Tsai SY, Tsai MJ, Xu HE. Identification of COUP-TFII orphan nuclear receptor as a retinoic acid-activated receptor. PLoS Biol. 2008 Sep 16; 6(9):e227. PMID: 18798693; PMCID: PMC2535662.
    55. Yan J, Erdem H, Li R, Cai Y, Ayala G, Ittmann M, Yu-Lee LY, Tsai SY, Tsai MJ. Steroid receptor coactivator-3/AIB1 promotes cell migration and invasiveness through focal adhesion turnover and matrix metalloproteinase expression. Cancer Res. 2008 Jul 1; 68(13):5460-8. PMID: 18593949; PMCID: PMC2826835.
    56. Yi P, Feng Q, Amazit L, Lonard DM, Tsai SY, Tsai MJ, O'Malley BW. Atypical protein kinase C regulates dual pathways for degradation of the oncogenic coactivator SRC-3/AIB1. Mol Cell. 2008 Feb 29; 29(4):465-76. PMID: 18313384; PMCID: PMC2293272.
    57. Franco HL, Jeong JW, Tsai SY, Lydon JP, DeMayo FJ. In vivo analysis of progesterone receptor action in the uterus during embryo implantation. Semin Cell Dev Biol. 2008 Apr; 19(2):178-86. PMID: 18280760.
      View in: PubMed
    58. Faedo A, Tomassy GS, Ruan Y, Teichmann H, Krauss S, Pleasure SJ, Tsai SY, Tsai MJ, Studer M, Rubenstein JL. COUP-TFI coordinates cortical patterning, neurogenesis, and laminar fate and modulates MAPK/ERK, AKT, and beta-catenin signaling. Cereb Cortex. 2008 Sep; 18(9):2117-31. PMID: 18165280; PMCID: PMC2733307.
    59. Srinivasan RS, Dillard ME, Lagutin OV, Lin FJ, Tsai S, Tsai MJ, Samokhvalov IM, Oliver G. Lineage tracing demonstrates the venous origin of the mammalian lymphatic vasculature. Genes Dev. 2007 Oct 1; 21(19):2422-32. PMID: 17908929; PMCID: PMC1993873.
    60. Lin FJ, Tsai MJ, Tsai SY. Artery and vein formation: a tug of war between different forces. EMBO Rep. 2007 Oct; 8(10):920-4. PMID: 17906673; PMCID: PMC2002564.
    61. Lee KY, Jeong JW, Tsai SY, Lydon JP, DeMayo FJ. Mouse models of implantation. Trends Endocrinol Metab. 2007 Aug; 18(6):234-9. PMID: 17588769.
      View in: PubMed
    62. Kurihara I, Lee DK, Petit FG, Jeong J, Lee K, Lydon JP, DeMayo FJ, Tsai MJ, Tsai SY. COUP-TFII mediates progesterone regulation of uterine implantation by controlling ER activity. PLoS Genet. 2007 Jun; 3(6):e102. PMID: 17590085; PMCID: PMC1892047.
    63. Lee KY, Jeong JW, Wang J, Ma L, Martin JF, Tsai SY, Lydon JP, DeMayo FJ. Bmp2 is critical for the murine uterine decidual response. Mol Cell Biol. 2007 Aug; 27(15):5468-78. PMID: 17515606; PMCID: PMC1952078.
    64. Petit FG, Jamin SP, Kurihara I, Behringer RR, DeMayo FJ, Tsai MJ, Tsai SY. Deletion of the orphan nuclear receptor COUP-TFII in uterus leads to placental deficiency. Proc Natl Acad Sci U S A. 2007 Apr 10; 104(15):6293-8. PMID: 17404209; PMCID: PMC1851059.
    65. Qin J, Suh JM, Kim BJ, Yu CT, Tanaka T, Kodama T, Tsai MJ, Tsai SY. The expression pattern of nuclear receptors during cerebellar development. Dev Dyn. 2007 Mar; 236(3):810-20. PMID: 17205580.
      View in: PubMed
    66. Han SJ, Tsai SY, Tsai MJ, O'Malley BW. Distinct temporal and spatial activities of RU486 on progesterone receptor function in reproductive organs of ovariectomized mice. Endocrinology. 2007 May; 148(5):2471-86. PMID: 17303655.
