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RAJAGOPAL SEKHAR

TitleProfessor
InstitutionBaylor College of Medicine
DepartmentDepartment of Medicine
AddressOne Baylor Plaza
Houston, TX 77030
Email
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    Other Positions
    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentHuffington Center on Aging
    DivisionHuffington Ctr on Aging


    Collapse Biography 
    Collapse education and training
    St. John's Medical College, Bangalore, IndiaM.D.1990Doctor Of Medicine
    University of Oklahoma, Tulsa, OKInternal Medicine Residency
    Baylor College of Medicine, Houston, TXClinical Endocrinology Fellowship
    Baylor College of Medicine, HoustonResearch Fellowship

    Collapse Research 
    Collapse research activities and funding
    R01AG068260     (SEKHAR, RAJAGOPAL VISWANATH)Sep 30, 2020 - Apr 30, 2025
    NIH
    Glutathione, Brain Metabolism and Inflammation in Alzheimer's Disease
    Role: Principal Investigator
    R01AG054131     (SEKHAR, RAJAGOPAL VISWANATH)Sep 15, 2017 - May 31, 2022
    NIH
    Age- Related Mild Cognitive Impairment and novel protective role of Glutathione: implications for Alzheimer's Disease
    Role: Principal Investigator
    R01AG041782     (SEKHAR, RAJAGOPAL VISWANATH)Sep 1, 2012 - May 31, 2018
    NIH
    Correcting glutathione deficiency to restore mitochondrial fat oxidation in aging
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Kumar P, Osahon OW, Sekhar RV. GlyNAC (Glycine and N-Acetylcysteine) Supplementation in Old Mice Improves Brain Glutathione Deficiency, Oxidative Stress, Glucose Uptake, Mitochondrial Dysfunction, Genomic Damage, Inflammation and Neurotrophic Factors to Reverse Age-Associated Cognitive Decline: Implications for Improving Brain Health in Aging. Antioxidants (Basel). 2023 May 04; 12(5). PMID: 37237908; PMCID: PMC10215265.
      Citations:    
    2. Kumar P, Liu C, Suliburk J, Hsu JW, Muthupillai R, Jahoor F, Minard CG, Taffet GE, Sekhar RV. Supplementing Glycine and N-Acetylcysteine (GlyNAC) in Older Adults Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Physical Function, and Aging Hallmarks: A Randomized Clinical Trial. J Gerontol A Biol Sci Med Sci. 2023 01 26; 78(1):75-89. PMID: 35975308; PMCID: PMC9879756.
      Citations:    
    3. Kumar P, Osahon OW, Sekhar RV. GlyNAC (Glycine and N-Acetylcysteine) Supplementation in Mice Increases Length of Life by Correcting Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Abnormalities in Mitophagy and Nutrient Sensing, and Genomic Damage. Nutrients. 2022 Mar 07; 14(5). PMID: 35268089; PMCID: PMC8912885.
      Citations:    Fields:    Translation:AnimalsCells
    4. Sekhar RV. 'Analogy-Based Comprehensive Diabetes Education' (ABCDE) Improves Glycemic Control of Diabetic Patients in an Underserved Population: Results of a Retrospective Chart Analysis. Healthcare (Basel). 2022 Feb 22; 10(3). PMID: 35326887; PMCID: PMC8953270.
      Citations:    
    5. Sekhar RV. GlyNAC (Glycine and N-Acetylcysteine) Supplementation Improves Impaired Mitochondrial Fuel Oxidation and Lowers Insulin Resistance in Patients with Type 2 Diabetes: Results of a Pilot Study. Antioxidants (Basel). 2022 Jan 13; 11(1). PMID: 35052658; PMCID: PMC8773349.
      Citations:    
    6. Kumar P, Osahon O, Vides DB, Hanania N, Minard CG, Sekhar RV. Severe Glutathione Deficiency, Oxidative Stress and Oxidant Damage in Adults Hospitalized with COVID-19: Implications for GlyNAC (Glycine and N-Acetylcysteine) Supplementation. Antioxidants (Basel). 2021 Dec 27; 11(1). PMID: 35052554; PMCID: PMC8773164.
