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JAKE A. KUSHNER

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pediatrics
Address6701 Fannin Street, Suite 1020
Houston TX 77030
Email
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    Other Positions
    TitleAssociate Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular & Cellular Biology
    DivisionMolecular & Cellular Biology


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    Collapse keywords
    Islets, beta cells, pancreas, insulin, diabetes, type 1 diabetes, stem cells, developmental biology


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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Cox AR, Barrandon O, Cai EP, Rios JS, Chavez J, Bonnyman CW, Lam CJ, Yi P, Melton DA, Kushner JA. Resolving Discrepant Findings on ANGPTL8 in ?-Cell Proliferation: A Collaborative Approach to Resolving the Betatrophin Controversy. PLoS One. 2016; 11(7):e0159276. PMID: 27410263; PMCID: PMC4943640.
    2. Burns AM, Kushner JA, Ward MA, Turner TL, Kline MW, Orange JS. Strengthening the Pipeline for Clinician-Scientists: The Pediatrician-Scientist Training and Development Program at Texas Children's Hospital. J Pediatr. 2016 May; 172:5-6.e5. PMID: 27112081.
      View in: PubMed
    3. Cox AR, Lam CJ, Rankin MM, King KA, Chen P, Martinez R, Li C, Kushner JA. Extreme obesity induces massive beta cell expansion in mice through self-renewal and does not alter the beta cell lineage. Diabetologia. 2016 Jun; 59(6):1231-41. PMID: 27003683; PMCID: PMC4869735.
    4. Yu Q, Zhao B, Gui J, Katlinski KV, Brice A, Gao Y, Li C, Kushner JA, Koumenis C, Diehl JA, Fuchs SY. Type I interferons mediate pancreatic toxicities of PERK inhibition. Proc Natl Acad Sci U S A. 2015 Dec 15; 112(50):15420-5. PMID: 26627716.
      View in: PubMed
    5. Ackerman KG, Lee B, Kushner JA. Dissatisfaction with maintenance of certification in academic pediatrics. Pediatr Res. 2016 Mar; 79(2):240-2. PMID: 26421351.
      View in: PubMed
    6. Michels A, Zhang L, Khadra A, Kushner JA, Redondo MJ, Pietropaolo M. Prediction and prevention of type 1 diabetes: update on success of prediction and struggles at prevention. Pediatr Diabetes. 2015 Nov; 16(7):465-84. PMID: 26202050.
      View in: PubMed
    7. Shields EJ, Lam CJ, Cox AR, Rankin MM, Van Winkle TJ, Hess RS, Kushner JA. Extreme Beta-Cell Deficiency in Pancreata of Dogs with Canine Diabetes. PLoS One. 2015; 10(6):e0129809. PMID: 26057531.
      View in: PubMed
    8. Cox AR, Lam CJ, Bonnyman CW, Chavez J, Rios JS, Kushner JA. Angiopoietin-like protein 8 (ANGPTL8)/betatrophin overexpression does not increase beta cell proliferation in mice. Diabetologia. 2015 Jul; 58(7):1523-31. PMID: 25917759.
      View in: PubMed
    9. Kushner JA, MacDonald PE, Atkinson MA. Stem cells to insulin secreting cells: two steps forward and now a time to pause? Cell Stem Cell. 2014 Nov 6; 15(5):535-6. PMID: 25517460.
      View in: PubMed
    10. Elahi D, Mirmira RG, Kushner JA. Editorial: in praise of scientific review officers. Mol Endocrinol. 2014 Jul; 28(7):987-8. PMID: 24983311.
      View in: PubMed
    11. Soleimanpour SA, Gupta A, Bakay M, Ferrari AM, Groff DN, Fadista J, Spruce LA, Kushner JA, Groop L, Seeholzer SH, Kaufman BA, Hakonarson H, Stoffers DA. The diabetes susceptibility gene Clec16a regulates mitophagy. Cell. 2014 Jun 19; 157(7):1577-90. PMID: 24949970; PMCID: PMC4184276.
