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STEPHEN PFLUGFELDER

TitleProfessor
InstitutionBaylor College of Medicine
DepartmentDepartment of Ophthalmology
Address6501 Fannin St
Houston, TX 77030
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    Collapse Research 
    Collapse research activities and funding
    U24EY035067     (DE PAIVA, CINTIA S.)Jul 1, 2023 - Jun 30, 2026
    NIH
    Multi-method investigation and characterization of the ocular microbiome
    Role: Co-Principal Investigator
    R01EY018090     (PFLUGFELDER, STEPHEN CARL)Aug 1, 2009 - Jul 31, 2011
    NIH
    Environmentally-Induced Ocular Surface Inflammation Mimicking Sjogren's Syndrome
    Role: Principal Investigator
    R01EY011915     (PFLUGFELDER, STEPHEN C)Aug 1, 1997 - Jun 30, 2024
    NIH
    Pathogenesis of Conjunctival Squamous Metaplasia
    Role: Principal Investigator
    R01EY008711     (PFLUGFELDER, STEPHEN CARL)Aug 1, 1990 - Jul 31, 1994
    NIH
    EBV AND OCULAR PATHOLOGY IN SJOGREN'S SYNDROME
    Role: Principal Investigator
    R03EY008193     (PFLUGFELDER, STEPHEN CARL)Mar 1, 1989 - Feb 28, 1990
    NIH
    DETECTION OF EPSTEIN-BARR VIRAL DNA IN OCULAR SPECIMENS
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Alam J, Yaman E, Silva GCV, Chen R, de Paiva CS, Stepp MA, Pflugfelder SC. Single cell analysis of short-term dry eye induced changes in cornea immune cell populations. Front Med (Lausanne). 2024; 11:1362336. PMID: 38560382; PMCID: PMC10978656.
      Citations:    
    2. Li JM, Lin N, Zhang Y, Chen X, Liu Z, Lu R, Bian F, Liu H, Pflugfelder SC, Li DQ. Ectoine protects corneal epithelial survival and barrier from hyperosmotic stress by promoting anti-inflammatory cytokine IL-37. Ocul Surf. 2024 Mar 13; 32:182-191. PMID: 38490477.
      Citations:    Fields:    
    3. Stern ME, Theofilopoulos AN, Steven P, Niederkorn JY, Fox R, Calonge M, Scheid C, Pflugfelder SC. Immunologic basis for development of keratoconjunctivitis sicca in systemic autoimmune diseases: Role of innate immune sensors. Ocul Surf. 2024 Feb 22; 32:130-138. PMID: 38395195.
      Citations:    Fields:    
    4. Chen X, Lin N, Li JM, Liu H, Abu-Romman A, Yaman E, Bian F, de Paiva CS, Pflugfelder SC, Li DQ. Ectoine, from a Natural Bacteria Protectant to a New Treatment of Dry Eye Disease. Pharmaceutics. 2024 Feb 05; 16(2). PMID: 38399289; PMCID: PMC10892505.
      Citations:    
    5. Ammassam Veettil R, Li W, Pflugfelder SC, Koch DD. A Mouse Model for Corneal Neovascularization by Alkali Burn. J Vis Exp. 2023 06 30; (196). PMID: 37458425.
      Citations:    Fields:    Translation:Animals
    6. Yoon SP, Yu Z, Pflugfelder SC, de Paiva CS. Differentially Expressed Tear Proteins in Sj?gren's Syndrome Keratoconjunctivitis Sicca. Transl Vis Sci Technol. 2023 06 01; 12(6):8. PMID: 37310735; PMCID: PMC10275389.
      Citations:    Fields:    Translation:Humans
    7. Oganov A, Yazdanpanah G, Jabbehdari S, Belamkar A, Pflugfelder S. Dry eye disease and blinking behaviors: A narrative review of methodologies for measuring blink dynamics and inducing blink response. Ocul Surf. 2023 Jul; 29:166-174. PMID: 37257694.
      Citations:    Fields:    
    8. Yu Z, Yazdanpanah G, Alam J, de Paiva CS, Pflugfelder S. Induction of Innate Inflammatory Pathways in the Corneal Epithelium in the Desiccating Stress Dry Eye Model. Invest Ophthalmol Vis Sci. 2023 04 03; 64(4):8. PMID: 37036417; PMCID: PMC10103726.
      Citations:    Fields:    Translation:Animals
    9. Ayres BD, Donnenfeld E, Farid M, Gaddie IB, Gupta PK, Holland E, Karpecki PM, Lindstrom R, Nichols KK, Pflugfelder SC, Starr CE, Yeu E. Clinical diagnosis and management of Demodex blepharitis: the Demodex Expert Panel on Treatment and Eyelid Health (DEPTH). Eye (Lond). 2023 Oct; 37(15):3249-3255. PMID: 36964261; PMCID: PMC10564779.
      Citations: 1     Fields:    
    10. de Souza RG, Huang D, Prahl S, Nakhleh L, Pflugfelder SC. Comparison of Efficacy and Inflammatory Response to Thermoconjunctivoplasty Performed with Cautery or Pulsed 1460 nm Laser. Int J Mol Sci. 2023 Mar 17; 24(6). PMID: 36982810; PMCID: PMC10053331.
      Citations:    Fields:    Translation:Animals
    11. Kikukawa Y, Tanaka S, Kosugi T, Pflugfelder SC. Non-invasive and objective tear film breakup detection on interference color images using convolutional neural networks. PLoS One. 2023; 18(3):e0282973. PMID: 36913382; PMCID: PMC10010540.
      Citations:    Fields:    Translation:Humans
    12. Farid M, Ayres BD, Donnenfeld E, Gaddie IB, Gupta PK, Holland E, Lindstrom R, Pflugfelder SC, Karpecki PM, Nichols KK, Starr CE, Yeu E. Delphi Panel Consensus Regarding Current Clinical Practice Management Options for Demodex blepharitis. Clin Ophthalmol. 2023; 17:667-679. PMID: 36875531; PMCID: PMC9983333.
      Citations:    
    13. Perez VL, Mah FS, Willcox M, Pflugfelder S. Anti-Inflammatories in the Treatment of Dry Eye Disease: A Review. J Ocul Pharmacol Ther. 2023 03; 39(2):89-101. PMID: 36796014.
      Citations: 1     Fields:    Translation:HumansCells
    14. Yazdanpanah G, Yen MT, Pflugfelder SC. Quantitative assessment of botulinum toxin injection on blink rate in blepharospasm. Orbit. 2023 Dec; 42(6):571-578. PMID: 36484152.
      Citations:    Fields:    
    15. Pflugfelder S, Nakhleh L, Kikukawa Y, Tanaka S, Kosugi T. Non-Invasive Tear Break-Up Detection with the Kowa DR-1a and Its Relationship to Dry Eye Clinical Severity. Int J Mol Sci. 2022 Nov 25; 23(23). PMID: 36499103; PMCID: PMC9737539.
      Citations:    Fields:    Translation:Humans
    16. Zhang Y, Li JM, Lu R, Liu Z, Chen X, de Paiva CS, Pflugfelder SC, Li DQ. Imbalanced IL-37/TNF-a/CTSS signaling disrupts corneal epithelial barrier in a dry eye model in vitro. Ocul Surf. 2022 10; 26:234-243. PMID: 36208723; PMCID: PMC10236502.
      Citations:    Fields:    Translation:HumansCells
    17. Ogawa Y, Dana R, Kim S, Jain S, Rosenblatt MI, Perez VL, Clayton JA, Alves M, Rocha EM, Amparo F, Seo KY, Wang Y, Shen J, Oh JY, Vanathi M, Nair S, Na KS, Riemens A, Sippel K, Soifer M, Wang S, Trindade M, Kim MK, Yoon CH, Yagi R, Hiratsuka R, Ogawa M, Shimizu E, Sato Y, Pflugfelder S, Tsubota K. Multicenter prospective validation study for international chronic ocular graft-versus-host disease consensus diagnostic criteria. Ocul Surf. 2022 10; 26:200-208. PMID: 36130695.
      Citations:    
    18. Wang M, Yennam S, Pflugfelder S. Initial experiences using plasma rich in growth factors to treat keratoneuralgia. Front Med (Lausanne). 2022; 9:946828. PMID: 36091697; PMCID: PMC9448984.
      Citations:    
    19. Uppada S, Zou D, Scott EM, Ko G, Pflugfelder S, Kumar MNVR, Ganugula R. Paclitaxel and Urolithin A Prevent Histamine-Induced Neurovascular Breakdown Alike, in an Ex Vivo Rat Eye Model. ACS Chem Neurosci. 2022 07 20; 13(14):2092-2098. PMID: 35574761; PMCID: PMC9928511.
      Citations:    Fields:    Translation:Animals
    20. Pflugfelder SC, Cao A, Galor A, Nichols KK, Cohen NA, Dalton M. Nicotinic acetylcholine receptor stimulation: A new approach for stimulating tear secretion in dry eye disease. Ocul Surf. 2022 07; 25:58-64. PMID: 35550851.
      Citations:    Fields:    
    21. Soifer M, Tovar A, Wang M, Mousa HM, Yennam S, Sabater AL, Pflugfelder SC, Perez VL. A multicenter report of the use of plasma rich in growth factors (PRGF) for the treatment of patients with ocular surface diseases in North America. Ocul Surf. 2022 07; 25:40-48. PMID: 35489588.
      Citations:    Fields:    
    22. Schaefer L, Hernandez H, Coats RA, Yu Z, Pflugfelder SC, Britton RA, de Paiva CS. Author Correction: Gut-derived butyrate suppresses ocular surface inflammation. Sci Rep. 2022 Apr 21; 12(1):6581. PMID: 35449441; PMCID: PMC9023559.
      Citations:    Fields:    
    23. Alam J, Yazdanpanah G, Ratnapriya R, Borcherding N, de Paiva CS, Li D, Pflugfelder SC. Single-cell transcriptional profiling of murine conjunctival immune cells reveals distinct populations expressing homeostatic and regulatory genes. Mucosal Immunol. 2022 04; 15(4):620-628. PMID: 35361907; PMCID: PMC9262780.
      Citations:    Fields:    Translation:AnimalsCells
    24. Alam J, Yazdanpanah G, Ratnapriya R, Borcherding N, de Paiva CS, Li D, Guimaraes de Souza R, Yu Z, Pflugfelder SC. IL-17 Producing Lymphocytes Cause Dry Eye and Corneal Disease With Aging in RXRa Mutant Mouse. Front Med (Lausanne). 2022; 9:849990. PMID: 35402439; PMCID: PMC8983848.
      Citations: 1     
    25. Schaefer L, Hernandez H, Coats RA, Yu Z, Pflugfelder SC, Britton RA, de Paiva CS. Gut-derived butyrate suppresses ocular surface inflammation. Sci Rep. 2022 03 16; 12(1):4512. PMID: 35296712; PMCID: PMC8927112.
      Citations: 1     Fields:    Translation:Animals
    26. Schaefer L, Trujillo-Vargas CM, Midani FS, Pflugfelder SC, Britton RA, de Paiva CS. Gut Microbiota From Sj?gren syndrome Patients Causes Decreased T Regulatory Cells in the Lymphoid Organs and Desiccation-Induced Corneal Barrier Disruption in Mice. Front Med (Lausanne). 2022; 9:852918. PMID: 35355610; PMCID: PMC8959809.
      Citations:    
    27. Wang M, Yennam S, McMillin J, Chen HH, de la Sen-Corcuera B, Hemmati R, Pflugfelder S. Combined therapy of ocular surface disease with plasma rich in growth factors and scleral contact lenses. Ocul Surf. 2022 01; 23:162-168. PMID: 34537416.
      Citations: 1     Fields:    Translation:Humans
    28. Dana R, Farid M, Gupta PK, Hamrah P, Karpecki P, McCabe CM, Nijm L, Pepose JS, Pflugfelder S, Rapuano CJ, Saini A, Gibbs SN, Broder MS. Expert consensus on the identification, diagnosis, and treatment of neurotrophic keratopathy. BMC Ophthalmol. 2021 Sep 08; 21(1):327. PMID: 34493256; PMCID: PMC8425140.
      Citations: 1     Fields:    Translation:Humans
    29. Li JM, Lu R, Zhang Y, Lin J, Hua X, Pflugfelder SC, Li DQ. IL-36a/IL-36RA/IL-38 signaling mediates inflammation and barrier disruption in human corneal epithelial cells under hyperosmotic stress. Ocul Surf. 2021 10; 22:163-171. PMID: 34428579; PMCID: PMC9034690.
      Citations: 3     Fields:    Translation:HumansCells
    30. Mitchell T, Murri M, Pflugfelder SC. Video Viewing Blink Rate in Normal and Dry Eyes. Eye Contact Lens. 2021 08 01; 47(8):442-444. PMID: 33900215; PMCID: PMC8316279.
      Citations: 1     Fields:    Translation:Humans
    31. Starr CE, Dana R, Pflugfelder SC, Holland EJ, Zhang S, Owen D, Brazzell K. Dry eye disease flares: A rapid evidence assessment. Ocul Surf. 2021 10; 22:51-59. PMID: 34303844.
      Citations: 4     Fields:    Translation:Humans
    32. de Paiva CS, Trujillo-Vargas CM, Schaefer L, Yu Z, Britton RA, Pflugfelder SC. Differentially Expressed Gene Pathways in the Conjunctiva of Sj?gren Syndrome Keratoconjunctivitis Sicca. Front Immunol. 2021; 12:702755. PMID: 34349764; PMCID: PMC8326832.
      Citations: 3     Fields:    Translation:HumansCells
    33. Alam J, de Paiva CS, Pflugfelder SC. Desiccation Induced Conjunctival Monocyte Recruitment and Activation - Implications for Keratoconjunctivitis. Front Immunol. 2021; 12:701415. PMID: 34305940; PMCID: PMC8297564.
      Citations: 5     Fields:    Translation:AnimalsCells
    34. Li JM, Kim S, Zhang Y, Bian F, Hu J, Lu R, Pflugfelder SC, Chen R, Li DQ. Single-Cell Transcriptomics Identifies a Unique Entity and Signature Markers of Transit-Amplifying Cells in Human Corneal Limbus. Invest Ophthalmol Vis Sci. 2021 07 01; 62(9):36. PMID: 34297801; PMCID: PMC8300054.
      Citations: 3     Fields:    Translation:HumansCells
    35. Gumus K, Pflugfelder SC. Conjunctivochalasis and Tear Osmolarity Are Associated With Reduced Conjunctival Epithelial Thickness in Dry Eye. Am J Ophthalmol. 2021 07; 227:35-44. PMID: 33571473; PMCID: PMC8184586.
      Citations: 1     Fields:    Translation:HumansCells
    36. Alam J, Yu Z, de Paiva CS, Pflugfelder SC. Retinoid Regulation of Ocular Surface Innate Inflammation. Int J Mol Sci. 2021 Jan 22; 22(3). PMID: 33499199; PMCID: PMC7866051.
      Citations: 3     Fields:    Translation:AnimalsCells
    37. Li DQ, Kim S, Li JM, Gao Q, Choi J, Bian F, Hu J, Zhang Y, Li J, Lu R, Li Y, Pflugfelder SC, Miao H, Chen R. Single-cell transcriptomics identifies limbal stem cell population and cell types mapping its differentiation trajectory in limbal basal epithelium of human cornea. Ocul Surf. 2021 04; 20:20-32. PMID: 33388438; PMCID: PMC8359589.
      Citations: 11     Fields:    Translation:HumansCells
    38. Tsubota K, Pflugfelder SC, Liu Z, Baudouin C, Kim HM, Messmer EM, Kruse F, Liang L, Carreno-Galeano JT, Rolando M, Yokoi N, Kinoshita S, Dana R. Defining Dry Eye from a Clinical Perspective. Int J Mol Sci. 2020 Dec 04; 21(23). PMID: 33291796; PMCID: PMC7730816.
      Citations: 17     Fields:    Translation:HumansAnimals
    39. Liu Z, Chen D, Chen X, Bian F, Gao N, Li J, Pflugfelder SC, Li DQ. Autophagy Activation Protects Ocular Surface from Inflammation in a Dry Eye Model In Vitro. Int J Mol Sci. 2020 Nov 26; 21(23). PMID: 33255884; PMCID: PMC7728298.
