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MARY K. ESTES

TitleDistinguished Service Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular Virology & Microbiology
AddressOne Baylor Plaza
Houston TX 77030
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    Other Positions
    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Medicine
    DivisionMedicine-Gastroenterology & Hepatol


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    1966 - 1967Beta Beta Beta
    1967Biology Award, Elmira College
    1974American Cancer Society Postdoctoral Fellowship (declined)
    1974 - 1976National Institutes of Health Postdoctoral Fellowship
    1987 - 1988ASM Foundation for Microbiology, Lecturer in Virology
    1992Wallace P. Rowe Award for Excellence in Virologic Research
    1992 - 1994ASM Foundation for Microbiology, Lecturer in Virology
    1994 - 2003Editor, Journal of Virology
    19951995 Michael E. DeBakey Award for Outstanding Research
    19961996 Elected Fellow, American Academy of Microbiology
    1996 - 1997President, American Society for Virology
    20002000 Elected Fellow, American Association for the Advancement of Science
    2000Researcher/Investigator of the Year, Crohn’s & Colitis Foundation Gold Key Award
    2005Elected Member, Institute of Medicine, National Academy of Science
    2005Member, Academy of Medicine, Engineering and Science of Texas
    2006Cullen Foundation Endowed Chair of Human and Molecular Virology
    2007Elected Member, National Academy of Sciences
    2007Associate Editor, PLoS Pathogens
    2009Distinguished Faculty Award, Baylor College of Medicine
    2009mBio Board of Editors
    2010Distinguished Service Professor, Baylor College of Medicine
    2010AGA Distinguished Achievement Award
    2011 - 2013Co-Editor in Chief, Current Opinion in Virology
    2011Elected Fellow, American Gastroenterological Association

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    Molecular Biology of Gastrointestinal Viruses

    The gastrointestinal (GI) tract represents the largest and most heterogeneous organ in the body. However, information on the molecular biology of most cell types in the GI tract remains limited. We are using viruses that infect distinct types of cells (enterocytes, crypt cells, M cells) in the GI tract as probes to learn about the biology, host response and gene expression of these cells. We are using multidisciplinary approaches to probe the structure and molecular biology of GI viruses to understand the basic mechanisms that control virus replication, morphogenesis, virus-host interactions, and pathogenesis.

    Our work uses two viruses, rotaviruses, the major cause of diarrhea in children and animals worldwide, and human caliciviruses, the major cause of epidemic gastroenteritis. Studies on the molecular biology of the rotaviruses seek to dissect the biologic, biochemical and structural role(s) inducing disease. Current studies are focusing on the rotavirus spike protein and the viral enterotoxin and how these proteins induce signaling pathways in cells that are important in immunity and pathogenesis. We are studying proteins expressed from inducible cDNAs in mammalian cells and virus-like particles (VLPs) produced using the baculovirus expression system. We aim to determine how specific domains of the viral proteins interact with intestinal cell receptors, affect cell signaling mechan-isms, and induce diarrhea. We also are evaluating how to effectively orally deliver virus-like particlesubunit vaccines to induce a mucosal immune response and protection from virus infection.

    Studies on the human caliciviruses are using molecular approaches to characterize Norwalk virus and related viruses. Sequence analysis and expression of genes from a cloned DNA library of Norwalk virus nucleic acid have classified this virus, determined its genome organization and relatedness to other Norwalk-like viruses and other gastroenteritis viruses such as astroviruses and enteroviruses, and produced new diagnostic assays. Use of these new assays is changing our understanding of the natural history and epidemiology of infections with these viruses. Notably, these viruses are being increasingly recognized as important causes of disease in children and in immunocompromised individuals. Expression of the capsid protein using mammalian and plant VLPs allowed the first crystallographic structure of a calicivirus to be solved and they are being tested directly as mucosal vaccines or as delivery systems for vaccines containing epitopes from other pathogens. Finally, the molecular basis of the restricted replication of Norwalk viruses to the gastrointestinal tract of humans is being probed by expression of Norwalk virus genes with different vectors and testing the interactions of virus with different cell lines and tissues derived from the gastrointestinal tract.


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Ramani S, Mamani N, Villena R, Bandyopadhyay AS, Gast C, Sato A, Laucirica D, Clemens R, Estes MK, O'Ryan ML. Rotavirus Serum IgA Immune Response in Children Receiving Rotarix Coadministered With bOPV or IPV. Pediatr Infect Dis J. 2016 Oct; 35(10):1137-9. PMID: 27254033.
      View in: PubMed
    2. In JG, Foulke-Abel J, Estes MK, Zachos NC, Kovbasnjuk O, Donowitz M. Human mini-guts: new insights into intestinal physiology and host-pathogen interactions. Nat Rev Gastroenterol Hepatol. 2016 Sep 28. PMID: 27677718.
      View in: PubMed
    3. Qu L, Murakami K, Broughman JR, Lay MK, Guix S, Tenge VR, Atmar RL, Estes MK. Replication of Human Norovirus RNA in Mammalian Cells Reveals Lack of Interferon Response. J Virol. 2016 Oct 1; 90(19):8906-23. PMID: 27466422.
      View in: PubMed
    4. Hesse S, Neill FH, Estes MK, Shanker S, Prasad BV, Ferreira J, Atmar RL. Correction for Hesse et al., Serological Responses to a Norovirus Nonstructural Fusion Protein after Vaccination and Infection. Clin Vaccine Immunol. 2016 Aug; 23(8):735. PMID: 27495982; PMCID: PMC4979171.
    5. Lloyd RE, Estes MK. Editorial overview: Viruses and cell metabolism. Curr Opin Virol. 2016 Aug; 19:vii-viii. PMID: 27619793.
      View in: PubMed
    6. Karandikar UC, Crawford SE, Ajami NJ, Murakami K, Kou B, Ettayebi K, Papanicolaou GA, Jongwutiwes U, Perales MA, Shia J, Mercer D, Finegold MJ, Vinjé J, Atmar RL, Estes MK. Detection of human norovirus in intestinal biopsies from immunocompromised transplant patients. J Gen Virol. 2016 Sep; 97(9):2291-300. PMID: 27412790.
      View in: PubMed
    7. Mills M, Estes MK. Physiologically relevant human tissue models for infectious diseases. Drug Discov Today. 2016 Sep; 21(9):1540-52. PMID: 27352632.
      View in: PubMed
    8. Prasad BV, Shanker S, Muhaxhiri Z, Deng L, Choi JM, Estes MK, Song Y, Palzkill T, Atmar RL. Antiviral targets of human noroviruses. Curr Opin Virol. 2016 Jun; 18:117-25. PMID: 27318434; PMCID: PMC4983487 [Available on 06/17/17].
    9. Menon VK, George S, Sarkar R, Giri S, Samuel P, Vivek R, Saravanabavan A, Liakath FB, Ramani S, Iturriza-Gomara M, Gray JJ, Brown DW, Estes MK, Kang G. Norovirus Gastroenteritis in a Birth Cohort in Southern India. PLoS One. 2016; 11(6):e0157007. PMID: 27284939; PMCID: PMC4902233.
    10. Ramani S, Estes MK, Atmar RL. Correlates of Protection against Norovirus Infection and Disease-Where Are We Now, Where Do We Go? PLoS Pathog. 2016 Apr; 12(4):e1005334. PMID: 27115358; PMCID: PMC4846004.
    11. Zachos NC, Kovbasnjuk O, Foulke-Abel J, In J, Blutt SE, de Jonge HR, Estes MK, Donowitz M. Human Enteroids/Colonoids and Intestinal Organoids Functionally Recapitulate Normal Intestinal Physiology and Pathophysiology. J Biol Chem. 2016 Feb 19; 291(8):3759-66. PMID: 26677228; PMCID: PMC4759158 [Available on 02/19/17].
    12. Hesse S, Neill FH, Estes MK, Shanker S, Prasad BV, Ferreira J, Atmar RL. Serological Responses to a Norovirus Nonstructural Fusion Protein after Vaccination and Infection. Clin Vaccine Immunol. 2016 Feb; 23(2):181-3. PMID: 26656120; PMCID: PMC4744919 [Available on 08/05/16].
    13. Foulke-Abel J, In J, Yin J, Zachos NC, Kovbasnjuk O, Estes MK, de Jonge H, Donowitz M. Human Enteroids as a Model of Upper Small Intestinal Ion Transport Physiology and Pathophysiology. Gastroenterology. 2016 Mar; 150(3):638-649.e8. PMID: 26677983; PMCID: PMC4766025 [Available on 03/01/17].
    14. Hyser JM, Estes MK. Pathophysiological Consequences of Calcium-Conducting Viroporins. Annu Rev Virol. 2015 Nov; 2(1):473-96. PMID: 26958925.
      View in: PubMed
    15. Kou B, Huang W, Neill FH, Palzkill T, Estes MK, Atmar RL. Norovirus Antigen Detection with a Combination of Monoclonal and Single-Chain Antibodies. J Clin Microbiol. 2015 Dec; 53(12):3916-8. PMID: 26447115.
      View in: PubMed
    16. Saxena K, Blutt SE, Ettayebi K, Zeng XL, Broughman JR, Crawford SE, Karandikar UC, Sastri NP, Conner ME, Opekun AR, Graham DY, Qureshi W, Sherman V, Foulke-Abel J, In J, Kovbasnjuk O, Zachos NC, Donowitz M, Estes MK. Human Intestinal Enteroids: a New Model To Study Human Rotavirus Infection, Host Restriction, and Pathophysiology. J Virol. 2015; 90(1):43-56. PMID: 26446608.
      View in: PubMed
    17. Hu L, Ramani S, Czako R, Sankaran B, Yu Y, Smith DF, Cummings RD, Estes MK, Venkataram Prasad BV. Structural basis of glycan specificity in neonate-specific bovine-human reassortant rotavirus. Nat Commun. 2015; 6:8346. PMID: 26420502.
      View in: PubMed
    18. Ye X, Van JN, Munoz FM, Revell PA, Kozinetz CA, Krance RA, Atmar RL, Estes MK, Koo HL. Noroviruses as a Cause of Diarrhea in Immunocompromised Pediatric Hematopoietic Stem Cell and Solid Organ Transplant Recipients. Am J Transplant. 2015 Jul; 15(7):1874-81. PMID: 25788003.
      View in: PubMed
    19. Ramani S, Neill FH, Opekun AR, Gilger MA, Graham DY, Estes MK, Atmar RL. Mucosal and Cellular Immune Responses to Norwalk Virus. J Infect Dis. 2015 Aug 1; 212(3):397-405. PMID: 25635121.
      View in: PubMed
    20. Czakó R, Atmar RL, Opekun AR, Gilger MA, Graham DY, Estes MK. Experimental human infection with Norwalk virus elicits a surrogate neutralizing antibody response with cross-genogroup activity. Clin Vaccine Immunol. 2015 Feb; 22(2):221-8. PMID: 25540269; PMCID: PMC4308873.
