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JANET S. BUTEL

TitleChair
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular Virology & Microbiology
AddressOne Baylor Plaza
Houston TX 77030
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    Other Positions
    TitleDistinguished Service Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular Virology & Microbiology
    DivisionMolecular Virology & Microbiology


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    Collapse Biography 
    Collapse awards and honors
    1963 - 1966National Science Foundation Graduate Fellowships
    1966Sigma Xi Research Award for Excellence in Research
    1972 - 1976American Cancer Society Faculty Research Award
    1986Joseph L. Melnick Professor of Virology, Baylor College of Medicine
    1988Fellow, American Association for the Advancement of Science
    1995Distinguished Service Professor, Baylor College of Medicine
    1997Included in “Women Pioneers in Texas Medicine” (Silverthorne and Fulgham, Texas A&M Univ. Press)
    20022002 Distinguished Alumnus, Graduate School of Biomedical Sciences Award, Baylor College of Medicine
    2003Kansas State University Alumni Fellow
    2004Fellow, American Academy of Microbiology
    2007Recipient, Am. Assoc. Cancer Research–Women in Cancer Research–Charlotte Friend Memorial Lecture
    2013Kyle and Josephine Morrow Chair in Molecular Virology and Microbiology, Baylor College of Medicine
    2014Honoree, Hearts of Gold: Honoring Women in Health & Medical Science Gala, The Harris County Medical Society and The Health Museum

    Collapse Overview 
    Collapse overview
    Polyomavirus Pathogenesis of Infections and Disease

    The Butel laboratory studies the biology and molecular biology of the polyomaviruses, with a primary focus on polyomavirus SV40. Originally isolated from monkeys, SV40 is a small DNA virus that is able to transform cells in culture and induce tumors in hamsters. As a model tumor virus, SV40 has provided many fundamental insights into the molecular basis of carcinogenesis.

    The large tumor antigen (T-ag) of SV40 is the major transforming protein of the virus, responsible for tumor causation in hamsters and transformation of many cell types in culture. It is a complex protein that possesses multiple functions important for replicating the viral DNA and for dysregulating cell cycle control. Sequence analysis of viral isolates has revealed differences in the structure of the noncoding viral regulatory region as well as the existence of a variable region at the C-terminus of T-ag that can classify SV40 strains into genogroups. We have identified rare variants of polyomaviruses, recovered from immunosuppressed hosts, that have lost the ability to express viral microRNAs.

    We have developed the Syrian golden hamster small animal model to study SV40 pathogenesis of infection and disease. Recent results from the hamster model identified broad tissue tropism for SV40 and provided the first evidence of expression and function of SV40 microRNA in vivo. Viral microRNA reduced viral DNA levels in infected tissues and may contribute to the establishment of persistent infections. Other findings include the significant effect of the structure of the viral regulatory region on both oncogenic potential and vertical transmission in vivo. As there was no effect on transforming activity in vitro, strain-specific factors must affect virus–host interactions that are not detectable using cultured cells. Both viral genetic variation and route of inoculation influence host antibody responses to viral proteins.

    Authentic SV40 can cause human infections. Findings from our studies include the detection of SV40 neutralizing antibodies in various population groups; the fecal excretion of polyomaviruses by humans, indicating a probable fecal–oral route of transmission; the detection of SV40 in normal and malignant lymphoid-rich tissues, suggesting that lymphoid cells are important in the pathogenesis of SV40 infections; and the variable frequency of SV40-positive lymphomas in two urban populations, emphasizing that SV40 infection and disease likely reflect population differences. The interaction of SV40 with human lymphocytes is under study.

    Collapse keywords
    Polyomavirus SV40
    SV40
    Simian virus 40
    Pathogenesis


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Tognon M, Corallini A, Manfrini M, Taronna A, Butel JS, Pietrobon S, Trevisiol L, Bononi I, Vaccher E, Barbanti-Brodano G, Martini F, Mazzoni E. Specific Antibodies Reacting with SV40 Large T Antigen Mimotopes in Serum Samples of Healthy Subjects. PLoS One. 2016; 11(1):e0145720. PMID: 26731525.
      View in: PubMed
    2. Comar M, Wong C, Tognon M, Butel JS. Neutralizing and IgG antibodies against simian virus 40 in healthy pregnant women in Italy. PLoS One. 2014; 9(10):e110700. PMID: 25335106; PMCID: PMC4205009.
    3. Vanchiere JA, Carillo B, Morrow AL, Jiang X, Ruiz-Palacios GM, Butel JS. Fecal Polyomavirus Excretion in Infancy. J Pediatric Infect Dis Soc. 2016 Jun; 5(2):210-3. PMID: 27199472.
      View in: PubMed
    4. Lednicky JA, Butel JS, Luetke MC, Loeb JC. Complete genomic sequence of a new Human polyomavirus 9 strain with an altered noncoding control region. Virus Genes. 2014 Dec; 49(3):490-2. PMID: 25260554.
      View in: PubMed
    5. Chen CJ, Burke JM, Kincaid RP, Azarm KD, Mireles N, Butel JS, Sullivan CS. Naturally arising strains of polyomaviruses with severely attenuated microRNA expression. J Virol. 2014 Nov; 88(21):12683-93. PMID: 25142594; PMCID: PMC4248899.
    6. Zhang S, Sroller V, Zanwar P, Chen CJ, Halvorson SJ, Ajami NJ, Hecksel CW, Swain JL, Wong C, Sullivan CS, Butel JS. Viral microRNA effects on pathogenesis of polyomavirus SV40 infections in syrian golden hamsters. PLoS Pathog. 2014 Feb; 10(2):e1003912. PMID: 24516384; PMCID: PMC3916418.
    7. Jasani B, Butel JS. Can SV40 infect and immortalize human B-lymphocytes and mesothelial cells as a natural pathogen? Leuk Res. 2013 Jun; 37(6):607-8. PMID: 23601746.
      View in: PubMed
    8. Swain JL, Sroller V, Wong C, Zhang S, Halvorson SJ, Herron AJ, Kozinetz CA, Butel JS. Effects of route of inoculation and viral genetic variation on antibody responses to polyomavirus SV40 in Syrian golden hamsters. Comp Med. 2012 Oct; 62(5):400-8. PMID: 23114044; PMCID: PMC3472605.
    9. Wong C, Vilchez RA, Quiroz J, Adam E, Butel JS. Ethnic differences in polyomavirus simian virus 40 seroprevalence among women in Houston, Texas. J Infect. 2013 Jan; 66(1):67-74. PMID: 22940252; PMCID: PMC3518614.
    10. Butel JS, Fan H. The diversity of human cancer viruses. Curr Opin Virol. 2012 Aug; 2(4):449-52. PMID: 22819022.
      View in: PubMed
    11. Kusne S, Vilchez RA, Zanwar P, Quiroz J, Mazur MJ, Heilman RL, Mulligan D, Butel JS. Polyomavirus JC urinary shedding in kidney and liver transplant recipients associated with reduced creatinine clearance. J Infect Dis. 2012 Sep 15; 206(6):875-80. PMID: 22802433; PMCID: PMC3501156.
    12. Butel JS. Patterns of polyomavirus SV40 infections and associated cancers in humans: a model. Curr Opin Virol. 2012 Aug; 2(4):508-14. PMID: 22771310; PMCID: PMC3422415.
    13. Toracchio S, Foyle A, Sroller V, Reed JA, Wu J, Kozinetz CA, Butel JS. Lymphotropism of Merkel cell polyomavirus infection, Nova Scotia, Canada. Emerg Infect Dis. 2010 Nov; 16(11):1702-9. PMID: 21029527; PMCID: PMC3294524.
    14. Broekema NM, Abend JR, Bennett SM, Butel JS, Vanchiere JA, Imperiale MJ. A system for the analysis of BKV non-coding control regions: application to clinical isolates from an HIV/AIDS patient. Virology. 2010 Nov 25; 407(2):368-73. PMID: 20869740; PMCID: PMC2957895.
    15. Thomas LD, Milstone AP, Vilchez RA, Zanwar P, Butel JS, Dummer JS. Polyomavirus infection and its impact on renal function and long-term outcomes after lung transplantation. Transplantation. 2009 Aug 15; 88(3):360-6. PMID: 19667938; PMCID: PMC2752200.
    16. Toracchio S, Kozinetz CA, Killen DE, Sheehan AM, Banez EI, Ittmann MM, Sroller V, Butel JS. Variable frequency of polyomavirus SV40 and herpesvirus EBV in lymphomas from two different urban population groups in Houston, TX. J Clin Virol. 2009 Oct; 46(2):154-60. PMID: 19631582; PMCID: PMC2739273.
    17. Vanchiere JA, Abudayyeh S, Copeland CM, Lu LB, Graham DY, Butel JS. Polyomavirus shedding in the stool of healthy adults. J Clin Microbiol. 2009 Aug; 47(8):2388-91. PMID: 19494079; PMCID: PMC2725650.
