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CHOEL KIM

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Biochemistry and Molecular Pharmacology
AddressOne Baylor Plaza
Houston, TX 77030
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    Collapse Research 
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    R21HL111953     (KIM, CHOEL WOONG)Jul 17, 2012 - Dec 30, 2014
    NIH
    TARGETING CGMP KINASES TO DEVELOP NEW THERAPEUTICS FOR HYPERTENSIVE DISEASES
    Role: Principal Investigator
    R01GM090161     (KIM, CHOEL WOONG)Jul 1, 2010 - Jun 30, 2021
    NIH
    Activation and Regulation Mechanisms of cGMP-dependent Protein Kinase I and II
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Sharma R, Kim JJ, Qin L, Henning P, Akimoto M, VanSchouwen B, Kaur G, Sankaran B, MacKenzie KR, Melacini G, Casteel DE, Herberg FW, Kim C. An auto-inhibited state of protein kinase G and implications for selective activation. Elife. 2022 08 05; 11. PMID: 35929723; PMCID: PMC9417419.
      Citations:    
    2. Sharma R, Choi KJ, Quan MD, Sharma S, Sankaran B, Park H, LaGrone A, Kim JJ, MacKenzie KR, Ferreon ACM, Kim C, Ferreon JC. Liquid condensation of reprogramming factor KLF4 with DNA provides a mechanism for chromatin organization. Nat Commun. 2021 09 22; 12(1):5579. PMID: 34552088; PMCID: PMC8458463.
      Citations: 3     Fields:    Translation:HumansCells
    3. Yu Z, Ku AF, Anglin JL, Sharma R, Ucisik MN, Faver JC, Li F, Nyshadham P, Simmons N, Sharma KL, Nagarajan S, Riehle K, Kaur G, Sankaran B, Storl-Desmond M, Palmer SS, Young DW, Kim C, Matzuk MM. Discovery and characterization of bromodomain 2-specific inhibitors of BRDT. Proc Natl Acad Sci U S A. 2021 03 02; 118(9). PMID: 33637650; PMCID: PMC7936271.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    4. Kim C, Sharma R. Cyclic nucleotide selectivity of protein kinase G isozymes. Protein Sci. 2021 02; 30(2):316-327. PMID: 33271627; PMCID: PMC7784742.
      Citations:    Fields:    Translation:AnimalsCells
    5. Chan MH, Aminzai S, Hu T, Taran A, Li S, Kim C, Pilz RB, Casteel DE. A substitution in cGMP-dependent protein kinase 1 associated with aortic disease induces an active conformation in the absence of cGMP. J Biol Chem. 2020 07 24; 295(30):10394-10405. PMID: 32506052; PMCID: PMC7383375.
      Citations:    Fields:    Translation:HumansCells
    6. Kim C, Sharma R, Casteel DE. Correction to: Crystal structure of PKG I? holoenzyme reveals a trans-inhibiting dimer assembly. J Transl Med. 2020 Jan 16; 18(1):27. PMID: 31948450; PMCID: PMC6966794.
      Citations: 1     Fields:    
    7. Sutton MN, Huang GY, Liang X, Sharma R, Reger AS, Mao W, Pang L, Rask PJ, Lee K, Gray JP, Hurwitz AM, Palzkill T, Millward SW, Kim C, Lu Z, Bast RC. DIRAS3-Derived Peptide Inhibits Autophagy in Ovarian Cancer Cells by Binding to Beclin1. Cancers (Basel). 2019 Apr 18; 11(4). PMID: 31003488; PMCID: PMC6521623.
      Citations: 7     
    8. Qin L, Sankaran B, Aminzai S, Casteel DE, Kim C. Structural basis for selective inhibition of human PKG Ia by the balanol-like compound N46. J Biol Chem. 2018 07 13; 293(28):10985-10992. PMID: 29769318; PMCID: PMC6052212.