    12. Hicks KA, Kushner JA, Heptulla R, Ham JN. Permanent neonatal diabetes mellitus in monozygotic twins achieving low-dose sulfonylurea therapy. J Pediatr Endocrinol Metab. 2014 Jan; 27(1-2):135-8. PMID: 23959658.
      View in: PubMed
    13. Kushner JA. The role of aging upon ? cell turnover. J Clin Invest. 2013 Mar; 123(3):990-5. PMID: 23454762; PMCID: PMC3582123.
    14. Rankin MM, Wilbur CJ, Rak K, Shields EJ, Granger A, Kushner JA. ?-Cells are not generated in pancreatic duct ligation-induced injury in adult mice. Diabetes. 2013 May; 62(5):1634-45. PMID: 23349489; PMCID: PMC3636617.
    15. Sartori DJ, Wilbur CJ, Long SY, Rankin MM, Li C, Bradfield JP, Hakonarson H, Grant SF, Pu WT, Kushner JA. GATA factors promote ER integrity and ?-cell survival and contribute to type 1 diabetes risk. Mol Endocrinol. 2014 Jan; 28(1):28-39. PMID: 24284823; PMCID: PMC3874454.
    16. Gao Y, Sartori DJ, Li C, Yu QC, Kushner JA, Simon MC, Diehl JA. PERK is required in the adult pancreas and is essential for maintenance of glucose homeostasis. Mol Cell Biol. 2012 Dec; 32(24):5129-39. PMID: 23071091; PMCID: PMC3510549.
    17. Chitnis NS, Pytel D, Bobrovnikova-Marjon E, Pant D, Zheng H, Maas NL, Frederick B, Kushner JA, Chodosh LA, Koumenis C, Fuchs SY, Diehl JA. miR-211 is a prosurvival microRNA that regulates chop expression in a PERK-dependent manner. Mol Cell. 2012 Nov 9; 48(3):353-64. PMID: 23022383; PMCID: PMC3496065.
    18. Kushner JA. Development. Esophageal stem cells, where art thou? Science. 2012 Aug 31; 337(6098):1051-2. PMID: 22936766; PMCID: PMC3762587.
    19. Rieck S, Zhang J, Li Z, Liu C, Naji A, Takane KK, Fiaschi-Taesch NM, Stewart AF, Kushner JA, Kaestner KH. Overexpression of hepatocyte nuclear factor-4? initiates cell cycle entry, but is not sufficient to promote ?-cell expansion in human islets. Mol Endocrinol. 2012 Sep; 26(9):1590-602. PMID: 22798294; PMCID: PMC3434530.
    20. Akirav EM, Baquero MT, Opare-Addo LW, Akirav M, Galvan E, Kushner JA, Rimm DL, Herold KC. Glucose and inflammation control islet vascular density and beta-cell function in NOD mice: control of islet vasculature and vascular endothelial growth factor by glucose. Diabetes. 2011 Mar; 60(3):876-83. PMID: 21307078; PMCID: PMC3046848.
    21. Tuttle AH, Rankin MM, Teta M, Sartori DJ, Stein GM, Kim GJ, Virgilio C, Granger A, Zhou D, Long SH, Schiffman AB, Kushner JA. Immunofluorescent detection of two thymidine analogues (CldU and IdU) in primary tissue. J Vis Exp. 2010; (46). PMID: 21178965; PMCID: PMC3159664.
    22. Rankin MM, Kushner JA. Aging induces a distinct gene expression program in mouse islets. Islets. 2010 Nov-Dec; 2(6):345-52. PMID: 21099336; PMCID: PMC3062249.
    23. Soleimanpour SA, Crutchlow MF, Ferrari AM, Raum JC, Groff DN, Rankin MM, Liu C, De León DD, Naji A, Kushner JA, Stoffers DA. Calcineurin signaling regulates human islet {beta}-cell survival. J Biol Chem. 2010 Dec 17; 285(51):40050-9. PMID: 20943662; PMCID: PMC3000987.