      Citations: 9     Fields:    Translation:HumansCells
    40. Kutlehria S, Hernandez H, de Souza RG, Lee A, Yu Z, Pflugfelder SC, Singh M, de Paiva CS, Trujillo-Vargas CM. Rapamycin Eyedrops Increased CD4+Foxp3+ Cells and Prevented Goblet Cell Loss in the Aged Ocular Surface. Int J Mol Sci. 2020 Nov 24; 21(23). PMID: 33255287; PMCID: PMC7727717.
      Citations:    Fields:    Translation:HumansAnimalsCells
    41. Perez VL, Stern ME, Pflugfelder SC. Inflammatory basis for dry eye disease flares. Exp Eye Res. 2020 12; 201:108294. PMID: 33039458; PMCID: PMC7736538.
      Citations: 10     Fields:    Translation:HumansCells
    42. Pflugfelder SC, Stern ME. The cornea in keratoconjunctivitis sicca. Exp Eye Res. 2020 12; 201:108295. PMID: 33038387; PMCID: PMC7736263.
      Citations: 5     Fields:    Translation:Humans
    43. Ganugula R, Arora M, Lepiz MA, Niu Y, Mallick BK, Pflugfelder SC, Scott EM, Kumar MNVR. Systemic anti-inflammatory therapy aided by double-headed nanoparticles in a canine model of acute intraocular inflammation. Sci Adv. 2020 08; 6(35):eabb7878. PMID: 32923645; PMCID: PMC7449680.
      Citations: 3     Fields:    Translation:Animals
    44. Kamal SM, Riccobono K, Kwok A, Edmond JC, Pflugfelder SC. Unilateral pediatric neurotrophic keratitis due to congenital left trigeminal nerve aplasia with PROSE (prosthetic replacement of the ocular surface ecosystem) treatment. Am J Ophthalmol Case Rep. 2020 Dec; 20:100854. PMID: 33094195; PMCID: PMC7568187.
      Citations: 3     
    45. Liu Z, Chen D, Chen X, Bian F, Qin W, Gao N, Xiao Y, Li J, Pflugfelder SC, Li DQ. Trehalose Induces Autophagy Against Inflammation by Activating TFEB Signaling Pathway in Human Corneal Epithelial Cells Exposed to Hyperosmotic Stress. Invest Ophthalmol Vis Sci. 2020 08 03; 61(10):26. PMID: 32785678; PMCID: PMC7441355.
      Citations: 10     Fields:    Translation:HumansCells
    46. Alam J, de Souza RG, Yu Z, Stern ME, de Paiva CS, Pflugfelder SC. Calcineurin Inhibitor Voclosporin Preserves Corneal Barrier and Conjunctival Goblet Cells in Experimental Dry Eye. J Ocul Pharmacol Ther. 2020 11; 36(9):679-685. PMID: 32721249; PMCID: PMC7703159.
      Citations: 4     Fields:    Translation:AnimalsCells
    47. Pflugfelder SC, de Paiva CS. Goblet cells promote tolerance induction in the conjunctiva. Mucosal Immunol. 2020 09; 13(5):717-718. PMID: 32616838; PMCID: PMC7888209.
      Citations: 3     Fields:    Translation:Cells
    48. Pflugfelder SC, Stern ME. Biological functions of tear film. Exp Eye Res. 2020 08; 197:108115. PMID: 32561483; PMCID: PMC7483968.
      Citations: 15     Fields:    Translation:Humans
    49. Utine CA, Li G, Asbell P, Pflugfelder S, Akpek E. Ocular surface disease associated with dupilumab treatment for atopic diseases. Ocul Surf. 2021 01; 19:151-156. PMID: 32439390.
      Citations: 7     Fields:    Translation:Humans
    50. Hu J, Gao N, Zhang Y, Chen X, Li J, Bian F, Chi W, Liu Z, de Paiva CS, Pflugfelder SC, Li DQ. IL-33/ST2/IL-9/IL-9R signaling disrupts ocular surface barrier in allergic inflammation. Mucosal Immunol. 2020 11; 13(6):919-930. PMID: 32358573; PMCID: PMC7572432.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    51. Khimani KS, Go JA, De Souza RG, Mitchell T, Yu Z, de Paiva CS, Saumur M, Pflugfelder SC. Regional Comparison of Goblet Cell Number and Area in Exposed and Covered Dry Eyes and Their Correlation with Tear MUC5AC. Sci Rep. 2020 02 19; 10(1):2933. PMID: 32076085; PMCID: PMC7031519.
      Citations: 2     Fields:    Translation:HumansCells
    52. de Paiva CS, Pflugfelder SC. Mechanisms of Disease in Sj?gren Syndrome-New Developments and Directions. Int J Mol Sci. 2020 Jan 19; 21(2). PMID: 31963817; PMCID: PMC7013496.
      Citations: 3     Fields:    Translation:HumansCells
    53. Alam J, de Paiva CS, Pflugfelder SC. Immune - Goblet cell interaction in the conjunctiva. Ocul Surf. 2020 04; 18(2):326-334. PMID: 31953222; PMCID: PMC7125021.
      Citations: 19     Fields:    Translation:AnimalsCells
    54. Trujillo-Vargas CM, Schaefer L, Alam J, Pflugfelder SC, Britton RA, de Paiva CS. The gut-eye-lacrimal gland-microbiome axis in Sj?gren Syndrome. Ocul Surf. 2020 04; 18(2):335-344. PMID: 31644955; PMCID: PMC7124975.
      Citations: 22     Fields:    Translation:Animals
    55. Wang C, Schaefer L, Bian F, Yu Z, Pflugfelder SC, Britton RA, de Paiva CS. Dysbiosis Modulates Ocular Surface Inflammatory Response to Liposaccharide. Invest Ophthalmol Vis Sci. 2019 10 01; 60(13):4224-4233. PMID: 31618426; PMCID: PMC6795342.
      Citations: 6     Fields:    Translation:Animals
    56. de Paiva CS, Pflugfelder SC, Ng SM, Akpek EK. Topical cyclosporine A therapy for dry eye syndrome. Cochrane Database Syst Rev. 2019 09 13; 9:CD010051. PMID: 31517988; PMCID: PMC6743670.
      Citations: 18     Fields:    Translation:Humans
    57. Hsu JI, Pflugfelder SC, Kim SJ. Ocular complications of atopic dermatitis. Cutis. 2019 Sep; 104(3):189-193. PMID: 31675394.
      Citations: 4     Fields:    Translation:Humans
    58. Pflugfelder SC, Massaro-Giordano M, Perez VL, Hamrah P, Deng SX, Espandar L, Foster CS, Affeldt J, Seedor JA, Afshari NA, Dana R, Chao W, Allegretti M, Mantelli F. Topical Recombinant Human Nerve Growth Factor (Cenegermin) for Neurotrophic Keratopathy: A Multicenter Randomized Vehicle-Controlled Pivotal Trial. Ophthalmology. 2020 01; 127(1):14-26. PMID: 31585826.
      Citations: 32     Fields:    Translation:Humans
    59. Deng R, Chen X, Zhang Y, Bian F, Gao N, Hu J, Wang C, de Souza RG, Lu F, Pflugfelder SC, Li DQ. Short ragweed pollen promotes M2 macrophage polarization via TSLP/TSLPR/OX40L signaling in allergic inflammation. Mucosal Immunol. 2019 09; 12(5):1141-1149. PMID: 31350466; PMCID: PMC7285437.
      Citations: 3     Fields:    Translation:AnimalsCells
    60. Bian F, Xiao Y, Barbosa FL, de Souza RG, Hernandez H, Yu Z, Pflugfelder SC, de Paiva CS. Age-associated antigen-presenting cell alterations promote dry-eye inducing Th1 cells. Mucosal Immunol. 2019 07; 12(4):897-908. PMID: 30696983; PMCID: PMC6599474.
      Citations: 17     Fields:    Translation:AnimalsCells
    61. Chen X, Deng R, Chi W, Hua X, Lu F, Bian F, Gao N, Li Z, Pflugfelder SC, de Paiva CS, Li DQ. IL-27 signaling deficiency develops Th17-enhanced Th2-dominant inflammation in murine allergic conjunctivitis model. Allergy. 2019 05; 74(5):910-921. PMID: 30515838; PMCID: PMC7190079.
      Citations: 13     Fields:    Translation:AnimalsCells
    62. Stepp MA, Pal-Ghosh S, Tadvalkar G, Williams AR, Pflugfelder SC, de Paiva CS. Reduced Corneal Innervation in the CD25 Null Model of Sj?gren Syndrome. Int J Mol Sci. 2018 Nov 30; 19(12). PMID: 30513621; PMCID: PMC6320862.
      Citations: 12     Fields:    Translation:Animals
    63. Stamer WD, Williams AM, Pflugfelder S, Coupland SE. Accessibility to and Quality of Human Eye Tissue for Research: A Cross-Sectional Survey of ARVO Members. Invest Ophthalmol Vis Sci. 2018 10 01; 59(12):4783-4792. PMID: 30304462.
      Citations: 5     Fields:    Translation:Humans
    64. Xiao Y, de Paiva CS, Yu Z, de Souza RG, Li DQ, Pflugfelder SC. Goblet cell-produced retinoic acid suppresses CD86 expression and IL-12 production in bone marrow-derived cells. Int Immunol. 2018 09 25; 30(10):457-470. PMID: 30010888; PMCID: PMC6153729.
      Citations: 16     Fields:    Translation:AnimalsCells
    65. Pflugfelder SC, Bian F, Gumus K, Farley W, Stern ME, De Paiva CS. Severity of Sj?gren's Syndrome Keratoconjunctivitis Sicca Increases with Increased Percentage of Conjunctival Antigen-Presenting Cells. Int J Mol Sci. 2018 Sep 14; 19(9). PMID: 30223431; PMCID: PMC6165102.
      Citations: 18     Fields:    Translation:HumansCells
    66. Guimaraes de Souza R, Yu Z, Stern ME, Pflugfelder SC, de Paiva CS. Suppression of Th1-Mediated Keratoconjunctivitis Sicca by Lifitegrast. J Ocul Pharmacol Ther. 2018 09; 34(7):543-549. PMID: 29958030; PMCID: PMC6909696.
      Citations: 14     Fields:    Translation:AnimalsCells
    67. Zaheer M, Wang C, Bian F, Yu Z, Hernandez H, de Souza RG, Simmons KT, Schady D, Swennes AG, Pflugfelder SC, Britton RA, de Paiva CS. Protective role of commensal bacteria in Sj?gren Syndrome. J Autoimmun. 2018 09; 93:45-56. PMID: 29934134; PMCID: PMC6108910.
      Citations: 25     Fields:    Translation:AnimalsCells
    68. Patel SN, Shetlar DJ, Pflugfelder SC. Bilateral Candida parapsilosis infiltration of nonhealing indolent epithelial defects in a diabetic patient with neurotrophic keratopathy. Can J Ophthalmol. 2018 12; 53(6):e224-e226. PMID: 30502998.
      Citations: 1     Fields:    Translation:HumansAnimals
    69. Yang J, Chandwani R, Gopinatth V, Boyce T, Pflugfelder SC, Huang D, Liu G. Near-infrared laser thermal conjunctivoplasty. Sci Rep. 2018 03 01; 8(1):3863. PMID: 29497112; PMCID: PMC5832782.
      Citations: 1     Fields:    Translation:Animals
    70. Wang C, Zaheer M, Bian F, Quach D, Swennes AG, Britton RA, Pflugfelder SC, de Paiva CS. Sj?gren-Like Lacrimal Keratoconjunctivitis in Germ-Free Mice. Int J Mol Sci. 2018 Feb 13; 19(2). PMID: 29438346; PMCID: PMC5855787.
      Citations: 31     Fields:    Translation:AnimalsCells
    71. Ko BY, Xiao Y, Barbosa FL, de Paiva CS, Pflugfelder SC. Goblet cell loss abrogates ocular surface immune tolerance. JCI Insight. 2018 02 08; 3(3). PMID: 29415888; PMCID: PMC5821180.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    72. Parra AS, Roth BM, Nguyen TM, Wang L, Pflugfelder SC, Al-Mohtaseb Z. Assessment of the Prosthetic Replacement of Ocular Surface Ecosystem (PROSE) scleral lens on visual acuity for corneal irregularity and ocular surface disease. Ocul Surf. 2018 04; 16(2):254-258. PMID: 29425812.
      Citations: 7     Fields:    Translation:Humans
    73. Stepp MA, Pal-Ghosh S, Tadvalkar G, Williams A, Pflugfelder SC, de Paiva CS. Reduced intraepithelial corneal nerve density and sensitivity accompany desiccating stress and aging in C57BL/6 mice. Exp Eye Res. 2018 04; 169:91-98. PMID: 29407221; PMCID: PMC5949876.
      Citations: 28     Fields:    Translation:AnimalsCells
    74. McDonnell PJ, Pflugfelder SC, Stern ME, Hardten DR, Conway T, Villanueva L, Hollander DA. Study design and baseline findings from the progression of ocular findings (PROOF) natural history study of dry eye. BMC Ophthalmol. 2017 Dec 28; 17(1):265. PMID: 29284427; PMCID: PMC5746001.
      Citations: 8     Fields:    Translation:Humans
    75. Pflugfelder SC, de Paiva CS. The Pathophysiology of Dry Eye Disease: What We Know and Future Directions for Research. Ophthalmology. 2017 11; 124(11S):S4-S13. PMID: 29055361; PMCID: PMC5657523.
      Citations: 100     Fields:    Translation:HumansCells
    76. Li J, Xiao Y, Coursey TG, Chen X, Deng R, Lu F, Pflugfelder SC, Li DQ. Identification for Differential Localization of Putative Corneal Epithelial Stem Cells in Mouse and Human. Sci Rep. 2017 07 12; 7(1):5169. PMID: 28701781; PMCID: PMC5507988.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    77. Barbosa FL, Xiao Y, Bian F, Coursey TG, Ko BY, Clevers H, de Paiva CS, Pflugfelder SC. Goblet Cells Contribute to Ocular Surface Immune Tolerance-Implications for Dry Eye Disease. Int J Mol Sci. 2017 May 05; 18(5). PMID: 28475124; PMCID: PMC5454891.
      Citations: 35     Fields:    Translation:AnimalsCells
    78. Jin H, Parker WT, Law NW, Clarke CL, Gisseman JD, Pflugfelder SC, Wang L, Al-Mohtaseb ZN. Evolving risk factors and antibiotic sensitivity patterns for microbial keratitis at a large county hospital. Br J Ophthalmol. 2017 11; 101(11):1483-1487. PMID: 28336675.
      Citations: 18     Fields:    Translation:Humans
    79. Zhao YE, Gong XH, Zhu XN, Li HM, Tu MJ, Coursey TG, Pflugfelder SC, Gu F, Chen D. Long-term outcomes of ciliary sulcus versus capsular bag fixation of intraocular lenses in children: An ultrasound biomicroscopy study. PLoS One. 2017; 12(3):e0172979. PMID: 28301497; PMCID: PMC5354427.
      Citations: 9     Fields:    Translation:Humans
    80. Gumus K, Schuetzle KL, Pflugfelder SC. Randomized Controlled Crossover Trial Comparing the Impact of Sham or Intranasal Tear Neurostimulation on Conjunctival Goblet Cell Degranulation. Am J Ophthalmol. 2017 May; 177:159-168. PMID: 28302532; PMCID: PMC5457166.
      Citations: 10     Fields:    Translation:HumansCells
    81. Bian F, Xiao Y, Zaheer M, Volpe EA, Pflugfelder SC, Li DQ, de Paiva CS. Inhibition of NLRP3 Inflammasome Pathway by Butyrate Improves Corneal Wound Healing in Corneal Alkali Burn. Int J Mol Sci. 2017 Mar 05; 18(3). PMID: 28273882; PMCID: PMC5372578.
      Citations: 25     Fields:    Translation:Animals
    82. Chi W, Hua X, Chen X, Bian F, Yuan X, Zhang L, Wang X, Chen D, Deng R, Li Z, Liu Y, de Paiva CS, Pflugfelder SC, Li DQ. Mitochondrial DNA oxidation induces imbalanced activity of NLRP3/NLRP6 inflammasomes by activation of caspase-8 and BRCC36 in dry eye. J Autoimmun. 2017 Jun; 80:65-76. PMID: 28238526; PMCID: PMC5536896.
      Citations: 25     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    83. Chen D, Qu Y, Hua X, Zhang L, Liu Z, Pflugfelder SC, Li DQ. A hyaluronan hydrogel scaffold-based xeno-free culture system for ex vivo expansion of human corneal epithelial stem cells. Eye (Lond). 2017 Jun; 31(6):962-971. PMID: 28211875; PMCID: PMC5518843.