    18. Shearer WT, Ochs HD, Lee BN, Cohen EN, Reuben JM, Cheng I, Thompson B, Butel JS, Blancher A, Abbal M, Aviles H, Sonnenfeld G. Immune responses in adult female volunteers during the bed-rest model of spaceflight: antibodies and cytokines. J Allergy Clin Immunol. 2009 Apr; 123(4):900-5. PMID: 19232702.
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    19. Patel NC, Halvorson SJ, Sroller V, Arrington AS, Wong C, Smith EO, Vilchez RA, Butel JS. Viral regulatory region effects on vertical transmission of polyomavirus SV40 in hamsters. Virology. 2009 Mar 30; 386(1):94-101. PMID: 19181358; PMCID: PMC2668977.
    20. McNees AL, Vilchez RA, Heard TC, Sroller V, Wong C, Herron AJ, Hamilton MJ, Davis WC, Butel JS. SV40 lymphomagenesis in Syrian golden hamsters. Virology. 2009 Feb 5; 384(1):114-24. PMID: 19038412; PMCID: PMC3648995.
    21. Javier RT, Butel JS. The history of tumor virology. Cancer Res. 2008 Oct 1; 68(19):7693-706. PMID: 18829521; PMCID: PMC3501656.
    22. Patel NC, Vilchez RA, Killen DE, Zanwar P, Sroller V, Eldin KW, López-Terrada D, Butel JS. Detection of polyomavirus SV40 in tonsils from immunocompetent children. J Clin Virol. 2008 Sep; 43(1):66-72. PMID: 18539521; PMCID: PMC2584969.
    23. Westfall LW, Shearer MH, Jumper CA, White GL, Papin JF, Eberle R, Butel JS, Bright RK, Kennedy RC. Evidence of simian virus 40 exposure in a colony of captive baboons. Virology. 2008 Jul 20; 377(1):54-62. PMID: 18485439; PMCID: PMC2527742.
    24. Sroller V, Vilchez RA, Stewart AR, Wong C, Butel JS. Influence of the viral regulatory region on tumor induction by simian virus 40 in hamsters. J Virol. 2008 Jan; 82(2):871-9. PMID: 17977966; PMCID: PMC2224577.
    25. Comar M, Rizzardi C, de Zotti R, Melato M, Bovenzi M, Butel JS, Campello C. SV40 multiple tissue infection and asbestos exposure in a hyperendemic area for malignant mesothelioma. Cancer Res. 2007 Sep 15; 67(18):8456-9. PMID: 17875683.
      View in: PubMed
    26. Vilchez RA, Butel JS. Polyomavirus SV40 and AIDS-related systemic non-Hodgkin's lymphoma. Cancer Treat Res. 2007; 133:215-40. PMID: 17672043.
      View in: PubMed
    27. Thomas LD, Vilchez RA, White ZS, Zanwar P, Milstone AP, Butel JS, Dummer S. A prospective longitudinal study of polyomavirus shedding in lung-transplant recipients. J Infect Dis. 2007 Feb 1; 195(3):442-9. PMID: 17205484.
      View in: PubMed
    28. Meneses A, Lopez-Terrada D, Zanwar P, Killen DE, Monterroso V, Butel JS, Vilchez RA. Lymphoproliferative disorders in Costa Rica and simian virus 40. Haematologica. 2005 Dec; 90(12):1635-42. PMID: 16330436.
      View in: PubMed
    29. Zhang S, McNees AL, Butel JS. Quantification of vertical transmission of Murine polyoma virus by real-time quantitative PCR. J Gen Virol. 2005 Oct; 86(Pt 10):2721-9. PMID: 16186225.
      View in: PubMed
    30. McNees AL, White ZS, Zanwar P, Vilchez RA, Butel JS. Specific and quantitative detection of human polyomaviruses BKV, JCV, and SV40 by real time PCR. J Clin Virol. 2005 Sep; 34(1):52-62. PMID: 16087125.
      View in: PubMed
    31. Vilchez RA, Lopez-Terrada D, Middleton JR, Finch CJ, Killen DE, Zanwar P, Jorgensen JL, Butel JS. Simian virus 40 tumor antigen expression and immunophenotypic profile of AIDS-related non-Hodgkin's lymphoma. Virology. 2005 Nov 10; 342(1):38-46. PMID: 16122775.
      View in: PubMed
    32. Vanchiere JA, Nicome RK, Greer JM, Demmler GJ, Butel JS. Frequent detection of polyomaviruses in stool samples from hospitalized children. J Infect Dis. 2005 Aug 15; 192(4):658-64. PMID: 16028135; PMCID: PMC4010313.
    33. Shearer WT, Zhang S, Reuben JM, Lee BN, Butel JS. Effects of radiation and latent virus on immune responses in a space flight model. J Allergy Clin Immunol. 2005 Jun; 115(6):1297-303. PMID: 15940150.
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    34. Vanchiere JA, White ZS, Butel JS. Detection of BK virus and simian virus 40 in the urine of healthy children. J Med Virol. 2005 Mar; 75(3):447-54. PMID: 15648074.
      View in: PubMed
    35. Nurgalieva ZZ, Wong C, Zhangabylov AK, Omarbekova ZE, Graham DY, Vilchez RA, Butel JS. Polyomavirus SV40 infections in Kazakhstan. J Infect. 2005 Feb; 50(2):142-8. PMID: 15667916.
      View in: PubMed
    36. Vilchez RA, Brayton CF, Wong C, Zanwar P, Killen DE, Jorgensen JL, Butel JS. Differential ability of two simian virus 40 strains to induce malignancies in weanling hamsters. Virology. 2004 Dec 5; 330(1):168-77. PMID: 15527843.
      View in: PubMed
    37. Forsman ZH, Lednicky JA, Fox GE, Willson RC, White ZS, Halvorson SJ, Wong C, Lewis AM, Butel JS. Phylogenetic analysis of polyomavirus simian virus 40 from monkeys and humans reveals genetic variation. J Virol. 2004 Sep; 78(17):9306-16. PMID: 15308725; PMCID: PMC506915.
    38. Vilchez RA, Butel JS. Emergent human pathogen simian virus 40 and its role in cancer. Clin Microbiol Rev. 2004 Jul; 17(3):495-508, table of contents. PMID: 15258090; PMCID: PMC452549.
    39. Vilchez RA, Butel JS. Re: Lack of serologic evidence for prevalent simian virus 40 infection in humans. J Natl Cancer Inst. 2004 Apr 21; 96(8):633; author reply 633-4. PMID: 15100343.
      View in: PubMed
    40. Milstone A, Vilchez RA, Geiger X, Fogo AB, Butel JS, Dummer S. Polyomavirus simian virus 40 infection associated with nephropathy in a lung-transplant recipient. Transplantation. 2004 Apr 15; 77(7):1019-24. PMID: 15087764.
      View in: PubMed
    41. Arrington AS, Moore MS, Butel JS. SV40-positive brain tumor in scientist with risk of laboratory exposure to the virus. Oncogene. 2004 Mar 18; 23(12):2231-5. PMID: 14676832.
      View in: PubMed
    42. Vilchez RA, Butel JS. Polyomavirus SV40 infection and lymphomas in Spain. Int J Cancer. 2003 Nov 10; 107(3):505-6; author reply 507-8. PMID: 14506754.
      View in: PubMed
    43. Ling PD, Vilchez RA, Keitel WA, Poston DG, Peng RS, White ZS, Visnegarwala F, Lewis DE, Butel JS. Epstein-Barr virus DNA loads in adult human immunodeficiency virus type 1-infected patients receiving highly active antiretroviral therapy. Clin Infect Dis. 2003 Nov 1; 37(9):1244-9. PMID: 14557970.
      View in: PubMed
    44. Vilchez RA, Butel JS. Simian virus 40 and its association with human lymphomas. Curr Oncol Rep. 2003 Sep; 5(5):372-9. PMID: 12895387.
      View in: PubMed
    45. Vilchez RA, Arrington AS, Butel JS. Re: Cancer incidence in Denmark following exposure to poliovirus vaccine contaminated with simian virus 40. J Natl Cancer Inst. 2003 Aug 20; 95(16):1249; author reply 1250. PMID: 12928352.
      View in: PubMed
    46. Vilchez RA, Butel JS. SV40 in human brain cancers and non-Hodgkin's lymphoma. Oncogene. 2003 Aug 11; 22(33):5164-72. PMID: 12910253.
      View in: PubMed
    47. Vilchez RA, Kozinetz CA, Arrington AS, Madden CR, Butel JS. Simian virus 40 in human cancers. Am J Med. 2003 Jun 1; 114(8):675-84. PMID: 12798456.
