Last Name


TitleClinical Assistant Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Medicine
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Yao J, Caballero OL, Huang Y, Lin C, Rimoldi D, Behren A, Cebon JS, Hung MC, Weinstein JN, Strausberg RL, Zhao Q. Altered Expression and Splicing of ESRP1 in Malignant Melanoma Correlates with Epithelial-Mesenchymal Status and Tumor-Associated Immune Cytolytic Activity. Cancer Immunol Res. 2016 Jun; 4(6):552-61. PMID: 27045022.
      View in: PubMed
    2. Zhou L, Liu Q, Yang M, Wang T, Yao J, Cheng J, Yuan J, Lin X, Zhao J, Tickner J, Xu J. Dihydroartemisinin, an Anti-Malaria Drug, Suppresses Estrogen Deficiency-Induced Osteoporosis, Osteoclast Formation, and RANKL-Induced Signaling Pathways. J Bone Miner Res. 2016 May; 31(5):964-74. PMID: 26684711.
      View in: PubMed
    3. Zhang L, Zhang S, Yao J, Lowery FJ, Zhang Q, Huang WC, Li P, Li M, Wang X, Zhang C, Wang H, Ellis K, Cheerathodi M, McCarty JH, Palmieri D, Saunus J, Lakhani S, Huang S, Sahin AA, Aldape KD, Steeg PS, Yu D. Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth. Nature. 2015 Nov 5; 527(7576):100-4. PMID: 26479035.
      View in: PubMed
    4. Yao J, Li J, Zhou L, Cheng J, Chim SM, Zhang G, Quinn JM, Tickner J, Zhao J, Xu J. Protein kinase C inhibitor, GF109203X attenuates osteoclastogenesis, bone resorption and RANKL-induced NF-?B and NFAT activity. J Cell Physiol. 2015 Jun; 230(6):1235-42. PMID: 25363829.
      View in: PubMed
    5. Gong AH, Wei P, Zhang S, Yao J, Yuan Y, Zhou AD, Lang FF, Heimberger AB, Rao G, Huang S. FoxM1 Drives a Feed-Forward STAT3-Activation Signaling Loop That Promotes the Self-Renewal and Tumorigenicity of Glioblastoma Stem-like Cells. Cancer Res. 2015 Jun 1; 75(11):2337-48. PMID: 25832656.
      View in: PubMed
    6. Klingler S, Guo B, Yao J, Yan H, Zhang L, Vaseva AV, Chen S, Canoll P, Horner JW, Wang YA, Paik JH, Ying H, Zheng H. Development of Resistance to EGFR-Targeted Therapy in Malignant Glioma Can Occur through EGFR-Dependent and -Independent Mechanisms. Cancer Res. 2015 May 15; 75(10):2109-19. PMID: 25808866; PMCID: PMC4433602.
    7. Jin JN, Yao J, Zhang QY, Yu C, Chen P, Liu WJ, Peng DN, Choi MM. An integrated approach of bioassay and molecular docking to study the dihydroxylation mechanism of pyrene by naphthalene dioxygenase in Rhodococcus sp. ustb-1. Chemosphere. 2015 Jun; 128:307-13. PMID: 25747183.
      View in: PubMed
    8. Yoshida T, Kim JH, Carver K, Su Y, Weremowicz S, Mulvey L, Yamamoto S, Brennan C, Mei S, Long H, Yao J, Polyak K. CLK2 Is an Oncogenic Kinase and Splicing Regulator in Breast Cancer. Cancer Res. 2015 Apr 1; 75(7):1516-26. PMID: 25670169.
      View in: PubMed
    9. Xu J, Acharya S, Sahin O, Zhang Q, Saito Y, Yao J, Wang H, Li P, Zhang L, Lowery FJ, Kuo WL, Xiao Y, Ensor J, Sahin AA, Zhang XH, Hung MC, Zhang JD, Yu D. 14-3-3? turns TGF-?'s function from tumor suppressor to metastasis promoter in breast cancer by contextual changes of Smad partners from p53 to Gli2. Cancer Cell. 2015 Feb 9; 27(2):177-92. PMID: 25670079; PMCID: PMC4325275.
    10. Qian C, Liu F, Ye B, Zhang X, Liang Y, Yao J. Notch4 promotes gastric cancer growth through activation of Wnt1/?-catenin signaling. Mol Cell Biochem. 2015 Mar; 401(1-2):165-74. PMID: 25511451.