      View in: PubMed
    67. Ray D, Terao Y, Fuhrken PG, Ma ZQ, DeMayo FJ, Christov K, Heerema NA, Franks R, Tsai SY, Papoutsakis ET, Kiyokawa H. Deregulated CDC25A expression promotes mammary tumorigenesis with genomic instability. Cancer Res. 2007 Feb 1; 67(3):984-91. PMID: 17283130.
      View in: PubMed
    68. Li C, Wu RC, Amazit L, Tsai SY, Tsai MJ, O'Malley BW. Specific amino acid residues in the basic helix-loop-helix domain of SRC-3 are essential for its nuclear localization and proteasome-dependent turnover. Mol Cell Biol. 2007 Feb; 27(4):1296-308. PMID: 17158932; PMCID: PMC1800725.
    69. Yan J, Yu CT, Ozen M, Ittmann M, Tsai SY, Tsai MJ. Steroid receptor coactivator-3 and activator protein-1 coordinately regulate the transcription of components of the insulin-like growth factor/AKT signaling pathway. Cancer Res. 2006 Nov 15; 66(22):11039-46. PMID: 17108143.
      View in: PubMed
    70. Louet JF, Coste A, Amazit L, Tannour-Louet M, Wu RC, Tsai SY, Tsai MJ, Auwerx J, O'Malley BW. Oncogenic steroid receptor coactivator-3 is a key regulator of the white adipogenic program. Proc Natl Acad Sci U S A. 2006 Nov 21; 103(47):17868-73. PMID: 17098861; PMCID: PMC1693839.
    71. Suh JM, Yu CT, Tang K, Tanaka T, Kodama T, Tsai MJ, Tsai SY. The expression profiles of nuclear receptors in the developing and adult kidney. Mol Endocrinol. 2006 Dec; 20(12):3412-20. PMID: 16973757.
      View in: PubMed
    72. Lee K, Jeong J, Kwak I, Yu CT, Lanske B, Soegiarto DW, Toftgard R, Tsai MJ, Tsai S, Lydon JP, DeMayo FJ. Indian hedgehog is a major mediator of progesterone signaling in the mouse uterus. Nat Genet. 2006 Oct; 38(10):1204-9. PMID: 16951680.
      View in: PubMed
    73. Yan J, Tsai SY, Tsai MJ. SRC-3/AIB1: transcriptional coactivator in oncogenesis. Acta Pharmacol Sin. 2006 Apr; 27(4):387-94. PMID: 16539836.
      View in: PubMed
    74. Li X, Lonard DM, Jung SY, Malovannaya A, Feng Q, Qin J, Tsai SY, Tsai MJ, O'Malley BW. The SRC-3/AIB1 coactivator is degraded in a ubiquitin- and ATP-independent manner by the REGgamma proteasome. Cell. 2006 Jan 27; 124(2):381-92. PMID: 16439211.
      View in: PubMed
    75. Yi P, Wu RC, Sandquist J, Wong J, Tsai SY, Tsai MJ, Means AR, O'Malley BW. Peptidyl-prolyl isomerase 1 (Pin1) serves as a coactivator of steroid receptor by regulating the activity of phosphorylated steroid receptor coactivator 3 (SRC-3/AIB1). Mol Cell Biol. 2005 Nov; 25(21):9687-99. PMID: 16227615; PMCID: PMC1265806.
    76. You LR, Takamoto N, Yu CT, Tanaka T, Kodama T, Demayo FJ, Tsai SY, Tsai MJ. Mouse lacking COUP-TFII as an animal model of Bochdalek-type congenital diaphragmatic hernia. Proc Natl Acad Sci U S A. 2005 Nov 8; 102(45):16351-6. PMID: 16251273; PMCID: PMC1283449.
    77. Schillinger KJ, Tsai SY, Taffet GE, Reddy AK, Marian AJ, Entman ML, Oka K, Chan L, O'Malley BW. Regulatable atrial natriuretic peptide gene therapy for hypertension. Proc Natl Acad Sci U S A. 2005 Sep 27; 102(39):13789-94. PMID: 16162668; PMCID: PMC1236585.
    78. Han SJ, Jeong J, Demayo FJ, Xu J, Tsai SY, Tsai MJ, O'Malley BW. Dynamic cell type specificity of SRC-1 coactivator in modulating uterine progesterone receptor function in mice. Mol Cell Biol. 2005 Sep; 25(18):8150-65. PMID: 16135805; PMCID: PMC1234322.