    21. Crawford SE, Ajami N, Parker TD, Kitamoto N, Natori K, Takeda N, Tanaka T, Kou B, Atmar RL, Estes MK. Mapping broadly reactive norovirus genogroup I and II monoclonal antibodies. Clin Vaccine Immunol. 2015 Feb; 22(2):168-77. PMID: 25428246; PMCID: PMC4308866.
    22. Kou B, Crawford SE, Ajami NJ, Czakó R, Neill FH, Tanaka TN, Kitamoto N, Palzkill TG, Estes MK, Atmar RL. Characterization of cross-reactive norovirus-specific monoclonal antibodies. Clin Vaccine Immunol. 2015 Feb; 22(2):160-7. PMID: 25428247; PMCID: PMC4308874.
    23. Zhang B, Chassaing B, Shi Z, Uchiyama R, Zhang Z, Denning TL, Crawford SE, Pruijssers AJ, Iskarpatyoti JA, Estes MK, Dermody TS, Ouyang W, Williams IR, Vijay-Kumar M, Gewirtz AT. Viral infection. Prevention and cure of rotavirus infection via TLR5/NLRC4-mediated production of IL-22 and IL-18. Science. 2014 Nov 14; 346(6211):861-5. PMID: 25395539; PMCID: PMC4788408.
    24. Sastri NP, Viskovska M, Hyser JM, Tanner MR, Horton LB, Sankaran B, Prasad BV, Estes MK. Structural plasticity of the coiled-coil domain of rotavirus NSP4. J Virol. 2014 Dec; 88(23):13602-12. PMID: 25231315; PMCID: PMC4248954.
    25. Bernstein DI, Atmar RL, Lyon GM, Treanor JJ, Chen WH, Jiang X, Vinjé J, Gregoricus N, Frenck RW, Moe CL, Al-Ibrahim MS, Barrett J, Ferreira J, Estes MK, Graham DY, Goodwin R, Borkowski A, Clemens R, Mendelman PM. Norovirus vaccine against experimental human GII.4 virus illness: a challenge study in healthy adults. J Infect Dis. 2015 Mar 15; 211(6):870-8. PMID: 25210140.
      View in: PubMed
    26. Katayama K, Murakami K, Sharp TM, Guix S, Oka T, Takai-Todaka R, Nakanishi A, Crawford SE, Atmar RL, Estes MK. Plasmid-based human norovirus reverse genetics system produces reporter-tagged progeny virus containing infectious genomic RNA. Proc Natl Acad Sci U S A. 2014 Sep 23; 111(38):E4043-52. PMID: 25192933; PMCID: PMC4183323.
    27. Viskovska M, Anish R, Hu L, Chow DC, Hurwitz AM, Brown NG, Palzkill T, Estes MK, Prasad BV. Probing the sites of interactions of rotaviral proteins involved in replication. J Virol. 2014 Nov; 88(21):12866-81. PMID: 25165107; PMCID: PMC4248930.
    28. Venkataram Prasad BV, Shanker S, Hu L, Choi JM, Crawford SE, Ramani S, Czako R, Atmar RL, Estes MK. Structural basis of glycan interaction in gastroenteric viral pathogens. Curr Opin Virol. 2014 Aug; 7:119-27. PMID: 25073118; PMCID: PMC4251800.
    29. Yu Y, Lasanajak Y, Song X, Hu L, Ramani S, Mickum ML, Ashline DJ, Prasad BV, Estes MK, Reinhold VN, Cummings RD, Smith DF. Human milk contains novel glycans that are potential decoy receptors for neonatal rotaviruses. Mol Cell Proteomics. 2014 Nov; 13(11):2944-60. PMID: 25048705; PMCID: PMC4223483.
    30. Ashline DJ, Yu Y, Lasanajak Y, Song X, Hu L, Ramani S, Prasad V, Estes MK, Cummings RD, Smith DF, Reinhold VN. Structural characterization by multistage mass spectrometry (MSn) of human milk glycans recognized by human rotaviruses. Mol Cell Proteomics. 2014 Nov; 13(11):2961-74. PMID: 25048706; PMCID: PMC4223484.
    31. Atmar RL, Opekun AR, Estes MK, Graham DY. Reply to Kirby et al. J Infect Dis. 2015 Jan 1; 211(1):167. PMID: 25015947; PMCID: PMC4859318.
    32. Qu L, Vongpunsawad S, Atmar RL, Prasad BV, Estes MK. Development of a Gaussia luciferase-based human norovirus protease reporter system: cell type-specific profile of Norwalk virus protease precursors and evaluation of inhibitors. J Virol. 2014 Sep; 88(18):10312-26. PMID: 25008934; PMCID: PMC4178847.
    33. Huang W, Samanta M, Crawford SE, Estes MK, Neill FH, Atmar RL, Palzkill T. Identification of human single-chain antibodies with broad reactivity for noroviruses. Protein Eng Des Sel. 2014 Oct; 27(10):339-49. PMID: 24946948; PMCID: PMC4191442.
    34. Foulke-Abel J, In J, Kovbasnjuk O, Zachos NC, Ettayebi K, Blutt SE, Hyser JM, Zeng XL, Crawford SE, Broughman JR, Estes MK, Donowitz M. Human enteroids as an ex-vivo model of host-pathogen interactions in the gastrointestinal tract. Exp Biol Med (Maywood). 2014 Sep; 239(9):1124-34. PMID: 24719375; PMCID: PMC4380516.
    35. Shanker S, Czako R, Sankaran B, Atmar RL, Estes MK, Prasad BV. Structural analysis of determinants of histo-blood group antigen binding specificity in genogroup I noroviruses. J Virol. 2014 Jun; 88(11):6168-80. PMID: 24648450; PMCID: PMC4093872.
    36. Ajami NJ, Kavanagh OV, Ramani S, Crawford SE, Atmar RL, Jiang ZD, Okhuysen PC, Estes MK, DuPont HL. Seroepidemiology of norovirus-associated travelers' diarrhea. J Travel Med. 2014 Jan-Feb; 21(1):6-11. PMID: 24383649; PMCID: PMC3904865.
    37. Ramani S, Atmar RL, Estes MK. Epidemiology of human noroviruses and updates on vaccine development. Curr Opin Gastroenterol. 2014 Jan; 30(1):25-33. PMID: 24232370; PMCID: PMC3955997.
    38. Kovbasnjuk O, Zachos NC, In J, Foulke-Abel J, Ettayebi K, Hyser JM, Broughman JR, Zeng XL, Middendorp S, de Jonge HR, Estes MK, Donowitz M. Human enteroids: preclinical models of non-inflammatory diarrhea. Stem Cell Res Ther. 2013; 4 Suppl 1:S3. PMID: 24564938; PMCID: PMC4029787.
    39. Atmar RL, Opekun AR, Gilger MA, Estes MK, Crawford SE, Neill FH, Ramani S, Hill H, Ferreira J, Graham DY. Determination of the 50% human infectious dose for Norwalk virus. J Infect Dis. 2014 Apr 1; 209(7):1016-22. PMID: 24253285; PMCID: PMC3952671.
    40. Criglar JM, Hu L, Crawford SE, Hyser JM, Broughman JR, Prasad BV, Estes MK. A novel form of rotavirus NSP2 and phosphorylation-dependent NSP2-NSP5 interactions are associated with viroplasm assembly. J Virol. 2014 Jan; 88(2):786-98. PMID: 24198401; PMCID: PMC3911676.
    41. Hyser JM, Utama B, Crawford SE, Broughman JR, Estes MK. Activation of the endoplasmic reticulum calcium sensor STIM1 and store-operated calcium entry by rotavirus requires NSP4 viroporin activity. J Virol. 2013 Dec; 87(24):13579-88. PMID: 24109210; PMCID: PMC3838237.
    42. Deng L, Muhaxhiri Z, Estes MK, Palzkill T, Prasad BV, Song Y. Synthesis, Activity and Structure-Activity Relationship of Noroviral Protease Inhibitors. Medchemcomm. 2013 Oct; 4(10). PMID: 24244836.
      View in: PubMed
    43. Hertel PM, Crawford SE, Bessard BC, Estes MK. Prevention of cholestasis in the murine rotavirus-induced biliary atresia model using passive immunization and nonreplicating virus-like particles. Vaccine. 2013 Nov 19; 31(48):5778-84. PMID: 23887039; PMCID: PMC3883562.
    44. Ramani S, Cortes-Penfield NW, Hu L, Crawford SE, Czako R, Smith DF, Kang G, Ramig RF, Le Pendu J, Prasad BV, Estes MK. The VP8* domain of neonatal rotavirus strain G10P[11] binds to type II precursor glycans. J Virol. 2013 Jul; 87(13):7255-64. PMID: 23616650; PMCID: PMC3700318.
    45. Menon VK, George S, Shanti AA, Saravanabavan A, Samuel P, Ramani S, Estes MK, Kang G. Exposure to human and bovine noroviruses in a birth cohort in southern India from 2002 to 2006. J Clin Microbiol. 2013 Jul; 51(7):2391-5. PMID: 23616452; PMCID: PMC3697716.
    46. Rogers JD, Ajami NJ, Fryszczyn BG, Estes MK, Atmar RL, Palzkill T. Identification and characterization of a peptide affinity reagent for detection of noroviruses in clinical samples. J Clin Microbiol. 2013 Jun; 51(6):1803-8. PMID: 23554202; PMCID: PMC3716098.
    47. Herbst-Kralovetz MM, Radtke AL, Lay MK, Hjelm BE, Bolick AN, Sarker SS, Atmar RL, Kingsley DH, Arntzen CJ, Estes MK, Nickerson CA. Lack of norovirus replication and histo-blood group antigen expression in 3-dimensional intestinal epithelial cells. Emerg Infect Dis. 2013 Mar; 19(3):431-8. PMID: 23622517; PMCID: PMC3647661.
    48. Crawford SE, Estes MK. Viroporin-mediated calcium-activated autophagy. Autophagy. 2013 May; 9(5):797-8. PMID: 23442576; PMCID: PMC3669193.
    49. Vongpunsawad S, Venkataram Prasad BV, Estes MK. Norwalk Virus Minor Capsid Protein VP2 Associates within the VP1 Shell Domain. J Virol. 2013 May; 87(9):4818-25. PMID: 23408637; PMCID: PMC3624303.
    50. Muhaxhiri Z, Deng L, Shanker S, Sankaran B, Estes MK, Palzkill T, Song Y, Prasad BV. Structural basis of substrate specificity and protease inhibition in Norwalk virus. J Virol. 2013 Apr; 87(8):4281-92. PMID: 23365454; PMCID: PMC3624372.