      View in: PubMed
    11. Koul D, Yao J, Wan S, Yuan Y, Sulman E, Lang F, Yung WK, Colman H. Retraction: Novel HSP90 inhibitor NVP-HSP990 targets cell-cycle regulators to ablate Olig 2-positive glioma tumor-initiating cells. Cancer Res. 2014 Nov 15; 74(22):6731-2. PMID: 25398854; PMCID: PMC4381954.
    12. Desai S, Ding M, Wang B, Lu Z, Zhao Q, Shaw K, Yung WK, Weinstein JN, Tan M, Yao J. Tissue-specific isoform switch and DNA hypomethylation of the pyruvate kinase PKM gene in human cancers. Oncotarget. 2014 Sep 30; 5(18):8202-10. PMID: 24077665; PMCID: PMC4226677.
    13. Castillo A, Paul A, Sun B, Huang TH, Wang Y, Yazinski SA, Tyler J, Li L, You MJ, Zou L, Yao J, Wang B. The BRCA1-interacting protein Abraxas is required for genomic stability and tumor suppression. Cell Rep. 2014 Aug 7; 8(3):807-17. PMID: 25066119; PMCID: PMC4149256.
    14. Zou Z, Zhang J, Zhang H, Liu H, Li Z, Cheng D, Chen J, Liu L, Ni M, Zhang Y, Yao J, Zhou J, Fu J, Liang Y. 3-Methyladenine can depress drug efflux transporters via blocking the PI3K-AKT-mTOR pathway thus sensitizing MDR cancer to chemotherapy. J Drug Target. 2014 Nov; 22(9):839-48. PMID: 25019701.
      View in: PubMed
    15. Hsu YH, Yao J, Chan LC, Wu TJ, Hsu JL, Fang YF, Wei Y, Wu Y, Huang WC, Liu CL, Chang YC, Wang MY, Li CW, Shen J, Chen MK, Sahin AA, Sood A, Mills GB, Yu D, Hortobagyi GN, Hung MC. Definition of PKC-?, CDK6, and MET as therapeutic targets in triple-negative breast cancer. Cancer Res. 2014 Sep 1; 74(17):4822-35. PMID: 24970481; PMCID: PMC4154991.
    16. Shi J, Wang Y, Zeng L, Wu Y, Deng J, Zhang Q, Lin Y, Li J, Kang T, Tao M, Rusinova E, Zhang G, Wang C, Zhu H, Yao J, Zeng YX, Evers BM, Zhou MM, Zhou BP. Disrupting the interaction of BRD4 with diacetylated Twist suppresses tumorigenesis in basal-like breast cancer. Cancer Cell. 2014 Feb 10; 25(2):210-25. PMID: 24525235; PMCID: PMC4004960.
    17. Saito N, Fu J, Zheng S, Yao J, Wang S, Liu DD, Yuan Y, Sulman EP, Lang FF, Colman H, Verhaak RG, Yung WK, Koul D. A high Notch pathway activation predicts response to ? secretase inhibitors in proneural subtype of glioma tumor-initiating cells. Stem Cells. 2014 Jan; 32(1):301-12. PMID: 24038660; PMCID: PMC3947402.
    18. Yao J, Caballero OL, Yung WK, Weinstein JN, Riggins GJ, Strausberg RL, Zhao Q. Tumor subtype-specific cancer-testis antigens as potential biomarkers and immunotherapeutic targets for cancers. Cancer Immunol Res. 2014 Apr; 2(4):371-9. PMID: 24764584; PMCID: PMC4007352.
    19. Qian C, Yao J, Wang J, Wang L, Xue M, Zhou T, Liu W, Si J. ERK1/2 inhibition enhances apoptosis induced by JAK2 silencing in human gastric cancer SGC7901 cells. Mol Cell Biochem. 2014 Feb; 387(1-2):159-70. PMID: 24178240.
      View in: PubMed
    20. Huang Y, Wu H, Xue R, Liu T, Dong L, Yao J, Zhang Y, Shen X. Identification of N-glycosylation in hepatocellular carcinoma patients' serum with a comparative proteomic approach. PLoS One. 2013; 8(10):e77161. PMID: 24143209; PMCID: PMC3797089.