    79. Zhou HJ, Yan J, Luo W, Ayala G, Lin SH, Erdem H, Ittmann M, Tsai SY, Tsai MJ. SRC-3 is required for prostate cancer cell proliferation and survival. Cancer Res. 2005 Sep 1; 65(17):7976-83. PMID: 16140970.
      View in: PubMed
    80. Han SJ, DeMayo FJ, Xu J, Tsai SY, Tsai MJ, O'Malley BW. Steroid receptor coactivator (SRC)-1 and SRC-3 differentially modulate tissue-specific activation functions of the progesterone receptor. Mol Endocrinol. 2006 Jan; 20(1):45-55. PMID: 16141356.
      View in: PubMed
    81. Ye X, Han SJ, Tsai SY, DeMayo FJ, Xu J, Tsai MJ, O'Malley BW. Roles of steroid receptor coactivator (SRC)-1 and transcriptional intermediary factor (TIF) 2 in androgen receptor activity in mice. Proc Natl Acad Sci U S A. 2005 Jul 5; 102(27):9487-92. PMID: 15983373; PMCID: PMC1172261.
    82. Takamoto N, Kurihara I, Lee K, Demayo FJ, Tsai MJ, Tsai SY. Haploinsufficiency of chicken ovalbumin upstream promoter transcription factor II in female reproduction. Mol Endocrinol. 2005 Sep; 19(9):2299-308. PMID: 15890675; PMCID: PMC1198323.
    83. You LR, Lin FJ, Lee CT, DeMayo FJ, Tsai MJ, Tsai SY. Suppression of Notch signalling by the COUP-TFII transcription factor regulates vein identity. Nature. 2005 May 5; 435(7038):98-104. PMID: 15875024.
      View in: PubMed
    84. Takamoto N, You LR, Moses K, Chiang C, Zimmer WE, Schwartz RJ, DeMayo FJ, Tsai MJ, Tsai SY. COUP-TFII is essential for radial and anteroposterior patterning of the stomach. Development. 2005 May; 132(9):2179-89. PMID: 15829524.
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    85. Tsai MJ, You LR, Tsai SY. Surprise in the Battle Field of Vein vs. Artery. Organogenesis. 2005 Apr; 2(2):31-2. PMID: 19521563; PMCID: PMC2634082.
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    188. Baniahmad A, Tsai SY, O'Malley BW, Tsai MJ. Kindred S thyroid hormone receptor is an active and constitutive silencer and a repressor for thyroid hormone and retinoic acid responses. Proc Natl Acad Sci U S A. 1992 Nov 15; 89(22):10633-7. PMID: 1359543; PMCID: PMC50395.
    189. Allan GF, Leng X, Tsai SY, Weigel NL, Edwards DP, Tsai MJ, O'Malley BW. Hormone and antihormone induce distinct conformational changes which are central to steroid receptor activation. J Biol Chem. 1992 Sep 25; 267(27):19513-20. PMID: 1326555.
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    190. Ing NH, Beekman JM, Tsai SY, Tsai MJ, O'Malley BW. Members of the steroid hormone receptor superfamily interact with TFIIB (S300-II). J Biol Chem. 1992 Sep 5; 267(25):17617-23. PMID: 1517211.
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    191. Cooney AJ, Tsai SY, O'Malley BW, Tsai MJ. Chicken ovalbumin upstream promoter transcription factor (COUP-TF) dimers bind to different GGTCA response elements, allowing COUP-TF to repress hormonal induction of the vitamin D3, thyroid hormone, and retinoic acid receptors. Mol Cell Biol. 1992 Sep; 12(9):4153-63. PMID: 1324415; PMCID: PMC360317.
    192. Bagchi MK, Tsai MJ, O'Malley BW, Tsai SY. Analysis of the mechanism of steroid hormone receptor-dependent gene activation in cell-free systems. Endocr Rev. 1992 Aug; 13(3):525-35. PMID: 1425487.
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    193. Bagchi MK, Tsai SY, Tsai MJ, O'Malley BW. Ligand and DNA-dependent phosphorylation of human progesterone receptor in vitro. Proc Natl Acad Sci U S A. 1992 Apr 1; 89(7):2664-8. PMID: 1557371; PMCID: PMC48722.
    194. Elliston JF, Beekman JM, Tsai SY, O'Malley BW, Tsai MJ. Hormone activation of baculovirus expressed progesterone receptors. J Biol Chem. 1992 Mar 15; 267(8):5193-8. PMID: 1544902.