    51. Crawford SE, Hyser JM, Utama B, Estes MK. Autophagy hijacked through viroporin-activated calcium/calmodulin-dependent kinase kinase-? signaling is required for rotavirus replication. Proc Natl Acad Sci U S A. 2012 Dec 11; 109(50):E3405-13. PMID: 23184977; PMCID: PMC3528557.
    52. Kavanagh O, Zeng XL, Ramani S, Mukhopadhya I, Crawford SE, Kang G, Estes MK. A time-resolved immunoassay to measure serum antibodies to the rotavirus VP6 capsid protein. J Virol Methods. 2013 Apr; 189(1):228-31. PMID: 23183143; PMCID: PMC3617367.
    53. Ajami NJ, Barry MA, Carrillo B, Muhaxhiri Z, Neill FH, Prasad BV, Opekun AR, Gilger MA, Graham DY, Atmar RL, Estes MK. Antibody responses to norovirus genogroup GI.1 and GII.4 proteases in volunteers administered Norwalk virus. Clin Vaccine Immunol. 2012 Dec; 19(12):1980-3. PMID: 23035177; PMCID: PMC3535860.
    54. Sharp TM, Crawford SE, Ajami NJ, Neill FH, Atmar RL, Katayama K, Utama B, Estes MK. Secretory pathway antagonism by calicivirus homologues of Norwalk virus nonstructural protein p22 is restricted to noroviruses. Virol J. 2012; 9:181. PMID: 22943503; PMCID: PMC3493335.
    55. Atmar RL, Estes MK. Norovirus vaccine development: next steps. Expert Rev Vaccines. 2012 Sep; 11(9):1023-5. PMID: 23151158; PMCID: PMC3757541.
    56. Koo HL, Neill FH, Estes MK, Munoz FM, Cameron A, DuPont HL, Atmar RL. Noroviruses: The Most Common Pediatric Viral Enteric Pathogen at a Large University Hospital After Introduction of Rotavirus Vaccination. J Pediatric Infect Dis Soc. 2013 Mar; 2(1):57-60. PMID: 23687584; PMCID: PMC3656546.
    57. Hu L, Chow DC, Patton JT, Palzkill T, Estes MK, Prasad BV. Crystallographic Analysis of Rotavirus NSP2-RNA Complex Reveals Specific Recognition of 5' GG Sequence for RTPase Activity. J Virol. 2012 Oct; 86(19):10547-57. PMID: 22811529; PMCID: PMC3457270.
    58. Hu L, Crawford SE, Hyser JM, Estes MK, Prasad BV. Rotavirus non-structural proteins: structure and function. Curr Opin Virol. 2012 Aug; 2(4):380-8. PMID: 22789743; PMCID: PMC3422752.
    59. Finkbeiner SR, Zeng XL, Utama B, Atmar RL, Shroyer NF, Estes MK. Stem cell-derived human intestinal organoids as an infection model for rotaviruses. MBio. 2012; 3(4):e00159-12. PMID: 22761392; PMCID: PMC3398537.
    60. Estes MK, Desselberger U. Rotaviruses: cause of vaccine-preventable disease yet many fundamental questions remain to be explored. Curr Opin Virol. 2012 Aug; 2(4):369-72. PMID: 22762866.
      View in: PubMed
    61. Hu L, Crawford SE, Czako R, Cortes-Penfield NW, Smith DF, Le Pendu J, Estes MK, Prasad BV. Cell attachment protein VP8* of a human rotavirus specifically interacts with A-type histo-blood group antigen. Nature. 2012 May 10; 485(7397):256-9. PMID: 22504179; PMCID: PMC3350622.
    62. Hyser JM, Utama B, Crawford SE, Estes MK. Genetic divergence of rotavirus nonstructural protein 4 results in distinct serogroup-specific viroporin activity and intracellular punctate structure morphologies. J Virol. 2012 May; 86(9):4921-34. PMID: 22357281; PMCID: PMC3347366.
    63. Hertel PM, Estes MK. Rotavirus and biliary atresia: can causation be proven? Curr Opin Gastroenterol. 2012 Jan; 28(1):10-7. PMID: 22123643.
      View in: PubMed
    64. Czakó R, Atmar RL, Opekun AR, Gilger MA, Graham DY, Estes MK. Serum hemagglutination inhibition activity correlates with protection from gastroenteritis in persons infected with Norwalk virus. Clin Vaccine Immunol. 2012 Feb; 19(2):284-7. PMID: 22190401; PMCID: PMC3272916.
    65. Atmar RL, Bernstein DI, Harro CD, Al-Ibrahim MS, Chen WH, Ferreira J, Estes MK, Graham DY, Opekun AR, Richardson C, Mendelman PM. Norovirus vaccine against experimental human Norwalk Virus illness. N Engl J Med. 2011 Dec 8; 365(23):2178-87. PMID: 22150036; PMCID: PMC3761795.
    66. Baclayon M, Shoemaker GK, Uetrecht C, Crawford SE, Estes MK, Prasad BV, Heck AJ, Wuite GJ, Roos WH. Prestress strengthens the shell of Norwalk virus nanoparticles. Nano Lett. 2011 Nov 9; 11(11):4865-9. PMID: 21967663; PMCID: PMC4059365.
    67. Gladstone BP, Ramani S, Mukhopadhya I, Muliyil J, Sarkar R, Rehman AM, Jaffar S, Gomara MI, Gray JJ, Brown DW, Desselberger U, Crawford SE, John J, Babji S, Estes MK, Kang G. Protective effect of natural rotavirus infection in an Indian birth cohort. N Engl J Med. 2011 Jul 28; 365(4):337-46. PMID: 21793745; PMCID: PMC3596855.
    68. Hertel PM, Crawford SE, Finegold MJ, Estes MK. Osteopontin upregulation in rotavirus-induced murine biliary atresia requires replicating virus but is not necessary for development of biliary atresia. Virology. 2011 Sep 1; 417(2):281-92. PMID: 21742364; PMCID: PMC3170515.
    69. Shanker S, Choi JM, Sankaran B, Atmar RL, Estes MK, Prasad BV. Structural analysis of histo-blood group antigen binding specificity in a norovirus GII.4 epidemic variant: implications for epochal evolution. J Virol. 2011 Sep; 85(17):8635-45. PMID: 21715503; PMCID: PMC3165782.
    70. Pan S, Wang S, Utama B, Huang L, Blok N, Estes MK, Moremen KW, Sifers RN. Golgi localization of ERManI defines spatial separation of the mammalian glycoprotein quality control system. Mol Biol Cell. 2011 Aug 15; 22(16):2810-22. PMID: 21697506; PMCID: PMC3154878.
    71. Matthijnssens J, Ciarlet M, McDonald SM, Attoui H, Bányai K, Brister JR, Buesa J, Esona MD, Estes MK, Gentsch JR, Iturriza-Gómara M, Johne R, Kirkwood CD, Martella V, Mertens PP, Nakagomi O, Parreño V, Rahman M, Ruggeri FM, Saif LJ, Santos N, Steyer A, Taniguchi K, Patton JT, Desselberger U, Van Ranst M. Uniformity of rotavirus strain nomenclature proposed by the Rotavirus Classification Working Group (RCWG). Arch Virol. 2011 Aug; 156(8):1397-413. PMID: 21597953; PMCID: PMC3398998.
    72. Kavanagh O, Estes MK, Reeck A, Raju RM, Opekun AR, Gilger MA, Graham DY, Atmar RL. Serological responses to experimental Norwalk virus infection measured using a quantitative duplex time-resolved fluorescence immunoassay. Clin Vaccine Immunol. 2011 Jul; 18(7):1187-90. PMID: 21593238; PMCID: PMC3147314.
    73. Criglar J, Greenberg HB, Estes MK, Ramig RF. Reconciliation of rotavirus temperature-sensitive mutant collections and assignment of reassortment groups D, J, and K to genome segments. J Virol. 2011 May; 85(10):5048-60. PMID: 21367894; PMCID: PMC3126177.
    74. da Silva AK, Kavanagh OV, Estes MK, Elimelech M. Adsorption and aggregation properties of norovirus GI and GII virus-like particles demonstrate differing responses to solution chemistry. Environ Sci Technol. 2011 Jan 15; 45(2):520-6. PMID: 21121659; PMCID: PMC3914881.
    75. Hyser JM, Collinson-Pautz MR, Utama B, Estes MK. Rotavirus disrupts calcium homeostasis by NSP4 viroporin activity. MBio. 2010; 1(5). PMID: 21151776; PMCID: PMC2999940.
    76. Sharp TM, Guix S, Katayama K, Crawford SE, Estes MK. Inhibition of cellular protein secretion by norwalk virus nonstructural protein p22 requires a mimic of an endoplasmic reticulum export signal. PLoS One. 2010; 5(10):e13130. PMID: 20976190; PMCID: PMC2956632.
    77. Reeck A, Kavanagh O, Estes MK, Opekun AR, Gilger MA, Graham DY, Atmar RL. Serological correlate of protection against norovirus-induced gastroenteritis. J Infect Dis. 2010 Oct 15; 202(8):1212-8. PMID: 20815703; PMCID: PMC2945238.
    78. Sharp TM, Estes MK. An inside job: subversion of the host secretory pathway by intestinal pathogens. Curr Opin Infect Dis. 2010 Oct; 23(5):464-9. PMID: 20717028; PMCID: PMC4050742.
    79. Lay MK, Atmar RL, Guix S, Bharadwaj U, He H, Neill FH, Sastry KJ, Yao Q, Estes MK. Norwalk virus does not replicate in human macrophages or dendritic cells derived from the peripheral blood of susceptible humans. Virology. 2010 Oct 10; 406(1):1-11. PMID: 20667573; PMCID: PMC2933743.
    80. Deal EM, Jaimes MC, Crawford SE, Estes MK, Greenberg HB. Rotavirus structural proteins and dsRNA are required for the human primary plasmacytoid dendritic cell IFNalpha response. PLoS Pathog. 2010; 6(6):e1000931. PMID: 20532161; PMCID: PMC2880586.
    81. Shoemaker GK, van Duijn E, Crawford SE, Uetrecht C, Baclayon M, Roos WH, Wuite GJ, Estes MK, Prasad BV, Heck AJ. Norwalk virus assembly and stability monitored by mass spectrometry. Mol Cell Proteomics. 2010 Aug; 9(8):1742-51. PMID: 20418222; PMCID: PMC2938053.
    82. Kavanagh OV, Ajami NJ, Cheng E, Ciarlet M, Guerrero RA, Zeng CQ, Crawford SE, Estes MK. Rotavirus enterotoxin NSP4 has mucosal adjuvant properties. Vaccine. 2010 Apr 19; 28(18):3106-11. PMID: 20197138; PMCID: PMC3663485.