    21. Kim YW, Koul D, Kim SH, Lucio-Eterovic AK, Freire PR, Yao J, Wang J, Almeida JS, Aldape K, Yung WK. Identification of prognostic gene signatures of glioblastoma: a study based on TCGA data analysis. Neuro Oncol. 2013 Jul; 15(7):829-39. PMID: 23502430; PMCID: PMC3688008.
    22. Fu J, Koul D, Yao J, Wang S, Yuan Y, Colman H, Sulman EP, Lang FF, Yung WK. Novel HSP90 inhibitor NVP-HSP990 targets cell-cycle regulators to ablate Olig2-positive glioma tumor-initiating cells. Cancer Res. 2013 May 15; 73(10):3062-74. PMID: 23492364; PMCID: PMC3655088.
    23. Dong C, Yuan T, Wu Y, Wang Y, Fan TW, Miriyala S, Lin Y, Yao J, Shi J, Kang T, Lorkiewicz P, St Clair D, Hung MC, Evers BM, Zhou BP. Loss of FBP1 by Snail-mediated repression provides metabolic advantages in basal-like breast cancer. Cancer Cell. 2013 Mar 18; 23(3):316-31. PMID: 23453623; PMCID: PMC3703516.
    24. Zhao Q, Caballero OL, Davis ID, Jonasch E, Tamboli P, Yung WK, Weinstein JN. Tumor-specific isoform switch of the fibroblast growth factor receptor 2 underlies the mesenchymal and malignant phenotypes of clear cell renal cell carcinomas. Clin Cancer Res. 2013 May 1; 19(9):2460-72. PMID: 23444225; PMCID: PMC3644028.
    25. Desai S, Liu Z, Yao J, Patel N, Chen J, Wu Y, Ahn EE, Fodstad O, Tan M. Heat shock factor 1 (HSF1) controls chemoresistance and autophagy through transcriptional regulation of autophagy-related protein 7 (ATG7). J Biol Chem. 2013 Mar 29; 288(13):9165-76. PMID: 23386620; PMCID: PMC3610989.
    26. Garnett J, Chumbalkar V, Vaillant B, Gururaj AE, Hill KS, Latha K, Yao J, Priebe W, Colman H, Elferink LA, Bogler O. Regulation of HGF expression by ?EGFR-mediated c-Met activation in glioblastoma cells. Neoplasia. 2013 Jan; 15(1):73-84. PMID: 23359207; PMCID: PMC3556940.
    27. Yang SG, Wang B, Chen P, Yu CB, Deng M, Yao J, Zhu CX, Ren JJ, Wu W, Ju B, Shen JF, Chen Y, Li MD, Ruan B, Li L. Effectiveness of HBV vaccination in infants and prediction of HBV prevalence trend under new vaccination plan: findings of a large-scale investigation. PLoS One. 2012; 7(10):e47808. PMID: 23094094; PMCID: PMC3477110.
    28. Yao J, Zhao Q, Yuan Y, Zhang L, Liu X, Yung WK, Weinstein JN. Identification of common prognostic gene expression signatures with biological meanings from microarray gene expression datasets. PLoS One. 2012; 7(9):e45894. PMID: 23029298; PMCID: PMC3448701.
    29. Xiang H, Zhao W, Sun Y, Qian W, Xing J, Zhou Y, Yao J, Xu J, Wang Y, Yao H, Hu Z. CD86 gene variants and susceptibility to pancreatic cancer. J Cancer Res Clin Oncol. 2012 Dec; 138(12):2061-7. PMID: 22821131.
      View in: PubMed
    30. Ren L, Zhang Q, Yao J, Sun Z, Kaneko R, Yan Z, Nanot S, Jin Z, Kawayama I, Tonouchi M, Tour JM, Kono J. Terahertz and infrared spectroscopy of gated large-area graphene. Nano Lett. 2012 Jul 11; 12(7):3711-5. PMID: 22663563.
      View in: PubMed
    31. Dong C, Wu Y, Yao J, Wang Y, Yu Y, Rychahou PG, Evers BM, Zhou BP. G9a interacts with Snail and is critical for Snail-mediated E-cadherin repression in human breast cancer. J Clin Invest. 2012 Apr; 122(4):1469-86. PMID: 22406531; PMCID: PMC3314447.
    32. Chiu WT, Lee HT, Huang FJ, Aldape KD, Yao J, Steeg PS, Chou CY, Lu Z, Xie K, Huang S. Caveolin-1 upregulation mediates suppression of primary breast tumor growth and brain metastases by stat3 inhibition. Cancer Res. 2011 Jul 15; 71(14):4932-43. PMID: 21622714; PMCID: PMC4170798.