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    195. Lee JK, Tam JW, Tsai MJ, Tsai SY. Identification of cis- and trans-acting factors regulating the expression of the human insulin receptor gene. J Biol Chem. 1992 Mar 5; 267(7):4638-45. PMID: 1311316.
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    196. Bagchi MK, Tsai SY, Tsai MJ, O'Malley BW. Progesterone enhances target gene transcription by receptor free of heat shock proteins hsp90, hsp56, and hsp70. Mol Cell Biol. 1991 Oct; 11(10):4998-5004. PMID: 1922029; PMCID: PMC361487.
    197. Bradshaw MS, Tsai SY, Leng XH, Dobson AD, Conneely OM, O'Malley BW, Tsai MJ. Studies on the mechanism of functional cooperativity between progesterone and estrogen receptors. J Biol Chem. 1991 Sep 5; 266(25):16684-90. PMID: 1885597.
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    198. Cooney AJ, Tsai SY, O'Malley BW, Tsai MJ. Chicken ovalbumin upstream promoter transcription factor binds to a negative regulatory region in the human immunodeficiency virus type 1 long terminal repeat. J Virol. 1991 Jun; 65(6):2853-60. PMID: 2033658; PMCID: PMC240909.
    199. Allan GF, Ing NH, Tsai SY, Srinivasan G, Weigel NL, Thompson EB, Tsai MJ, O'Malley BW. Synergism between steroid response and promoter elements during cell-free transcription. J Biol Chem. 1991 Mar 25; 266(9):5905-10. PMID: 2005127.
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    200. Allan GF, Tsai SY, O'Malley BW, Tsai MJ. Steroid hormone receptors and in vitro transcription. Bioessays. 1991 Feb; 13(2):73-8. PMID: 2029268.
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    201. Wang LH, Ing NH, Tsai SY, O'Malley BW, Tsai MJ. The COUP-TFs compose a family of functionally related transcription factors. Gene Expr. 1991; 1(3):207-16. PMID: 1820218.
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    202. O'Malley BW, Tsai SY, Bagchi M, Weigel NL, Schrader WT, Tsai MJ. Molecular mechanism of action of a steroid hormone receptor. Recent Prog Horm Res. 1991; 47:1-24; discussion 24-6. PMID: 1745818.
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    203. Elliston JF, Fawell SE, Klein-Hitpass L, Tsai SY, Tsai MJ, Parker MG, O'Malley BW. Mechanism of estrogen receptor-dependent transcription in a cell-free system. Mol Cell Biol. 1990 Dec; 10(12):6607-12. PMID: 2247075; PMCID: PMC362937.
    204. Tsai SY, Srinivasan G, Allan GF, Thompson EB, O'Malley BW, Tsai MJ. Recombinant human glucocorticoid receptor induces transcription of hormone response genes in vitro. J Biol Chem. 1990 Oct 5; 265(28):17055-61. PMID: 2170364.
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    205. Elliston JF, Tsai SY, O'Malley BW, Tsai MJ. Superactive estrogen receptors. Potent activators of gene expression. J Biol Chem. 1990 Jul 15; 265(20):11517-21. PMID: 2164005.
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    206. Bagchi MK, Tsai SY, Tsai MJ, O'Malley BW. Identification of a functional intermediate in receptor activation in progesterone-dependent cell-free transcription. Nature. 1990 Jun 7; 345(6275):547-50. PMID: 2348863.
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    207. Bagchi MK, Tsai SY, Weigel NL, Tsai MJ, O'Malley BW. Regulation of in vitro transcription by progesterone receptor. Characterization and kinetic studies. J Biol Chem. 1990 Mar 25; 265(9):5129-34. PMID: 2318886.
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    208. Klein-Hitpass L, Tsai SY, Weigel NL, Allan GF, Riley D, Rodriguez R, Schrader WT, Tsai MJ, O'Malley BW. The progesterone receptor stimulates cell-free transcription by enhancing the formation of a stable preinitiation complex. Cell. 1990 Jan 26; 60(2):247-57. PMID: 2153462.
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    209. Pastorcic M, Bagchi MK, Tsai SY, Tsai MJ, O'Malley BW. Multiple protein binding sites within the ovalbumin gene 5'-flanking region: isolation and characterization of sequence-specific binding proteins. Nucleic Acids Res. 1989 Aug 25; 17(16):6693-711. PMID: 2780293; PMCID: PMC318360.