      View in: PubMed
    48. Vilchez RA, Butel JS. Re: Trends in U.S. pleural mesothelioma incidence rates following simian virus 40 contamination of early poliovirus vaccines. J Natl Cancer Inst. 2003 May 7; 95(9):687; author reply 689. PMID: 12734326.
      View in: PubMed
    49. Vilchez RA, Butel JS. Simian virus 40 infection in lymphoproliferative disorders. Lancet. 2003 May 3; 361(9368):1565; author reply 1565-6. PMID: 12737902.
      View in: PubMed
    50. Ling PD, Lednicky JA, Keitel WA, Poston DG, White ZS, Peng R, Liu Z, Mehta SK, Pierson DL, Rooney CM, Vilchez RA, Smith EO, Butel JS. The dynamics of herpesvirus and polyomavirus reactivation and shedding in healthy adults: a 14-month longitudinal study. J Infect Dis. 2003 May 15; 187(10):1571-80. PMID: 12721937.
      View in: PubMed
    51. Lednicky JA, Vilchez RA, Keitel WA, Visnegarwala F, White ZS, Kozinetz CA, Lewis DE, Butel JS. Polyomavirus JCV excretion and genotype analysis in HIV-infected patients receiving highly active antiretroviral therapy. AIDS. 2003 Apr 11; 17(6):801-7. PMID: 12660526.
      View in: PubMed
    52. Vilchez RA, Kozinetz CA, Butel JS. Conventional epidemiology and the link between SV40 and human cancers. Lancet Oncol. 2003 Mar; 4(3):188-91. PMID: 12623365.
      View in: PubMed
    53. Butel JS, Wong C, Vilchez RA, Szücs G, Dömök I, Kríz B, Slonim D, Adam E. Detection of antibodies to polyomavirus SV40 in two central European countries. Cent Eur J Public Health. 2003 Mar; 11(1):3-8. PMID: 12690795.
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    54. Vilchez RA, Finch CJ, Jorgensen JL, Butel JS. The clinical epidemiology of Hodgkin lymphoma in HIV-infected patients in the highly active antiretroviral therapy (HAART) era. Medicine (Baltimore). 2003 Mar; 82(2):77-81. PMID: 12640183.
      View in: PubMed
    55. Sonnenfeld G, Butel JS, Shearer WT. Effects of the space flight environment on the immune system. Rev Environ Health. 2003 Jan-Mar; 18(1):1-17. PMID: 12875508.
      View in: PubMed
    56. Vilchez RA, Butel JS. An overview of the biology and viral pathogenesis of lymphoproliferative disorders in HIV-infected patients. Res Initiat Treat Action. 2003; 9(1):14-8. PMID: 14971361.
      View in: PubMed
    57. Butel JS, Vilchez RA, Jorgensen JL, Kozinetz CA. Association between SV40 and non-Hodgkin's lymphoma. Leuk Lymphoma. 2003; 44 Suppl 3:S33-9. PMID: 15202523.
      View in: PubMed
    58. Gazdar AF, Butel JS, Carbone M. SV40 and human tumours: myth, association or causality? Nat Rev Cancer. 2002 Dec; 2(12):957-64. PMID: 12459734.
      View in: PubMed
    59. Kwak EJ, Vilchez RA, Randhawa P, Shapiro R, Butel JS, Kusne S. Pathogenesis and management of polyomavirus infection in transplant recipients. Clin Infect Dis. 2002 Nov 1; 35(9):1081-7. PMID: 12384842.
      View in: PubMed
    60. Vilchez RA, Butel JS, Kusne S. Polyomaviruses in solid-organ transplant recipients. Transplantation. 2002 Aug 27; 74(4):579-80; author reply 580-1. PMID: 12352925.
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    61. Vilchez RA, Arrington AS, Butel JS. Polyomaviruses in kidney transplant recipients. Am J Transplant. 2002 May; 2(5):481. PMID: 12123217.
      View in: PubMed
    62. Vilchez RA, Madden CR, Kozinetz CA, Halvorson SJ, White ZS, Jorgensen JL, Finch CJ, Butel JS. Association between simian virus 40 and non-Hodgkin lymphoma. Lancet. 2002 Mar 9; 359(9309):817-23. PMID: 11897278.
      View in: PubMed
    63. Vilchez RA, Kozinetz CA, Jorgensen JL, Kroll MH, Butel JS. AIDS-related systemic non-Hodgkin's lymphoma at a large community program. AIDS Res Hum Retroviruses. 2002 Mar 1; 18(4):237-42. PMID: 11860669.
      View in: PubMed
    64. Lednicky JA, Halvorson SJ, Butel JS. PCR detection and DNA sequence analysis of the regulatory region of lymphotropic papovavirus in peripheral blood mononuclear cells of an immunocompromised rhesus macaque. J Clin Microbiol. 2002 Mar; 40(3):1056-9. PMID: 11880438; PMCID: PMC120229.
    65. Vilchez RA, Lednicky JA, Halvorson SJ, White ZS, Kozinetz CA, Butel JS. Detection of polyomavirus simian virus 40 tumor antigen DNA in AIDS-related systemic non-Hodgkin lymphoma. J Acquir Immune Defic Syndr. 2002 Feb 1; 29(2):109-16. PMID: 11832678.
      View in: PubMed
    66. Hollmann CA, Kittrell FS, Medina D, Butel JS. Wnt-1 and int-2 mammary oncogene effects on the beta-catenin pathway in immortalized mouse mammary epithelial cells are not sufficient for tumorigenesis. Oncogene. 2001 Nov 15; 20(52):7645-57. PMID: 11753642.
      View in: PubMed
    67. Vilchez RA, Kozinetz CA, Butel JS. The changing incidence of four AIDS-related malignancies in a large urban center. AIDS Patient Care STDS. 2001 Aug; 15(8):405-6. PMID: 11522213.
      View in: PubMed
    68. Lednicky JA, Butel JS. Simian virus 40 regulatory region structural diversity and the association of viral archetypal regulatory regions with human brain tumors. Semin Cancer Biol. 2001 Feb; 11(1):39-47. PMID: 11243898.
      View in: PubMed
    69. Butel JS. Increasing evidence for involvement of SV40 in human cancer. Dis Markers. 2001; 17(3):167-72. PMID: 11790883; PMCID: PMC3851658.
    70. Vilchez R, Butel JS. Systemic non-Hodgkin's lymphoma in persons with HIV infection. Res Initiat Treat Action. 2000 Sep; 6(3):15-8. PMID: 11708161.
      View in: PubMed
    71. Butel JS, Lednicky JA. Response to more about: cell and molecular biology of simian virus 40: implications for human infections and disease. J Natl Cancer Inst. 2000 Mar 15; 92(6):496-7. PMID: 10716972.
      View in: PubMed
    72. Butel JS. Viral carcinogenesis: revelation of molecular mechanisms and etiology of human disease. Carcinogenesis. 2000 Mar; 21(3):405-26. PMID: 10688861.
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    73. Arrington AS, Lednicky JA, Butel JS. Molecular characterization of SV40 DNA in multiple samples from a human mesothelioma. Anticancer Res. 2000 Mar-Apr; 20(2A):879-84. PMID: 10810370.
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    74. Jerry DJ, Kittrell FS, Kuperwasser C, Laucirica R, Dickinson ES, Bonilla PJ, Butel JS, Medina D. A mammary-specific model demonstrates the role of the p53 tumor suppressor gene in tumor development. Oncogene. 2000 Feb 21; 19(8):1052-8. PMID: 10713689.
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    75. Hollmann CA, Medina D, Butel JS. Transfection of mouse mammary epithelial cells. In Vitro Cell Dev Biol Anim. 2000 Feb; 36(2):74-6. PMID: 10718361.
      View in: PubMed
    76. Butel JS. Simian virus 40, poliovirus vaccines, and human cancer: research progress versus media and public interests. Bull World Health Organ. 2000; 78(2):195-8. PMID: 10743284; PMCID: PMC2560680.
    77. Butel JS, Jafar S, Wong C, Arrington AS, Opekun AR, Finegold MJ, Adam E. Evidence of SV40 infections in hospitalized children. Hum Pathol. 1999 Dec; 30(12):1496-502. PMID: 10667429.
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    78. Butel JS, Arrington AS, Wong C, Lednicky JA, Finegold MJ. Molecular evidence of simian virus 40 infections in children. J Infect Dis. 1999 Sep; 180(3):884-7. PMID: 10438386.
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    79. Pinkas J, Naber SP, Butel JS, Medina D, Jerry DJ. Expression of MDM2 during mammary tumorigenesis. Int J Cancer. 1999 Apr 12; 81(2):292-8. PMID: 10188733.
      View in: PubMed
    80. Lednicky JA, Butel JS. Polyomaviruses and human tumors: a brief review of current concepts and interpretations. Front Biosci. 1999 Feb 15; 4:D153-64. PMID: 9989950.