      Citations: 4     Fields:    Translation:HumansCells
    9. Campbell JC, VanSchouwen B, Lorenz R, Sankaran B, Herberg FW, Melacini G, Kim C. Crystal structure of cGMP-dependent protein kinase I? cyclic nucleotide-binding-B domain : Rp-cGMPS complex reveals an apo-like, inactive conformation. FEBS Lett. 2017 Jan; 591(1):221-230. PMID: 27914169; PMCID: PMC5407887.
      Citations: 4     Fields:    Translation:Cells
    10. Cho KJ, Casteel DE, Prakash P, Tan L, van der Hoeven D, Salim AA, Kim C, Capon RJ, Lacey E, Cunha SR, Gorfe AA, Hancock JF. AMPK and Endothelial Nitric Oxide Synthase Signaling Regulates K-Ras Plasma Membrane Interactions via Cyclic GMP-Dependent Protein Kinase 2. Mol Cell Biol. 2016 12 15; 36(24):3086-3099. PMID: 27697864; PMCID: PMC5126295.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    11. Campbell JC, Tischer A, Machha V, Moon-Tasson L, Sankaran B, Kim C, Auton M. Data on the purification and crystallization of the loss-of-function von Willebrand disease variant (p.Gly1324Ser) of the von Willebrand factor A1 domain. Data Brief. 2016 Jun; 7:1700-1706. PMID: 27761512; PMCID: PMC5063811.
      Citations: 5     
    12. Kim JJ, Lorenz R, Arold ST, Reger AS, Sankaran B, Casteel DE, Herberg FW, Kim C. Crystal Structure of PKG I:cGMP Complex Reveals a cGMP-Mediated Dimeric Interface that Facilitates cGMP-Induced Activation. Structure. 2016 05 03; 24(5):710-720. PMID: 27066748; PMCID: PMC4856591.
      Citations: 21     Fields:    Translation:HumansCells
    13. Campbell JC, Kim JJ, Li KY, Huang GY, Reger AS, Matsuda S, Sankaran B, Link TM, Yuasa K, Ladbury JE, Casteel DE, Kim C. Structural Basis of Cyclic Nucleotide Selectivity in cGMP-dependent Protein Kinase II. J Biol Chem. 2016 Mar 11; 291(11):5623-5633. PMID: 26769964; PMCID: PMC4786703.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    14. Qin L, Reger AS, Guo E, Yang MP, Zwart P, Casteel DE, Kim C. Structures of cGMP-Dependent Protein Kinase (PKG) Ia Leucine Zippers Reveal an Interchain Disulfide Bond Important for Dimer Stability. Biochemistry. 2015 Jul 28; 54(29):4419-22. PMID: 26132214; PMCID: PMC4838416.
      Citations: 12     Fields:    Translation:HumansCells
    15. Reger AS, Yang MP, Koide-Yoshida S, Guo E, Mehta S, Yuasa K, Liu A, Casteel DE, Kim C. Crystal structure of the cGMP-dependent protein kinase II leucine zipper and Rab11b protein complex reveals molecular details of G-kinase-specific interactions. J Biol Chem. 2014 Sep 12; 289(37):25393-403. PMID: 25070890; PMCID: PMC4162144.
      Citations: 11     Fields:    Translation:HumansCells
    16. Campeau PM, Kasperaviciute D, Lu JT, Burrage LC, Kim C, Hori M, Powell BR, Stewart F, van den Ende J, Rump P, Nampoothiri S, Aftimos S, Mey A, Nair LD, Begleiter ML, De Bie I, Meenakshi G, Murray ML, Golabi M, Blair E, Male A, Kariminejad A, Newman WG, Bhaskar SS, Dickerson JE, Kerr B, Banka S, Giltay JC, Tostevin A, Wiszniewska J, Cheung SW, Hennekam RC, Gibbs RA, Lee BH, Sisodiya SM, F?lix TM, Wisniewska M, Kayserili H, Repetto GM, Giuliano F, Wieczorek D. The genetic basis of DOORS syndrome: an exome-sequencing study. Lancet Neurol. 2014 Jan; 13(1):44-58. PMID: 24291220; PMCID: PMC3895324.