    33. Chen M, Gong L, Qi X, Xing G, Luan Y, Wu Y, Xiao Y, Yao J, Li Y, Xue X, Pan G, Ren J. Inhibition of renal NQO1 activity by dicoumarol suppresses nitroreduction of aristolochic acid I and attenuates its nephrotoxicity. Toxicol Sci. 2011 Aug; 122(2):288-96. PMID: 21613233.
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    34. de Groot JF, Lamborn KR, Chang SM, Gilbert MR, Cloughesy TF, Aldape K, Yao J, Jackson EF, Lieberman F, Robins HI, Mehta MP, Lassman AB, Deangelis LM, Yung WK, Chen A, Prados MD, Wen PY. Phase II study of aflibercept in recurrent malignant glioma: a North American Brain Tumor Consortium study. J Clin Oncol. 2011 Jul 1; 29(19):2689-95. PMID: 21606416; PMCID: PMC3139373.
    35. Xue X, Gong L, Qi X, Wu Y, Xing G, Yao J, Luan Y, Xiao Y, Li Y, Wu X, Chen M, Gu J, Ren J. Knockout of hepatic P450 reductase aggravates triptolide-induced toxicity. Toxicol Lett. 2011 Aug 10; 205(1):47-54. PMID: 21596114.
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    36. Irie HY, Shrestha Y, Selfors LM, Frye F, Iida N, Wang Z, Zou L, Yao J, Lu Y, Epstein CB, Natesan S, Richardson AL, Polyak K, Mills GB, Hahn WC, Brugge JS. PTK6 regulates IGF-1-induced anchorage-independent survival. PLoS One. 2010; 5(7):e11729. PMID: 20668531; PMCID: PMC2909213.
    37. Xu X, Qiao M, Zhang Y, Jiang Y, Wei P, Yao J, Gu B, Wang Y, Lu J, Wang Z, Tang Z, Sun Y, Wu W, Shi Q. Quantitative proteomics study of breast cancer cell lines isolated from a single patient: discovery of TIMM17A as a marker for breast cancer. Proteomics. 2010 Apr; 10(7):1374-90. PMID: 20198662.
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    38. Yao J, Zhang JL, Wu YQ, Lu ZJ. [Contrasting study of erythritol and xylitol on Streptococcus mutans]. Hua Xi Kou Qiang Yi Xue Za Zhi. 2009 Dec; 27(6):603-5. PMID: 20077891.
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    39. Kligys K, Yao J, Yu D, Jones JC. 14-3-3zeta/tau heterodimers regulate Slingshot activity in migrating keratinocytes. Biochem Biophys Res Commun. 2009 Jun 12; 383(4):450-4. PMID: 19371722; PMCID: PMC2727353.
    40. Neal CL, Yao J, Yang W, Zhou X, Nguyen NT, Lu J, Danes CG, Guo H, Lan KH, Ensor J, Hittelman W, Hung MC, Yu D. 14-3-3zeta overexpression defines high risk for breast cancer recurrence and promotes cancer cell survival. Cancer Res. 2009 Apr 15; 69(8):3425-32. PMID: 19318578; PMCID: PMC2671640.
    41. Yan XX, Peng Q, Li Q, Zhang K, Yao J, Hou XL, Wu YD. Highly diastereoselective switchable enantioselective Mannich reaction of glycine derivatives with imines. J Am Chem Soc. 2008 Nov 5; 130(44):14362-3. PMID: 18841892.
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    42. Hu M, Yao J, Carroll DK, Weremowicz S, Chen H, Carrasco D, Richardson A, Violette S, Nikolskaya T, Nikolsky Y, Bauerlein EL, Hahn WC, Gelman RS, Allred C, Bissell MJ, Schnitt S, Polyak K. Regulation of in situ to invasive breast carcinoma transition. Cancer Cell. 2008 May; 13(5):394-406. PMID: 18455123; PMCID: PMC3705908.
    43. Zhao X, Goswami M, Pokhriyal N, Ma H, Du H, Yao J, Victor TA, Polyak K, Sturgis CD, Band H, Band V. Cyclooxygenase-2 expression during immortalization and breast cancer progression. Cancer Res. 2008 Jan 15; 68(2):467-75. PMID: 18199541.