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    81. Butel JS, Lednicky JA. Cell and molecular biology of simian virus 40: implications for human infections and disease. J Natl Cancer Inst. 1999 Jan 20; 91(2):119-34. PMID: 9923853.
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    82. Medina D, Stephens LC, Bonilla PJ, Hollmann CA, Schwahn D, Kuperwasser C, Jerry DJ, Butel JS, Meyn RE. Radiation-induced tumorigenesis in preneoplastic mouse mammary glands in vivo: significance of p53 status and apoptosis. Mol Carcinog. 1998 Jul; 22(3):199-207. PMID: 9688146.
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    83. Lednicky JA, Arrington AS, Stewart AR, Dai XM, Wong C, Jafar S, Murphey-Corb M, Butel JS. Natural isolates of simian virus 40 from immunocompromised monkeys display extensive genetic heterogeneity: new implications for polyomavirus disease. J Virol. 1998 May; 72(5):3980-90. PMID: 9557685; PMCID: PMC109625.
    84. Stewart AR, Lednicky JA, Butel JS. Sequence analyses of human tumor-associated SV40 DNAs and SV40 viral isolates from monkeys and humans. J Neurovirol. 1998 Apr; 4(2):182-93. PMID: 9584955.
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    85. Jafar S, Rodriguez-Barradas M, Graham DY, Butel JS. Serological evidence of SV40 infections in HIV-infected and HIV-negative adults. J Med Virol. 1998 Apr; 54(4):276-84. PMID: 9557293.
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    86. Becker SA, Lee TH, Butel JS, Slagle BL. Hepatitis B virus X protein interferes with cellular DNA repair. J Virol. 1998 Jan; 72(1):266-72. PMID: 9420223; PMCID: PMC109372.
    87. Lednicky JA, Butel JS. Consideration of PCR methods for the detection of SV40 in tissue and DNA specimens. Dev Biol Stand. 1998; 94:155-64. PMID: 9776238.
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    88. Tevethia SS, Mylin L, Newmaster R, Epler M, Lednicky JA, Butel JS, Tevethia MJ. Cytotoxic T lymphocyte recognition sequences as markers for distinguishing among tumour antigens encoded by SV40, BKV and JCV. Dev Biol Stand. 1998; 94:329-39. PMID: 9776254.
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    89. Levine A, Butel J, Dörries K, Goedert J, Frisque R, Garcea R, Morris A, O'Neill F, Shah K. SV40 as a putative human commensal. Dev Biol Stand. 1998; 94:245-69. PMID: 9776246.
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    90. Butel JS, Jafar S, Stewart AR, Lednicky JA. Detection of authentic SV40 DNA sequences in human brain and bone tumours. Dev Biol Stand. 1998; 94:23-32. PMID: 9776222.
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    91. Lednicky JA, Stewart AR, Jenkins JJ, Finegold MJ, Butel JS. SV40 DNA in human osteosarcomas shows sequence variation among T-antigen genes. Int J Cancer. 1997 Sep 4; 72(5):791-800. PMID: 9311596.
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    92. Rubelj I, Venable SF, Lednicky J, Butel JS, Bilyeu T, Darlington G, Surmacz E, Campisi J, Pereira-Smith OM. Loss of T-antigen sequences allows SV40-transformed human cells in crisis to acquire a senescent-like phenotype. J Gerontol A Biol Sci Med Sci. 1997 Sep; 52(5):B229-34. PMID: 9310070.
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    93. Sitterlin D, Lee TH, Prigent S, Tiollais P, Butel JS, Transy C. Interaction of the UV-damaged DNA-binding protein with hepatitis B virus X protein is conserved among mammalian hepadnaviruses and restricted to transactivation-proficient X-insertion mutants. J Virol. 1997 Aug; 71(8):6194-9. PMID: 9223516; PMCID: PMC191882.
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    96. Al-Ubaidi MR, Mangini NJ, Quiambao AB, Myers KM, Abler AS, Chang CJ, Tso MO, Butel JS, Hollyfield JG. Unscheduled DNA replication precedes apoptosis of photoreceptors expressing SV40 T antigen. Exp Eye Res. 1997 Apr; 64(4):573-85. PMID: 9227276.
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    98. Krishnamoorthy RR, Lee TH, Butel JS, Das HK. Apolipoprotein B gene regulatory factor-2 (BRF-2) is structurally and immunologically highly related to hepatitis B virus X associated protein-1 (XAP-1). Biochemistry. 1997 Jan 28; 36(4):960-9. PMID: 9020796.
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    99. Lednicky JA, Jafar S, Wong C, Butel JS. High-fidelity PCR amplification of infectious copies of the complete simian virus 40 genome from plasmids and virus-infected cell lysates. Gene. 1997 Jan 15; 184(2):189-95. PMID: 9031627.
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    100. Marriott SJ, Lee TH, Slagle BL, Butel JS. Activation of the HTLV-I long terminal repeat by the hepatitis B virus X protein. Virology. 1996 Oct 1; 224(1):206-13. PMID: 8862415.
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    101. Stewart AR, Lednicky JA, Benzick US, Tevethia MJ, Butel JS. Identification of a variable region at the carboxy terminus of SV40 large T-antigen. Virology. 1996 Jul 15; 221(2):355-61. PMID: 8661447.
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    102. Slagle BL, Lee TH, Medina D, Finegold MJ, Butel JS. Increased sensitivity to the hepatocarcinogen diethylnitrosamine in transgenic mice carrying the hepatitis B virus X gene. Mol Carcinog. 1996 Apr; 15(4):261-9. PMID: 8634084.
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    103. Butel JS, Lee TH, Slagle BL. Is the DNA repair system involved in hepatitis-B-virus-mediated hepatocellular carcinogenesis? Trends Microbiol. 1996 Mar; 4(3):119-24. PMID: 8868091.
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    104. Lednicky JA, Garcea RL, Bergsagel DJ, Butel JS. Natural simian virus 40 strains are present in human choroid plexus and ependymoma tumors. Virology. 1995 Oct 1; 212(2):710-7. PMID: 7571441.
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    105. Mukhopadhyay R, Medina D, Butel JS. Expression of the mouse mammary tumor virus long terminal repeat open reading frame promotes tumorigenic potential of hyperplastic mouse mammary epithelial cells. Virology. 1995 Aug 1; 211(1):74-93. PMID: 7645239.
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    106. Lopez-Cepero M, Wang Y, Keydar I, Brandt-Carlson C, Butel JS, Lopez DM. Detection of retroviral superantigen and products of the envelope gene from endogenous mouse mammary tumor virus in B cells from BALB/c mice. Cell Immunol. 1995 Jul; 163(2):191-7. PMID: 7606792.
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    107. Aguilar-Cordova E, Chinen J, Donehower LA, Harper JW, Rice AP, Butel JS, Belmont JW. Inhibition of HIV-1 by a double transdominant fusion gene. Gene Ther. 1995 May; 2(3):181-6. PMID: 7614248.
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    108. Lednicky JA, Wong C, Butel JS. Artificial modification of the viral regulatory region improves tissue culture growth of SV40 strain 776. Virus Res. 1995 Feb; 35(2):143-53. PMID: 7762288.
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    109. Lee TH, Elledge SJ, Butel JS. Hepatitis B virus X protein interacts with a probable cellular DNA repair protein. J Virol. 1995 Feb; 69(2):1107-14. PMID: 7815490; PMCID: PMC188683.
    110. Ozbun MA, Butel JS. Tumor suppressor p53 mutations and breast cancer: a critical analysis. Adv Cancer Res. 1995; 66:71-141. PMID: 7793321.
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    111. Butel JS, Lee TH, Slagle BL. Viral co-factors in liver cancer: lessons from hepatitis B virus. Princess Takamatsu Symp. 1995; 25:185-98. PMID: 8875624.
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    112. Fromm L, Shawlot W, Gunning K, Butel JS, Overbeek PA. The retinoblastoma protein-binding region of simian virus 40 large T antigen alters cell cycle regulation in lenses of transgenic mice. Mol Cell Biol. 1994 Oct; 14(10):6743-54. PMID: 7935393; PMCID: PMC359205.
    113. Sawai ET, Rasmussen G, Butel JS. Construction of SV40 deletion mutants and delimitation of the binding domain for heat shock protein to the amino terminus of large T-antigen. Virus Res. 1994 Mar; 31(3):367-78. PMID: 8191789.
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    114. Jerry DJ, Butel JS, Donehower LA, Paulson EJ, Cochran C, Wiseman RW, Medina D. Infrequent p53 mutations in 7,12-dimethylbenz[a]anthracene-induced mammary tumors in BALB/c and p53 hemizygous mice. Mol Carcinog. 1994 Mar; 9(3):175-83. PMID: 8142019.
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    115. Jerry DJ, Medina D, Butel JS. p53 mutations in COMMA-D cells. In Vitro Cell Dev Biol Anim. 1994 Feb; 30A(2):87-9. PMID: 8012661.