      Citations: 51     Fields:    Translation:Humans
    17. Huang GY, Kim JJ, Reger AS, Lorenz R, Moon EW, Zhao C, Casteel DE, Bertinetti D, Vanschouwen B, Selvaratnam R, Pflugrath JW, Melacini G, Herberg FW, Kim C, Sankaran B. Structural basis for cyclic-nucleotide selectivity and cGMP-selective activation of PKG I. Structure. 2014 Jan 07; 22(1):116-24. PMID: 24239458; PMCID: PMC4019043.
      Citations: 31     Fields:    Translation:HumansCells
    18. Guo DC, Regalado E, Casteel DE, Santos-Cortez RL, Gong L, Kim JJ, Dyack S, Horne SG, Chang G, Jondeau G, Boileau C, Coselli JS, Li Z, Leal SM, Shendure J, Rieder MJ, Bamshad MJ, Nickerson DA, GenTAC Registry Consortium, National Heart, Lung, and Blood Institute Grand Opportunity Exome Sequencing Project, Kim C, Milewicz DM. Recurrent gain-of-function mutation in PRKG1 causes thoracic aortic aneurysms and acute aortic dissections. Am J Hum Genet. 2013 Aug 08; 93(2):398-404. PMID: 23910461; PMCID: PMC3738837.
      Citations: 90     Fields:    Translation:HumansCells
    19. Kryshtafovych A, Moult J, Bartual SG, Bazan JF, Berman H, Casteel DE, Christodoulou E, Everett JK, Hausmann J, Heidebrecht T, Hills T, Hui R, Hunt JF, Seetharaman J, Joachimiak A, Kennedy MA, Kim C, Lingel A, Michalska K, Montelione GT, Perrakis A, Pizarro JC, van Raaij MJ, Ramelot TA, Rousseau F, Tong L, Wernimont AK, Young J, Schwede T, Otero JM. Target highlights in CASP9: Experimental target structures for the critical assessment of techniques for protein structure prediction. Proteins. 2011; 79 Suppl 10:6-20. PMID: 22020785; PMCID: PMC3692002.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    20. Lee JH, Li S, Liu T, Hsu S, Kim C, Woods VL, Casteel DE. The amino terminus of cGMP-dependent protein kinase I? increases the dynamics of the protein's cGMP-binding pockets. Int J Mass Spectrom. 2011 Apr 30; 302(1-3):44-52. PMID: 21643460; PMCID: PMC3107041.
      Citations: 7     
    21. Kim JJ, Casteel DE, Huang G, Kwon TH, Ren RK, Zwart P, Headd JJ, Brown NG, Chow DC, Palzkill T, Kim C. Co-crystal structures of PKG I? (92-227) with cGMP and cAMP reveal the molecular details of cyclic-nucleotide binding. PLoS One. 2011 Apr 19; 6(4):e18413. PMID: 21526164; PMCID: PMC3080414.
      Citations: 31     Fields:    Translation:HumansCells
    22. Casteel DE, Smith-Nguyen EV, Sankaran B, Roh SH, Pilz RB, Kim C. A crystal structure of the cyclic GMP-dependent protein kinase I{beta} dimerization/docking domain reveals molecular details of isoform-specific anchoring. J Biol Chem. 2010 Oct 22; 285(43):32684-32688. PMID: 20826808; PMCID: PMC2963381.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    23. Kim C, Cheng CY, Saldanha SA, Taylor SS. PKA-I holoenzyme structure reveals a mechanism for cAMP-dependent activation. Cell. 2007 Sep 21; 130(6):1032-43. PMID: 17889648.
      Citations: 175     Fields:    Translation:Cells
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