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    44. Zhang Q, Wang L, Jiang Y, Fang L, Pan P, Gong S, Yao J, Tang YW, Vermund SH, Jia Y. Early infant human immunodeficiency virus type 1 detection suitable for resource-limited settings with multiple circulating subtypes by use of nested three-monoplex DNA PCR and dried blood spots. J Clin Microbiol. 2008 Feb; 46(2):721-6. PMID: 18077639; PMCID: PMC2238144.
    45. Shipitsin M, Campbell LL, Argani P, Weremowicz S, Bloushtain-Qimron N, Yao J, Nikolskaya T, Serebryiskaya T, Beroukhim R, Hu M, Halushka MK, Sukumar S, Parker LM, Anderson KS, Harris LN, Garber JE, Richardson AL, Schnitt SJ, Nikolsky Y, Gelman RS, Polyak K. Molecular definition of breast tumor heterogeneity. Cancer Cell. 2007 Mar; 11(3):259-73. PMID: 17349583.
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    46. Yao J, Lambowitz AM. Gene targeting in gram-negative bacteria by use of a mobile group II intron ("Targetron") expressed from a broad-host-range vector. Appl Environ Microbiol. 2007 Apr; 73(8):2735-43. PMID: 17322321; PMCID: PMC1855620.
    47. Duan L, Yao J, Wu X, Fan M. Growth suppression induced by Notch1 activation involves Wnt-beta-catenin down-regulation in human tongue carcinoma cells. Biol Cell. 2006 Aug; 98(8):479-90. PMID: 16608439.
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    48. Yao J, Zhong J, Fang Y, Geisinger E, Novick RP, Lambowitz AM. Use of targetrons to disrupt essential and nonessential genes in Staphylococcus aureus reveals temperature sensitivity of Ll.LtrB group II intron splicing. RNA. 2006 Jul; 12(7):1271-81. PMID: 16741231; PMCID: PMC1484445.
    49. Tan M, Lan KH, Yao J, Lu CH, Sun M, Neal CL, Lu J, Yu D. Selective inhibition of ErbB2-overexpressing breast cancer in vivo by a novel TAT-based ErbB2-targeting signal transducers and activators of transcription 3-blocking peptide. Cancer Res. 2006 Apr 1; 66(7):3764-72. PMID: 16585203.
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    50. Yao J, Zhong J, Lambowitz AM. Gene targeting using randomly inserted group II introns (targetrons) recovered from an Escherichia coli gene disruption library. Nucleic Acids Res. 2005; 33(10):3351-62. PMID: 15947133; PMCID: PMC1148171.
    51. Zhang FJ, Yao J, Zhao HX, Feng X, Lu LH, Han N, Liu ZY, Lin H. [Influencing factors of single-platform method of flow cytometry in the detection of immunophenotype of peripheral blood lymphocytes in HIV/AIDS patients]. Zhonghua Yi Xue Za Zhi. 2005 Jan 12; 85(2):124-6. PMID: 15774223.
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    52. Li L, Wei FL, Mei S, Feng X, Yao J, Jin X, Cao YZ. Virological and immunological outcomes in HIV-1-infected Chinese patients treated with a combination of Efavirenz and Indinavir for 48 weeks. Chin Med J (Engl). 2004 Mar; 117(3):347-52. PMID: 15043771.
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    53. Yang W, Klos KS, Zhou X, Yao J, Yang Y, Smith TL, Shi D, Yu D. ErbB2 overexpression in human breast carcinoma is correlated with p21Cip1 up-regulation and tyrosine-15 hyperphosphorylation of p34Cdc2: poor responsiveness to chemotherapy with cyclophoshamide methotrexate, and 5-fluorouracil is associated with Erb2 overexpression and with p21Cip1 overexpression. Cancer. 2003 Sep 15; 98(6):1123-30. PMID: 12973835.
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    54. Yan J, Feng X, Tian JH, Xie Y, Yao J, He ZP, Xu DZ. [Predictors associated with clinical deterioration in SARS patients]. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2003 Sep; 17(3):222-4. PMID: 15340562.
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    55. Berger DH, Feng XH, Yao J, Saha D, Beauchamp RD, Lin X. Resistance to transforming growth factor-beta occurs in the presence of normal Smad activation. Surgery. 2002 Aug; 132(2):310-6. PMID: 12219028.
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