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    116. Hsu HC, Peng SY, Lai PL, Sheu JC, Chen DS, Lin LI, Slagle BL, Butel JS. Allelotype and loss of heterozygosity of p53 in primary and recurrent hepatocellular carcinomas. A study of 150 patients. Cancer. 1994 Jan 1; 73(1):42-7. PMID: 7506118.
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    117. Harvey M, McArthur MJ, Montgomery CA, Butel JS, Bradley A, Donehower LA. Spontaneous and carcinogen-induced tumorigenesis in p53-deficient mice. Nat Genet. 1993 Nov; 5(3):225-9. PMID: 8275085.
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    118. Ozbun MA, Medina D, Butel JS. p53 mutations in mouse mammary epithelial cells: instability in culture and discordant selection of mutations in vitro versus in vivo. Cell Growth Differ. 1993 Oct; 4(10):811-9. PMID: 8274450.
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    119. Jerry DJ, Ozbun MA, Kittrell FS, Lane DP, Medina D, Butel JS. Mutations in p53 are frequent in the preneoplastic stage of mouse mammary tumor development. Cancer Res. 1993 Jul 15; 53(14):3374-81. PMID: 8324748.
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    120. Ozbun MA, Jerry DJ, Kittrell FS, Medina D, Butel JS. p53 mutations selected in vivo when mouse mammary epithelial cells form hyperplastic outgrowths are not necessary for establishment of mammary cell lines in vitro. Cancer Res. 1993 Apr 1; 53(7):1646-52. PMID: 8453637.
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    121. Brandt-Carlson C, Butel JS, Wheeler D. Phylogenetic and structural analyses of MMTV LTR ORF sequences of exogenous and endogenous origins. Virology. 1993 Mar; 193(1):171-85. PMID: 8382394.
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    122. Wolff J, Wong C, Cheng H, Poyet P, Butel JS, Rosen JM. Differential effects of the simian virus 40 early genes on mammary epithelial cell growth, morphology, and gene expression. Exp Cell Res. 1992 Sep; 202(1):67-76. PMID: 1324845.
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    123. Sawai ET, Butel JS. Epitope mapping and conformational analysis of SV40 T-antigen deletion mutants. Virology. 1992 Aug; 189(2):782-5. PMID: 1379393.
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    124. Bergsagel DJ, Finegold MJ, Butel JS, Kupsky WJ, Garcea RL. DNA sequences similar to those of simian virus 40 in ependymomas and choroid plexus tumors of childhood. N Engl J Med. 1992 Apr 9; 326(15):988-93. PMID: 1312224.
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    125. Donehower LA, Harvey M, Slagle BL, McArthur MJ, Montgomery CA, Butel JS, Bradley A. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature. 1992 Mar 19; 356(6366):215-21. PMID: 1552940.
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    126. Scorsone KA, Zhou YZ, Butel JS, Slagle BL. p53 mutations cluster at codon 249 in hepatitis B virus-positive hepatocellular carcinomas from China. Cancer Res. 1992 Mar 15; 52(6):1635-8. PMID: 1311638.
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    127. Slagle BL, Lee TH, Butel JS. Hepatitis B virus and hepatocellular carcinoma. Prog Med Virol. 1992; 39:167-203. PMID: 1317597.
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    128. Brandt-Carlson C, Butel JS. Detection and characterization of a glycoprotein encoded by the mouse mammary tumor virus long terminal repeat gene. J Virol. 1991 Nov; 65(11):6051-60. PMID: 1656086; PMCID: PMC250273.
    129. Markesich DC, Sawai ET, Butel JS, Graham DY. Investigations on etiology of Crohn's disease. Humoral immune response to stress (heat shock) proteins. Dig Dis Sci. 1991 Apr; 36(4):454-60. PMID: 1901035.
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    130. Maxwell SA, Ames SK, Sawai ET, Decker GL, Cook RG, Butel JS. Simian virus 40 large T antigen and p53 are microtubule-associated proteins in transformed cells. Cell Growth Differ. 1991 Feb; 2(2):115-27. PMID: 1648952.
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    131. Slagle BL, Zhou YZ, Butel JS. Hepatitis B virus integration event in human chromosome 17p near the p53 gene identifies the region of the chromosome commonly deleted in virus-positive hepatocellular carcinomas. Cancer Res. 1991 Jan 1; 51(1):49-54. PMID: 1670994.
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    132. Lee TH, Finegold MJ, Shen RF, DeMayo JL, Woo SL, Butel JS. Hepatitis B virus transactivator X protein is not tumorigenic in transgenic mice. J Virol. 1990 Dec; 64(12):5939-47. PMID: 2243380; PMCID: PMC248767.
    133. Durban EM, Knepper JE, Medina D, Butel JS. Influence of mammary cell differentiation on the expression of proteins encoded by endogenous BALB/c mouse mammary tumor virus genes. Virus Res. 1990 Jul; 16(3):307-23. PMID: 2168113.
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    134. Butel JS, Sepulveda AR, Finegold MJ, Woo SL. SV40 large T antigen directed by regulatory elements of the human alpha-1-antitrypsin gene. A transgenic mouse system that exhibits stages in liver carcinogenesis. Intervirology. 1990; 31(2-4):85-100. PMID: 2142679.
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    135. Sepulveda AR, Finegold MJ, Smith B, Slagle BL, DeMayo JL, Shen RF, Woo SL, Butel JS. Development of a transgenic mouse system for the analysis of stages in liver carcinogenesis using tissue-specific expression of SV40 large T-antigen controlled by regulatory elements of the human alpha-1-antitrypsin gene. Cancer Res. 1989 Nov 1; 49(21):6108-17. PMID: 2551499.
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    136. Sawai ET, Butel JS. Association of a cellular heat shock protein with simian virus 40 large T antigen in transformed cells. J Virol. 1989 Sep; 63(9):3961-73. PMID: 2760986; PMCID: PMC250993.
    137. Danielson KG, Knepper JE, Kittrell FS, Butel JS, Medina D, Durban EM. Clonal populations of the mouse mammary cell line, COMMA-D, which retain capability of morphogenesis in vivo. In Vitro Cell Dev Biol. 1989 Jun; 25(6):535-43. PMID: 2544547.
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    138. Donehower LA, Slagle BL, Wilde M, Darlington G, Butel JS. Identification of a conserved sequence in the non-coding regions of many human genes. Nucleic Acids Res. 1989 Jan 25; 17(2):699-710. PMID: 2536922; PMCID: PMC331613.
    139. Butel JS, Jarvis DL, Maxwell SA. SV40 T-antigen as a dual oncogene: structure and function of the plasma membrane-associated population. Ann N Y Acad Sci. 1989; 567:104-21. PMID: 2552888.
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    140. Maxwell SA, Santos M, Wong C, Rasmussen G, Butel JS. Solubilization of SV40 plasma-membrane-associated large tumor antigen using single-phase concentrations of 1-butanol. Mol Carcinog. 1989; 2(6):322-35. PMID: 2533506.
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    141. Knepper JE, Kittrell FS, Medina D, Butel JS. Spontaneous progression of hyperplastic outgrowths of the D1 lineage to mammary tumors: expression of mouse mammary tumor virus and cellular proto-oncogenes. Mol Carcinog. 1989; 1(4):229-38. PMID: 2551332.
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    142. Melnick JL, Butel JS. Neurologic tumors in offspring after inoculation of mothers with killed-poliovirus vaccine. N Engl J Med. 1988 Nov 3; 319(18):1226. PMID: 2845271.
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    143. Zhou YZ, Slagle BL, Donehower LA, vanTuinen P, Ledbetter DH, Butel JS. Structural analysis of a hepatitis B virus genome integrated into chromosome 17p of a human hepatocellular carcinoma. J Virol. 1988 Nov; 62(11):4224-31. PMID: 2845134; PMCID: PMC253855.
    144. Jarvis DL, Butel JS. Biochemical properties of SV40 large tumor antigen as a glycosylated protein. J Biol Chem. 1988 Oct 25; 263(30):15288-96. PMID: 3170583.
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    145. Jarvis DL, Chan WK, Estes MK, Butel JS. The cellular secretory pathway is not utilized for biosynthesis, modification, or intracellular transport of the simian virus 40 large tumor antigen. J Virol. 1987 Dec; 61(12):3950-9. PMID: 2824825; PMCID: PMC256015.
    146. Knepper JE, Medina D, Butel JS. Activation of endogenous MMTV proviruses in murine mammary cancer induced by chemical carcinogen. Int J Cancer. 1987 Sep 15; 40(3):414-22. PMID: 3040604.
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    147. Pinkert CA, Brinster RL, Palmiter RD, Wong C, Butel JS. Tumorigenesis in transgenic mice by a nuclear transport-defective SV40 large T-antigen gene. Virology. 1987 Sep; 160(1):169-75. PMID: 2820126.