    83. Patel NC, Hertel PM, Estes MK, de la Morena M, Petru AM, Noroski LM, Revell PA, Hanson IC, Paul ME, Rosenblatt HM, Abramson SL. Vaccine-acquired rotavirus in infants with severe combined immunodeficiency. N Engl J Med. 2010 Jan 28; 362(4):314-9. PMID: 20107217; PMCID: PMC4103739.
    84. Gladstone BP, Das AR, Rehman AM, Jaffar S, Estes MK, Muliyil J, Kang G, Bose A. Burden of illness in the first 3 years of life in an Indian slum. J Trop Pediatr. 2010 Aug; 56(4):221-6. PMID: 20028725; PMCID: PMC3693507.
    85. Glass RI, Parashar UD, Estes MK. Norovirus gastroenteritis. N Engl J Med. 2009 Oct 29; 361(18):1776-85. PMID: 19864676; PMCID: PMC3880795.
    86. Greenberg HB, Estes MK. Rotaviruses: from pathogenesis to vaccination. Gastroenterology. 2009 May; 136(6):1939-51. PMID: 19457420; PMCID: PMC3690811.
    87. Hyser JM, Estes MK. Rotavirus vaccines and pathogenesis: 2008. Curr Opin Gastroenterol. 2009 Jan; 25(1):36-43. PMID: 19114772; PMCID: PMC2673536.
    88. Li Z, Baker ML, Jiang W, Estes MK, Prasad BV. Rotavirus architecture at subnanometer resolution. J Virol. 2009 Feb; 83(4):1754-66. PMID: 19036817; PMCID: PMC2643745.
    89. Atmar RL, Opekun AR, Gilger MA, Estes MK, Crawford SE, Neill FH, Graham DY. Norwalk virus shedding after experimental human infection. Emerg Infect Dis. 2008 Oct; 14(10):1553-7. PMID: 18826818; PMCID: PMC2609865.
    90. Matthijnssens J, Ciarlet M, Rahman M, Attoui H, Bányai K, Estes MK, Gentsch JR, Iturriza-Gómara M, Kirkwood CD, Martella V, Mertens PP, Nakagomi O, Patton JT, Ruggeri FM, Saif LJ, Santos N, Steyer A, Taniguchi K, Desselberger U, Van Ranst M. Recommendations for the classification of group A rotaviruses using all 11 genomic RNA segments. Arch Virol. 2008; 153(8):1621-9. PMID: 18604469; PMCID: PMC2556306.
    91. Choi JM, Hutson AM, Estes MK, Prasad BV. Atomic resolution structural characterization of recognition of histo-blood group antigens by Norwalk virus. Proc Natl Acad Sci U S A. 2008 Jul 8; 105(27):9175-80. PMID: 18599458; PMCID: PMC2453692.
    92. Seo NS, Zeng CQ, Hyser JM, Utama B, Crawford SE, Kim KJ, Höök M, Estes MK. Integrins alpha1beta1 and alpha2beta1 are receptors for the rotavirus enterotoxin. Proc Natl Acad Sci U S A. 2008 Jul 1; 105(26):8811-8. PMID: 18587047; PMCID: PMC3021436.
    93. Blutt SE, Warfield KL, Estes MK, Conner ME. Differential requirements for T cells in viruslike particle- and rotavirus-induced protective immunity. J Virol. 2008 Mar; 82(6):3135-8. PMID: 18184712; PMCID: PMC2259010.
    94. Hyser JM, Zeng CQ, Beharry Z, Palzkill T, Estes MK. Epitope mapping and use of epitope-specific antisera to characterize the VP5* binding site in rotavirus SA11 NSP4. Virology. 2008 Mar 30; 373(1):211-28. PMID: 18164740; PMCID: PMC2377065.
    95. Guix S, Asanaka M, Katayama K, Crawford SE, Neill FH, Atmar RL, Estes MK. Norwalk virus RNA is infectious in mammalian cells. J Virol. 2007 Nov; 81(22):12238-48. PMID: 17855551; PMCID: PMC2168986.
    96. Beau I, Cotte-Laffitte J, Géniteau-Legendre M, Estes MK, Servin AL. An NSP4-dependant mechanism by which rotavirus impairs lactase enzymatic activity in brush border of human enterocyte-like Caco-2 cells. Cell Microbiol. 2007 Sep; 9(9):2254-66. PMID: 17506819.
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    97. Banerjee I, Gladstone BP, Le Fevre AM, Ramani S, Iturriza-Gomara M, Gray JJ, Brown DW, Estes MK, Muliyil JP, Jaffar S, Kang G. Neonatal infection with G10P[11] rotavirus did not confer protection against subsequent rotavirus infection in a community cohort in Vellore, South India. J Infect Dis. 2007 Mar 1; 195(5):625-32. PMID: 17262703; PMCID: PMC2483790.
    98. Berkova Z, Crawford SE, Blutt SE, Morris AP, Estes MK. Expression of rotavirus NSP4 alters the actin network organization through the actin remodeling protein cofilin. J Virol. 2007 Apr; 81(7):3545-53. PMID: 17229686; PMCID: PMC1866088.
    99. Ramani S, Banerjee I, Gladstone BP, Sarkar R, Selvapandian D, Le Fevre AM, Jaffar S, Iturriza-Gomara M, Gray JJ, Estes MK, Brown DW, Kang G. Geographic information systems and genotyping in identification of rotavirus G12 infections in residents of an urban slum with subsequent detection in hospitalized children: emergence of G12 genotype in South India. J Clin Microbiol. 2007 Feb; 45(2):432-7. PMID: 17135437; PMCID: PMC1829045.
    100. Larsson MM, Rydell GE, Grahn A, Rodriguez-Diaz J, Akerlind B, Hutson AM, Estes MK, Larson G, Svensson L. Antibody prevalence and titer to norovirus (genogroup II) correlate with secretor (FUT2) but not with ABO phenotype or Lewis (FUT3) genotype. J Infect Dis. 2006 Nov 15; 194(10):1422-7. PMID: 17054072.
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    101. Estes MK, Prasad BV, Atmar RL. Noroviruses everywhere: has something changed? Curr Opin Infect Dis. 2006 Oct; 19(5):467-74. PMID: 16940871.
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    102. Jiang X, Jayaram H, Kumar M, Ludtke SJ, Estes MK, Prasad BV. Cryoelectron microscopy structures of rotavirus NSP2-NSP5 and NSP2-RNA complexes: implications for genome replication. J Virol. 2006 Nov; 80(21):10829-35. PMID: 16928740; PMCID: PMC1641785.
    103. Zhang X, Buehner NA, Hutson AM, Estes MK, Mason HS. Tomato is a highly effective vehicle for expression and oral immunization with Norwalk virus capsid protein. Plant Biotechnol J. 2006 Jul; 4(4):419-32. PMID: 17177807.
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    104. Banerjee I, Ramani S, Primrose B, Moses P, Iturriza-Gomara M, Gray JJ, Jaffar S, Monica B, Muliyil JP, Brown DW, Estes MK, Kang G. Comparative study of the epidemiology of rotavirus in children from a community-based birth cohort and a hospital in South India. J Clin Microbiol. 2006 Jul; 44(7):2468-74. PMID: 16825366; PMCID: PMC1489461.
    105. Atmar RL, Estes MK. The epidemiologic and clinical importance of norovirus infection. Gastroenterol Clin North Am. 2006 Jun; 35(2):275-90, viii. PMID: 16880066.
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    106. Le Guyader F, Loisy F, Atmar RL, Hutson AM, Estes MK, Ruvoën-Clouet N, Pommepuy M, Le Pendu J. Norwalk virus-specific binding to oyster digestive tissues. Emerg Infect Dis. 2006 Jun; 12(6):931-6. PMID: 16707048; PMCID: PMC2596755.
    107. Berkova Z, Crawford SE, Trugnan G, Yoshimori T, Morris AP, Estes MK. Rotavirus NSP4 induces a novel vesicular compartment regulated by calcium and associated with viroplasms. J Virol. 2006 Jun; 80(12):6061-71. PMID: 16731945; PMCID: PMC1472611.
    108. Chen R, Neill JD, Estes MK, Prasad BV. X-ray structure of a native calicivirus: structural insights into antigenic diversity and host specificity. Proc Natl Acad Sci U S A. 2006 May 23; 103(21):8048-53. PMID: 16702551; PMCID: PMC1472427.
    109. Zeitler CE, Estes MK, Venkataram Prasad BV. X-ray crystallographic structure of the Norwalk virus protease at 1.5-A resolution. J Virol. 2006 May; 80(10):5050-8. PMID: 16641296; PMCID: PMC1472067.
    110. Crawford SE, Patel DG, Cheng E, Berkova Z, Hyser JM, Ciarlet M, Finegold MJ, Conner ME, Estes MK. Rotavirus viremia and extraintestinal viral infection in the neonatal rat model. J Virol. 2006 May; 80(10):4820-32. PMID: 16641274; PMCID: PMC1472071.
    111. Choi NW, Estes MK, Langridge WH. Synthesis of a ricin toxin B subunit-rotavirus VP7 fusion protein in potato. Mol Biotechnol. 2006 Feb; 32(2):117-28. PMID: 16444013.
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    112. Tanaka T, Kitamoto N, Jiang X, Estes MK. High efficiency cross-reactive monoclonal antibody production by oral immunization with recombinant norwalk virus-like particles. Microbiol Immunol. 2006; 50(11):883-8. PMID: 17116984.
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    113. Pesavento JB, Crawford SE, Estes MK, Prasad BV. Rotavirus proteins: structure and assembly. Curr Top Microbiol Immunol. 2006; 309:189-219. PMID: 16913048.
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    114. Choi NW, Estes MK, Langridge WH. Ricin toxin B subunit enhancement of rotavirus NSP4 immunogenicity in mice. Viral Immunol. 2006; 19(1):54-63. PMID: 16553550.
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    115. Choi NW, Estes MK, Langridge WH. Synthesis and assembly of a cholera toxin B subunit-rotavirus VP7 fusion protein in transgenic potato. Mol Biotechnol. 2005 Nov; 31(3):193-202. PMID: 16230769.
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    116. Choi NW, Estes MK, Langridge WH. Oral immunization with a shiga toxin B subunit: rotavirus NSP4(90) fusion protein protects mice against gastroenteritis. Vaccine. 2005 Oct 25; 23(44):5168-76. PMID: 16040169.
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    117. Vizzi E, Calviño E, González R, Pérez-Schael I, Ciarlet M, Kang G, Estes MK, Liprandi F, Ludert JE. Evaluation of serum antibody responses against the rotavirus nonstructural protein NSP4 in children after rhesus rotavirus tetravalent vaccination or natural infection. Clin Diagn Lab Immunol. 2005 Oct; 12(10):1157-63. PMID: 16210477; PMCID: PMC1247833.