    210. Wang LH, Tsai SY, Cook RG, Beattie WG, Tsai MJ, O'Malley BW. COUP transcription factor is a member of the steroid receptor superfamily. Nature. 1989 Jul 13; 340(6229):163-6. PMID: 2739739.
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    211. Tsai SY, Tsai MJ, O'Malley BW. Cooperative binding of steroid hormone receptors contributes to transcriptional synergism at target enhancer elements. Cell. 1989 May 5; 57(3):443-8. PMID: 2566384.
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    212. Klein-Hitpass L, Tsai SY, Greene GL, Clark JH, Tsai MJ, O'Malley BW. Specific binding of estrogen receptor to the estrogen response element. Mol Cell Biol. 1989 Jan; 9(1):43-9. PMID: 2927397; PMCID: PMC362143.
    213. Bagchi MK, Elliston JF, Tsai SY, Edwards DP, Tsai MJ, O'Malley BW. Steroid hormone-dependent interaction of human progesterone receptor with its target enhancer element. Mol Endocrinol. 1988 Dec; 2(12):1221-9. PMID: 3216861.
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    214. Tsai SY, Carlstedt-Duke J, Weigel NL, Dahlman K, Gustafsson JA, Tsai MJ, O'Malley BW. Molecular interactions of steroid hormone receptor with its enhancer element: evidence for receptor dimer formation. Cell. 1988 Oct 21; 55(2):361-9. PMID: 3167984.
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    215. Li Y, Shen RF, Tsai SY, Woo SL. Multiple hepatic trans-acting factors are required for in vitro transcription of the human alpha-1-antitrypsin gene. Mol Cell Biol. 1988 Oct; 8(10):4362-9. PMID: 3263567; PMCID: PMC365509.
    216. Hwung YP, Wang LH, Tsai SY, Tsai MJ. Differential binding of the chicken ovalbumin upstream promoter (COUP) transcription factor to two different promoters. J Biol Chem. 1988 Sep 15; 263(26):13470-4. PMID: 3047126.
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    217. Hwung YP, Crowe DT, Wang LH, Tsai SY, Tsai MJ. The COUP transcription factor binds to an upstream promoter element of the rat insulin II gene. Mol Cell Biol. 1988 May; 8(5):2070-7. PMID: 3290646; PMCID: PMC363386.
    218. Tsai MJ, Tsai SY, Klein-Hitpass L, Bagchi M, Elliston JF, Carlstedt-Duke J, Gustafsson JA, Gustafsson JK, O'Malley BW. Cooperative interactions of steroid hormone receptors with their cognate response elements. Cold Spring Harb Symp Quant Biol. 1988; 53 Pt 2:829-33. PMID: 3254786.
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    219. Wang LH, Tsai SY, Wang H, Sagami I, Tsai MJ, O'Malley BW. The studies of COUP transcription factor from HeLa cells: purification and partial characterization. Prog Clin Biol Res. 1988; 284:37-51. PMID: 3217427.
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    220. Crowe DT, Hwung YP, Tsai SY, Tsai MJ. Characterization of the cis and trans elements essential for rat insulin II gene expression. Prog Clin Biol Res. 1988; 284:211-24. PMID: 3064102.
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    221. Bagchi MK, Tsai SY, Tsai MJ, O'Malley BW. Purification and characterization of chicken ovalbumin gene upstream promoter transcription factor from homologous oviduct cells. Mol Cell Biol. 1987 Dec; 7(12):4151-8. PMID: 3437886; PMCID: PMC368095.
    222. Wang LH, Tsai SY, Sagami I, Tsai MJ, O'Malley BW. Purification and characterization of chicken ovalbumin upstream promoter transcription factor from HeLa cells. J Biol Chem. 1987 Nov 25; 262(33):16080-6. PMID: 3680243.
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    223. Shen RF, Li Y, Sifers RN, Wang H, Hardick C, Tsai SY, Woo SL. Tissue-specific expression of the human alpha 1-antitrypsin gene is controlled by multiple cis-regulatory elements. Nucleic Acids Res. 1987 Oct 26; 15(20):8399-415. PMID: 2823229; PMCID: PMC306367.
    224. Tsai SY, Sagami I, Wang H, Tsai MJ, O'Malley BW. Interactions between a DNA-binding transcription factor (COUP) and a non-DNA binding factor (S300-II). Cell. 1987 Aug 28; 50(5):701-9. PMID: 3040258.