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    148. Zhou YZ, Butel JS, Li PJ, Finegold MJ, Melnick JL. Integrated state of subgenomic fragments of hepatitis B virus DNA in hepatocellular carcinoma from mainland China. J Natl Cancer Inst. 1987 Aug; 79(2):223-31. PMID: 3037150.
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    149. Slagle BL, Medina D, Butel JS. Mammary cancer stages in BALB/cV mice: mouse mammary tumor virus expression and virus-host interactions. J Natl Cancer Inst. 1987 Aug; 79(2):323-35. PMID: 3037152.
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    150. Gama-Sosa MA, Breznik T, Butel JS, Medina D, Cohen JC. Mammary preneoplasia and tumorigenesis in the BALB/c mouse: structure and modification of mouse mammary tumor virus DNA sequences. Virus Res. 1987 Feb; 7(1):1-15. PMID: 3031894.
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    151. Butel JS, Wong C, Evans BK. Fluctuation of simian virus 40 (SV40) super T-antigen expression in tumors induced by SV40-transformed mouse mammary epithelial cells. J Virol. 1986 Nov; 60(2):817-21. PMID: 3022016; PMCID: PMC288965.
    152. Lanford RE, Jacob JR, Butel JS. Genomic organization of the simian virus 40-adenovirus 7 hybrid virus, PARA(cT), that encodes a nuclear transport defective simian virus 40 T antigen. Virology. 1986 Nov; 155(1):271-6. PMID: 3022475.
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    153. Butel JS, Jarvis DL. The plasma-membrane-associated form of SV40 large tumor antigen: biochemical and biological properties. Biochim Biophys Acta. 1986 Oct 28; 865(2):171-95. PMID: 3021222.
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    154. Knepper JE, Medina D, Butel JS. Differential expression of endogenous mouse mammary tumor virus genes during development of the BALB/c mammary gland. J Virol. 1986 Aug; 59(2):518-21. PMID: 3016314; PMCID: PMC253107.
    155. Lumpkin CK, Knepper JE, Butel JS, Smith JR, Pereira-Smith OM. Mitogenic effects of the proto-oncogene and oncogene forms of c-H-ras DNA in human diploid fibroblasts. Mol Cell Biol. 1986 Aug; 6(8):2990-3. PMID: 3785220; PMCID: PMC367870.
    156. Jarvis DL, Cole CN, Butel JS. Absence of a structural basis for intracellular recognition and differential localization of nuclear and plasma membrane-associated forms of simian virus 40 large tumor antigen. Mol Cell Biol. 1986 Mar; 6(3):758-67. PMID: 3022127; PMCID: PMC367576.
    157. Butel JS. SV40 large T-antigen: dual oncogene. Cancer Surv. 1986; 5(2):343-65. PMID: 3022925.
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    158. Amini S, Lewis AM, Israel MA, Butel JS, Bolen JB. Analysis of pp60c-src protein kinase activity in hamster embryo cells transformed by simian virus 40, human adenoviruses, and bovine papillomavirus 1. J Virol. 1986 Jan; 57(1):357-61. PMID: 2416954; PMCID: PMC252736.
    159. Lanford RE, Butel JS. Replicative functions of the SV40(cT)-3 mutant defective for nuclear transport of T antigen. Virology. 1985 Nov; 147(1):72-80. PMID: 2998072.
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    160. Kennedy RC, Dreesman GR, Butel JS, Lanford RE. Suppression of in vivo tumor formation induced by simian virus 40-transformed cells in mice receiving antiidiotypic antibodies. J Exp Med. 1985 Jun 1; 161(6):1432-49. PMID: 2409201; PMCID: PMC2187644.
    161. Durban EM, Medina D, Butel JS. Comparative analysis of casein synthesis during mammary cell differentiation in collagen and mammary gland development in vivo. Dev Biol. 1985 Jun; 109(2):288-98. PMID: 3996752.
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    162. Lanford RE, Hyland JK, Baserga R, Butel JS. Induction of cellular DNA synthesis by a simian virus 40 mutant defective in nuclear transport of T antigen. Mol Cell Biol. 1985 Jun; 5(6):1531-3. PMID: 2993869; PMCID: PMC366887.
    163. Santos M, Butel JS. Surface T-antigen expression in simian virus 40-transformed mouse cells: correlation with cell growth rate. Mol Cell Biol. 1985 May; 5(5):1051-7. PMID: 2987673; PMCID: PMC366821.
    164. Slagle BL, Wheeler DA, Hager GL, Medina D, Butel JS. Molecular basis of altered mouse mammary tumor virus expression in the D-2 hyperplastic alveolar nodule line of BALB/c mice. Virology. 1985 May; 143(1):1-15. PMID: 2414907.
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    165. Slagle BL, Butel JS. Identification and characterization of a mouse mammary tumor virus protein uniquely expressed on the surface of BALB/cV mammary tumor cells. Virology. 1985 May; 143(1):127-42. PMID: 2997998.
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    166. Lanford RE, Wong C, Butel JS. Differential ability of a T-antigen transport-defective mutant of simian virus 40 to transform primary and established rodent cells. Mol Cell Biol. 1985 May; 5(5):1043-50. PMID: 2987672; PMCID: PMC366820.
    167. Jarvis DL, Butel JS. Modification of simian virus 40 large tumor antigen by glycosylation. Virology. 1985 Mar; 141(2):173-89. PMID: 3002015.
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    168. Lane HW, Butel JS, Howard C, Shepherd F, Halligan R, Medina D. The role of high levels of dietary fat in 7,12-dimethylbenzanthracene-induced mouse mammary tumorigenesis: lack of an effect on lipid peroxidation. Carcinogenesis. 1985 Mar; 6(3):403-7. PMID: 3919956.
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    169. Santos M, Butel JS. Antigenic structure of simian virus 40 large tumor antigen and association with cellular protein p53 on the surfaces of simian virus 40-infected and -transformed cells. J Virol. 1984 Aug; 51(2):376-83. PMID: 6205166; PMCID: PMC254448.
    170. Breznik T, Traina-Dorge V, Gama-Sosa M, Gehrke CW, Ehrlich M, Medina D, Butel JS, Cohen JC. Mouse mammary tumor virus DNA methylation: tissue-specific variation. Virology. 1984 Jul 15; 136(1):69-77. PMID: 6330997.
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    171. Lanford RE, Butel JS. Construction and characterization of an SV40 mutant defective in nuclear transport of T antigen. Cell. 1984 Jul; 37(3):801-13. PMID: 6086146.
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    172. Danielson KG, Oborn CJ, Durban EM, Butel JS, Medina D. Epithelial mouse mammary cell line exhibiting normal morphogenesis in vivo and functional differentiation in vitro. Proc Natl Acad Sci U S A. 1984 Jun; 81(12):3756-60. PMID: 6587390; PMCID: PMC345298.
    173. Scheidtmann KH, Schickedanz J, Walter G, Lanford RE, Butel JS. Differential phosphorylation of cytoplasmic and nuclear variants of simian virus 40 large T antigen encoded by simian virus 40-adenovirus 7 hybrid viruses. J Virol. 1984 May; 50(2):636-40. PMID: 6323765; PMCID: PMC255692.
    174. Slagle BL, Lanford RE, Medina D, Butel JS. Expression of mammary tumor virus proteins in preneoplastic outgrowth lines and mammary tumors of BALB/cV mice. Cancer Res. 1984 May; 44(5):2155-62. PMID: 6324998.
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    175. Jarvis DL, Lanford RE, Butel JS. Structural comparisons of wild-type and nuclear transport-defective simian virus 40 large tumor antigens. Virology. 1984 Apr 15; 134(1):168-76. PMID: 6324467.
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    176. Butel JS, Wong C, Medina D. Transformation of mouse mammary epithelial cells by papovavirus SV40. Exp Mol Pathol. 1984 Feb; 40(1):79-108. PMID: 6319177.
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    177. Santos M, Butel JS. Dynamic nature of the association of large tumor antigen and p53 cellular protein with the surfaces of simian virus 40-transformed cells. J Virol. 1984 Jan; 49(1):50-6. PMID: 6690721; PMCID: PMC255423.
    178. Steiner MR, Richards CS, Butel JS, Medina D. Correlation of amino acid fucoside labeling patterns with tumorigenicity of mouse mammary epithelial cells. Cancer Res. 1983 Jun; 43(6):2628-31. PMID: 6406050.
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    179. Wheeler DA, Butel JS, Medina D, Cardiff RD, Hager GL. Transcription of mouse mammary tumor virus: identification of a candidate mRNA for the long terminal repeat gene product. J Virol. 1983 Apr; 46(1):42-9. PMID: 6298469; PMCID: PMC255091.
    180. Santos M, Butel JS. Association of SV40 large tumor antigen and cellular proteins on the surface of SV40-transformed mouse cells. Virology. 1982 Jul 15; 120(1):1-17. PMID: 6285591.