      Citations: 12     Fields:    Translation:HumansCells
    84. Pflugfelder SC, Gumus K, Feuerman J, Alex A. Tear Volume-based Diagnostic Classification for Tear Dysfunction. Int Ophthalmol Clin. 2017; 57(2):1-12. PMID: 28282310; PMCID: PMC5347476.
      Citations: 4     Fields:    Translation:Humans
    85. Gumus K, Pflugfelder SC. Anterior Segment Optical Coherence Tomography (AS-OCT) in the Management of Dry Eye. Int Ophthalmol Clin. 2017; 57(2):13-22. PMID: 28282311.
      Citations: 3     Fields:    Translation:Humans
    86. Gumus K, Pflugfelder SC. Intranasal Tear Neurostimulation: An Emerging Concept in the Treatment of Dry Eye. Int Ophthalmol Clin. 2017; 57(2):101-108. PMID: 28282317.
      Citations: 7     Fields:    Translation:Humans
    87. Stern ME, Pflugfelder SC. What We Have Learned From Animal Models of Dry Eye. Int Ophthalmol Clin. 2017; 57(2):109-118. PMID: 28282318; PMCID: PMC5347474.
      Citations: 9     Fields:    Translation:HumansAnimals
    88. Pflugfelder SC, Stern M, Zhang S, Shojaei A. LFA-1/ICAM-1 Interaction as a Therapeutic Target in Dry Eye Disease. J Ocul Pharmacol Ther. 2017 Jan/Feb; 33(1):5-12. PMID: 27906544; PMCID: PMC5240001.
      Citations: 35     Fields:    Translation:HumansAnimals
    89. Li J, Zhang L, Chen X, Chen D, Hua X, Bian F, Deng R, Lu F, Li Z, Pflugfelder SC, Li DQ. Pollen/TLR4 Innate Immunity Signaling Initiates IL-33/ST2/Th2 Pathways in Allergic Inflammation. Sci Rep. 2016 10 31; 6:36150. PMID: 27796360; PMCID: PMC5087075.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    90. Coursey TG, Bian F, Zaheer M, Pflugfelder SC, Volpe EA, de Paiva CS. Age-related spontaneous lacrimal keratoconjunctivitis is accompanied by dysfunctional T regulatory cells. Mucosal Immunol. 2017 05; 10(3):743-756. PMID: 27706128; PMCID: PMC5380589.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    91. Volpe EA, Henriksson JT, Wang C, Barbosa FL, Zaheer M, Zhang X, Pflugfelder SC, de Paiva CS. Interferon-gamma deficiency protects against aging-related goblet cell loss. Oncotarget. 2016 10 04; 7(40):64605-64614. PMID: 27623073; PMCID: PMC5323102.
      Citations: 16     Fields:    Translation:AnimalsCells
    92. Marcano DC, Shin CS, Lee B, Isenhart LC, Liu X, Li F, Jester JV, Pflugfelder SC, Simpson J, Acharya G. Synergistic Cysteamine Delivery Nanowafer as an Efficacious Treatment Modality for Corneal Cystinosis. Mol Pharm. 2016 10 03; 13(10):3468-3477. PMID: 27571217.
      Citations: 9     Fields:    Translation:Animals
    93. Bian F, Shin CS, Wang C, Pflugfelder SC, Acharya G, De Paiva CS. Dexamethasone Drug Eluting Nanowafers Control Inflammation in Alkali-Burned Corneas Associated With Dry Eye. Invest Ophthalmol Vis Sci. 2016 06 01; 57(7):3222-30. PMID: 27327581; PMCID: PMC4928693.
      Citations: 10     Fields:    Translation:Animals
    94. Simmons KT, Xiao Y, Pflugfelder SC, de Paiva CS. Inflammatory Response to Lipopolysaccharide on the Ocular Surface in a Murine Dry Eye Model. Invest Ophthalmol Vis Sci. 2016 05 01; 57(6):2443-51. PMID: 27136463; PMCID: PMC4857831.
      Citations: 16     Fields:    Translation:AnimalsCells
    95. de Paiva CS, Jones DB, Stern ME, Bian F, Moore QL, Corbiere S, Streckfus CF, Hutchinson DS, Ajami NJ, Petrosino JF, Pflugfelder SC. Altered Mucosal Microbiome Diversity and Disease Severity in Sj?gren Syndrome. Sci Rep. 2016 Apr 18; 6:23561. PMID: 27087247; PMCID: PMC4834578.
      Citations: 119     Fields:    Translation:HumansAnimals
    96. Coursey TG, Tukler Henriksson J, Barbosa FL, de Paiva CS, Pflugfelder SC. Interferon-?-Induced Unfolded Protein Response in Conjunctival Goblet Cells as a Cause of Mucin Deficiency in Sj?gren Syndrome. Am J Pathol. 2016 06; 186(6):1547-58. PMID: 27085137; PMCID: PMC4901135.
      Citations: 46     Fields:    Translation:HumansAnimalsCells
    97. Bian F, Wang C, Tukler-Henriksson J, Pflugfelder SC, Camodeca C, Nuti E, Rossello A, Li DQ, de Paiva CS. MMP-8 Is Critical for Dexamethasone Therapy in Alkali-Burned Corneas Under Dry Eye Conditions. J Cell Physiol. 2016 11; 231(11):2506-16. PMID: 26923552; PMCID: PMC4946998.
      Citations: 5     Fields:    Translation:AnimalsCells
    98. Kohanim S, Palioura S, Saeed HN, Akpek EK, Amescua G, Basu S, Blomquist PH, Bouchard CS, Dart JK, Gai X, Gregory DG, Iyer G, Jacobs DS, Johnson AJ, Kinoshita S, Mantagos IS, Mehta JS, Perez VL, Pflugfelder SC, Sangwan VS, Sippel KC, Sotozono C, Srinivasan B, Tan DT, Tandon R, Tseng SC, Ueta M, Chodosh J, Gomes JA. Acute and Chronic Ophthalmic Involvement in Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis - A Comprehensive Review and Guide to Therapy. II. Ophthalmic Disease. Ocul Surf. 2016 04; 14(2):168-88. PMID: 26882981.
      Citations: 45     Fields:    Translation:Humans
    99. Perez VL, Pflugfelder SC, Zhang S, Shojaei A, Haque R. Lifitegrast, a Novel Integrin Antagonist for Treatment of Dry Eye Disease. Ocul Surf. 2016 04; 14(2):207-15. PMID: 26807723.
      Citations: 57     Fields:    Translation:Humans
    100. Li J, Hua X, Zhang L, Lu F, Coursey TG, Pflugfelder SC, Li DQ. Blueberry Component Pterostilbene Protects Corneal Epithelial Cells from Inflammation via Anti-oxidative Pathway. Sci Rep. 2016 Jan 14; 6:19408. PMID: 26762881; PMCID: PMC4725955.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    101. Bian F, Pelegrino FS, Henriksson JT, Pflugfelder SC, Volpe EA, Li DQ, de Paiva CS. Differential Effects of Dexamethasone and Doxycycline on Inflammation and MMP Production in Murine Alkali-Burned Corneas Associated with Dry Eye. Ocul Surf. 2016 04; 14(2):242-54. PMID: 26772899; PMCID: PMC4842328.
      Citations: 26     Fields:    Translation:Animals
    102. Kohanim S, Palioura S, Saeed HN, Akpek EK, Amescua G, Basu S, Blomquist PH, Bouchard CS, Dart JK, Gai X, Gregory DG, Iyer G, Jacobs DS, Johnson AJ, Kinoshita S, Mantagos IS, Mehta JS, Perez VL, Pflugfelder SC, Sangwan VS, Sippel KC, Sotozono C, Srinivasan B, Tan DT, Tandon R, Tseng SC, Ueta M, Chodosh J, Gomes JA. Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis--A Comprehensive Review and Guide to Therapy. I. Systemic Disease. Ocul Surf. 2016 Jan; 14(1):2-19. PMID: 26549248.
      Citations: 39     Fields:    Translation:Humans
    103. Pflugfelder SC, De Paiva CS, Moore QL, Volpe EA, Li DQ, Gumus K, Zaheer ML, Corrales RM. Aqueous Tear Deficiency Increases Conjunctival Interferon-? (IFN-?) Expression and Goblet Cell Loss. Invest Ophthalmol Vis Sci. 2015 Nov; 56(12):7545-50. PMID: 26618646; PMCID: PMC4669202.
      Citations: 56     Fields:    Translation:HumansCells
    104. Zhang L, Su Z, Zhang Z, Lin J, Li DQ, Pflugfelder SC. Effects of azithromycin on gene expression profiles of proinflammatory and anti-inflammatory mediators in the eyelid margin and conjunctiva of patients with meibomian gland disease. JAMA Ophthalmol. 2015 Oct; 133(10):1117-23. PMID: 26204109; PMCID: PMC5496815.
      Citations: 20     Fields:    Translation:HumansCells
    105. Bauskar A, Mack WJ, Mauris J, Heur M, Nagel BA, Kolar GR, Gleave ME, Nakamura T, Kinoshita S, Moradian-Oldak J, Panjwani N, Pflugfelder SC, Wilson MR, Fini ME, Jeong S, Arg?eso P. Clusterin Seals the Ocular Surface Barrier in Mouse Dry Eye. PLoS One. 2015; 10(9):e0138958. PMID: 26402857; PMCID: PMC4581869.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    106. Krauss AH, Corrales RM, Pelegrino FS, Tukler-Henriksson J, Pflugfelder SC, de Paiva CS. Improvement of Outcome Measures of Dry Eye by a Novel Integrin Antagonist in the Murine Desiccating Stress Model. Invest Ophthalmol Vis Sci. 2015 Sep; 56(10):5888-95. PMID: 26348638; PMCID: PMC4566400.
      Citations: 11     Fields:    Translation:AnimalsCells
    107. Rahman EZ, Lam PK, Chu CK, Moore Q, Pflugfelder SC. Corneal Sensitivity in Tear Dysfunction and its Correlation With Clinical Parameters and Blink Rate. Am J Ophthalmol. 2015 Nov; 160(5):858-866.e5. PMID: 26255576; PMCID: PMC4661092.
      Citations: 19     Fields:    Translation:Humans
    108. Hua X, Deng R, Li J, Chi W, Su Z, Lin J, Pflugfelder SC, Li DQ. Protective Effects of L-Carnitine Against Oxidative Injury by Hyperosmolarity in Human Corneal Epithelial Cells. Invest Ophthalmol Vis Sci. 2015 Aug; 56(9):5503-11. PMID: 26284556; PMCID: PMC4544189.
      Citations: 24     Fields:    Translation:HumansCells
    109. Coursey TG, Henriksson JT, Marcano DC, Shin CS, Isenhart LC, Ahmed F, De Paiva CS, Pflugfelder SC, Acharya G. Dexamethasone nanowafer as an effective therapy for dry eye disease. J Control Release. 2015 Sep 10; 213:168-174. PMID: 26184051.
      Citations: 22     Fields:    Translation:Animals
    110. Bian F, Pelegrino FS, Pflugfelder SC, Volpe EA, Li DQ, de Paiva CS. Desiccating Stress-Induced MMP Production and Activity Worsens Wound Healing in Alkali-Burned Corneas. Invest Ophthalmol Vis Sci. 2015 Jul; 56(8):4908-18. PMID: 26225631; PMCID: PMC4525635.
      Citations: 11     Fields:    Translation:Animals
    111. Tukler Henriksson J, Coursey TG, Corry DB, De Paiva CS, Pflugfelder SC. IL-13 Stimulates Proliferation and Expression of Mucin and Immunomodulatory Genes in Cultured Conjunctival Goblet Cells. Invest Ophthalmol Vis Sci. 2015 Jul; 56(8):4186-97. PMID: 26132778; PMCID: PMC4495812.
      Citations: 43     Fields:    Translation:AnimalsCells
    112. Hua X, Yuan X, Li Z, Coursey TG, Pflugfelder SC, Li DQ. A Novel Innate Response of Human Corneal Epithelium to Heat-killed Candida albicans by Producing Peptidoglycan Recognition Proteins. PLoS One. 2015; 10(6):e0128039. PMID: 26039076; PMCID: PMC4454663.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    113. Deng R, Hua X, Li J, Chi W, Zhang Z, Lu F, Zhang L, Pflugfelder SC, Li DQ. Oxidative stress markers induced by hyperosmolarity in primary human corneal epithelial cells. PLoS One. 2015; 10(5):e0126561. PMID: 26024535; PMCID: PMC4449087.
      Citations: 57     Fields:    Translation:HumansCells
    114. Moore QL, De Paiva CS, Pflugfelder SC. Effects of Dry Eye Therapies on Environmentally Induced Ocular Surface Disease. Am J Ophthalmol. 2015 Jul; 160(1):135-42.e1. PMID: 25868759; PMCID: PMC4464943.
      Citations: 14     Fields:    Translation:HumansCTClinical Trials
    115. You IC, Bian F, Volpe EA, de Paiva CS, Pflugfelder SC. Age-Related Conjunctival Disease in the C57BL/6.NOD-Aec1Aec2 Mouse Model of Sj?gren Syndrome Develops Independent of Lacrimal Dysfunction. Invest Ophthalmol Vis Sci. 2015 Apr; 56(4):2224-33. PMID: 25758816; PMCID: PMC4687887.
      Citations: 17     Fields:    Translation:Animals
    116. You IC, Coursey TG, Bian F, Barbosa FL, de Paiva CS, Pflugfelder SC. Macrophage Phenotype in the Ocular Surface of Experimental Murine Dry Eye Disease. Arch Immunol Ther Exp (Warsz). 2015 Aug; 63(4):299-304. PMID: 25772203; PMCID: PMC4523394.
      Citations: 22     Fields:    Translation:AnimalsCells
    117. Bian F, Barbosa FL, Corrales RM, Pelegrino FS, Volpe EA, Pflugfelder SC, de Paiva CS. Altered balance of interleukin-13/interferon-gamma contributes to lacrimal gland destruction and secretory dysfunction in CD25 knockout model of Sj?gren's syndrome. Arthritis Res Ther. 2015 Mar 10; 17:53. PMID: 25889094; PMCID: PMC4392623.
      Citations: 18     Fields:    Translation:Animals
    118. Qu Y, Chi W, Hua X, Deng R, Li J, Liu Z, Pflugfelder SC, Li DQ. Unique expression pattern and functional role of periostin in human limbal stem cells. PLoS One. 2015; 10(2):e0117139. PMID: 25658308; PMCID: PMC4319935.
      Citations: 9     Fields:    Translation:HumansCells
    119. Yuan X, Marcano DC, Shin CS, Hua X, Isenhart LC, Pflugfelder SC, Acharya G. Ocular drug delivery nanowafer with enhanced therapeutic efficacy. ACS Nano. 2015 Feb 24; 9(2):1749-58. PMID: 25585134.
      Citations: 36     Fields:    Translation:AnimalsCells
    120. Foulks GN, Forstot SL, Donshik PC, Forstot JZ, Goldstein MH, Lemp MA, Nelson JD, Nichols KK, Pflugfelder SC, Tanzer JM, Asbell P, Hammitt K, Jacobs DS. Clinical guidelines for management of dry eye associated with Sj?gren disease. Ocul Surf. 2015 Apr; 13(2):118-32. PMID: 25881996.
      Citations: 59     Fields:    Translation:Humans
    121. Coursey TG, Bohat R, Barbosa FL, Pflugfelder SC, de Paiva CS. Desiccating stress-induced chemokine expression in the epithelium is dependent on upregulation of NKG2D/RAE-1 and release of IFN-? in experimental dry eye. J Immunol. 2014 Nov 15; 193(10):5264-72. PMID: 25288568; PMCID: PMC4225173.
      Citations: 31     Fields:    Translation:AnimalsCells
    122. Hua X, Su Z, Deng R, Lin J, Li DQ, Pflugfelder SC. Effects of L-carnitine, erythritol and betaine on pro-inflammatory markers in primary human corneal epithelial cells exposed to hyperosmotic stress. Curr Eye Res. 2015 Jul; 40(7):657-67. PMID: 25271595; PMCID: PMC4793974.
      Citations: 30     Fields:    Translation:HumansCells
    123. Deng R, Su Z, Hua X, Zhang Z, Li DQ, Pflugfelder SC. Osmoprotectants suppress the production and activity of matrix metalloproteinases induced by hyperosmolarity in primary human corneal epithelial cells. Mol Vis. 2014; 20:1243-52. PMID: 25352733; PMCID: PMC4165325.