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    225. Sagami I, Tsai SY, Wang H, Tsai MJ, O'Malley BW. Identification of two factors required for transcription of the ovalbumin gene. Mol Cell Biol. 1986 Dec; 6(12):4259-67. PMID: 3796602; PMCID: PMC367207.
    226. Pastorcic M, Wang H, Elbrecht A, Tsai SY, Tsai MJ, O'Malley BW. Control of transcription initiation in vitro requires binding of a transcription factor to the distal promoter of the ovalbumin gene. Mol Cell Biol. 1986 Aug; 6(8):2784-91. PMID: 3785213; PMCID: PMC367845.
    227. Elbrecht A, Tsai SY, Tsai MJ, O'Malley BW. Identification by exonuclease footprinting of a distal promoter-binding protein from HeLa cell extracts. DNA. 1985 Jun; 4(3):233-40. PMID: 2988892.
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    228. Selvanayagam CS, Tsai SY, Tsai MJ, Selvanayagam P, Saunders GF. Multiple origins of transcription for the human placental lactogen genes. J Biol Chem. 1984 Dec 10; 259(23):14642-6. PMID: 6209277.
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    229. Tsai SY, Dicker P, Fang P, Tsai MJ, O'Malley BW. Generation of monoclonal antibodies to RNA polymerase II for the identification of transcriptional factors. J Biol Chem. 1984 Sep 25; 259(18):11587-93. PMID: 6381502.
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    230. Dicker PD, Tsai SY, Weigel NL, Tsai MJ, Schrader WT, O'Malley BW. Monoclonal antibody to the hen oviduct progesterone receptor produced following in vitro immunization. J Steroid Biochem. 1984 Jan; 20(1):43-50. PMID: 6538613.
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    231. Zarucki-Schulz T, Tsai SY, Itakura K, Soberon X, Wallace RB, Tsai MJ, Woo SL, O'Malley BW. Point mutagenesis of the ovalbumin gene promoter sequence and its effect on in vitro transcription. J Biol Chem. 1982 Sep 25; 257(18):11070-7. PMID: 6286680.
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    232. Tsai SY, Tsai MJ, Kops LE, Minghetti PP, O'Malley BW. Transcription factors from oviduct and HeLa cells are similar. J Biol Chem. 1981 Dec 25; 256(24):13055-9. PMID: 6895517.
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    233. Tsai SY, Tsai MJ, O'Malley BW. Specific 5' flanking sequences are required for faithful initiation of in vitro transcription of the ovalbumin gene. Proc Natl Acad Sci U S A. 1981 Feb; 78(2):879-83. PMID: 6262780; PMCID: PMC319907.
    234. Roop DR, Tsai SY, Tsai MJ, O'Malley BW. Definition of the transcription unit of the natural ovalbumin gene. Prog Clin Biol Res. 1981; 66 Pt B:381-92. PMID: 6273930.
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    235. Tsai SY, Roop DR, Stumph WE, Tsai MJ, O'Malley BW. Evidence that deoxyribonucleic acid sequences flanking the ovalbumin gene are not transcribed. Biochemistry. 1980 Apr 29; 19(9):1755-61. PMID: 6246933.
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    236. Tsai SY, Tsai MJ, Lin CT, O'Malley BW. Effect of estrogen on ovalbumin gene expression in differentiated nontarget tissues. Biochemistry. 1979 Dec 11; 18(25):5726-31. PMID: 518866.
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    237. Woo SL, Tsai SY, Tsai MJ, Lai EC, Mace ML, O'Malley BW. Cloning and expression of a pseudo-ovalbumin gene. Biochem Biophys Res Commun. 1979 Aug 13; 89(3):997-1005. PMID: 385002.
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    238. Tsai MJ, Tsai SY, O'Malley BW. Distribution of RNA transcripts from structural and intervening sequences of the ovalbumin gene. Science. 1979 Apr 20; 204(4390):314-6. PMID: 432646.
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    239. Swaneck GE, Tsai SY, Tsai MJ, Nordstrom JL, Roop DR, O'Malley BW. The ovalbumin gene: transcriptional regulation by estrogen. Adv Exp Med Biol. 1979; 117:461-85. PMID: 474290.
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    240. Tsai SY, Roop DR, Tsai MJ, Stein JP, Means AR, O'Malley BW. Effect of estrogen on gene expression in the chick oviduct. Regulation of the ovomucoid gene. Biochemistry. 1978 Dec 26; 17(26):5773-80. PMID: 728435.