    118. Choi NW, Estes MK, Langridge WH. Mucosal immunization with a ricin toxin B subunit-rotavirus NSP4 fusion protein stimulates a Th1 lymphocyte response. J Biotechnol. 2006 Jan 24; 121(2):272-83. PMID: 16181698.
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    119. Blutt SE, Warfield KL, O'Neal CM, Estes MK, Conner ME. Host, viral, and vaccine factors that determine protective efficacy induced by rotavirus and virus-like particles (VLPs). Vaccine. 2006 Feb 20; 24(8):1170-9. PMID: 16191453.
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    120. Hutson AM, Airaud F, LePendu J, Estes MK, Atmar RL. Norwalk virus infection associates with secretor status genotyped from sera. J Med Virol. 2005 Sep; 77(1):116-20. PMID: 16032732.
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    121. Asanaka M, Atmar RL, Ruvolo V, Crawford SE, Neill FH, Estes MK. Replication and packaging of Norwalk virus RNA in cultured mammalian cells. Proc Natl Acad Sci U S A. 2005 Jul 19; 102(29):10327-32. PMID: 16002473; PMCID: PMC1177355.
    122. Pesavento JB, Crawford SE, Roberts E, Estes MK, Prasad BV. pH-induced conformational change of the rotavirus VP4 spike: implications for cell entry and antibody neutralization. J Virol. 2005 Jul; 79(13):8572-80. PMID: 15956598; PMCID: PMC1143764.
    123. Parker TD, Kitamoto N, Tanaka T, Hutson AM, Estes MK. Identification of Genogroup I and Genogroup II broadly reactive epitopes on the norovirus capsid. J Virol. 2005 Jun; 79(12):7402-9. PMID: 15919896; PMCID: PMC1143648.
    124. Nurgalieva ZZ, Conner ME, Opekun AR, Zheng CQ, Elliott SN, Ernst PB, Osato M, Estes MK, Graham DY. B-cell and T-cell immune responses to experimental Helicobacter pylori infection in humans. Infect Immun. 2005 May; 73(5):2999-3006. PMID: 15845507; PMCID: PMC1087341.
    125. Scofield VL, Montufar-Solis D, Cheng E, Estes MK, Klein JR. Intestinal TSH production is localized in crypt enterocytes and in villus 'hotblocks' and is coupled to IL-7 production: evidence for involvement of TSH during acute enteric virus infection. Immunol Lett. 2005 Jun 15; 99(1):36-44. PMID: 15894109; PMCID: PMC2894696.
    126. Chakravarty S, Hutson AM, Estes MK, Prasad BV. Evolutionary trace residues in noroviruses: importance in receptor binding, antigenicity, virion assembly, and strain diversity. J Virol. 2005 Jan; 79(1):554-68. PMID: 15596848; PMCID: PMC538680.
    127. Moe CL, Sair A, Lindesmith L, Estes MK, Jaykus LA. Diagnosis of norwalk virus infection by indirect enzyme immunoassay detection of salivary antibodies to recombinant norwalk virus antigen. Clin Diagn Lab Immunol. 2004 Nov; 11(6):1028-34. PMID: 15539501; PMCID: PMC524746.
    128. Blutt SE, Crawford SE, Warfield KL, Lewis DE, Estes MK, Conner ME. The VP7 outer capsid protein of rotavirus induces polyclonal B-cell activation. J Virol. 2004 Jul; 78(13):6974-81. PMID: 15194774; PMCID: PMC421650.
    129. Huang H, Schroeder F, Estes MK, McPherson T, Ball JM. Interaction(s) of rotavirus non-structural protein 4 (NSP4) C-terminal peptides with model membranes. Biochem J. 2004 Jun 15; 380(Pt 3):723-33. PMID: 15012630; PMCID: PMC1224213.
    130. Hutson AM, Atmar RL, Estes MK. Norovirus disease: changing epidemiology and host susceptibility factors. Trends Microbiol. 2004 Jun; 12(6):279-87. PMID: 15165606.
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    131. Chen R, Neill JD, Noel JS, Hutson AM, Glass RI, Estes MK, Prasad BV. Inter- and intragenus structural variations in caliciviruses and their functional implications. J Virol. 2004 Jun; 78(12):6469-79. PMID: 15163740; PMCID: PMC416503.
    132. Duizer E, Schwab KJ, Neill FH, Atmar RL, Koopmans MP, Estes MK. Laboratory efforts to cultivate noroviruses. J Gen Virol. 2004 Jan; 85(Pt 1):79-87. PMID: 14718622.
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    133. Bertolotti-Ciarlet A, Crawford SE, Hutson AM, Estes MK. The 3' end of Norwalk virus mRNA contains determinants that regulate the expression and stability of the viral capsid protein VP1: a novel function for the VP2 protein. J Virol. 2003 Nov; 77(21):11603-15. PMID: 14557646; PMCID: PMC229252.
    134. Blutt SE, Kirkwood CD, Parreño V, Warfield KL, Ciarlet M, Estes MK, Bok K, Bishop RF, Conner ME. Rotavirus antigenaemia and viraemia: a common event? Lancet. 2003 Nov 1; 362(9394):1445-9. PMID: 14602437.
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    135. Bertolotti-Ciarlet A, Ciarlet M, Crawford SE, Conner ME, Estes MK. Immunogenicity and protective efficacy of rotavirus 2/6-virus-like particles produced by a dual baculovirus expression vector and administered intramuscularly, intranasally, or orally to mice. Vaccine. 2003 Sep 8; 21(25-26):3885-900. PMID: 12922123.
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    136. Tacket CO, Sztein MB, Losonsky GA, Wasserman SS, Estes MK. Humoral, mucosal, and cellular immune responses to oral Norwalk virus-like particles in volunteers. Clin Immunol. 2003 Sep; 108(3):241-7. PMID: 14499247.
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    137. Berkova Z, Morris AP, Estes MK. Cytoplasmic calcium measurement in rotavirus enterotoxin-enhanced green fluorescent protein (NSP4-EGFP) expressing cells loaded with Fura-2. Cell Calcium. 2003 Jul; 34(1):55-68. PMID: 12767893.
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    138. Glass PJ, Zeng CQ, Estes MK. Two nonoverlapping domains on the Norwalk virus open reading frame 3 (ORF3) protein are involved in the formation of the phosphorylated 35K protein and in ORF3-capsid protein interactions. J Virol. 2003 Mar; 77(6):3569-77. PMID: 12610132; PMCID: PMC149496.
    139. Hutson AM, Atmar RL, Marcus DM, Estes MK. Norwalk virus-like particle hemagglutination by binding to h histo-blood group antigens. J Virol. 2003 Jan; 77(1):405-15. PMID: 12477845; PMCID: PMC140602.
    140. Kitamoto N, Tanaka T, Natori K, Takeda N, Nakata S, Jiang X, Estes MK. Cross-reactivity among several recombinant calicivirus virus-like particles (VLPs) with monoclonal antibodies obtained from mice immunized orally with one type of VLP. J Clin Microbiol. 2002 Jul; 40(7):2459-65. PMID: 12089262; PMCID: PMC120573.
    141. Casola A, Garofalo RP, Crawford SE, Estes MK, Mercurio F, Crowe SE, Brasier AR. Interleukin-8 gene regulation in intestinal epithelial cells infected with rotavirus: role of viral-induced IkappaB kinase activation. Virology. 2002 Jun 20; 298(1):8-19. PMID: 12093168.
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    142. Hutson AM, Atmar RL, Graham DY, Estes MK. Norwalk virus infection and disease is associated with ABO histo-blood group type. J Infect Dis. 2002 May 1; 185(9):1335-7. PMID: 12001052.
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    143. Bertolotti-Ciarlet A, White LJ, Chen R, Prasad BV, Estes MK. Structural requirements for the assembly of Norwalk virus-like particles. J Virol. 2002 Apr; 76(8):4044-55. PMID: 11907243; PMCID: PMC136079.
    144. Ciarlet M, Ludert JE, Iturriza-Gómara M, Liprandi F, Gray JJ, Desselberger U, Estes MK. Initial interaction of rotavirus strains with N-acetylneuraminic (sialic) acid residues on the cell surface correlates with VP4 genotype, not species of origin. J Virol. 2002 Apr; 76(8):4087-95. PMID: 11907248; PMCID: PMC136071.
    145. Ciarlet M, Hyser JM, Estes MK. Sequence analysis of the VP4, VP6, VP7, and NSP4 gene products of the bovine rotavirus WC3. Virus Genes. 2002 Mar; 24(2):107-18. PMID: 12018701.
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    146. Ciarlet M, Crawford SE, Cheng E, Blutt SE, Rice DA, Bergelson JM, Estes MK. VLA-2 (alpha2beta1) integrin promotes rotavirus entry into cells but is not necessary for rotavirus attachment. J Virol. 2002 Feb; 76(3):1109-23. PMID: 11773387; PMCID: PMC135817.
    147. Ciarlet M, Conner ME, Finegold MJ, Estes MK. Group A rotavirus infection and age-dependent diarrheal disease in rats: a new animal model to study the pathophysiology of rotavirus infection. J Virol. 2002 Jan; 76(1):41-57. PMID: 11739670; PMCID: PMC135688.
    148. Ciarlet M, Crawford SE, Estes MK. Differential infection of polarized epithelial cell lines by sialic acid-dependent and sialic acid-independent rotavirus strains. J Virol. 2001 Dec; 75(23):11834-50. PMID: 11689665; PMCID: PMC114770.
    149. Guerrero RA, Ball JM, Krater SS, Pacheco SE, Clements JD, Estes MK. Recombinant Norwalk virus-like particles administered intranasally to mice induce systemic and mucosal (fecal and vaginal) immune responses. J Virol. 2001 Oct; 75(20):9713-22. PMID: 11559804; PMCID: PMC114543.
    150. Ciarlet M, Estes MK. Interactions between rotavirus and gastrointestinal cells. Curr Opin Microbiol. 2001 Aug; 4(4):435-41. PMID: 11495808.
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    151. Crawford SE, Mukherjee SK, Estes MK, Lawton JA, Shaw AL, Ramig RF, Prasad BV. Trypsin cleavage stabilizes the rotavirus VP4 spike. J Virol. 2001 Jul; 75(13):6052-61. PMID: 11390607; PMCID: PMC114321.
    152. Lawton JA, Estes MK, Prasad BV. Identification and characterization of a transcription pause site in rotavirus. J Virol. 2001 Feb; 75(4):1632-42. PMID: 11160661; PMCID: PMC114072.
    153. Schwab KJ, Neill FH, Le Guyader F, Estes MK, Atmar RL. Development of a reverse transcription-PCR-DNA enzyme immunoassay for detection of "Norwalk-like" viruses and hepatitis A virus in stool and shellfish. Appl Environ Microbiol. 2001 Feb; 67(2):742-9. PMID: 11157239; PMCID: PMC92643.