      Citations: 20     Fields:    Translation:HumansCells
    124. Sheppard JD, Donnenfeld ED, Holland EJ, Slonim CB, Solomon KD, McDonald MB, Perry HD, Lane SS, Pflugfelder SC, Samudre SS, Solomon R. Effect of loteprednol etabonate 0.5% on initiation of dry eye treatment with topical cyclosporine 0.05%. Eye Contact Lens. 2014 Sep; 40(5):289-96. PMID: 25083776.
      Citations: 24     Fields:    Translation:Humans
    125. Pflugfelder SC, Stern ME. Mucosal environmental sensors in the pathogenesis of dry eye. Expert Rev Clin Immunol. 2014 Sep; 10(9):1137-40. PMID: 25075545.
      Citations: 14     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    126. Vo RC, Stafeeva K, Aldave AJ, Stulting RD, Moore Q, Pflugfelder SC, Chungfat NC, Holsclaw DS, Margolis TP, Deng SX. Complications related to a cosmetic eye-whitening procedure. Am J Ophthalmol. 2014 Nov; 158(5):967-73. PMID: 25072832.
      Citations: 2     Fields:    Translation:Humans
    127. Pflugfelder SC, Karpecki PM, Perez VL. Treatment of blepharitis: recent clinical trials. Ocul Surf. 2014 Oct; 12(4):273-84. PMID: 25284773.
      Citations: 18     Fields:    Translation:Humans
    128. Hua X, Yuan X, Tang X, Li Z, Pflugfelder SC, Li DQ. Human corneal epithelial cells produce antimicrobial peptides LL-37 and ?-defensins in response to heat-killed Candida albicans. Ophthalmic Res. 2014; 51(4):179-86. PMID: 24662332; PMCID: PMC5744485.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    129. Foulks GN, Pflugfelder SC. New testing options for diagnosing and grading dry eye disease. Am J Ophthalmol. 2014 Jun; 157(6):1122-9. PMID: 24631478; PMCID: PMC4062650.
      Citations: 9     Fields:    Translation:Humans
    130. Pflugfelder SC. What causes dryness in Sj?gren's syndrome patients and how can it be targeted? Expert Rev Clin Immunol. 2014 Apr; 10(4):425-7. PMID: 24564508.
      Citations: 3     Fields:    Translation:Humans
    131. Deng R, Su Z, Lu F, Zhang L, Lin J, Zhang X, de Paiva CS, Pflugfelder SC, Li DQ. A potential link between bacterial pathogens and allergic conjunctivitis by dendritic cells. Exp Eye Res. 2014 Mar; 120:118-26. PMID: 24486456; PMCID: PMC4057919.
      Citations: 5     Fields:    Translation:AnimalsCells
    132. McClellan AJ, Volpe EA, Zhang X, Darlington GJ, Li DQ, Pflugfelder SC, de Paiva CS. Ocular surface disease and dacryoadenitis in aging C57BL/6 mice. Am J Pathol. 2014 Mar; 184(3):631-43. PMID: 24389165; PMCID: PMC3936306.
      Citations: 43     Fields:    Translation:HumansAnimalsCells
    133. Chen JJ, Applebaum DS, Sun GS, Pflugfelder SC. Atopic keratoconjunctivitis: A review. J Am Acad Dermatol. 2014 Mar; 70(3):569-75. PMID: 24342754.
      Citations: 33     Fields:    Translation:Humans
    134. Zhang X, De Paiva CS, Su Z, Volpe EA, Li DQ, Pflugfelder SC. Topical interferon-gamma neutralization prevents conjunctival goblet cell loss in experimental murine dry eye. Exp Eye Res. 2014 Jan; 118:117-24. PMID: 24315969; PMCID: PMC3901360.
      Citations: 36     Fields:    Translation:AnimalsCells
    135. Villani E, Baudouin C, Efron N, Hamrah P, Kojima T, Patel SV, Pflugfelder SC, Zhivov A, Dogru M. In vivo confocal microscopy of the ocular surface: from bench to bedside. Curr Eye Res. 2014 Mar; 39(3):213-31. PMID: 24215436; PMCID: PMC3960287.
      Citations: 75     Fields:    Translation:Humans
    136. Coursey TG, Gandhi NB, Volpe EA, Pflugfelder SC, de Paiva CS. Chemokine receptors CCR6 and CXCR3 are necessary for CD4(+) T cell mediated ocular surface disease in experimental dry eye disease. PLoS One. 2013; 8(11):e78508. PMID: 24223818; PMCID: PMC3817213.
      Citations: 30     Fields:    Translation:AnimalsCells
    137. Suhalim JL, Parfitt GJ, Xie Y, De Paiva CS, De Pavia CS, Pflugfelder SC, Shah TN, Potma EO, Brown DJ, Jester JV. Effect of desiccating stress on mouse meibomian gland function. Ocul Surf. 2014 Jan; 12(1):59-68. PMID: 24439047; PMCID: PMC3896889.
      Citations: 24     Fields:    Translation:AnimalsCells
    138. Singh R, McClellan AJ, Weikert MP, Scoper SV, Joly TJ, Whitley WO, Kakkar E, Pflugfelder SC, Sheppard JD. Long-term Supplementation With n-6 and n-3 PUFAs Improves Moderate-to-Severe Keratoconjunctivitis Sicca: A Randomized Double-Blind Clinical Trial. Cornea. 2013 Oct; 32(10):1297-304. PMID: 23884332.
      Citations: 26     Fields:    Translation:Humans
    139. Tung CI, Perin AF, Gumus K, Pflugfelder SC. Tear meniscus dimensions in tear dysfunction and their correlation with clinical parameters. Am J Ophthalmol. 2014 Feb; 157(2):301-310.e1. PMID: 24315297; PMCID: PMC3946984.
      Citations: 28     Fields:    Translation:Humans
    140. Zhang X, Schaumburg CS, Coursey TG, Siemasko KF, Volpe EA, Gandhi NB, Li DQ, Niederkorn JY, Stern ME, Pflugfelder SC, de Paiva CS. CD8? cells regulate the T helper-17 response in an experimental murine model of Sj?gren syndrome. Mucosal Immunol. 2014 Mar; 7(2):417-27. PMID: 24022789; PMCID: PMC3869878.
      Citations: 27     Fields:    Translation:AnimalsCells
    141. Pflugfelder SC, Corrales RM, de Paiva CS. T helper cytokines in dry eye disease. Exp Eye Res. 2013 Dec; 117:118-25. PMID: 24012834; PMCID: PMC3855838.
      Citations: 61     Fields:    Translation:HumansAnimalsCells
    142. Gandhi NB, Su Z, Zhang X, Volpe EA, Pelegrino FS, Rahman SA, Li DQ, Pflugfelder SC, de Paiva CS. Dendritic cell-derived thrombospondin-1 is critical for the generation of the ocular surface Th17 response to desiccating stress. J Leukoc Biol. 2013 Dec; 94(6):1293-301. PMID: 23983225; PMCID: PMC4051277.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    143. Alex A, Edwards A, Hays JD, Kerkstra M, Shih A, de Paiva CS, Pflugfelder SC. Factors predicting the ocular surface response to desiccating environmental stress. Invest Ophthalmol Vis Sci. 2013 May 07; 54(5):3325-32. PMID: 23572103; PMCID: PMC3648229.
      Citations: 18     Fields:    Translation:HumansCells
    144. Lin J, Zhang L, Zhao G, Su Z, Deng R, Pflugfelder SC, Li DQ. A novel interleukin 33/ST2 signaling regulates inflammatory response in human corneal epithelium. PLoS One. 2013; 8(4):e60963. PMID: 23585867; PMCID: PMC3622010.
      Citations: 13     Fields:    Translation:HumansCells
    145. Henriksson JT, De Paiva CS, Farley W, Pflugfelder SC, Burns AR, Bergmanson JP. Morphologic alterations of the palpebral conjunctival epithelium in a dry eye model. Cornea. 2013 Apr; 32(4):483-90. PMID: 23146932; PMCID: PMC3578023.
      Citations: 6     Fields:    Translation:AnimalsCells
    146. Dimit R, Gire A, Pflugfelder SC, Bergmanson JP. Patient ocular conditions and clinical outcomes using a PROSE scleral device. Cont Lens Anterior Eye. 2013 Aug; 36(4):159-63. PMID: 23499361.
      Citations: 13     Fields:    Translation:Humans
    147. Redfern RL, Patel N, Hanlon S, Farley W, Gondo M, Pflugfelder SC, McDermott AM. Toll-like receptor expression and activation in mice with experimental dry eye. Invest Ophthalmol Vis Sci. 2013 Feb 28; 54(2):1554-63. PMID: 23372055; PMCID: PMC4604718.
      Citations: 28     Fields:    Translation:HumansAnimals
    148. Stern ME, Schaumburg CS, Pflugfelder SC. Dry eye as a mucosal autoimmune disease. Int Rev Immunol. 2013 Feb; 32(1):19-41. PMID: 23360156; PMCID: PMC3587314.
      Citations: 114     Fields:    Translation:HumansAnimalsCells
    149. Su Z, Lin J, Lu F, Zhang X, Zhang L, Gandhi NB, de Paiva CS, Pflugfelder SC, Li DQ. Potential autocrine regulation of interleukin-33/ST2 signaling of dendritic cells in allergic inflammation. Mucosal Immunol. 2013 Sep; 6(5):921-30. PMID: 23299617; PMCID: PMC3904307.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    150. Ling JD, Gire A, Pflugfelder SC. PROSE therapy used to minimize corneal trauma in patients with corneal epithelial defects. Am J Ophthalmol. 2013 Apr; 155(4):615-619, 619.e1-2. PMID: 23218704.
      Citations: 6     Fields:    Translation:Humans
    151. Lin J, Yoon KC, Zhang L, Su Z, Lu R, Ma P, De Paiva CS, Pflugfelder SC, Li DQ. A native-like corneal construct using donor corneal stroma for tissue engineering. PLoS One. 2012; 7(11):e49571. PMID: 23166715; PMCID: PMC3499466.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    152. de Paiva CS, Schwartz CE, Pflugfelder SC, Gj?rstrup P. Resolvin E1 (RX-10001) reduces corneal epithelial barrier disruption and protects against goblet cell loss in a murine model of dry eye. Cornea. 2012 Nov; 31(11):1299-303. PMID: 22257864.
      Citations: 40     Fields:    Translation:AnimalsCells
    153. Pelegrino FS, Volpe EA, Gandhi NB, Li DQ, Pflugfelder SC, de Paiva CS. Deletion of interferon-? delays onset and severity of dacryoadenitis in CD25KO mice. Arthritis Res Ther. 2012 Nov 01; 14(6):R234. PMID: 23116218; PMCID: PMC3674599.
      Citations: 21     Fields:    Translation:AnimalsCells
    154. Gumus K, Pflugfelder SC. Increasing prevalence and severity of conjunctivochalasis with aging detected by anterior segment optical coherence tomography. Am J Ophthalmol. 2013 Feb; 155(2):238-242.e2. PMID: 23036571.
      Citations: 19     Fields:    Translation:Humans
    155. Lu R, Bian F, Lin J, Su Z, Qu Y, Pflugfelder SC, Li DQ. Identification of human fibroblast cell lines as a feeder layer for human corneal epithelial regeneration. PLoS One. 2012; 7(6):e38825. PMID: 22723892; PMCID: PMC3377680.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    156. Zhang X, Volpe EA, Gandhi NB, Schaumburg CS, Siemasko KF, Pangelinan SB, Kelly SD, Hayday AC, Li DQ, Stern ME, Niederkorn JY, Pflugfelder SC, De Paiva CS. NK cells promote Th-17 mediated corneal barrier disruption in dry eye. PLoS One. 2012; 7(5):e36822. PMID: 22590618; PMCID: PMC3348128.
      Citations: 51     Fields:    Translation:HumansAnimalsCells
    157. Stern ME, Schaumburg CS, Siemasko KF, Gao J, Wheeler LA, Grupe DA, De Paiva CS, Calder VL, Calonge M, Niederkorn JY, Pflugfelder SC. Autoantibodies contribute to the immunopathogenesis of experimental dry eye disease. Invest Ophthalmol Vis Sci. 2012 Apr 24; 53(4):2062-75. PMID: 22395876; PMCID: PMC6713471.
      Citations: 34     Fields:    Translation:AnimalsCells
    158. Gumus K, Lee S, Yen MT, Pflugfelder SC. Botulinum toxin injection for the management of refractory filamentary keratitis. Arch Ophthalmol. 2012 Apr; 130(4):446-50. PMID: 22491914.
      Citations: 2     Fields:    Translation:Humans
    159. Lu R, Qu Y, Ge J, Zhang L, Su Z, Pflugfelder SC, Li DQ. Transcription factor TCF4 maintains the properties of human corneal epithelial stem cells. Stem Cells. 2012 Apr; 30(4):753-61. PMID: 22232078; PMCID: PMC5610543.
      Citations: 33     Fields:    Translation:HumansCells
    160. De Paiva CS, Volpe EA, Gandhi NB, Zhang X, Zheng X, Pitcher JD, Farley WJ, Stern ME, Niederkorn JY, Li DQ, Flavell RA, Pflugfelder SC. Disruption of TGF-? signaling improves ocular surface epithelial disease in experimental autoimmune keratoconjunctivitis sicca. PLoS One. 2011; 6(12):e29017. PMID: 22194977; PMCID: PMC3237576.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    161. Pelegrino FS, Pflugfelder SC, De Paiva CS. Low humidity environmental challenge causes barrier disruption and cornification of the mouse corneal epithelium via a c-jun N-terminal kinase 2 (JNK2) pathway. Exp Eye Res. 2012 Jan; 94(1):150-6. PMID: 22166618; PMCID: PMC3259221.
      Citations: 11     Fields:    Translation:AnimalsCells
    162. Pflugfelder SC, Baudouin C. Challenges in the clinical measurement of ocular surface disease in glaucoma patients. Clin Ophthalmol. 2011; 5:1575-83. PMID: 22125404; PMCID: PMC3218167.
      Citations: 13     
    163. Chang E, McClellan AJ, Farley WJ, Li DQ, Pflugfelder SC, De Paiva CS. Biodegradable PLGA-Based Drug Delivery Systems for Modulating Ocular Surface Disease under Experimental Murine Dry Eye. J Clin Exp Ophthalmol. 2011 Nov 01; 2(11). PMID: 23560247; PMCID: PMC3614373.
      Citations: 7     
    164. Pflugfelder SC. Tear dysfunction and the cornea: LXVIII Edward Jackson Memorial Lecture. Am J Ophthalmol. 2011 Dec; 152(6):900-909.e1. PMID: 22019306; PMCID: PMC3223272.
      Citations: 36     Fields:    Translation:Humans
    165. Schaumburg CS, Siemasko KF, De Paiva CS, Wheeler LA, Niederkorn JY, Pflugfelder SC, Stern ME. Ocular surface APCs are necessary for autoreactive T cell-mediated experimental autoimmune lacrimal keratoconjunctivitis. J Immunol. 2011 Oct 01; 187(7):3653-62. PMID: 21880984.
      Citations: 75     Fields:    Translation:AnimalsCells
    166. Zhang X, Chen W, De Paiva CS, Volpe EA, Gandhi NB, Farley WJ, Li DQ, Niederkorn JY, Stern ME, Pflugfelder SC. Desiccating stress induces CD4+ T-cell-mediated Sj?gren's syndrome-like corneal epithelial apoptosis via activation of the extrinsic apoptotic pathway by interferon-?. Am J Pathol. 2011 Oct; 179(4):1807-14. PMID: 21843497; PMCID: PMC3181354.
      Citations: 37     Fields:    Translation:AnimalsCells
    167. Zhang X, Chen W, De Paiva CS, Corrales RM, Volpe EA, McClellan AJ, Farley WJ, Li DQ, Pflugfelder SC. Interferon-? exacerbates dry eye-induced apoptosis in conjunctiva through dual apoptotic pathways. Invest Ophthalmol Vis Sci. 2011 Aug 09; 52(9):6279-85. PMID: 21474767; PMCID: PMC3176027.
      Citations: 57     Fields:    Translation:AnimalsCells
    168. Li DQ, Zhang L, Pflugfelder SC, De Paiva CS, Zhang X, Zhao G, Zheng X, Su Z, Qu Y. Short ragweed pollen triggers allergic inflammation through Toll-like receptor 4-dependent thymic stromal lymphopoietin/OX40 ligand/OX40 signaling pathways. J Allergy Clin Immunol. 2011 Dec; 128(6):1318-1325.e2. PMID: 21820713; PMCID: PMC3229670.