      Citations: 8     
    7. Sekhar RV. GlyNAC Supplementation Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Aging Hallmarks, Metabolic Defects, Muscle Strength, Cognitive Decline, and Body Composition: Implications for Healthy Aging. J Nutr. 2021 12 03; 151(12):3606-3616. PMID: 34587244.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    8. Sekhar RV. Supplementing glycine and N-acetylcysteine (GlyNAC) rapidly improves health-related quality of life and lowers perception of fatigue in patients with HIV. AIDS. 2021 07 15; 35(9):1522-1524. PMID: 34185721.
      Citations: 1     Fields:    Translation:Humans
    9. Kumar P, Liu C, Hsu JW, Chacko S, Minard C, Jahoor F, Sekhar RV. Glycine and N-acetylcysteine (GlyNAC) supplementation in older adults improves glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, insulin resistance, endothelial dysfunction, genotoxicity, muscle strength, and cognition: Results of a pilot clinical trial. Clin Transl Med. 2021 03; 11(3):e372. PMID: 33783984; PMCID: PMC8002905.
      Citations: 11     Fields:    Translation:HumansCells
    10. Kumar P, Liu C, Suliburk JW, Minard CG, Muthupillai R, Chacko S, Hsu JW, Jahoor F, Sekhar RV. Supplementing Glycine and N-acetylcysteine (GlyNAC) in Aging HIV Patients Improves Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Endothelial Dysfunction, Insulin Resistance, Genotoxicity, Strength, and Cognition: Results of an Open-Label Clinical Trial. Biomedicines. 2020 Sep 30; 8(10). PMID: 33007928; PMCID: PMC7601820.
      Citations: 4     
    11. Cieslik KA, Sekhar RV, Granillo A, Reddy A, Medrano G, Heredia CP, Entman ML, Hamilton DJ, Li S, Reineke E, Gupte AA, Zhang A, Taffet GE. Improved Cardiovascular Function in Old Mice After N-Acetyl Cysteine and Glycine Supplemented Diet: Inflammation and Mitochondrial Factors. J Gerontol A Biol Sci Med Sci. 2018 08 10; 73(9):1167-1177. PMID: 29538624; PMCID: PMC6093357.
      Citations: 10     Fields:    Translation:AnimalsCells
    12. Sekhar RV, Liu CW, Rice S. Increasing glutathione concentrations with cysteine and glycine supplementation lowers inflammation in HIV patients. AIDS. 2015 Sep 10; 29(14):1899-900. PMID: 26372395.
      Citations: 2     Fields:    Translation:Humans
    13. Sekhar RV. Treatment of dyslipidemia in HIV. Curr Atheroscler Rep. 2015 Apr; 17(4):493. PMID: 25702057.
      Citations: 5     Fields:    Translation:Humans
    14. Nguyen D, Hsu JW, Jahoor F, Sekhar RV. Effect of increasing glutathione with cysteine and glycine supplementation on mitochondrial fuel oxidation, insulin sensitivity, and body composition in older HIV-infected patients. J Clin Endocrinol Metab. 2014 Jan; 99(1):169-77. PMID: 24081740; PMCID: PMC3879663.
      Citations: 32     Fields:    Translation:HumansCellsCTClinical Trials
    15. Agarwal N, Iyer D, Patel SG, Sekhar RV, Phillips TM, Schubert U, Oplt T, Buras ED, Samson SL, Couturier J, Lewis DE, Rodriguez-Barradas MC, Jahoor F, Kino T, Kopp JB, Balasubramanyam A. HIV-1 Vpr induces adipose dysfunction in vivo through reciprocal effects on PPAR/GR co-regulation. Sci Transl Med. 2013 Nov 27; 5(213):213ra164. PMID: 24285483; PMCID: PMC4009012.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    16. Misra R, Chandra P, Riechman SE, Long DM, Shinde S, Pownall HJ, Coraza I, Lewis DE, Sekhar RV, Balasubramanyam A. Relationship of ethnicity and CD4 Count with glucose metabolism among HIV patients on Highly-Active Antiretroviral Therapy (HAART). BMC Endocr Disord. 2013 Apr 22; 13:13. PMID: 23607267; PMCID: PMC3751670.
      Citations: 5     Fields:    
    17. Nguyen D, Samson SL, Reddy VT, Gonzalez EV, Sekhar RV. Impaired mitochondrial fatty acid oxidation and insulin resistance in aging: novel protective role of glutathione. Aging Cell. 2013 Jun; 12(3):415-25. PMID: 23534396.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    18. Sekhar RV, Jahoor F, Iyer D, Guthikonda A, Paranilam J, Elhaj F, Coraza I, Balasubramanyam A. Leptin replacement therapy does not improve the abnormal lipid kinetics of hypoleptinemic patients with HIV-associated lipodystrophy syndrome. Metabolism. 2012 Oct; 61(10):1395-403. PMID: 22542724.