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    181. Lanford RE, Butel JS. Intracellular transport of SV40 large tumor antigen: a mutation which abolishes migration to the nucleus does not prevent association with the cell surface. Virology. 1982 May; 119(1):169-84. PMID: 6280381.
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    182. Soule HR, Lanford RE, Butel JS. Detection of simian virus 40 surface-associated large tumor antigen by enzyme-catalyzed radioiodination. Int J Cancer. 1982 Mar 15; 29(3):337-44. PMID: 6279527.
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    183. Santos M, Butel JS. Detection of a complex of SV40 large tumor antigen and 53K cellular protein on the surface of SV40-transformed mouse cells. J Cell Biochem. 1982; 19(2):127-44. PMID: 6294133.
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    184. Richards CS, Medina D, Butel JS, Steiner MR. Correlation of surface fucopeptide patterns with tumorigenicity of mouse mammary epithelial cells. Cancer Res. 1981 Dec; 41(12 Pt 1):4967-72. PMID: 7306996.
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    185. Butel JS, Dusing-Swartz S, Socher SH, Medina D. Partial expression of endogenous mouse mammary tumor virus in mammary tumors induced in BALB/c mice by chemical, hormonal, and physical agents. J Virol. 1981 May; 38(2):571-80. PMID: 6264129; PMCID: PMC171188.
    186. Lanford RE, Butel JS. Effect of nuclear localization of large tumor antigen on growth potential of SV40-transformed cells. Virology. 1981 Apr 15; 110(1):147-58. PMID: 6259826.
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    187. Dudley JP, Medina D, Butel JS. Characterization of a 7,12-dimethylbenz(alpha)anthracene-induced BALB/c mouse mammary tumor epithelial cell line. In Vitro. 1980 Nov; 16(11):941-8. PMID: 6778814.
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    188. Lanford RE, Butel JS. Inhibition of nuclear migration of wild-type SV40 tumor antigen by a transport-defective mutant of SV40-adenovirus 7 hybrid virus. Virology. 1980 Sep; 105(2):303-13. PMID: 6252682.
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    189. Lanford RE, Butel JS. Biochemical characterization of nuclear and cytoplasmic forms of SV40 tumor antigens encoded by parental and transport-detective mutant SV40-adenovirus 7 hybrid viruses. Virology. 1980 Sep; 105(2):314-27. PMID: 6252683.
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    190. Soule HR, Lanford RE, Butel JS. Antigenic and immunogenic characteristics of nuclear and membrane-associated simian virus 40 tumor antigen. J Virol. 1980 Feb; 33(2):887-901. PMID: 6157837; PMCID: PMC288614.
    191. Medina D, Butel JS, Socher SH, Miller FL. Mammary tumorigenesis in 7,12-dimethybenzanthracene-treated C57BL x DBA/2f F1 mice. Cancer Res. 1980 Feb; 40(2):368-73. PMID: 6243251.
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    192. Dusing-Swartz S, Medina D, Butel JS, Socher SH. Mouse mammary tumor virus genome expression in chemical carcinogen-induced mammary tumors in low- and high-tumor-incidence mouse strains. Proc Natl Acad Sci U S A. 1979 Oct; 76(10):5360-4. PMID: 228289; PMCID: PMC413142.
    193. Lanford RE, Butel JS. Antigenic relationship of SV40 early proteins to purified large T polypeptide. Virology. 1979 Sep; 97(2):295-306. PMID: 89756.
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    194. Dudley JP, Butel JS. Effect of dexamethasone on expression of endogenous mouse mammary tumor virus sequences in BALB/c tumor cell lines. Virology. 1979 Jul 30; 96(2):453-62. PMID: 223313.
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    195. Soule HR, Butel JS. Subcellular Localization of simian virus 40 large tumor antigen. J Virol. 1979 May; 30(2):523-32. PMID: 224215; PMCID: PMC353356.
    196. Dudley JP, Butel JS, Socher SH, Rosen JM. Detection of mouse mammary tumor virus RNA in BALB/c tumor cell lines of nonviral etiologies. J Virol. 1978 Dec; 28(3):743-52. PMID: 215778; PMCID: PMC525798.
    197. Dudley JP, Rosen JM, Butel JS. Differential expression of poly(A)-adjacent sequences of mammary tumor virus RNA in murine mammary cells. Proc Natl Acad Sci U S A. 1978 Dec; 75(12):5797-801. PMID: 83648; PMCID: PMC393062.
    198. Steiner MR, Altenburg B, Richards CS, Dudley JP, Medina D, Butel JS. Differential response of cultured mouse mammary cells of varying tumorigenicity to cytochalasin B. Cancer Res. 1978 Sep; 38(9):2719-21. PMID: 679176.
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    199. Butel JS, Soule HR. Role of the simian virus 40 gene A product in regulation of DNA synthesis in transformed cells. J Virol. 1978 Jun; 26(3):584-94. PMID: 209212; PMCID: PMC525884.
    200. Noonan CA, Butel JS. Transformation by viruses: simian virus 40 as a model system. Natl Cancer Inst Monogr. 1978 May; (48):227-37. PMID: 219355.
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    201. Noonan CA, Butel JS. Temperature-sensitive mutants of simian virus 40. I. Isolation aand preliminary characterization of B/C gene mutants. Intervirology. 1978; 10(3):181-95. PMID: 210137.
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    202. Estes MK, Butel JS. Genetic evidence for a temperature-sensitive lesion in the adenovirus 7 region of the PARA genome. Intervirology. 1978; 9(5):261-75. PMID: 413806.
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    203. Farber FE, Smith EM, Dudley JP, Dixon RA, Butel JS. Altered intracellular transport of exogenous DNA by murine mammary tumor cell lines. J Natl Cancer Inst. 1977 Oct; 59(4):1257-62. PMID: 561855.
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    204. Butel JS, Dudley JP, Medina D. Comparison of the growth properties in vitro and transplantability of continuous mouse mammary tumor cell lines and clonal derivatives. Cancer Res. 1977 Jun; 37(6):1892-900. PMID: 192465.
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    205. Estes MK, Butel JS. Characterization of a temperature-sensitive mutant of human adenovirus type 7. J Virol. 1977 Mar; 21(3):1159-69. PMID: 850305; PMCID: PMC515657.
    206. Vollet JJ, Brugge JS, Noonan CA, Butel JS. The role of SV40 gene A in the alteration of microfilaments in transformed cells. Exp Cell Res. 1977 Mar 1; 105(1):119-26. PMID: 190024.
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    207. Noonan CA, Brugge JS, Butel JS. Characterization of simian cells tranformed by temperature-sensitive mutants of simian virus 40. J Virol. 1976 Jun; 18(3):1106-19. PMID: 178917; PMCID: PMC354810.
    208. Kellermayer M, Talas M, Wong C, Busch H, Butel JS. The solubility characteristics of SV 40 tumor antigen. Exp Cell Res. 1976 May; 99(2):456-60. PMID: 178516.
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    209. Butel JS, Estes MK. Properties of cells transformed by DNA tumor viruses. In Vitro. 1975 May-Jun; 11(3):142-50. PMID: 170196.
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    210. Brugge JS, Butel JS. Role of simian virus 40 gene A function in maintenance of transformation. J Virol. 1975 Mar; 15(3):619-35. PMID: 163376; PMCID: PMC354498.
    211. Butel JS, Brugge JS, Noonan CA. Transformation of primate and rodent cells by temperature-sensitive mutants of SV40. Cold Spring Harb Symp Quant Biol. 1975; 39 Pt 1:25-36. PMID: 169066.
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    212. Butel JS. The role of SV40 viral genes in cellular transformation. Prog Med Virol. 1975; 21:88-102. PMID: 174159.
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    213. Butel JS, TAlas M, Ugur J, Melnick JL. Demonstration of infectious DNA in transformed cells. III. Correlation of detection of infectious DNA-protein complexes with persistence of virus in simian adenovirus SA7-induced tumor cells. Intervirology. 1975; 5(1-2):43-56. PMID: 1184347.
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    214. Kelly RK, Butel JS. Demonstration of infectious DNA in transformed cells. II. Characterization of uptake of SV40-transformed mouse cell DNA by simian cells. Arch Virol. 1975; 48(4):279-87. PMID: 173259.
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    215. Graham DY, Brown CH, Benrey J, Butel JS. Thrombocytopenia. A complication of mumps. JAMA. 1974 Mar 11; 227(10):1162-4. PMID: 4405899.
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    216. Melnick JL, Allison AC, Butel JS, Eckhart W, Eddy BE, Kit S, Levine AJ, Miles JA, Pagano JS, Sachs L, Vonka V. Papovaviridae. Intervirology. 1974; 3(1-2):106-20. PMID: 4373407.
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    217. Spira G, Estes MK, Dreesman GR, Butel JS, Rawls WE. Papovavirus structural polypeptides: comparison of human and rabbit papilloma viruses with simian virus 40. Intervirology. 1974; 3(4):220-31. PMID: 4142631.