      Citations: 46     Fields:    Translation:HumansAnimalsCells
    169. Zhang L, Lu R, Zhao G, Pflugfelder SC, Li DQ. TLR-mediated induction of pro-allergic cytokine IL-33 in ocular mucosal epithelium. Int J Biochem Cell Biol. 2011 Sep; 43(9):1383-91. PMID: 21684348; PMCID: PMC3175488.
      Citations: 41     Fields:    Translation:HumansCells
    170. Corrales RM, de Paiva CS, Li DQ, Farley WJ, Henriksson JT, Bergmanson JP, Pflugfelder SC. Entrapment of conjunctival goblet cells by desiccation-induced cornification. Invest Ophthalmol Vis Sci. 2011 Jun 01; 52(6):3492-9. PMID: 21421863; PMCID: PMC3109039.
      Citations: 29     Fields:    Translation:AnimalsCells
    171. Pitcher JD, De Paiva CS, Pelegrino FS, McClellan AJ, Raince JK, Pangelinan SB, Rahimy E, Farley WJ, Stern ME, Li DQ, Pflugfelder SC. Pharmacological cholinergic blockade stimulates inflammatory cytokine production and lymphocytic infiltration in the mouse lacrimal gland. Invest Ophthalmol Vis Sci. 2011 May 16; 52(6):3221-7. PMID: 21273534; PMCID: PMC3109024.
      Citations: 18     Fields:    Translation:AnimalsCells
    172. Lu R, Bian F, Zhang X, Qi H, Chuang EY, Pflugfelder SC, Li DQ. The ?-catenin/Tcf4/survivin signaling maintains a less differentiated phenotype and high proliferative capacity of human corneal epithelial progenitor cells. Int J Biochem Cell Biol. 2011 May; 43(5):751-9. PMID: 21292023; PMCID: PMC3131198.
      Citations: 20     Fields:    Translation:HumansCells
    173. Gumus K, Gire A, Pflugfelder SC. The impact of the Boston ocular surface prosthesis on wavefront higher-order aberrations. Am J Ophthalmol. 2011 Apr; 151(4):682-690.e2. PMID: 21269603.
      Citations: 13     Fields:    Translation:Humans
    174. Gumus K, Crockett CH, Rao K, Yeu E, Weikert MP, Shirayama M, Hada S, Pflugfelder SC. Noninvasive assessment of tear stability with the tear stability analysis system in tear dysfunction patients. Invest Ophthalmol Vis Sci. 2011 Jan; 52(1):456-61. PMID: 20631241; PMCID: PMC3053291.
      Citations: 23     Fields:    Translation:Humans
    175. De Paiva CS, Raince JK, McClellan AJ, Shanmugam KP, Pangelinan SB, Volpe EA, Corrales RM, Farley WJ, Corry DB, Li DQ, Pflugfelder SC. Homeostatic control of conjunctival mucosal goblet cells by NKT-derived IL-13. Mucosal Immunol. 2011 Jul; 4(4):397-408. PMID: 21178983; PMCID: PMC3577073.
      Citations: 51     Fields:    Translation:AnimalsCells
    176. Gumus K, Gire A, Pflugfelder SC. The successful use of Boston ocular surface prosthesis in the treatment of persistent corneal epithelial defect after herpes zoster ophthalmicus. Cornea. 2010 Dec; 29(12):1465-8. PMID: 20847682.
      Citations:    Fields:    Translation:Humans
    177. Gumus K, Crockett CH, Pflugfelder SC. Anterior segment optical coherence tomography: a diagnostic instrument for conjunctivochalasis. Am J Ophthalmol. 2010 Dec; 150(6):798-806. PMID: 20869039; PMCID: PMC3577926.
      Citations: 26     Fields:    Translation:Humans
    178. Bian F, Qi H, Ma P, Zhang L, Yoon KC, Pflugfelder SC, Li DQ. An immunoprotective privilege of corneal epithelial stem cells against Th17 inflammatory stress by producing glial cell-derived neurotrophic factor. Stem Cells. 2010 Dec; 28(12):2172-81. PMID: 20936708; PMCID: PMC3577923.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    179. Qi H, Zheng X, Yuan X, Pflugfelder SC, Li DQ. Potential localization of putative stem/progenitor cells in human bulbar conjunctival epithelium. J Cell Physiol. 2010 Oct; 225(1):180-5. PMID: 20458737; PMCID: PMC8317437.
      Citations: 11     Fields:    Translation:HumansCells
    180. Zheng X, De Paiva CS, Rao K, Li DQ, Farley WJ, Stern M, Pflugfelder SC. Evaluation of the transforming growth factor-beta activity in normal and dry eye human tears by CCL-185 cell bioassay. Cornea. 2010 Sep; 29(9):1048-54. PMID: 20539212; PMCID: PMC3582018.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    181. Haque RM, Torkildsen GL, Brubaker K, Zink RC, Kowalski RP, Mah FS, Pflugfelder SC. Multicenter open-label study evaluating the efficacy of azithromycin ophthalmic solution 1% on the signs and symptoms of subjects with blepharitis. Cornea. 2010 Aug; 29(8):871-7. PMID: 20508503.
      Citations: 19     Fields:    Translation:Humans
    182. Nettune GR, Pflugfelder SC. Post-LASIK tear dysfunction and dysesthesia. Ocul Surf. 2010 Jul; 8(3):135-45. PMID: 20712970; PMCID: PMC3579556.
      Citations: 33     Fields:    Translation:Humans
    183. Rahimy E, Pitcher JD, Pangelinan SB, Chen W, Farley WJ, Niederkorn JY, Stern ME, Li DQ, Pflugfelder SC, De Paiva CS. Spontaneous autoimmune dacryoadenitis in aged CD25KO mice. Am J Pathol. 2010 Aug; 177(2):744-53. PMID: 20566743; PMCID: PMC2913359.
      Citations: 29     Fields:    Translation:AnimalsCells
    184. Li DQ, Zhou N, Zhang L, Ma P, Pflugfelder SC. Suppressive effects of azithromycin on zymosan-induced production of proinflammatory mediators by human corneal epithelial cells. Invest Ophthalmol Vis Sci. 2010 Nov; 51(11):5623-9. PMID: 20538995; PMCID: PMC3061501.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    185. Chen Z, Li Z, Basti S, Farley WJ, Pflugfelder SC. Altered morphology and function of the lacrimal functional unit in protein kinase C{alpha} knockout mice. Invest Ophthalmol Vis Sci. 2010 Nov; 51(11):5592-600. PMID: 20505191; PMCID: PMC3061498.
      Citations: 7     Fields:    Translation:Animals
    186. Stern ME, Schaumburg CS, Dana R, Calonge M, Niederkorn JY, Pflugfelder SC. Autoimmunity at the ocular surface: pathogenesis and regulation. Mucosal Immunol. 2010 Sep; 3(5):425-42. PMID: 20485329; PMCID: PMC3577924.
      Citations: 50     Fields:    Translation:HumansAnimals
    187. Bian F, Liu W, Yoon KC, Lu R, Zhou N, Ma P, Pflugfelder SC, Li DQ. Molecular signatures and biological pathway profiles of human corneal epithelial progenitor cells. Int J Biochem Cell Biol. 2010 Jul; 42(7):1142-53. PMID: 20363357; PMCID: PMC2939451.
      Citations: 14     Fields:    Translation:HumansCells
    188. Zheng X, de Paiva CS, Li DQ, Farley WJ, Pflugfelder SC. Desiccating stress promotion of Th17 differentiation by ocular surface tissues through a dendritic cell-mediated pathway. Invest Ophthalmol Vis Sci. 2010 Jun; 51(6):3083-91. PMID: 20130281; PMCID: PMC2891467.
      Citations: 44     Fields:    Translation:AnimalsCells
    189. Zheng X, Ma P, de Paiva CS, Cunningham MA, Hwang CS, Pflugfelder SC, Li DQ. TSLP and downstream molecules in experimental mouse allergic conjunctivitis. Invest Ophthalmol Vis Sci. 2010 Jun; 51(6):3076-82. PMID: 20107175; PMCID: PMC2891466.
      Citations: 19     Fields:    Translation:AnimalsCells
    190. Zheng X, Bian F, Ma P, De Paiva CS, Stern M, Pflugfelder SC, Li DQ. Induction of Th17 differentiation by corneal epithelial-derived cytokines. J Cell Physiol. 2010 Jan; 222(1):95-102. PMID: 19746420; PMCID: PMC2789678.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    191. Miller KL, Walt JG, Mink DR, Satram-Hoang S, Wilson SE, Perry HD, Asbell PA, Pflugfelder SC. Minimal clinically important difference for the ocular surface disease index. Arch Ophthalmol. 2010 Jan; 128(1):94-101. PMID: 20065224.
      Citations: 131     Fields:    Translation:Humans
    192. De Paiva CS, Hwang CS, Pitcher JD, Pangelinan SB, Rahimy E, Chen W, Yoon KC, Farley WJ, Niederkorn JY, Stern ME, Li DQ, Pflugfelder SC. Age-related T-cell cytokine profile parallels corneal disease severity in Sjogren's syndrome-like keratoconjunctivitis sicca in CD25KO mice. Rheumatology (Oxford). 2010 Feb; 49(2):246-58. PMID: 20007286; PMCID: PMC2909796.
      Citations: 59     Fields:    Translation:AnimalsCells
    193. Rao K, Leveque C, Pflugfelder SC. Corneal nerve regeneration in neurotrophic keratopathy following autologous plasma therapy. Br J Ophthalmol. 2010 May; 94(5):584-91. PMID: 19965821; PMCID: PMC3575078.
      Citations: 27     Fields:    Translation:HumansCells
    194. De Paiva CS, Pangelinan SB, Chang E, Yoon KC, Farley WJ, Li DQ, Pflugfelder SC. Essential role for c-Jun N-terminal kinase 2 in corneal epithelial response to desiccating stress. Arch Ophthalmol. 2009 Dec; 127(12):1625-31. PMID: 20008718; PMCID: PMC3583514.
      Citations: 21     Fields:    Translation:AnimalsCells
    195. De Paiva CS, Yoon KC, Pangelinan SB, Pham S, Puthenparambil LM, Chuang EY, Farley WJ, Stern ME, Li DQ, Pflugfelder SC. Cleavage of functional IL-2 receptor alpha chain (CD25) from murine corneal and conjunctival epithelia by MMP-9. J Inflamm (Lond). 2009 Oct 31; 6:31. PMID: 19878594; PMCID: PMC2777897.
      Citations: 18     
    196. Yoon KC, Park CS, You IC, Choi HJ, Lee KH, Im SK, Park HY, Pflugfelder SC. Expression of CXCL9, -10, -11, and CXCR3 in the tear film and ocular surface of patients with dry eye syndrome. Invest Ophthalmol Vis Sci. 2010 Feb; 51(2):643-50. PMID: 19850844; PMCID: PMC3258976.
      Citations: 65     Fields:    Translation:HumansCellsCTClinical Trials
    197. Rao K, Farley WJ, Pflugfelder SC. Association between high tear epidermal growth factor levels and corneal subepithelial fibrosis in dry eye conditions. Invest Ophthalmol Vis Sci. 2010 Feb; 51(2):844-9. PMID: 19815739; PMCID: PMC2868446.
      Citations: 18     Fields:    Translation:Humans
    198. Ma P, Wang Z, Pflugfelder SC, Li DQ. Toll-like receptors mediate induction of peptidoglycan recognition proteins in human corneal epithelial cells. Exp Eye Res. 2010 Jan; 90(1):130-6. PMID: 19799901; PMCID: PMC2836933.
      Citations: 17     Fields:    Translation:Humans
    199. Chen JJ, Rao K, Pflugfelder SC. Corneal epithelial opacity in dysfunctional tear syndrome. Am J Ophthalmol. 2009 Sep; 148(3):376-82. PMID: 19541283; PMCID: PMC2740942.
      Citations: 6     Fields:    Translation:Humans
    200. Yeh S, de Paiva CS, Hwang CS, Trinca K, Lingappan A, Rafati JK, Farley WJ, Li DQ, Pflugfelder SC. Spontaneous T cell mediated keratoconjunctivitis in Aire-deficient mice. Br J Ophthalmol. 2009 Sep; 93(9):1260-4. PMID: 19429577; PMCID: PMC3586820.
      Citations: 9     Fields:    Translation:AnimalsCells
    201. Donnenfeld E, Pflugfelder SC. Topical ophthalmic cyclosporine: pharmacology and clinical uses. Surv Ophthalmol. 2009 May-Jun; 54(3):321-38. PMID: 19422961.
      Citations: 45     Fields:    Translation:Humans
    202. Pflugfelder SC, Stern ME, Symposium Participants. Immunoregulation on the ocular surface: 2nd Cullen Symposium. Ocul Surf. 2009 Apr; 7(2):67-77. PMID: 19383275.
      Citations: 16     Fields:    Translation:HumansCells
    203. Chotikavanich S, de Paiva CS, Li de Q, Chen JJ, Bian F, Farley WJ, Pflugfelder SC. Production and activity of matrix metalloproteinase-9 on the ocular surface increase in dysfunctional tear syndrome. Invest Ophthalmol Vis Sci. 2009 Jul; 50(7):3203-9. PMID: 19255163; PMCID: PMC3594995.
      Citations: 128     Fields:    Translation:HumansCells
    204. De Paiva CS, Chotikavanich S, Pangelinan SB, Pitcher JD, Fang B, Zheng X, Ma P, Farley WJ, Siemasko KF, Niederkorn JY, Stern ME, Li DQ, Pflugfelder SC. IL-17 disrupts corneal barrier following desiccating stress. Mucosal Immunol. 2009 May; 2(3):243-53. PMID: 19242409; PMCID: PMC3594767.
      Citations: 192     Fields:    Translation:HumansAnimalsCells
    205. Ma P, Bian F, Wang Z, Zheng X, Chotikavanich S, Pflugfelder SC, Li DQ. Human corneal epithelium-derived thymic stromal lymphopoietin links the innate and adaptive immune responses via TLRs and Th2 cytokines. Invest Ophthalmol Vis Sci. 2009 Jun; 50(6):2702-9. PMID: 19151401; PMCID: PMC5496816.
      Citations: 30     Fields:    Translation:HumansCells
    206. Lam H, Bleiden L, de Paiva CS, Farley W, Stern ME, Pflugfelder SC. Tear cytokine profiles in dysfunctional tear syndrome. Am J Ophthalmol. 2009 Feb; 147(2):198-205. e1. PMID: 18992869; PMCID: PMC3582020.
      Citations: 173     Fields:    Translation:Humans
    207. de Paiva CS, Pflugfelder SC. Rationale for anti-inflammatory therapy in dry eye syndrome. Arq Bras Oftalmol. 2008 Nov-Dec; 71(6 Suppl):89-95. PMID: 19274418.
      Citations: 33     Fields:    Translation:Humans
    208. Qi H, Shine HD, Li DQ, de Paiva CS, Farley WJ, Jones DB, Pflugfelder SC. Glial cell-derived neurotrophic factor gene delivery enhances survival of human corneal epithelium in culture and the overexpression of GDNF in bioengineered constructs. Exp Eye Res. 2008 Dec; 87(6):580-6. PMID: 18938159; PMCID: PMC4529993.
      Citations: 8     Fields:    Translation:HumansCells
    209. Qi H, Li DQ, Bian F, Chuang EY, Jones DB, Pflugfelder SC. Expression of glial cell-derived neurotrophic factor and its receptor in the stem-cell-containing human limbal epithelium. Br J Ophthalmol. 2008 Sep; 92(9):1269-74. PMID: 18723744; PMCID: PMC2906381.
      Citations: 12     Fields:    Translation:HumansCells
    210. Pflugfelder SC, de Paiva CS, Li DQ, Stern ME. Epithelial-immune cell interaction in dry eye. Cornea. 2008 Sep; 27 Suppl 1:S9-11. PMID: 18813079; PMCID: PMC4082978.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    211. Beardsley RM, De Paiva CS, Power DF, Pflugfelder SC. Desiccating stress decreases apical corneal epithelial cell size--modulation by the metalloproteinase inhibitor doxycycline. Cornea. 2008 Sep; 27(8):935-40. PMID: 18724157; PMCID: PMC3575099.