    154. Prasad BV, Crawford S, Lawton JA, Pesavento J, Hardy M, Estes MK. Structural studies on gastroenteritis viruses. Novartis Found Symp. 2001; 238:26-37; discussion 37-46. PMID: 11444031.
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    155. Estes MK, Kang G, Zeng CQ, Crawford SE, Ciarlet M. Pathogenesis of rotavirus gastroenteritis. Novartis Found Symp. 2001; 238:82-96; discussion 96-100. PMID: 11444037.
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    156. Atmar RL, Estes MK. Diagnosis of noncultivatable gastroenteritis viruses, the human caliciviruses. Clin Microbiol Rev. 2001 Jan; 14(1):15-37. PMID: 11148001; PMCID: PMC88960.
    157. Ciarlet M, Estes MK. Rotavirus and calicivirus infections of the gastrointestinal tract. Curr Opin Gastroenterol. 2001 Jan; 17(1):10-6. PMID: 17031143.
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    158. Zhang M, Zeng CQ, Morris AP, Estes MK. A functional NSP4 enterotoxin peptide secreted from rotavirus-infected cells. J Virol. 2000 Dec; 74(24):11663-70. PMID: 11090165; PMCID: PMC112448.
    159. Gilpatrick SG, Schwab KJ, Estes MK, Atmar RL. Development of an immunomagnetic capture reverse transcription-PCR assay for the detection of Norwalk virus. J Virol Methods. 2000 Oct; 90(1):69-78. PMID: 11011082.
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    160. Glass PJ, White LJ, Ball JM, Leparc-Goffart I, Hardy ME, Estes MK. Norwalk virus open reading frame 3 encodes a minor structural protein. J Virol. 2000 Jul; 74(14):6581-91. PMID: 10864672; PMCID: PMC112168.
    161. Ciarlet M, Estes MK, Conner ME. Simian rhesus rotavirus is a unique heterologous (non-lapine) rotavirus strain capable of productive replication and horizontal transmission in rabbits. J Gen Virol. 2000 May; 81(Pt 5):1237-49. PMID: 10769066.
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    162. Venkataram Prasad BV, Hardy ME, Estes MK. Structural studies of recombinant Norwalk capsids. J Infect Dis. 2000 May; 181 Suppl 2:S317-21. PMID: 10804144.
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    163. Estes MK, Ball JM, Guerrero RA, Opekun AR, Gilger MA, Pacheco SS, Graham DY. Norwalk virus vaccines: challenges and progress. J Infect Dis. 2000 May; 181 Suppl 2:S367-73. PMID: 10804150.
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    164. Hale AD, Tanaka TN, Kitamoto N, Ciarlet M, Jiang X, Takeda N, Brown DW, Estes MK. Identification of an epitope common to genogroup 1 "norwalk-like viruses". J Clin Microbiol. 2000 Apr; 38(4):1656-60. PMID: 10747162; PMCID: PMC86516.
    165. Lawton JA, Estes MK, Prasad BV. Mechanism of genome transcription in segmented dsRNA viruses. Adv Virus Res. 2000; 55:185-229. PMID: 11050943.
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    166. Ciarlet M, Liprandi F, Conner ME, Estes MK. Species specificity and interspecies relatedness of NSP4 genetic groups by comparative NSP4 sequence analyses of animal rotaviruses. Arch Virol. 2000; 145(2):371-83. PMID: 10752559.
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    167. Schwab KJ, Neill FH, Fankhauser RL, Daniels NA, Monroe SS, Bergmire-Sweat DA, Estes MK, Atmar RL. Development of methods to detect "Norwalk-like viruses" (NLVs) and hepatitis A virus in delicatessen foods: application to a food-borne NLV outbreak. Appl Environ Microbiol. 2000 Jan; 66(1):213-8. PMID: 10618226; PMCID: PMC91808.
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    169. Prasad BV, Hardy ME, Dokland T, Bella J, Rossmann MG, Estes MK. X-ray crystallographic structure of the Norwalk virus capsid. Science. 1999 Oct 8; 286(5438):287-90. PMID: 10514371.
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    170. Morris AP, Scott JK, Ball JM, Zeng CQ, O'Neal WK, Estes MK. NSP4 elicits age-dependent diarrhea and Ca(2+)mediated I(-) influx into intestinal crypts of CF mice. Am J Physiol. 1999 Aug; 277(2 Pt 1):G431-44. PMID: 10444458.
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    171. Ball JM, Graham DY, Opekun AR, Gilger MA, Guerrero RA, Estes MK. Recombinant Norwalk virus-like particles given orally to volunteers: phase I study. Gastroenterology. 1999 Jul; 117(1):40-8. PMID: 10381908.
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    172. Crawford SE, Estes MK, Ciarlet M, Barone C, O'Neal CM, Cohen J, Conner ME. Heterotypic protection and induction of a broad heterotypic neutralization response by rotavirus-like particles. J Virol. 1999 Jun; 73(6):4813-22. PMID: 10233942; PMCID: PMC112524.
    173. Lawton JA, Estes MK, Prasad BV. Comparative structural analysis of transcriptionally competent and incompetent rotavirus-antibody complexes. Proc Natl Acad Sci U S A. 1999 May 11; 96(10):5428-33. PMID: 10318900; PMCID: PMC21876.
    174. Ciarlet M, Estes MK. Human and most animal rotavirus strains do not require the presence of sialic acid on the cell surface for efficient infectivity. J Gen Virol. 1999 Apr; 80 ( Pt 4):943-8. PMID: 10211964.
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    175. Estes MK, Morris AP. A viral enterotoxin. A new mechanism of virus-induced pathogenesis. Adv Exp Med Biol. 1999; 473:73-82. PMID: 10659345.
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    176. Hale AD, Crawford SE, Ciarlet M, Green J, Gallimore C, Brown DW, Jiang X, Estes MK. Expression and self-assembly of Grimsby virus: antigenic distinction from Norwalk and Mexico viruses. Clin Diagn Lab Immunol. 1999 Jan; 6(1):142-5. PMID: 9874680; PMCID: PMC95676.
    177. Schwab KJ, Neill FH, Estes MK, Metcalf TG, Atmar RL. Distribution of Norwalk virus within shellfish following bioaccumulation and subsequent depuration by detection using RT-PCR. J Food Prot. 1998 Dec; 61(12):1674-80. PMID: 9874348.
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    178. Ciarlet M, Gilger MA, Barone C, McArthur M, Estes MK, Conner ME. Rotavirus disease, but not infection and development of intestinal histopathological lesions, is age restricted in rabbits. Virology. 1998 Nov 25; 251(2):343-60. PMID: 9837799.
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    179. Ciarlet M, Crawford SE, Barone C, Bertolotti-Ciarlet A, Ramig RF, Estes MK, Conner ME. Subunit rotavirus vaccine administered parenterally to rabbits induces active protective immunity. J Virol. 1998 Nov; 72(11):9233-46. PMID: 9765471; PMCID: PMC110343.
    180. Zhang M, Zeng CQ, Dong Y, Ball JM, Saif LJ, Morris AP, Estes MK. Mutations in rotavirus nonstructural glycoprotein NSP4 are associated with altered virus virulence. J Virol. 1998 May; 72(5):3666-72. PMID: 9557647; PMCID: PMC109587.
    181. O'Neal CM, Clements JD, Estes MK, Conner ME. Rotavirus 2/6 viruslike particles administered intranasally with cholera toxin, Escherichia coli heat-labile toxin (LT), and LT-R192G induce protection from rotavirus challenge. J Virol. 1998 Apr; 72(4):3390-3. PMID: 9525668; PMCID: PMC109829.
    182. Ciarlet M, Estes MK, Barone C, Ramig RF, Conner ME. Analysis of host range restriction determinants in the rabbit model: comparison of homologous and heterologous rotavirus infections. J Virol. 1998 Mar; 72(3):2341-51. PMID: 9499095; PMCID: PMC109534.
    183. Ball JM, Hardy ME, Atmar RL, Conner ME, Estes MK. Oral immunization with recombinant Norwalk virus-like particles induces a systemic and mucosal immune response in mice. J Virol. 1998 Feb; 72(2):1345-53. PMID: 9445035; PMCID: PMC124613.
    184. Zeng CQ, Estes MK, Charpilienne A, Cohen J. The N terminus of rotavirus VP2 is necessary for encapsidation of VP1 and VP3. J Virol. 1998 Jan; 72(1):201-8. PMID: 9420216; PMCID: PMC109365.
    185. O'Neal CM, Crawford SE, Estes MK, Conner ME. Rotavirus virus-like particles administered mucosally induce protective immunity. J Virol. 1997 Nov; 71(11):8707-17. PMID: 9343229; PMCID: PMC192335.
    186. White LJ, Hardy ME, Estes MK. Biochemical characterization of a smaller form of recombinant Norwalk virus capsids assembled in insect cells. J Virol. 1997 Oct; 71(10):8066-72. PMID: 9311906; PMCID: PMC192173.
    187. Lawton JA, Zeng CQ, Mukherjee SK, Cohen J, Estes MK, Prasad BV. Three-dimensional structural analysis of recombinant rotavirus-like particles with intact and amino-terminal-deleted VP2: implications for the architecture of the VP2 capsid layer. J Virol. 1997 Oct; 71(10):7353-60. PMID: 9311813; PMCID: PMC192080.
    188. Dong Y, Zeng CQ, Ball JM, Estes MK, Morris AP. The rotavirus enterotoxin NSP4 mobilizes intracellular calcium in human intestinal cells by stimulating phospholipase C-mediated inositol 1,4,5-trisphosphate production. Proc Natl Acad Sci U S A. 1997 Apr 15; 94(8):3960-5. PMID: 9108087; PMCID: PMC20550.
    189. Schwab KJ, Estes MK, Neill FH, Atmar RL. Use of heat release and an internal RNA standard control in reverse transcription-PCR detection of Norwalk virus from stool samples. J Clin Microbiol. 1997 Feb; 35(2):511-4. PMID: 9003630; PMCID: PMC229614.
    190. Ciarlet M, Estes MK, Conner ME. Comparative amino acid sequence analysis of the outer capsid protein VP4 from four lapine rotavirus strains reveals identity with genotype P[14] human rotaviruses. Arch Virol. 1997; 142(5):1059-69. PMID: 9191871.
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    191. Conner ME, Graham DY, Estes MK. Determination of the duration of a primary immune response and the ID50 of ALA rabbit rotavirus in rabbits. Arch Virol. 1997; 142(11):2281-94. PMID: 9672593.
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    192. Estes MK, Ball JM, Crawford SE, O'Neal C, Opekun AA, Graham DY, Conner ME. Virus-like particle vaccines for mucosal immunization. Adv Exp Med Biol. 1997; 412:387-95. PMID: 9192045.