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    241. Tsai MJ, Tsai SY, Chang CW, O'Malley BW. Effect of estrogen on gene expression in the chick oviduct. In vitro transcription of the ovalbumin gene. Biochim Biophys Acta. 1978 Dec 21; 521(2):689-707. PMID: 367441.
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    242. Roop DR, Nordstrom JL, Tsai SY, Tsai MJ, O'Malley BW. Transcription of structural and intervening sequences in the ovalbumin gene and identification of potential ovalbumin mRNA precursors. Cell. 1978 Oct; 15(2):671-85. PMID: 719758.
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    243. O'Malley BW, Tsai MJ, Tsai SY, Towle HC. Regulation of gene expression in chick oviduct. Cold Spring Harb Symp Quant Biol. 1978; 42 Pt 2:605-15. PMID: 354851.
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    244. Towle HC, Tsai MJ, Tsai SY, O'Malley BW. Effect of estrogen on gene expression in the chick oviduct. J Biol Chem. 1977 Apr 10; 252(7):2396-404. PMID: 321457.
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    245. Tsai SY, Tsai MJ, Harris SE, O'Malley BW. Effects of estrogen on gene expression in the chick oviduct. Control of ovalbumin gene expression by non-histone proteins. J Biol Chem. 1976 Oct 25; 251(20):6475-8. PMID: 977585.
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    246. Tsai MJ, Tsai SY, Towle HC, O'Malley BW. Effect of estrogen on gene expression in the chick oviduct. Studies on the initiation of RNA synthesis on chromatin in vitro. J Biol Chem. 1976 Sep 25; 251(18):5565-74. PMID: 786984.
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    247. Tsai SY, Harris SE, Tsai MJ, O'Malley BW. Effects of estrogen on gene expression in chick oviduct. The role of chromatin proteins in regulating transcription of the ovalbumin gene. J Biol Chem. 1976 Aug 10; 251(15):4713-21. PMID: 947905.
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    248. Kalimi M, Tsai SY, Tsai MJ, Clark JH, O'Malley BW. Effect of estrogen on gene expression in the chick oviduct. Correlation between nuclear-bound estrogen receptor and chromatin initiation site for transcription. J Biol Chem. 1976 Jan 25; 251(2):516-23. PMID: 173720.
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    249. Towle HC, Tsai MJ, Hirose M, Tsai SY, Schwartz RJ, Parker MG, O'Malley BW. Regulation of transcription of the eucaryotic genome. Symp Soc Dev Biol. 1976; (34):107-36. PMID: 798339.
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    250. Tsai SY, Tsai MJ, Schwartz R, Kalimi M, Clark JH, O'Malley BW. Effects of estrogen on gene expression in chick oviduct: nuclear receptor levels and initiation of transcription. Proc Natl Acad Sci U S A. 1975 Nov; 72(11):4228-32. PMID: 172899; PMCID: PMC388693.
    251. Tsai MJ, Schwartz RJ, Tsai SY, O'Malley BW . Effect of estrogen on gene expression in the chick oviduct IV. Initiation of RNA synthesis on DNA and chromatin. 1975; 250(13):5165-5174.
    252. Schwartz RJ, Tsai MJ, Tsai SY, O'Malley BW . Effect of estrogen on gene expression in the chick oviduct V. Changes in the number of RNA polymerase binding and initiation sites in chromatin. 1975; 250(13):5175-5182.
    253. Tsai S, Arlinghaus RB. Formation of mengovirus-like particles in cell-free extracts from virus-infected cells. Biochem Biophys Res Commun. 1974 Apr 8; 57(3):733-9. PMID: 4363940.
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    254. Naso WANG CS, Tsai S, Arlinghaus RB. Ribosomes from Rauscher leukemia virus-infected cells and their response to Rauscher viral RNA and polyuridylic acid. Biochim Biophys Acta. 1973 Oct 26; 324(3):346-64. PMID: 4762415.
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    255. Yang S, Criddle RS. In vitro biosynthesis of membrane proteins in isolated mitochondria from Saccharomyces carlsbergensis. Biochemistry. 1970 Jul 21; 9(15):3063-72. PMID: 5474805.
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    256. Yang S, Criddle RS. Identification of a major membrane fraction as a product of synthesis by isolated yeast mitochondria. Biochem Biophys Res Commun. 1969 May 22; 35(4):429-36. PMID: 5788500.
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