      Citations: 20     Fields:    Translation:AnimalsCells
    212. Chuang EY, Li DQ, Bian F, Zheng X, Pflugfelder SC. Effects of contact lens multipurpose solutions on human corneal epithelial survival and barrier function. Eye Contact Lens. 2008 Sep; 34(5):281-6. PMID: 18779668; PMCID: PMC8313347.
      Citations: 9     Fields:    Translation:HumansCells
    213. Narayanan S, Corrales RM, Farley W, McDermott AM, Pflugfelder SC. Interleukin-1 receptor-1-deficient mice show attenuated production of ocular surface inflammatory cytokines in experimental dry eye. Cornea. 2008 Aug; 27(7):811-7. PMID: 18650668.
      Citations: 25     Fields:    Translation:Animals
    214. Siemasko KF, Gao J, Calder VL, Hanna R, Calonge M, Pflugfelder SC, Niederkorn JY, Stern ME. In vitro expanded CD4+CD25+Foxp3+ regulatory T cells maintain a normal phenotype and suppress immune-mediated ocular surface inflammation. Invest Ophthalmol Vis Sci. 2008 Dec; 49(12):5434-40. PMID: 18658093.
      Citations: 29     Fields:    Translation:AnimalsCells
    215. Corrales RM, Luo L, Chang EY, Pflugfelder SC. Effects of osmoprotectants on hyperosmolar stress in cultured human corneal epithelial cells. Cornea. 2008 Jun; 27(5):574-9. PMID: 18520508.
      Citations: 44     Fields:    Translation:HumansCells
    216. Pflugfelder SC. Prevalence, burden, and pharmacoeconomics of dry eye disease. Am J Manag Care. 2008 Apr; 14(3 Suppl):S102-6. PMID: 18452369.
      Citations: 66     Fields:    Translation:Humans
    217. Wilhelmus KR, Jones DB, Matoba AY, Hamill MB, Pflugfelder SC, Weikert MP. Bilateral acanthamoeba keratitis. Am J Ophthalmol. 2008 Feb; 145(2):193-197. PMID: 18222188.
      Citations: 12     Fields:    Translation:Humans
    218. Chen Z, Tong L, Li Z, Yoon KC, Qi H, Farley W, Li DQ, Pflugfelder SC. Hyperosmolarity-induced cornification of human corneal epithelial cells is regulated by JNK MAPK. Invest Ophthalmol Vis Sci. 2008 Feb; 49(2):539-49. PMID: 18234997; PMCID: PMC8320337.
      Citations: 34     Fields:    Translation:HumansCells
    219. Pflugfelder SC, De Paiva CS, Villarreal AL, Stern ME. Effects of sequential artificial tear and cyclosporine emulsion therapy on conjunctival goblet cell density and transforming growth factor-beta2 production. Cornea. 2008 Jan; 27(1):64-9. PMID: 18245969.
      Citations: 53     Fields:    Translation:HumansCells
    220. Yoon KC, De Paiva CS, Qi H, Chen Z, Farley WJ, Li DQ, Stern ME, Pflugfelder SC. Desiccating environmental stress exacerbates autoimmune lacrimal keratoconjunctivitis in non-obese diabetic mice. J Autoimmun. 2008 Jun; 30(4):212-21. PMID: 17988834; PMCID: PMC2443953.
      Citations: 21     Fields:    Translation:AnimalsCells
    221. Qi H, Chuang EY, Yoon KC, de Paiva CS, Shine HD, Jones DB, Pflugfelder SC, Li DQ. Patterned expression of neurotrophic factors and receptors in human limbal and corneal regions. Mol Vis. 2007 Oct 16; 13:1934-41. PMID: 17982417; PMCID: PMC2185513.
      Citations: 29     Fields:    Translation:Humans
    222. Pflugfelder SC, Stern ME. Future directions in therapeutic interventions for conjunctival inflammatory disorders. Curr Opin Allergy Clin Immunol. 2007 Oct; 7(5):450-3. PMID: 17873588.
      Citations: 3     Fields:    Translation:HumansAnimals
    223. Qi H, Li DQ, Shine HD, Chen Z, Yoon KC, Jones DB, Pflugfelder SC. Nerve growth factor and its receptor TrkA serve as potential markers for human corneal epithelial progenitor cells. Exp Eye Res. 2008 Jan; 86(1):34-40. PMID: 17980361; PMCID: PMC2198932.
      Citations: 37     Fields:    Translation:HumansCells
    224. Yoon KC, De Paiva CS, Qi H, Chen Z, Farley WJ, Li DQ, Pflugfelder SC. Expression of Th-1 chemokines and chemokine receptors on the ocular surface of C57BL/6 mice: effects of desiccating stress. Invest Ophthalmol Vis Sci. 2007 Jun; 48(6):2561-9. PMID: 17525185.
      Citations: 90     Fields:    Translation:AnimalsCells
    225. Corrales RM, Villarreal A, Farley W, Stern ME, Li DQ, Pflugfelder SC. Strain-related cytokine profiles on the murine ocular surface in response to desiccating stress. Cornea. 2007 Jun; 26(5):579-84. PMID: 17525655.
      Citations: 43     Fields:    Translation:AnimalsCells
    226. De Paiva CS, Villarreal AL, Corrales RM, Rahman HT, Chang VY, Farley WJ, Stern ME, Niederkorn JY, Li DQ, Pflugfelder SC. Dry eye-induced conjunctival epithelial squamous metaplasia is modulated by interferon-gamma. Invest Ophthalmol Vis Sci. 2007 Jun; 48(6):2553-60. PMID: 17525184.
      Citations: 136     Fields:    Translation:AnimalsCells
    227. Luo L, Li DQ, Pflugfelder SC. Hyperosmolarity-induced apoptosis in human corneal epithelial cells is mediated by cytochrome c and MAPK pathways. Cornea. 2007 May; 26(4):452-60. PMID: 17457195.
      Citations: 54     Fields:    Translation:HumansCells
    228. Parghi C, McKnight GT, Pflugfelder SC. Prominent corneal nerves in a patient with multiple myeloma. Cornea. 2007 Feb; 26(2):220-2. PMID: 17251817.
      Citations: 4     Fields:    Translation:Humans
    229. Villareal AL, Farley W, Pflugfelder SC. Effect of topical ophthalmic epinastine and olopatadine on tear volume in mice. Eye Contact Lens. 2006 Dec; 32(6):272-6. PMID: 17099387.
      Citations: 16     Fields:    Translation:Animals
    230. Tong L, Chen Z, De Paiva CS, Beuerman R, Li DQ, Pflugfelder SC. Transglutaminase participates in UVB-induced cell death pathways in human corneal epithelial cells. Invest Ophthalmol Vis Sci. 2006 Oct; 47(10):4295-301. PMID: 17003418.
      Citations: 8     Fields:    Translation:HumansCells
    231. Behrens A, Doyle JJ, Stern L, Chuck RS, McDonnell PJ, Azar DT, Dua HS, Hom M, Karpecki PM, Laibson PR, Lemp MA, Meisler DM, Del Castillo JM, O'Brien TP, Pflugfelder SC, Rolando M, Schein OD, Seitz B, Tseng SC, van Setten G, Wilson SE, Yiu SC, Dysfunctional tear syndrome study group. Dysfunctional tear syndrome: a Delphi approach to treatment recommendations. Cornea. 2006 Sep; 25(8):900-7. PMID: 17102664.
      Citations: 130     Fields:    Translation:Humans
    232. Chen Z, Li DQ, Tong L, Stewart P, Chu C, Pflugfelder SC. Targeted inhibition of p57 and p15 blocks transforming growth factor beta-inhibited proliferation of primary cultured human limbal epithelial cells. Mol Vis. 2006 Aug 23; 12:983-94. PMID: 16943770; PMCID: PMC2906388.
      Citations: 13     Fields:    Translation:HumansCells
    233. Pflugfelder SC. Is autologous serum a tonic for the ailing corneal epithelium? Am J Ophthalmol. 2006 Aug; 142(2):316-7. PMID: 16876515.
      Citations: 19     Fields:    Translation:Humans
    234. Corrales RM, Stern ME, De Paiva CS, Welch J, Li DQ, Pflugfelder SC. Desiccating stress stimulates expression of matrix metalloproteinases by the corneal epithelium. Invest Ophthalmol Vis Sci. 2006 Aug; 47(8):3293-302. PMID: 16877394.
      Citations: 70     Fields:    Translation:AnimalsCells
    235. De Paiva CS, Corrales RM, Villarreal AL, Farley W, Li DQ, Stern ME, Pflugfelder SC. Apical corneal barrier disruption in experimental murine dry eye is abrogated by methylprednisolone and doxycycline. Invest Ophthalmol Vis Sci. 2006 Jul; 47(7):2847-56. PMID: 16799024.
      Citations: 75     Fields:    Translation:Animals
    236. Chen Z, Mok H, Pflugfelder SC, Li DQ, Barry MA. Improved transduction of human corneal epithelial progenitor cells with cell-targeting adenoviral vectors. Exp Eye Res. 2006 Oct; 83(4):798-806. PMID: 16793039; PMCID: PMC2906397.
      Citations: 6     Fields:    Translation:HumansCells
    237. Tong L, Corrales RM, Chen Z, Villarreal AL, De Paiva CS, Beuerman R, Li DQ, Pflugfelder SC. Expression and regulation of cornified envelope proteins in human corneal epithelium. Invest Ophthalmol Vis Sci. 2006 May; 47(5):1938-46. PMID: 16639001; PMCID: PMC2906387.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    238. De Paiva CS, Corrales RM, Villarreal AL, Farley WJ, Li DQ, Stern ME, Pflugfelder SC. Corticosteroid and doxycycline suppress MMP-9 and inflammatory cytokine expression, MAPK activation in the corneal epithelium in experimental dry eye. Exp Eye Res. 2006 Sep; 83(3):526-35. PMID: 16643899.
      Citations: 158     Fields:    Translation:AnimalsCells
    239. Niederkorn JY, Stern ME, Pflugfelder SC, De Paiva CS, Corrales RM, Gao J, Siemasko K. Desiccating stress induces T cell-mediated Sj?gren's Syndrome-like lacrimal keratoconjunctivitis. J Immunol. 2006 Apr 01; 176(7):3950-7. PMID: 16547229.
      Citations: 157     Fields:    Translation:AnimalsCells
    240. De Paiva CS, Chen Z, Koch DD, Hamill MB, Manuel FK, Hassan SS, Wilhelmus KR, Pflugfelder SC. The incidence and risk factors for developing dry eye after myopic LASIK. Am J Ophthalmol. 2006 Mar; 141(3):438-45. PMID: 16490488.
      Citations: 60     Fields:    Translation:Humans
    241. Chen Z, Evans WH, Pflugfelder SC, Li DQ. Gap junction protein connexin 43 serves as a negative marker for a stem cell-containing population of human limbal epithelial cells. Stem Cells. 2006 May; 24(5):1265-73. PMID: 16424398; PMCID: PMC2906383.
      Citations: 43     Fields:    Translation:HumansCells
    242. Pflugfelder SC. Integrating restasis into the management of dry eye. Int Ophthalmol Clin. 2006; 46(4):101-3. PMID: 17060796.
      Citations: 4     Fields:    Translation:Humans
    243. Li DQ, Luo L, Chen Z, Kim HS, Song XJ, Pflugfelder SC. JNK and ERK MAP kinases mediate induction of IL-1beta, TNF-alpha and IL-8 following hyperosmolar stress in human limbal epithelial cells. Exp Eye Res. 2006 Apr; 82(4):588-96. PMID: 16202406; PMCID: PMC2198933.
      Citations: 130     Fields:    Translation:HumansCells
    244. McDermott AM, Perez V, Huang AJ, Pflugfelder SC, Stern ME, Baudouin C, Beuerman RW, Burns AR, Calder VL, Calonge M, Chodosh J, Coster DJ, Dana R, Hazlett LD, Jones DB, Kim SK, Knop E, Li DQ, Mitchell BM, Niederkorn JY, Pearlman E, Wilhelmus KR, Kurie E. Pathways of corneal and ocular surface inflammation: a perspective from the cullen symposium. Ocul Surf. 2005 Oct; 3(4 Suppl):S131-8. PMID: 17216102.
      Citations: 20     Fields:    
    245. Li DQ, Pflugfelder SC. Matrix metalloproteinases in corneal inflammation. Ocul Surf. 2005 Oct; 3(4 Suppl):S198-202. PMID: 17216119.
      Citations: 18     Fields:    
    246. Stern ME, Siemasko KF, Gao J, Calonge M, Niederkorn JY, Pflugfelder SC. Evaluation of ocular surface inflammation in the presence of dry eye and allergic conjunctival disease. Ocul Surf. 2005 Oct; 3(4 Suppl):S161-4. PMID: 17216110.
      Citations: 12     Fields:    
    247. Barber LD, Pflugfelder SC, Tauber J, Foulks GN. Phase III safety evaluation of cyclosporine 0.1% ophthalmic emulsion administered twice daily to dry eye disease patients for up to 3 years. Ophthalmology. 2005 Oct; 112(10):1790-4. PMID: 16102833.
      Citations: 48     Fields:    Translation:HumansCTClinical Trials
    248. Pflugfelder SC, de Paiva CS, Tong L, Luo L, Stern ME, Li DQ. Stress-activated protein kinase signaling pathways in dry eye and ocular surface disease. Ocul Surf. 2005 Oct; 3(4 Suppl):S154-7. PMID: 17216108.
      Citations: 16     Fields:    
    249. Luo L, Li DQ, Corrales RM, Pflugfelder SC. Hyperosmolar saline is a proinflammatory stress on the mouse ocular surface. Eye Contact Lens. 2005 Sep; 31(5):186-93. PMID: 16163009.
      Citations: 113     Fields:    Translation:AnimalsCells
    250. De Paiva CS, Pflugfelder SC, Li DQ. Cell size correlates with phenotype and proliferative capacity in human corneal epithelial cells. Stem Cells. 2006 Feb; 24(2):368-75. PMID: 16123387; PMCID: PMC2906390.
      Citations: 49     Fields:    Translation:HumansAnimalsCells
    251. Thomas JW, Pflugfelder SC. Therapy of progressive rheumatoid arthritis-associated corneal ulceration with infliximab. Cornea. 2005 Aug; 24(6):742-4. PMID: 16015096.
      Citations: 21     Fields:    Translation:Humans
    252. Stewart P, Chen Z, Farley W, Olmos L, Pflugfelder SC. Effect of experimental dry eye on tear sodium concentration in the mouse. Eye Contact Lens. 2005 Jul; 31(4):175-8. PMID: 16021005.
      Citations: 20     Fields:    Translation:Animals
    253. Li DQ, Chen Z, Song XJ, de Paiva CS, Kim HS, Pflugfelder SC. Partial enrichment of a population of human limbal epithelial cells with putative stem cell properties based on collagen type IV adhesiveness. Exp Eye Res. 2005 Apr; 80(4):581-90. PMID: 15781286; PMCID: PMC2906384.
      Citations: 35     Fields:    Translation:HumansCells
    254. Kim HS, Luo L, Pflugfelder SC, Li DQ. Doxycycline inhibits TGF-beta1-induced MMP-9 via Smad and MAPK pathways in human corneal epithelial cells. Invest Ophthalmol Vis Sci. 2005 Mar; 46(3):840-8. PMID: 15728539.
      Citations: 50     Fields:    Translation:HumansCells
    255. Strong B, Farley W, Stern ME, Pflugfelder SC. Topical cyclosporine inhibits conjunctival epithelial apoptosis in experimental murine keratoconjunctivitis sicca. Cornea. 2005 Jan; 24(1):80-5. PMID: 15604871.
      Citations: 44     Fields:    Translation:AnimalsCells
    256. Pflugfelder SC, Farley W, Luo L, Chen LZ, de Paiva CS, Olmos LC, Li DQ, Fini ME. Matrix metalloproteinase-9 knockout confers resistance to corneal epithelial barrier disruption in experimental dry eye. Am J Pathol. 2005 Jan; 166(1):61-71. PMID: 15632000; PMCID: PMC1602302.
      Citations: 114     Fields:    Translation:AnimalsCells
    257. de Paiva CS, Chen Z, Corrales RM, Pflugfelder SC, Li DQ. ABCG2 transporter identifies a population of clonogenic human limbal epithelial cells. Stem Cells. 2005; 23(1):63-73. PMID: 15625123; PMCID: PMC2906389.