      Citations: 9     Fields:    Translation:Humans
    19. Nguyen D, Sekhar RV. Lack of evidence to support a beneficial role for glutathione depletion on body weight or glucose tolerance. Obesity (Silver Spring). 2012 Sep; 20(9):1756. PMID: 22926456.
      Citations: 1     Fields:    Translation:Animals
    20. Sekhar RV, Patel SG, Guthikonda AP, Reid M, Balasubramanyam A, Taffet GE, Jahoor F. Deficient synthesis of glutathione underlies oxidative stress in aging and can be corrected by dietary cysteine and glycine supplementation. Am J Clin Nutr. 2011 Sep; 94(3):847-53. PMID: 21795440; PMCID: PMC3155927.
      Citations: 98     Fields:    Translation:HumansCellsCTClinical Trials
    21. Balasubramanyam A, Coraza I, Smith EO, Scott LW, Patel P, Iyer D, Taylor AA, Giordano TP, Sekhar RV, Clark P, Cuevas-Sanchez E, Kamble S, Ballantyne CM, Pownall HJ. Combination of niacin and fenofibrate with lifestyle changes improves dyslipidemia and hypoadiponectinemia in HIV patients on antiretroviral therapy: results of "heart positive," a randomized, controlled trial. J Clin Endocrinol Metab. 2011 Jul; 96(7):2236-47. PMID: 21565796; PMCID: PMC3135191.
      Citations: 26     Fields:    Translation:Humans
    22. Sekhar RV, McKay SV, Patel SG, Guthikonda AP, Reddy VT, Balasubramanyam A, Jahoor F. Glutathione synthesis is diminished in patients with uncontrolled diabetes and restored by dietary supplementation with cysteine and glycine. Diabetes Care. 2011 Jan; 34(1):162-7. PMID: 20929994; PMCID: PMC3005481.
      Citations: 118     Fields:    Translation:Humans
    23. Sekhar RV, Patel SG, D'Amico S, Shi J, Balasubramanyam A, Rehman K, Jahoor F, Visnegarwala F. Effects of rosiglitazone on abnormal lipid kinetics in HIV-associated dyslipidemic lipodystrophy: a stable isotope study. Metabolism. 2011 Jun; 60(6):754-60. PMID: 20832829.
      Citations: 3     Fields:    Translation:HumansCells
    24. Sekhar RV, Balasubramanyam A. Treatment of dyslipidemia in HIV-infected patients. Expert Opin Pharmacother. 2010 Aug; 11(11):1845-54. PMID: 20486828.
      Citations: 3     Fields:    Translation:Humans
    25. Balasubramanyam A, Rao S, Misra R, Sekhar RV, Ballantyne CM. Prevalence of metabolic syndrome and associated risk factors in Asian Indians. J Immigr Minor Health. 2008 Aug; 10(4):313-23. PMID: 18026838.
      Citations: 18     Fields:    Translation:Humans
    26. Chang E, Sekhar R, Patel S, Balasubramanyam A. Dysregulated energy expenditure in HIV-infected patients: a mechanistic review. Clin Infect Dis. 2007 Jun 01; 44(11):1509-17. PMID: 17479951.
      Citations: 10     Fields:    Translation:HumansCells
    27. Balasubramanyam A, Mersmann H, Jahoor F, Phillips TM, Sekhar RV, Schubert U, Brar B, Iyer D, Smith EO, Takahashi H, Lu H, Anderson P, Kino T, Henklein P, Kopp JB. Effects of transgenic expression of HIV-1 Vpr on lipid and energy metabolism in mice. Am J Physiol Endocrinol Metab. 2007 Jan; 292(1):E40-8. PMID: 16882932.
      Citations: 16     Fields:    Translation:AnimalsCells
    28. Samson SL, Pownall HJ, Scott LW, Ballantyne CM, Smith EO, Sekhar RV, Balasubramanyam A. Heart positive: design of a randomized controlled clinical trial of intensive lifestyle intervention, niacin and fenofibrate for HIV lipodystrophy/dyslipidemia. Contemp Clin Trials. 2006 Dec; 27(6):518-30. PMID: 16914390.