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    193. Hardy ME, Kramer SF, Treanor JJ, Estes MK. Human calicivirus genogroup II capsid sequence diversity revealed by analyses of the prototype Snow Mountain agent. Arch Virol. 1997; 142(7):1469-79. PMID: 9267456.
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    194. Numata K, Hardy ME, Nakata S, Chiba S, Estes MK. Molecular characterization of morphologically typical human calicivirus Sapporo. Arch Virol. 1997; 142(8):1537-52. PMID: 9672617.
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    195. Le Guyader F, Neill FH, Estes MK, Monroe SS, Ando T, Atmar RL. Detection and analysis of a small round-structured virus strain in oysters implicated in an outbreak of acute gastroenteritis. Appl Environ Microbiol. 1996 Nov; 62(11):4268-72. PMID: 8900022; PMCID: PMC168251.
    196. Tian P, Ball JM, Zeng CQ, Estes MK. The rotavirus nonstructural glycoprotein NSP4 possesses membrane destabilization activity. J Virol. 1996 Oct; 70(10):6973-81. PMID: 8794341; PMCID: PMC190747.
    197. White LJ, Ball JM, Hardy ME, Tanaka TN, Kitamoto N, Estes MK. Attachment and entry of recombinant Norwalk virus capsids to cultured human and animal cell lines. J Virol. 1996 Oct; 70(10):6589-97. PMID: 8794293; PMCID: PMC190699.
    198. Estes MK. Advances in molecular biology: impact on rotavirus vaccine development. J Infect Dis. 1996 Sep; 174 Suppl 1:S37-46. PMID: 8752289.
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    199. Conner ME, Zarley CD, Hu B, Parsons S, Drabinski D, Greiner S, Smith R, Jiang B, Corsaro B, Barniak V, Madore HP, Crawford S, Estes MK. Virus-like particles as a rotavirus subunit vaccine. J Infect Dis. 1996 Sep; 174 Suppl 1:S88-92. PMID: 8752296.
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    200. Prasad BV, Rothnagel R, Zeng CQ, Jakana J, Lawton JA, Chiu W, Estes MK. Visualization of ordered genomic RNA and localization of transcriptional complexes in rotavirus. Nature. 1996 Aug 1; 382(6590):471-3. PMID: 8684490.
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    201. Zeng CQ, Wentz MJ, Cohen J, Estes MK, Ramig RF. Characterization and replicase activity of double-layered and single-layered rotavirus-like particles expressed from baculovirus recombinants. J Virol. 1996 May; 70(5):2736-42. PMID: 8627747; PMCID: PMC190130.
    202. Ball JM, Tian P, Zeng CQ, Morris AP, Estes MK. Age-dependent diarrhea induced by a rotaviral nonstructural glycoprotein. Science. 1996 Apr 5; 272(5258):101-4. PMID: 8600515.
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    203. Hardy ME, Tanaka TN, Kitamoto N, White LJ, Ball JM, Jiang X, Estes MK. Antigenic mapping of the recombinant Norwalk virus capsid protein using monoclonal antibodies. Virology. 1996 Mar 1; 217(1):252-61. PMID: 8599210.
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    204. Ball JM, Estes MK, Hardy ME, Conner ME, Opekun AR, Graham DY. Recombinant Norwalk virus-like particles as an oral vaccine. Arch Virol Suppl. 1996; 12:243-9. PMID: 9015121.
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    205. Conner ME, Crawford SE, Barone C, O'Neal C, Zhou YJ, Fernandez F, Parwani A, Saif LJ, Cohen J, Estes MK. Rotavirus subunit vaccines. Arch Virol Suppl. 1996; 12:199-206. PMID: 9015116.
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    206. Shaw AL, Rothnagel R, Zeng CQ, Lawton JA, Ramig RF, Estes MK, Prasad BV. Rotavirus structure: interactions between the structural proteins. Arch Virol Suppl. 1996; 12:21-7. PMID: 9015098.
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    207. Tian P, Ball JM, Zeng CQ, Estes MK. Rotavirus protein expression is important for virus assembly and pathogenesis. Arch Virol Suppl. 1996; 12:69-77. PMID: 9015103.
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    208. Atmar RL, Neill FH, Woodley CM, Manger R, Fout GS, Burkhardt W, Leja L, McGovern ER, Le Guyader F, Metcalf TG, Estes MK. Collaborative evaluation of a method for the detection of Norwalk virus in shellfish tissues by PCR. Appl Environ Microbiol. 1996 Jan; 62(1):254-8. PMID: 8572702; PMCID: PMC167792.
    209. Le Guyader F, Estes MK, Hardy ME, Neill FH, Green J, Brown DW, Atmar RL. Evaluation of a degenerate primer for the PCR detection of human caliciviruses. Arch Virol. 1996; 141(11):2225-35. PMID: 8973536.
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    210. Prasad BV, Hardy ME, Jiang X, Estes MK. Structure of Norwalk virus. Arch Virol Suppl. 1996; 12:237-42. PMID: 9015120.
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    211. Wentz MJ, Zeng CQ, Patton JT, Estes MK, Ramig RF. Identification of the minimal replicase and the minimal promoter of (-)-strand synthesis, functional in rotavirus RNA replication in vitro. Arch Virol Suppl. 1996; 12:59-67. PMID: 9015102.
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    212. Hardy ME, Estes MK. Completion of the Norwalk virus genome sequence. Virus Genes. 1996; 12(3):287-90. PMID: 8883366.
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    213. Tian P, Estes MK, Hu Y, Ball JM, Zeng CQ, Schilling WP. The rotavirus nonstructural glycoprotein NSP4 mobilizes Ca2+ from the endoplasmic reticulum. J Virol. 1995 Sep; 69(9):5763-72. PMID: 7637021; PMCID: PMC189437.
    214. Atmar RL, Neill FH, Romalde JL, Le Guyader F, Woodley CM, Metcalf TG, Estes MK. Detection of Norwalk virus and hepatitis A virus in shellfish tissues with the PCR. Appl Environ Microbiol. 1995 Aug; 61(8):3014-8. PMID: 7487032; PMCID: PMC167576.
    215. Hardy ME, White LJ, Ball JM, Estes MK. Specific proteolytic cleavage of recombinant Norwalk virus capsid protein. J Virol. 1995 Mar; 69(3):1693-8. PMID: 7853506; PMCID: PMC188770.
    216. Jiang X, Wang J, Estes MK. Characterization of SRSVs using RT-PCR and a new antigen ELISA. Arch Virol. 1995; 140(2):363-74. PMID: 7710362.
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    217. Metcalf TG, Melnick JL, Estes MK. Environmental virology: from detection of virus in sewage and water by isolation to identification by molecular biology--a trip of over 50 years. Annu Rev Microbiol. 1995; 49:461-87. PMID: 8561468.
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    218. Chen D, Zeng CQ, Wentz MJ, Gorziglia M, Estes MK, Ramig RF. Template-dependent, in vitro replication of rotavirus RNA. J Virol. 1994 Nov; 68(11):7030-9. PMID: 7933085; PMCID: PMC237140.
    219. Crawford SE, Labbé M, Cohen J, Burroughs MH, Zhou YJ, Estes MK. Characterization of virus-like particles produced by the expression of rotavirus capsid proteins in insect cells. J Virol. 1994 Sep; 68(9):5945-52. PMID: 8057471; PMCID: PMC237000.
    220. Prasad BV, Rothnagel R, Jiang X, Estes MK. Three-dimensional structure of baculovirus-expressed Norwalk virus capsids. J Virol. 1994 Aug; 68(8):5117-25. PMID: 8035511; PMCID: PMC236455.
    221. Matson DO, O'Ryan ML, Pickering LK, Estes MK. Assessment of epitope-blocking assays for measuring antibody to rotavirus. J Virol Methods. 1994 Jul; 48(2-3):293-300. PMID: 7527405.
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    222. Graham DY, Jiang X, Tanaka T, Opekun AR, Madore HP, Estes MK. Norwalk virus infection of volunteers: new insights based on improved assays. J Infect Dis. 1994 Jul; 170(1):34-43. PMID: 8014518.
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    223. Romalde JL, Estes MK, Szücs G, Atmar RL, Woodley CM, Metcalf TG. In situ detection of hepatitis A virus in cell cultures and shellfish tissues. Appl Environ Microbiol. 1994 Jun; 60(6):1921-6. PMID: 8031087; PMCID: PMC201581.
    224. Zhou YJ, Burns JW, Morita Y, Tanaka T, Estes MK. Localization of rotavirus VP4 neutralization epitopes involved in antibody-induced conformational changes of virus structure. J Virol. 1994 Jun; 68(6):3955-64. PMID: 7514681; PMCID: PMC236901.
    225. Zeng CQ, Labbé M, Cohen J, Prasad BV, Chen D, Ramig RF, Estes MK. Characterization of rotavirus VP2 particles. Virology. 1994 May 15; 201(1):55-65. PMID: 8178489.
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    226. Tian P, Hu Y, Schilling WP, Lindsay DA, Eiden J, Estes MK. The nonstructural glycoprotein of rotavirus affects intracellular calcium levels. J Virol. 1994 Jan; 68(1):251-7. PMID: 8254736; PMCID: PMC236284.
    227. Conner ME, Matson DO, Estes MK. Rotavirus vaccines and vaccination potential. Curr Top Microbiol Immunol. 1994; 185:285-337. PMID: 8050282.
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    228. Conner ME, Crawford SE, Barone C, Estes MK. Rotavirus vaccine administered parenterally induces protective immunity. J Virol. 1993 Nov; 67(11):6633-41. PMID: 8411366; PMCID: PMC238101.
    229. Jiang X, Wang M, Wang K, Estes MK. Sequence and genomic organization of Norwalk virus. Virology. 1993 Jul; 195(1):51-61. PMID: 8391187.
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    230. Au KS, Mattion NM, Estes MK. A subviral particle binding domain on the rotavirus nonstructural glycoprotein NS28. Virology. 1993 Jun; 194(2):665-73. PMID: 7684873.
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    231. Matson DO, O'Ryan ML, Herrera I, Pickering LK, Estes MK. Fecal antibody responses to symptomatic and asymptomatic rotavirus infections. J Infect Dis. 1993 Mar; 167(3):577-83. PMID: 8440929.
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    232. Atmar RL, Metcalf TG, Neill FH, Estes MK. Detection of enteric viruses in oysters by using the polymerase chain reaction. Appl Environ Microbiol. 1993 Feb; 59(2):631-5. PMID: 8382024; PMCID: PMC202159.
    233. Kitamoto N, Mattion NM, Estes MK. Alterations in the sequence of the gene 4 from a human rotavirus after multiple passages in HepG2 liver cells. Arch Virol. 1993; 130(1-2):179-85. PMID: 8389116.