      Citations: 110     Fields:    Translation:HumansAnimalsCells
    258. Luo L, Li DQ, Doshi A, Farley W, Corrales RM, Pflugfelder SC. Experimental dry eye stimulates production of inflammatory cytokines and MMP-9 and activates MAPK signaling pathways on the ocular surface. Invest Ophthalmol Vis Sci. 2004 Dec; 45(12):4293-301. PMID: 15557435.
      Citations: 218     Fields:    Translation:AnimalsCells
    259. Li DQ, Chen Z, Song XJ, Luo L, Pflugfelder SC. Stimulation of matrix metalloproteinases by hyperosmolarity via a JNK pathway in human corneal epithelial cells. Invest Ophthalmol Vis Sci. 2004 Dec; 45(12):4302-11. PMID: 15557436.
      Citations: 115     Fields:    Translation:HumansCells
    260. Seth RK, Su GW, Pflugfelder SC. Mucous membrane pemphigoid in a patient with chronic lymphocytic leukemia. Cornea. 2004 Oct; 23(7):740-3. PMID: 15448507.
      Citations: 2     Fields:    Translation:Humans
    261. Pflugfelder SC, Maskin SL, Anderson B, Chodosh J, Holland EJ, De Paiva CS, Bartels SP, Micuda T, Proskin HM, Vogel R. A randomized, double-masked, placebo-controlled, multicenter comparison of loteprednol etabonate ophthalmic suspension, 0.5%, and placebo for treatment of keratoconjunctivitis sicca in patients with delayed tear clearance. Am J Ophthalmol. 2004 Sep; 138(3):444-57. PMID: 15364229.
      Citations: 65     Fields:    Translation:HumansCTClinical Trials
    262. Kim HS, Shang T, Chen Z, Pflugfelder SC, Li DQ. TGF-beta1 stimulates production of gelatinase (MMP-9), collagenases (MMP-1, -13) and stromelysins (MMP-3, -10, -11) by human corneal epithelial cells. Exp Eye Res. 2004 Aug; 79(2):263-74. PMID: 15325573.
      Citations: 30     Fields:    Translation:HumansCells
    263. Kim HS, Jun Song X, de Paiva CS, Chen Z, Pflugfelder SC, Li DQ. Phenotypic characterization of human corneal epithelial cells expanded ex vivo from limbal explant and single cell cultures. Exp Eye Res. 2004 Jul; 79(1):41-9. PMID: 15183099; PMCID: PMC2906376.
      Citations: 94     Fields:    Translation:HumansCells
    264. Stern ME, Pflugfelder SC. Inflammation in dry eye. Ocul Surf. 2004 Apr; 2(2):124-30. PMID: 17216083.
      Citations: 68     Fields:    
    265. de Paiva CS, Pflugfelder SC. Tear clearance implications for ocular surface health. Exp Eye Res. 2004 Mar; 78(3):395-7. PMID: 15106918.
      Citations: 10     Fields:    Translation:Humans
    266. Stern ME, Gao J, Siemasko KF, Beuerman RW, Pflugfelder SC. The role of the lacrimal functional unit in the pathophysiology of dry eye. Exp Eye Res. 2004 Mar; 78(3):409-16. PMID: 15106920.
      Citations: 152     Fields:    Translation:HumansAnimalsCells
    267. Pflugfelder SC. Antiinflammatory therapy for dry eye. Am J Ophthalmol. 2004 Feb; 137(2):337-42. PMID: 14962426.
      Citations: 124     Fields:    Translation:Humans
    268. Pflugfelder SC. Hormonal deficiencies and dry eye. Arch Ophthalmol. 2004 Feb; 122(2):273-4. PMID: 14769606.
      Citations:    Fields:    Translation:Humans
    269. Chen Z, de Paiva CS, Luo L, Kretzer FL, Pflugfelder SC, Li DQ. Characterization of putative stem cell phenotype in human limbal epithelia. Stem Cells. 2004; 22(3):355-66. PMID: 15153612; PMCID: PMC2906385.
      Citations: 180     Fields:    Translation:HumansCells
    270. De Paiva CS, Pflugfelder SC. Corneal epitheliopathy of dry eye induces hyperesthesia to mechanical air jet stimulation. Am J Ophthalmol. 2004 Jan; 137(1):109-15. PMID: 14700652.
      Citations: 53     Fields:    Translation:HumansCells
    271. Hernandez-Illas M, Tozman E, Fulcher SF, Jundt JW, Davis J, Pflugfelder SC. Recombinant human tumor necrosis factor receptor Fc fusion protein (Etanercept): experience as a therapy for sight-threatening scleritis and sterile corneal ulceration. Eye Contact Lens. 2004 Jan; 30(1):2-5. PMID: 14722460.
      Citations: 9     Fields:    Translation:Humans
    272. Song XJ, Li DQ, Farley W, Luo LH, Heuckeroth RO, Milbrandt J, Pflugfelder SC. Neurturin-deficient mice develop dry eye and keratoconjunctivitis sicca. Invest Ophthalmol Vis Sci. 2003 Oct; 44(10):4223-9. PMID: 14507865.
      Citations: 39     Fields:    Translation:AnimalsCells
    273. Donnenfeld ED, Azar DT, Holland EJ, Palmon FR, Pflugfelder SC, Rubenstein JB, Solomon R. Infectious keratitis after laser in situ keratomileusis: results of an ASCRS survey. J Cataract Refract Surg. 2003 Oct; 29(10):2001-6. PMID: 14604725.
      Citations: 17     Fields:    Translation:HumansCells
    274. Wall V, Yen MT, Yang MC, Huang AJ, Pflugfelder SC. Management of the late ocular sequelae of Stevens-Johnson syndrome. Ocul Surf. 2003 Oct; 1(4):192-201. PMID: 17075650.
      Citations: 3     Fields:    
    275. Li DQ, Shang TY, Kim HS, Solomon A, Lokeshwar BL, Pflugfelder SC. Regulated expression of collagenases MMP-1, -8, and -13 and stromelysins MMP-3, -10, and -11 by human corneal epithelial cells. Invest Ophthalmol Vis Sci. 2003 Jul; 44(7):2928-36. PMID: 12824233.
      Citations: 34     Fields:    Translation:HumansCells
    276. de Paiva CS, Lindsey JL, Pflugfelder SC. Assessing the severity of keratitis sicca with videokeratoscopic indices. Ophthalmology. 2003 Jun; 110(6):1102-9. PMID: 12799233.
      Citations: 31     Fields:    Translation:Humans
    277. Pflugfelder SC. The Ocular Surface Center at the Baylor College of Medicine, Houston. Ocul Surf. 2003 Apr; 1(2):89-90. PMID: 17075639.
      Citations:    Fields:    
    278. Karp CL, Tuli SS, Yoo SH, Vroman DT, Alfonso EC, Huang AH, Pflugfelder SC, Culbertson WW. Infectious keratitis after LASIK. Ophthalmology. 2003 Mar; 110(3):503-10. PMID: 12623812.
      Citations: 17     Fields:    Translation:HumansCells
    279. Yeh S, Song XJ, Farley W, Li DQ, Stern ME, Pflugfelder SC. Apoptosis of ocular surface cells in experimentally induced dry eye. Invest Ophthalmol Vis Sci. 2003 Jan; 44(1):124-9. PMID: 12506064.
      Citations: 103     Fields:    Translation:AnimalsCells
    280. Pflugfelder SC. Anti-inflammatory therapy of dry eye. Ocul Surf. 2003 Jan; 1(1):31-6. PMID: 17075627.
      Citations: 21     Fields:    
    281. De Paiva CS, Harris LD, Pflugfelder SC. Keratoconus-like topographic changes in keratoconjunctivitis sicca. Cornea. 2003 Jan; 22(1):22-4. PMID: 12502943.
      Citations: 4     Fields:    Translation:Humans
    282. Pflugfelder SC, Liu Z, Feuer W, Verm A. Corneal thickness indices discriminate between keratoconus and contact lens-induced corneal thinning. Ophthalmology. 2002 Dec; 109(12):2336-41. PMID: 12466180.
      Citations: 33     Fields:    Translation:Humans
    283. Dursun D, Wang M, Monroy D, Li DQ, Lokeshwar BL, Stern ME, Pflugfelder SC. A mouse model of keratoconjunctivitis sicca. Invest Ophthalmol Vis Sci. 2002 Mar; 43(3):632-8. PMID: 11867577.
      Citations: 101     Fields:    Translation:AnimalsCells
    284. Dursun D, Wang M, Monroy D, Li DQ, Lokeshwar BL, Stern M, Pflugfelder SC. Experimentally induced dry eye produces ocular surface inflammation and epithelial disease. Adv Exp Med Biol. 2002; 506(Pt A):647-55. PMID: 12613973.
      Citations: 18     Fields:    Translation:AnimalsCells
    285. Pflugfelder SC, Solomon A, Dursun D, Li DQ. Dry eye and delayed tear clearance: "a call to arms.". Adv Exp Med Biol. 2002; 506(Pt B):739-43. PMID: 12613986.
      Citations: 9     Fields:    Translation:HumansAnimals
    286. Li DQ, Lokeshwar BL, Solomon A, Monroy D, Ji Z, Pflugfelder SC. Regulation of MMP-9 production by human corneal epithelial cells. Exp Eye Res. 2001 Oct; 73(4):449-59. PMID: 11825017.
      Citations: 79     Fields:    Translation:Humans
    287. Battat L, Macri A, Dursun D, Pflugfelder SC. Effects of laser in situ keratomileusis on tear production, clearance, and the ocular surface. Ophthalmology. 2001 Jul; 108(7):1230-5. PMID: 11425680.
      Citations: 60     Fields:    Translation:Humans
    288. Dursun D, Kim MC, Solomon A, Pflugfelder SC. Treatment of recalcitrant recurrent corneal erosions with inhibitors of matrix metalloproteinase-9, doxycycline and corticosteroids. Am J Ophthalmol. 2001 Jul; 132(1):8-13. PMID: 11438047.
      Citations: 45     Fields:    Translation:Humans
    289. Solomon A, Rosenblatt M, Monroy D, Ji Z, Pflugfelder SC, Tseng SC. Suppression of interleukin 1alpha and interleukin 1beta in human limbal epithelial cells cultured on the amniotic membrane stromal matrix. Br J Ophthalmol. 2001 Apr; 85(4):444-9. PMID: 11264135; PMCID: PMC1723909.
      Citations: 86     Fields:    Translation:HumansCells
    290. Yen MT, Pflugfelder SC, Feuer WJ. The effect of punctal occlusion on tear production, tear clearance, and ocular surface sensation in normal subjects. Am J Ophthalmol. 2001 Mar; 131(3):314-23. PMID: 11239863.
      Citations: 17     Fields:    Translation:Humans
    291. Liu Z, Carvajal M, Carraway CA, Carraway K, Pflugfelder SC. Expression of the receptor tyrosine kinases, epidermal growth factor receptor, ErbB2, and ErbB3, in human ocular surface epithelia. Cornea. 2001 Jan; 20(1):81-5. PMID: 11189010.
      Citations: 31     Fields:    Translation:HumansAnimals
    292. Macri A, Pflugfelder S. Correlation of the Schirmer 1 and fluorescein clearance tests with the severity of corneal epithelial and eyelid disease. Arch Ophthalmol. 2000 Dec; 118(12):1632-8. PMID: 11115257.
      Citations: 18     Fields:    Translation:Humans
    293. Pflugfelder SC, Solomon A, Stern ME. The diagnosis and management of dry eye: a twenty-five-year review. Cornea. 2000 Sep; 19(5):644-9. PMID: 11009316.
      Citations: 90     Fields:    Translation:HumansAnimals
    294. Liu Z, Xie Y, Zhang M, Pflugfelder SC. [The abnormal expression of epidermal growth factor receptor family in pterygium]. Zhonghua Yan Ke Za Zhi. 2000 Sep; 36(5):372-4, 25. PMID: 11853633.
      Citations:    Fields:    Translation:Humans
    295. Dursun D, Monroy D, Knighton R, Tervo T, Vesaluoma M, Carraway K, Feuer W, Pflugfelder SC. The effects of experimental tear film removal on corneal surface regularity and barrier function. Ophthalmology. 2000 Sep; 107(9):1754-60. PMID: 10964840.
      Citations: 19     Fields:    Translation:Humans
    296. Solomon A, Rosenblatt M, Li DQ, Liu Z, Monroy D, Ji Z, Lokeshwar BL, Pflugfelder SC. Doxycycline inhibition of interleukin-1 in the corneal epithelium. Invest Ophthalmol Vis Sci. 2000 Aug; 41(9):2544-57. PMID: 10937565.
      Citations: 38     Fields:    Translation:HumansCells
    297. Wang MX, Shen DJ, Liu JC, Pflugfelder SC, Alfonso EC, Forster RK. Recurrent fungal keratitis and endophthalmitis. Cornea. 2000 Jul; 19(4):558-60. PMID: 10928778.
      Citations: 5     Fields:    Translation:HumansAnimalsPHPublic Health
    298. Turner K, Pflugfelder SC, Ji Z, Feuer WJ, Stern M, Reis BL. Interleukin-6 levels in the conjunctival epithelium of patients with dry eye disease treated with cyclosporine ophthalmic emulsion. Cornea. 2000 Jul; 19(4):492-6. PMID: 10928765.
      Citations: 51     Fields:    Translation:HumansCTClinical Trials
    299. Macri A, Rolando M, Pflugfelder S. A standardized visual scale for evaluation of tear fluorescein clearance. Ophthalmology. 2000 Jul; 107(7):1338-43. PMID: 10889108.
      Citations: 20     Fields:    Translation:Humans
    300. Sobrin L, Liu Z, Monroy DC, Solomon A, Selzer MG, Lokeshwar BL, Pflugfelder SC. Regulation of MMP-9 activity in human tear fluid and corneal epithelial culture supernatant. Invest Ophthalmol Vis Sci. 2000 Jun; 41(7):1703-9. PMID: 10845589.
      Citations: 43     Fields:    Translation:HumansCells
    301. Pflugfelder SC, Liu Z, Monroy D, Li DQ, Carvajal ME, Price-Schiavi SA, Idris N, Solomon A, Perez A, Carraway KL. Detection of sialomucin complex (MUC4) in human ocular surface epithelium and tear fluid. Invest Ophthalmol Vis Sci. 2000 May; 41(6):1316-26. PMID: 10798646.
      Citations: 51     Fields:    Translation:Humans
    302. Liu Z, Carvajal M, Carothers Carraway CA, Carraway KL, Pflugfelder SC. Increased expression of the type 1 growth factor receptor family in the conjunctival epithelium of patients with keratoconjunctivitis sicca. Am J Ophthalmol. 2000 Apr; 129(4):472-80. PMID: 10764856.
      Citations: 6     Fields:    Translation:Humans
    303. Liu Z, Xie Y, Zhang M, Pflugfelder SC. [The effect of artificial tears on corneal surface regularity in dry eye]. Zhonghua Yan Ke Za Zhi. 2000 Mar; 36(2):131-4. PMID: 11853602.
      Citations: 3     Fields:    Translation:Humans
    304. Liu Z, Pflugfelder SC. The effects of long-term contact lens wear on corneal thickness, curvature, and surface regularity. Ophthalmology. 2000 Jan; 107(1):105-11. PMID: 10647727.
      Citations: 32     Fields:    Translation:Humans
    305. Afonso AA, Sobrin L, Monroy DC, Selzer M, Lokeshwar B, Pflugfelder SC. Tear fluid gelatinase B activity correlates with IL-1alpha concentration and fluorescein clearance in ocular rosacea. Invest Ophthalmol Vis Sci. 1999 Oct; 40(11):2506-12. PMID: 10509643.
      Citations: 60     Fields:    Translation:Humans
    306. Pflugfelder SC, Jones D, Ji Z, Afonso A, Monroy D. Altered cytokine balance in the tear fluid and conjunctiva of patients with Sj?gren's syndrome keratoconjunctivitis sicca. Curr Eye Res. 1999 Sep; 19(3):201-11. PMID: 10487957.
      Citations: 180     Fields:    Translation:HumansCells
    307. Liu Z, Pflugfelder SC. Corneal thickness is reduced in dry eye. Cornea. 1999 Jul; 18(4):403-7. PMID: 10422850.
      Citations: 34     Fields:    Translation:Humans
    308. Liu Z, Huang AJ, Pflugfelder SC. Evaluation of corneal thickness and topography in normal eyes using the Orbscan corneal topography system. Br J Ophthalmol. 1999 Jul; 83(7):774-8. PMID: 10381661; PMCID: PMC1723104.