      Citations: 6     Fields:    Translation:Humans
    29. D'Amico S, Shi J, Sekhar RV, Jahoor F, Ellis KJ, Rehman K, Willis J, Maldonado M, Balasubramanyam A. Physiologic growth hormone replacement improves fasting lipid kinetics in patients with HIV lipodystrophy syndrome. Am J Clin Nutr. 2006 Jul; 84(1):204-11. PMID: 16825697.
      Citations: 7     Fields:    Translation:HumansCells
    30. Balasubramanyam A, Sekhar RV. HIV-associated lipodystrophy syndrome: an accelerated form of the metabolic syndrome of insulin resistance due to altered fat distribution. Res Initiat Treat Action. 2006; 12(1):5-11. PMID: 17153230.
      Citations: 2     Fields:    Translation:Humans
    31. Sekhar RV, Goodman JC, Balasubramanyam A, Tatro JB, Mihaly E. Regulation of body weight by proopiomelanocortin peptides in humans: lessons from the Nelson syndrome. Ann Intern Med. 2005 Aug 02; 143(3):238-9. PMID: 16061931.
      Citations:    Fields:    Translation:Humans
    32. Sekhar RV, Jahoor F, Pownall HJ, Rehman K, Gaubatz J, Iyer D, Balasubramanyam A. Severely dysregulated disposal of postprandial triacylglycerols exacerbates hypertriacylglycerolemia in HIV lipodystrophy syndrome. Am J Clin Nutr. 2005 Jun; 81(6):1405-10. PMID: 15941894.
      Citations: 23     Fields:    Translation:HumansCells
    33. Sekhar RV, Jahoor F, Pownall HJ, Ballantyne CM, Balasubramanyam A. Cardiovascular implications of HIV-associated dyslipidemic lipodystrophy. Curr Atheroscler Rep. 2004 May; 6(3):173-9. PMID: 15068741.
      Citations: 6     Fields:    Translation:Humans
    34. Balasubramanyam A, Sekhar RV, Jahoor F, Jones PH, Pownall HJ. Pathophysiology of dyslipidemia and increased cardiovascular risk in HIV lipodystrophy: a model of 'systemic steatosis'. Curr Opin Lipidol. 2004 Feb; 15(1):59-67. PMID: 15166810.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    35. Shi J, Sekhar RV, Balasubramanyam A, Ellis K, Reeds PJ, Jahoor F, Sharma MD. Short- and long-term effects of growth hormone (GH) replacement on protein metabolism in GH-deficient adults. J Clin Endocrinol Metab. 2003 Dec; 88(12):5827-33. PMID: 14671176.
      Citations: 4     Fields:    Translation:HumansCells
    36. Sekhar RV, Jahoor F, White AC, Pownall HJ, Visnegarwala F, Rodriguez-Barradas MC, Sharma M, Reeds PJ, Balasubramanyam A. Metabolic basis of HIV-lipodystrophy syndrome. Am J Physiol Endocrinol Metab. 2002 Aug; 283(2):E332-7. PMID: 12110539.
      Citations: 41     Fields:    Translation:HumansCells
    37. Sekhar RV, Culbert S, Hoots WK, Klein MJ, Zietz H, Vassilopoulou-Sellin R. Severe osteopenia in a young boy with Kostmann's congenital neutropenia treated with granulocyte colony-stimulating factor: suggested therapeutic approach. Pediatrics. 2001 Sep; 108(3):E54. PMID: 11533372.
      Citations: 7     Fields:    Translation:HumansCells
    38. Sekhar RV, Vassilopoulou-Sellin R. Interplay of pregnancy, lactation, and hyperthyroidism leading to severe osteoporosis in a young woman. Endocr Pract. 2001 Jul-Aug; 7(4):262-6. PMID: 11497477.
      Citations: 3     Fields:    Translation:Humans
    39. Sekhar RV, Shetty PS, Kurpad AV. Diet induced thermogenesis with oral & intravenous feeding in chronically undernourished human subjects. Indian J Med Res. 1998 Dec; 108:265-71. PMID: 9919009.
      Citations: 1     Fields:    Translation:Humans
    40. Andrade C, Rao NS, Sekhar RV, Rani MA, Venkataraman BV. Relationship between rate of administration of electroconvulsive shocks and rate of learning in rats: implications for the practice of ECT. Convuls Ther. 1994 Sep; 10(3):206-11. PMID: 7834257.
      Citations: 1     Fields:    Translation:Animals
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