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    218. Tálas M, Butel JS. Infectious DNA-protein complex from cells productively infected with simian adenovirus SA7. Intervirology. 1974; 3(1-2):54-62. PMID: 4215774.
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    219. Cook TA, Brunschwig JP, Butel JS, Cohn AM, Goepfert H, Rawls WE. Laryngeal papilloma: etiologic and therapeutic considerations. Ann Otol Rhinol Laryngol. 1973 Sep-Oct; 82(5):649-55. PMID: 4743394.
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    220. Tevethia SS, Butel JS. Induction of common transplantation antigen by various isolates of papovavirus SV40 and by virus rescued from transformed cells. Intervirology. 1973; 2(3):200-5. PMID: 4366480.
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    221. Guentzel MJ, Butel JS. Biological and biophysical characterization of SV40 cytoplasmic T-antigen-inducing mutants of PARA-adenovirus 7. Arch Gesamte Virusforsch. 1973; 43(1):74-87. PMID: 4367381.
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    222. Boyd VA, Butel JS. Demonstration of infectious deoxyribonucleic acid in transformed cells. I. Recovery of simian virus 40 from yielder and nonyielder transformed cells. J Virol. 1972 Sep; 10(3):399-409. PMID: 4342048; PMCID: PMC356479.
    223. Butel JS, Melnick JL. Recent advances in molecular pathology. The state of the viral genome in cells transformed by simian virus 40: a review. Exp Mol Pathol. 1972 Aug; 17(1):103-19. PMID: 4339647.
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    224. Butel JS. Studies with human papilloma virus modeled after known papovavirus systems. J Natl Cancer Inst. 1972 Feb; 48(2):285-99. PMID: 4347032.
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    225. Butel JS, Tevethia SS, Melnick JL. Oncogenicity and cell transformation by papovavirus SV40: the role of the viral genome. Adv Cancer Res. 1972; 15:1-55. PMID: 4333789.
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    226. Butel JS, Richardson LS, Melnick JL. Variation in properties of SV40-transformed simian cell lines detected by superinfection with SV40 and human adenoviruses. Virology. 1971 Dec; 46(3):844-55. PMID: 4332978.
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    227. Nachtigal M, Melnick JL, Butel JS. Chromosomal changes in Syrian hamster cells transformed by simian virus 40 (SV40) and variants of defective SV40 (PARA). J Natl Cancer Inst. 1971 Jul; 47(1):35-45. PMID: 4328195.
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    228. Butel JS, Tevethia SS, Nachtigal M. Malignant transformation in vitro by "non-oncogenic" variants of defective SV40 (PARA). J Immunol. 1971 Apr; 106(4):969-74. PMID: 4324260.
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    229. Melnick JL, Butel JS, Tevethia SS, Biswal N, Benyesh-Melnick M. Cell transformation by viruses. I. Significance of virus-specific antigens induced by deoxyribonucleic acid-containing tumor viruses. II. Complementary ribonucleic acid in cells transformed by ribonucleic acid-containing tumor viruses. In Vitro. 1971 Mar-Apr; 6(5):335-48. PMID: 4360732.
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    230. Butel JS, Melnick JL, Tevethia SS. Effect of adenovirus type 12 on tumor induction by SV40 and para (defective SV40). Int J Cancer. 1971 Jan 15; 7(1):112-8. PMID: 4322932.
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    231. Richardson LS, Butel JS. Properties of transformed hamster cells containing SV40 tumor antigen in the cytoplasm. Int J Cancer. 1971 Jan 15; 7(1):75-85. PMID: 4322939.
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    232. Nachtigal M, Butel JS. Variation in response of syrian hamster lung cells to complete or defective SV40 (PARA). Proc Soc Exp Biol Med. 1970 Dec; 135(3):727-31. PMID: 4321031.
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    233. Butel JS, Guentzel MJ, Rapp F. Variants of defective simian papovavirus 40 (PARA) characterized by cytoplasmic localization of simian papovavirus 40 tumor antigen. J Virol. 1969 Nov; 4(5):632-41. PMID: 4311795; PMCID: PMC375919.
    234. Rapp F, Pauluzzi S, Butel JS. Variation in properties of plaque progeny of PARA (defective simian papovavirus 40)-adenovirus 7. J Virol. 1969 Nov; 4(5):626-31. PMID: 4311794; PMCID: PMC375918.
    235. Butel JS, Rapp F. Replication of defective simian virus 40 and a monkey cell-adapting component in human kidney cells. J Virol. 1968 May; 2(5):541-2. PMID: 4301318; PMCID: PMC375643.
    236. Butel JS. Characterization of the strain of adenovirus type 7 carrying the defective monkey cell-adapting component. J Virol. 1967 Oct; 1(5):876-82. PMID: 4316236; PMCID: PMC375364.
    237. Rapp F, Butel JS, Tevethia SS, Melnick JL. Comparison of ability of defective foreign genomes (PARA and MAC) carried by human adenoviruses to induce SV40 transplantation immunity. J Immunol. 1967 Aug; 99(2):386-91. PMID: 4291652.
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    238. Butel JS, Rapp F. Complementation between a defective monkey cell-adapting component and human adenoviruses in simian cells. Virology. 1967 Apr; 31(4):573-84. PMID: 4290192.
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    239. Rapp F, Butel JS, Tevethia SS, Katz M, Melnick JL. Antigenic analysis of tumors and sera from aimals inoculated with para-adenovirus populations. J Immunol. 1966 Dec; 97(6):833-9. PMID: 4289076.
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    240. Butel JS, Melnick JL, Rapp F. Detection of biologically active adenovirions unable to plaque in human cells. J Bacteriol. 1966 Aug; 92(2):433-8. PMID: 16562132.
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    241. Feldman LA, Butel JS, Rapp F. Interaction of a simian papovavirus and adenoviruses. I. Induction of adenovirus tumor antigen during abortive infection of simian cells. J Bacteriol. 1966 Feb; 91(2):813-8. PMID: 4286827; PMCID: PMC314934.
    242. Butel JS, Rapp F. Replication in simian cells of defective viruses in an SV40-adenovirus "hybrid" population. J Bacteriol. 1966 Jan; 91(1):278-84. PMID: 4285535; PMCID: PMC315946.
    243. Butel JS, Rapp F. The effect of arabinofuranosylcytosine on the growth cycle of simian virus 40. Virology. 1965 Dec; 27(4):490-5. PMID: 4285374.
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    244. Rapp F, Butel JS, Melnick JL. SV40-adenovirus "hybrid" populations: transfer of SV40 determinants from one type of adenovirus to another. Proc Natl Acad Sci U S A. 1965 Sep; 54(3):717-24. PMID: 4286418; PMCID: PMC219733.
    245. Rapp F, Butel JS, Wallis C. Protection of Measles Virus by Sulfate Ions Against Thermal Inactivation. J Bacteriol. 1965 Jul; 90(1):132-5. PMID: 16562007; PMCID: PMC315604.
    246. RAPP F, BUTEL JS, FELDMAN LA, KITAHARA T, MELNICK JL. DIFFERENTIAL EFFECTS OF INHIBITORS ON THE STEPS LEADING TO THE FORMATION OF SV40 TUMOR AND VIRUS ANTIGENS. J Exp Med. 1965 Jun 1; 121:935-44. PMID: 14319408; PMCID: PMC2138018.
    247. KITAHARA T, BUTEL JS, RAPP F, MELNICK JL. CORRELATION BETWEEN COMPLEMENT-FIXING CELL ANTIBODY AND IMMUNOFLUORESCENT NUCLEAR ANTIBODY IN HAMSTERS BEARING 'SV40'-INDUCED TUMORS. Nature. 1965 Feb 13; 205:717. PMID: 14287428.
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    248. RAPP F, MELNICK JL, BUTEL JS, KITAHARA T. THE INCORPORATION OF SV40 MATERIAL INTO ADENOVIRUS 7 AS MEASURED BY INTRANUCLEAR SYNTHESIS OF SV40 TUMOR ANTIGEN. Proc Natl Acad Sci U S A. 1964 Dec; 52:1348-52. PMID: 14243507; PMCID: PMC300451.
    249. RAPP F, KITAHARA T, BUTEL JS, MELNICK JL. SYNTHESIS OF SV40 TUMOR ANTIGEN DURING REPLICATION OF SIMIAN PAPOVAVIRUS (SV40). Proc Natl Acad Sci U S A. 1964 Nov; 52:1138-42. PMID: 14231432; PMCID: PMC300410.
    250. RAPP F, BUTEL JS, MELNICK JL. VIRUS-INDUCED INTRANUCLEAR ANTIGEN IN CELLS TRANSFORMED BY PAPOVAVIRUS SV40. Proc Soc Exp Biol Med. 1964 Aug-Sep; 116:1131-5. PMID: 14230365.
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