    24. Perl S, Kushner JA, Buchholz BA, Meeker AK, Stein GM, Hsieh M, Kirby M, Pechhold S, Liu EH, Harlan DM, Tisdale JF. Significant human beta-cell turnover is limited to the first three decades of life as determined by in vivo thymidine analog incorporation and radiocarbon dating. J Clin Endocrinol Metab. 2010 Oct; 95(10):E234-9. PMID: 20660050; PMCID: PMC3050099.
    25. Kushner JA, Weir GC, Bonner-Weir S. Ductal origin hypothesis of pancreatic regeneration under attack. Cell Metab. 2010 Jan; 11(1):2-3. PMID: 20085728; PMCID: PMC3762572.
    26. Liang L, Guo WH, Esquiliano DR, Asai M, Rodriguez S, Giraud J, Kushner JA, White MF, Lopez MF. Insulin-like growth factor 2 and the insulin receptor, but not insulin, regulate fetal hepatic glycogen synthesis. Endocrinology. 2010 Feb; 151(2):741-7. PMID: 20032056; PMCID: PMC2817628.
    27. Granger A, Kushner JA. Cellular origins of beta-cell regeneration: a legacy view of historical controversies. J Intern Med. 2009 Oct; 266(4):325-38. PMID: 19765178; PMCID: PMC3762574.
    28. He LM, Sartori DJ, Teta M, Opare-Addo LM, Rankin MM, Long SY, Diehl JA, Kushner JA. Cyclin D2 protein stability is regulated in pancreatic beta-cells. Mol Endocrinol. 2009 Nov; 23(11):1865-75. PMID: 19628581; PMCID: PMC2775938.
    29. Rankin MM, Kushner JA. Adaptive beta-cell proliferation is severely restricted with advanced age. Diabetes. 2009 Jun; 58(6):1365-72. PMID: 19265026; PMCID: PMC2682671.
    30. Szabolcs M, Keniry M, Simpson L, Reid LJ, Koujak S, Schiff SC, Davidian G, Licata S, Gruvberger-Saal S, Murty VV, Nandula S, Efstratiadis A, Kushner JA, White MF, Parsons R. Irs2 inactivation suppresses tumor progression in Pten+/- mice. Am J Pathol. 2009 Jan; 174(1):276-86. PMID: 19095950; PMCID: PMC2631340.
    31. Akirav E, Kushner JA, Herold KC. Beta-cell mass and type 1 diabetes: going, going, gone? Diabetes. 2008 Nov; 57(11):2883-8. PMID: 18971435; PMCID: PMC2570380.
    32. Kiel MJ, He S, Ashkenazi R, Gentry SN, Teta M, Kushner JA, Jackson TL, Morrison SJ. Haematopoietic stem cells do not asymmetrically segregate chromosomes or retain BrdU. Nature. 2007 Sep 13; 449(7159):238-42. PMID: 17728714; PMCID: PMC2633872.
    33. Sherry NA, Chen W, Kushner JA, Glandt M, Tang Q, Tsai S, Santamaria P, Bluestone JA, Brillantes AM, Herold KC. Exendin-4 improves reversal of diabetes in NOD mice treated with anti-CD3 monoclonal antibody by enhancing recovery of beta-cells. Endocrinology. 2007 Nov; 148(11):5136-44. PMID: 17673522.
      View in: PubMed
    34. Podcheko A, Northcott P, Bikopoulos G, Lee A, Bommareddi SR, Kushner JA, Farhang-Fallah J, Rozakis-Adcock M. Identification of a WD40 repeat-containing isoform of PHIP as a novel regulator of beta-cell growth and survival. Mol Cell Biol. 2007 Sep; 27(18):6484-96. PMID: 17636024; PMCID: PMC2099606.
    35. Teta M, Rankin MM, Long SY, Stein GM, Kushner JA. Growth and regeneration of adult beta cells does not involve specialized progenitors. Dev Cell. 2007 May; 12(5):817-26. PMID: 17488631.
      View in: PubMed
    36. Ablamunits V, Sherry NA, Kushner JA, Herold KC. Autoimmunity and beta cell regeneration in mouse and human type 1 diabetes: the peace is not enough. Ann N Y Acad Sci. 2007 Apr; 1103:19-32. PMID: 17376841.