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    234. Graf R, Mattera R, Codina J, Estes MK, Birnbaumer L. A truncated recombinant alpha subunit of Gi3 with a reduced affinity for beta gamma dimers and altered guanosine 5'-3-O-(thio)triphosphate binding. J Biol Chem. 1992 Dec 5; 267(34):24307-14. PMID: 1332951.
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    235. Graf R, Mattera R, Codina J, Evans T, Ho YK, Estes MK, Birnbaumer L. Studies on the interaction of alpha subunits of GTP-binding proteins with beta gamma dimers. Eur J Biochem. 1992 Dec 1; 210(2):609-19. PMID: 1459143.
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    236. Jiang X, Wang M, Graham DY, Estes MK. Expression, self-assembly, and antigenicity of the Norwalk virus capsid protein. J Virol. 1992 Nov; 66(11):6527-32. PMID: 1328679; PMCID: PMC240146.
    237. Jiang X, Wang J, Graham DY, Estes MK. Detection of Norwalk virus in stool by polymerase chain reaction. J Clin Microbiol. 1992 Oct; 30(10):2529-34. PMID: 1383265; PMCID: PMC270473.
    238. Mattion NM, Cohen J, Aponte C, Estes MK. Characterization of an oligomerization domain and RNA-binding properties on rotavirus nonstructural protein NS34. Virology. 1992 Sep; 190(1):68-83. PMID: 1326821.
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    239. Gilger MA, Matson DO, Conner ME, Rosenblatt HM, Finegold MJ, Estes MK. Extraintestinal rotavirus infections in children with immunodeficiency. J Pediatr. 1992 Jun; 120(6):912-7. PMID: 1317419.
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    240. Piedra PA, Kasel JA, Norton HJ, Garcia-Prats JA, Rayford Y, Estes MK, Hull R, Baker CJ. Description of an adenovirus type 8 outbreak in hospitalized neonates born prematurely. Pediatr Infect Dis J. 1992 Jun; 11(6):460-5. PMID: 1608683.
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    241. Liu M, Mattion NM, Estes MK. Rotavirus VP3 expressed in insect cells possesses guanylyltransferase activity. Virology. 1992 May; 188(1):77-84. PMID: 1314468.
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    242. Matson DO, O'Ryan ML, Pickering LK, Chiba S, Nakata S, Raj P, Estes MK. Characterization of serum antibody responses to natural rotavirus infections in children by VP7-specific epitope-blocking assays. J Clin Microbiol. 1992 May; 30(5):1056-61. PMID: 1374761; PMCID: PMC265223.
    243. Raj P, Matson DO, Coulson BS, Bishop RF, Taniguchi K, Urasawa S, Greenberg HB, Estes MK. Comparisons of rotavirus VP7-typing monoclonal antibodies by competition binding assay. J Clin Microbiol. 1992 Mar; 30(3):704-11. PMID: 1372622; PMCID: PMC265136.
    244. Chen DY, Estes MK, Ramig RF. Specific interactions between rotavirus outer capsid proteins VP4 and VP7 determine expression of a cross-reactive, neutralizing VP4-specific epitope. J Virol. 1992 Jan; 66(1):432-9. PMID: 1370090; PMCID: PMC238303.
    245. Zhou YJ, Estes MK, Jiang X, Metcalf TG. Concentration and detection of hepatitis A virus and rotavirus from shellfish by hybridization tests. Appl Environ Microbiol. 1991 Oct; 57(10):2963-8. PMID: 1660697; PMCID: PMC183905.
    246. Kitamoto N, Ramig RF, Matson DO, Estes MK. Comparative growth of different rotavirus strains in differentiated cells (MA104, HepG2, and CaCo-2). Virology. 1991 Oct; 184(2):729-37. PMID: 1653495.
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    247. Conner ME, Gilger MA, Estes MK, Graham DY. Serologic and mucosal immune response to rotavirus infection in the rabbit model. J Virol. 1991 May; 65(5):2562-71. PMID: 1850029; PMCID: PMC240613.
    248. Mattion NM, Mitchell DB, Both GW, Estes MK. Expression of rotavirus proteins encoded by alternative open reading frames of genome segment 11. Virology. 1991 Mar; 181(1):295-304. PMID: 1847258.
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    249. Mattion NM, Estes MK. Sequence of a rotavirus gene 4 associated with unique biologic properties. Arch Virol. 1991; 120(1-2):109-13. PMID: 1656916.
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    250. Xi JN, Graham DY, Wang KN, Estes MK. Norwalk virus genome cloning and characterization. Science. 1990 Dec 14; 250(4987):1580-3. PMID: 2177224.
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    251. Matson DO, Estes MK. Impact of rotavirus infection at a large pediatric hospital. J Infect Dis. 1990 Sep; 162(3):598-604. PMID: 2167331.
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    252. Matson DO, Estes MK, Burns JW, Greenberg HB, Taniguchi K, Urasawa S. Serotype variation of human group A rotaviruses in two regions of the USA. J Infect Dis. 1990 Sep; 162(3):605-14. PMID: 2167332.
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    253. Matson DO, Estes MK, Tanaka T, Bartlett AV, Pickering LK. Asymptomatic human calicivirus infection in a day care center. Pediatr Infect Dis J. 1990 Mar; 9(3):190-6. PMID: 2159612.
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    254. Bellinzoni RB, Mattion NM, Matson DO, Blackhall J, La Torre JL, Scodeller EA, Urasawa S, Taniguchi K, Estes MK. Porcine rotaviruses antigenically related to human rotavirus serotypes 1 and 2. J Clin Microbiol. 1990 Mar; 28(3):633-6. PMID: 2157739; PMCID: PMC269683.
    255. Prasad BV, Burns JW, Marietta E, Estes MK, Chiu W. Localization of VP4 neutralization sites in rotavirus by three-dimensional cryo-electron microscopy. Nature. 1990 Feb 1; 343(6257):476-9. PMID: 2153941.
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    256. Au KS, Chan WK, Burns JW, Estes MK. Receptor activity of rotavirus nonstructural glycoprotein NS28. J Virol. 1989 Nov; 63(11):4553-62. PMID: 2552139; PMCID: PMC251088.
    257. Liu M, Estes MK. Nucleotide sequence of the simian rotavirus SA11 genome segment 3. Nucleic Acids Res. 1989 Oct 11; 17(19):7991. PMID: 2552420; PMCID: PMC334910.
    258. Welch SK, Crawford SE, Estes MK. Rotavirus SA11 genome segment 11 protein is a nonstructural phosphoprotein. J Virol. 1989 Sep; 63(9):3974-82. PMID: 2548010; PMCID: PMC250994.
    259. Bellinzoni R, Xi JA, Tanaka TN, Scodeller E, Estes MK. Rotavirus gene detection with biotinylated single-stranded RNA probes. Mol Cell Probes. 1989 Sep; 3(3):233-44. PMID: 2552300.
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    260. Chen D, Burns JW, Estes MK, Ramig RF. Phenotypes of rotavirus reassortants depend upon the recipient genetic background. Proc Natl Acad Sci U S A. 1989 May; 86(10):3743-7. PMID: 2542946; PMCID: PMC287216.
    261. Xi JN, Estes MK, Metcalf TG. In situ hybridization for quantitative assay of infectious hepatitis A virus. J Clin Microbiol. 1989 May; 27(5):874-9. PMID: 2545742; PMCID: PMC267446.
    262. Burns JW, Chen D, Estes MK, Ramig RF. Biological and immunological characterization of a simian rotavirus SA11 variant with an altered genome segment 4. Virology. 1989 Apr; 169(2):427-35. PMID: 2539699.
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    263. Burns JW, Welch SK, Nakata S, Estes MK. Characterization of monoclonal antibodies to human group B rotavirus and their use in an antigen detection enzyme-linked immunosorbent assay. J Clin Microbiol. 1989 Feb; 27(2):245-50. PMID: 2536755; PMCID: PMC267285.
    264. Estes MK, Conner ME, Gilger MA, Graham DY. Molecular biology and immunology of rotavirus infections. Immunol Invest. 1989 Jan-May; 18(1-4):571-81. PMID: 2659520.
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    265. Matson DO, Estes MK, Glass RI, Bartlett AV, Penaranda M, Calomeni E, Tanaka T, Nakata S, Chiba S. Human calicivirus-associated diarrhea in children attending day care centers. J Infect Dis. 1989 Jan; 159(1):71-8. PMID: 2535867.
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    266. Merson JR, Hull RA, Estes MK, Kasel JA. Molecular cloning and sequence determination of the fusion protein gene of human parainfluenza virus type 1. Virology. 1988 Nov; 167(1):97-105. PMID: 2847427.
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    267. Nakata S, Estes MK, Chiba S. Detection of human calicivirus antigen and antibody by enzyme-linked immunosorbent assays. J Clin Microbiol. 1988 Oct; 26(10):2001-5. PMID: 3182991; PMCID: PMC266805.
    268. Chan WK, Au KS, Estes MK. Topography of the simian rotavirus nonstructural glycoprotein (NS28) in the endoplasmic reticulum membrane. Virology. 1988 Jun; 164(2):435-42. PMID: 2835861.
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    269. Burns JW, Greenberg HB, Shaw RD, Estes MK. Functional and topographical analyses of epitopes on the hemagglutinin (VP4) of the simian rotavirus SA11. J Virol. 1988 Jun; 62(6):2164-72. PMID: 2452900; PMCID: PMC253319.
    270. Conner ME, Estes MK, Graham DY. Rabbit model of rotavirus infection. J Virol. 1988 May; 62(5):1625-33. PMID: 2833612; PMCID: PMC253190.
    271. Liu M, Offit PA, Estes MK. Identification of the simian rotavirus SA11 genome segment 3 product. Virology. 1988 Mar; 163(1):26-32. PMID: 2831664.
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    272. Tanaka TN, Conner ME, Graham DY, Estes MK. Molecular characterization of three rabbit rotavirus strains. Arch Virol. 1988; 98(3-4):253-65. PMID: 2831858.
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    273. Jarvis DL, Chan WK, Estes MK, Butel JS. The cellular secretory pathway is not utilized for biosynthesis, modification, or intracellular transport of the simian virus 40 large tumor antigen. J Virol. 1987 Dec; 61(12):3950-9. PMID: 2824825; PMCID: PMC256015.
    274. Jiang X, Estes MK, Metcalf TG. Detection of hepatitis A virus by hybridization with single-stranded RNA probes. Appl Environ Microbiol. 1987 Oct; 53(10):2487-95. PMID: 2447830; PMCID: PMC204134.
    275. Nakata S, Petrie BL, Calomeni EP, Estes MK. Electron microscopy procedure influences detection of rotaviruses. J Clin Microbiol. 1987 Oct; 25(10):1902-6. PMID: 2444622; PMCID: PMC269364.
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