      View in: PubMed
    37. Sherry NA, Kushner JA, Glandt M, Kitamura T, Brillantes AM, Herold KC. Effects of autoimmunity and immune therapy on beta-cell turnover in type 1 diabetes. Diabetes. 2006 Dec; 55(12):3238-45. PMID: 17130466.
      View in: PubMed
    38. Kushner JA. Beta-cell growth: an unusual paradigm of organogenesis that is cyclin D2/Cdk4 dependent. Cell Cycle. 2006 Feb; 5(3):234-7. PMID: 16410729.
      View in: PubMed
    39. Kushner JA, Simpson L, Wartschow LM, Guo S, Rankin MM, Parsons R, White MF. Phosphatase and tensin homolog regulation of islet growth and glucose homeostasis. J Biol Chem. 2005 Nov 25; 280(47):39388-93. PMID: 16170201.
      View in: PubMed
    40. Teta M, Long SY, Wartschow LM, Rankin MM, Kushner JA. Very slow turnover of beta-cells in aged adult mice. Diabetes. 2005 Sep; 54(9):2557-67. PMID: 16123343.
      View in: PubMed
    41. Kushner JA, Ciemerych MA, Sicinska E, Wartschow LM, Teta M, Long SY, Sicinski P, White MF. Cyclins D2 and D1 are essential for postnatal pancreatic beta-cell growth. Mol Cell Biol. 2005 May; 25(9):3752-62. PMID: 15831479; PMCID: PMC1084308.
    42. Yi X, Schubert M, Peachey NS, Suzuma K, Burks DJ, Kushner JA, Suzuma I, Cahill C, Flint CL, Dow MA, Leshan RL, King GL, White MF. Insulin receptor substrate 2 is essential for maturation and survival of photoreceptor cells. J Neurosci. 2005 Feb 2; 25(5):1240-8. PMID: 15689562.
      View in: PubMed
    43. Lin X, Taguchi A, Park S, Kushner JA, Li F, Li Y, White MF. Dysregulation of insulin receptor substrate 2 in beta cells and brain causes obesity and diabetes. J Clin Invest. 2004 Oct; 114(7):908-16. PMID: 15467829; PMCID: PMC518668.
    44. Pawlak DB, Kushner JA, Ludwig DS. Effects of dietary glycaemic index on adiposity, glucose homoeostasis, and plasma lipids in animals. Lancet. 2004 Aug 28-Sep 3; 364(9436):778-85. PMID: 15337404.
      View in: PubMed
    45. Kushner JA, Haj FG, Klaman LD, Dow MA, Kahn BB, Neel BG, White MF. Islet-sparing effects of protein tyrosine phosphatase-1b deficiency delays onset of diabetes in IRS2 knockout mice. Diabetes. 2004 Jan; 53(1):61-6. PMID: 14693698.
      View in: PubMed
    46. Schubert M, Brazil DP, Burks DJ, Kushner JA, Ye J, Flint CL, Farhang-Fallah J, Dikkes P, Warot XM, Rio C, Corfas G, White MF. Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation. J Neurosci. 2003 Aug 6; 23(18):7084-92. PMID: 12904469.
      View in: PubMed
    47. Kushner JA, Ye J, Schubert M, Burks DJ, Dow MA, Flint CL, Dutta S, Wright CV, Montminy MR, White MF. Pdx1 restores beta cell function in Irs2 knockout mice. J Clin Invest. 2002 May; 109(9):1193-201. PMID: 11994408; PMCID: PMC150960.
    48. Mellon SH, Kushner JA, Vaisse C. Expression and regulation of adrenodoxin and P450scc mRNA in rodent tissues. DNA Cell Biol. 1991 Jun; 10(5):339-47. PMID: 1863358.
      View in: PubMed
    49. Zhou QY, Grandy DK, Thambi L, Kushner JA, Van Tol HH, Cone R, Pribnow D, Salon J, Bunzow JR, Civelli O. Cloning and expression of human and rat D1 dopamine receptors. Nature. 1990 Sep 6; 347(6288):76-80. PMID: 2168520.
      View in: PubMed
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