      Citations: 44     Fields:    Translation:Humans
    309. Liu Z, Pflugfelder SC. Corneal surface regularity and the effect of artificial tears in aqueous tear deficiency. Ophthalmology. 1999 May; 106(5):939-43. PMID: 10328393.
      Citations: 46     Fields:    Translation:HumansCTClinical Trials
    310. Afonso AA, Monroy D, Stern ME, Feuer WJ, Tseng SC, Pflugfelder SC. Correlation of tear fluorescein clearance and Schirmer test scores with ocular irritation symptoms. Ophthalmology. 1999 Apr; 106(4):803-10. PMID: 10201606.
      Citations: 54     Fields:    Translation:Humans
    311. Marsh P, Pflugfelder SC. Topical nonpreserved methylprednisolone therapy for keratoconjunctivitis sicca in Sj?gren syndrome. Ophthalmology. 1999 Apr; 106(4):811-6. PMID: 10201607.
      Citations: 78     Fields:    Translation:HumansCTClinical Trials
    312. Stern ME, Beuerman RW, Fox RI, Gao J, Mircheff AK, Pflugfelder SC. The pathology of dry eye: the interaction between the ocular surface and lacrimal glands. Cornea. 1998 Nov; 17(6):584-9. PMID: 9820935.
      Citations: 215     Fields:    Translation:HumansAnimalsCells
    313. Ford JG, Huang AJ, Pflugfelder SC, Alfonso EC, Forster RK, Miller D. Nontuberculous mycobacterial keratitis in south Florida. Ophthalmology. 1998 Sep; 105(9):1652-8. PMID: 9754173.
      Citations: 16     Fields:    Translation:HumansCells
    314. Demirbas NH, Pflugfelder SC. Topographic pattern and apex location of keratoconus on elevation topography maps. Cornea. 1998 Sep; 17(5):476-84. PMID: 9756441.
      Citations: 8     Fields:    Translation:Humans
    315. Pflugfelder SC. Advances in the diagnosis and management of keratoconjunctivitis sicca. Curr Opin Ophthalmol. 1998 Aug; 9(4):50-3. PMID: 10387469.
      Citations: 1     Fields:    Translation:HumansAnimals
    316. Pflugfelder SC. Tear fluid influence on the ocular surface. Adv Exp Med Biol. 1998; 438:611-7. PMID: 9634944.
      Citations: 6     Fields:    Translation:HumansCells
    317. Stern ME, Beuerman RW, Fox RI, Gao J, Mircheff AK, Pflugfelder SC. A unified theory of the role of the ocular surface in dry eye. Adv Exp Med Biol. 1998; 438:643-51. PMID: 9634949.
      Citations: 35     Fields:    Translation:HumansAnimals
    318. Jones DT, Monroy D, Ji Z, Pflugfelder SC. Alterations of ocular surface gene expression in Sj?gren's syndrome. Adv Exp Med Biol. 1998; 438:533-6. PMID: 9634933.
      Citations: 33     Fields:    Translation:HumansCells
    319. Barton K, Nava A, Monroy DC, Pflugfelder SC. Cytokines and tear function in ocular surface disease. Adv Exp Med Biol. 1998; 438:461-9. PMID: 9634922.
      Citations: 9     Fields:    Translation:Humans
    320. Pflugfelder SC, Tseng SC, Sanabria O, Kell H, Garcia CG, Felix C, Feuer W, Reis BL. Evaluation of subjective assessments and objective diagnostic tests for diagnosing tear-film disorders known to cause ocular irritation. Cornea. 1998 Jan; 17(1):38-56. PMID: 9436879.
      Citations: 143     Fields:    Translation:HumansCTClinical Trials
    321. Barton K, Monroy DC, Nava A, Pflugfelder SC. Inflammatory cytokines in the tears of patients with ocular rosacea. Ophthalmology. 1997 Nov; 104(11):1868-74. PMID: 9373119.
      Citations: 25     Fields:    Translation:Humans
    322. Gupta A, Heigle T, Pflugfelder SC. Nasolacrimal stimulation of aqueous tear production. Cornea. 1997 Nov; 16(6):645-8. PMID: 9395874.
      Citations: 16     Fields:    Translation:Humans
    323. Nava A, Barton K, Monroy DC, Pflugfelder SC. The effects of age, gender, and fluid dynamics on the concentration of tear film epidermal growth factor. Cornea. 1997 Jul; 16(4):430-8. PMID: 9220241.
      Citations: 14     Fields:    Translation:Humans
    324. Jones DT, Monroy D, Pflugfelder SC. A novel method of tear collection: comparison of glass capillary micropipettes with porous polyester rods. Cornea. 1997 Jul; 16(4):450-8. PMID: 9220244.
      Citations: 13     Fields:    Translation:Humans
    325. Barton K, Miller D, Pflugfelder SC. Corneal chromoblastomycosis. Cornea. 1997 Mar; 16(2):235-9. PMID: 9071540.
      Citations: 8     Fields:    Translation:HumansAnimals
    326. Hoft RH, Pflugfelder SC, Forster RK, Ullman S, Polack FM, Schiff ER. Clinical evidence for hepatitis B transmission resulting from corneal transplantation. Cornea. 1997 Mar; 16(2):132-7. PMID: 9071524.
      Citations: 8     Fields:    Translation:HumansCellsPHPublic Health
    327. Pflugfelder SC, Tseng SC, Yoshino K, Monroy D, Felix C, Reis BL. Correlation of goblet cell density and mucosal epithelial membrane mucin expression with rose bengal staining in patients with ocular irritation. Ophthalmology. 1997 Feb; 104(2):223-35. PMID: 9052626.
      Citations: 74     Fields:    Translation:Humans
    328. Scott IU, Flynn HW, Feuer W, Pflugfelder SC, Alfonso EC, Forster RK, Miller D. Endophthalmitis associated with microbial keratitis. Ophthalmology. 1996 Nov; 103(11):1864-70. PMID: 8942882.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    329. Yoshino K, Monroy D, Pflugfelder SC. Cholinergic stimulation of lactoferrin and epidermal growth factor secretion by the human lacrimal gland. Cornea. 1996 Nov; 15(6):617-21. PMID: 8899275.
      Citations: 6     Fields:    Translation:Humans
    330. Gupta A, Monroy D, Ji Z, Yoshino K, Huang A, Pflugfelder SC. Transforming growth factor beta-1 and beta-2 in human tear fluid. Curr Eye Res. 1996 Jun; 15(6):605-14. PMID: 8670763.
      Citations: 42     Fields:    Translation:HumansAnimalsCells
    331. Yoshino K, Garg R, Monroy D, Ji Z, Pflugfelder SC. Production and secretion of transforming growth factor beta (TGF-beta) by the human lacrimal gland. Curr Eye Res. 1996 Jun; 15(6):615-24. PMID: 8670764.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    332. Pflugfelder SC. Differential diagnosis of dry eye conditions. Adv Dent Res. 1996 Apr; 10(1):9-12. PMID: 8934916.
      Citations: 6     Fields:    Translation:Humans
    333. Karp CL, Scott IU, Chang TS, Pflugfelder SC. Conjunctival intraepithelial neoplasia. A possible marker for human immunodeficiency virus infection? Arch Ophthalmol. 1996 Mar; 114(3):257-61. PMID: 8600883.
      Citations: 21     Fields:    Translation:Humans
    334. Heigle TJ, Pflugfelder SC. Aqueous tear production in patients with neurotrophic keratitis. Cornea. 1996 Mar; 15(2):135-8. PMID: 8925660.
      Citations: 32     Fields:    Translation:Humans
    335. Yoshino K, Tseng SC, Pflugfelder SC. Substrate modulation of morphology, growth, and tear protein production by cultured human lacrimal gland epithelial cells. Exp Cell Res. 1995 Sep; 220(1):138-51. PMID: 7664830.
      Citations: 12     Fields:    Translation:HumansCells
    336. Tu EY, Culbertson WW, Pflugfelder SC, Huang A, Chodosh JC. Therapy of nonnecrotizing anterior scleritis with subconjunctival corticosteroid injection. Ophthalmology. 1995 May; 102(5):718-24. PMID: 7777270.
      Citations: 8     Fields:    Translation:Humans
    337. Chodosh J, Miller D, Stroop WG, Pflugfelder SC. Adenovirus epithelial keratitis. Cornea. 1995 Mar; 14(2):167-74. PMID: 7743800.
      Citations: 20     Fields:    Translation:HumansCells
    338. Davis JL, Feuer W, Culbertson WW, Pflugfelder SC. Interpretation of intraocular and serum antibody levels in necrotizing retinitis. Retina. 1995; 15(3):233-40. PMID: 7569351.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    339. Jones DT, Monroy D, Ji Z, Atherton SS, Pflugfelder SC. Sj?gren's syndrome: cytokine and Epstein-Barr viral gene expression within the conjunctival epithelium. Invest Ophthalmol Vis Sci. 1994 Aug; 35(9):3493-504. PMID: 8056525.
      Citations: 47     Fields:    Translation:HumansCells
    340. Pflugfelder SC, Crouse CA, Atherton SS. Epstein-Barr virus and the lacrimal gland pathology of Sj?gren's syndrome. Adv Exp Med Biol. 1994; 350:641-6. PMID: 8030548.
      Citations: 1     Fields:    Translation:HumansCells
    341. Mao LK, Flynn HW, Miller D, Pflugfelder SC. Endophthalmitis caused by Staphylococcus aureus. Am J Ophthalmol. 1993 Nov 15; 116(5):584-9. PMID: 8238218.
      Citations: 8     Fields:    Translation:HumansCells
    342. Culbertson WW, Huang AJ, Mandelbaum SH, Pflugfelder SC, Boozalis GT, Miller D. Effective treatment of phlyctenular keratoconjunctivitis with oral tetracycline. Ophthalmology. 1993 Sep; 100(9):1358-66. PMID: 8371924.
      Citations: 9     Fields:    Translation:Humans
    343. Pflugfelder SC, Crouse CA, Monroy D, Yen M, Rowe M, Atherton SS. Epstein-Barr virus and the lacrimal gland pathology of Sj?gren's syndrome. Am J Pathol. 1993 Jul; 143(1):49-64. PMID: 8391219; PMCID: PMC1886957.
      Citations: 20     Fields:    Translation:HumansCells
    344. Winward KE, Pflugfelder SC, Flynn HW, Roussel TJ, Davis JL. Postoperative Propionibacterium endophthalmitis. Treatment strategies and long-term results. Ophthalmology. 1993 Apr; 100(4):447-51. PMID: 8479698.
      Citations: 14     Fields:    Translation:HumansCells
    345. Rubsamen PE, McLeish WM, Pflugfelder S, Miller D. Capnocytophaga endophthalmitis. Ophthalmology. 1993 Apr; 100(4):456-9. PMID: 8479700.
      Citations: 2     Fields:    Translation:HumansCells
    346. Pflugfelder SC, Crouse CA, Atherton SS. Ophthalmic manifestations of Epstein-Barr virus infection. Int Ophthalmol Clin. 1993; 33(1):95-101. PMID: 8394294.
      Citations: 2     Fields:    Translation:HumansCells
    347. Pflugfelder SC, Flynn HW. Infectious endophthalmitis. Infect Dis Clin North Am. 1992 Dec; 6(4):859-73. PMID: 1460267.
      Citations: 5     Fields:    Translation:HumansAnimals
    348. Yen MT, Pflugfelder SC, Crouse CA, Atherton SS. Cytoskeletal antigen expression in ocular mucosa-associated lymphoid tissue. Invest Ophthalmol Vis Sci. 1992 Oct; 33(11):3235-41. PMID: 1399428.
      Citations: 3     Fields:    Translation:Humans
    349. Irvine WD, Flynn HW, Miller D, Pflugfelder SC. Endophthalmitis caused by gram-negative organisms. Arch Ophthalmol. 1992 Oct; 110(10):1450-4. PMID: 1417545.
      Citations: 39     Fields:    Translation:HumansCells
    350. Simon MW, Miller D, Pflugfelder SC, Murchison JF, Huang AJ, Atherton SS. Comparison of immunocytology to tissue culture for diagnosis of presumed herpesvirus dendritic epithelial keratitis. Ophthalmology. 1992 Sep; 99(9):1408-13. PMID: 1328982.
      Citations: 1     Fields:    Translation:HumansCells
    351. Pflugfelder SC, Roussel TJ, Denham D, Feuer W, Mandelbaum S, Parel JM. Photogrammetric analysis of corneal trephination. Arch Ophthalmol. 1992 Aug; 110(8):1160-6. PMID: 1497532.
      Citations: 5     Fields:    Translation:Humans
    352. Mao LK, Flynn HW, Miller D, Pflugfelder SC. Endophthalmitis caused by streptococcal species. Arch Ophthalmol. 1992 Jun; 110(6):798-801. PMID: 1596227.
      Citations: 18     Fields:    Translation:HumansCells
    353. Pflugfelder SC, Murchison JF. Corneal toxicity with an antibiotic/steroid-soaked collagen shield. Arch Ophthalmol. 1992 Jan; 110(1):20. PMID: 1731715.
      Citations:    Fields:    Translation:Humans
    354. Kervick GN, Pflugfelder SC, Haimovici R, Brown H, Tozman E, Yee R. Paracentral rheumatoid corneal ulceration. Clinical features and cyclosporine therapy. Ophthalmology. 1992 Jan; 99(1):80-8. PMID: 1741146.
      Citations: 19     Fields:    Translation:HumansCells
    355. Nanda M, Pflugfelder SC, Holland S. Fulminant pseudomonal keratitis and scleritis in human immunodeficiency virus-infected patients. Arch Ophthalmol. 1991 Apr; 109(4):503-5. PMID: 2012549.
      Citations: 6     Fields:    Translation:Humans
    356. Fox GM, Joondeph BC, Flynn HW, Pflugfelder SC, Roussel TJ. Delayed-onset pseudophakic endophthalmitis. Am J Ophthalmol. 1991 Feb 15; 111(2):163-73. PMID: 1992736.
      Citations: 27     Fields:    Translation:HumansCells
    357. Fox GM, Crouse CA, Chuang EL, Pflugfelder SC, Cleary TJ, Nelson SJ, Atherton SS. Detection of herpesvirus DNA in vitreous and aqueous specimens by the polymerase chain reaction. Arch Ophthalmol. 1991 Feb; 109(2):266-71. PMID: 1847043.
      Citations: 34     Fields:    Translation:HumansCells
    358. Flynn HW, Pulido JS, Pflugfelder SC, Davis JL, Culbertson WW, Roussel TJ, Miller D. Endophthalmitis therapy: changing antibiotic sensitivity patterns and current therapeutic recommendations. Arch Ophthalmol. 1991 Feb; 109(2):175-6. PMID: 1993022.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    359. Kattan HM, Flynn HW, Pflugfelder SC, Robertson C, Forster RK. Nosocomial endophthalmitis survey. Current incidence of infection after intraocular surgery. Ophthalmology. 1991 Feb; 98(2):227-38. PMID: 2008282.
      Citations: 84     Fields:    Translation:Humans
    360. Feist RM, Lim JI, Joondeph BC, Pflugfelder SC, Mieler WF, Ticho BH, Resnick K. Penetrating ocular injury from contaminated eating utensils. Arch Ophthalmol. 1991 Jan; 109(1):63-6. PMID: 1987951.
      Citations: 2     Fields:    Translation:HumansCellsPHPublic Health
    361. Pepose JS, Akata RF, Pflugfelder SC, Voigt W. Mononuclear cell phenotypes and immunoglobulin gene rearrangements in lacrimal gland biopsies from patients with Sj?gren's syndrome. Ophthalmology. 1990 Dec; 97(12):1599-605. PMID: 1965021.
      Citations: 18     Fields:    Translation:HumansCells
    362. Pflugfelder SC, Huang A, Crouse C. Epstein-Barr virus keratitis after a chemical facial peel. Am J Ophthalmol. 1990 Nov 15; 110(5):571-3. PMID: 2173408.
      Citations: 6     Fields:    Translation:HumansCells
    363. Kattan HM, Pflugfelder SC. Nocardia scleritis. Am J Ophthalmol. 1990 Oct 15; 110(4):446-7. PMID: 2220994.
      Citations: 8     Fields:    Translation:Humans
    364. Duffner LR, Pflugfelder SC, Mandelbaum S, Childress LL. Potential bacterial contamination in fluorescein-anesthetic solutions. Am J Ophthalmol. 1990 Aug 15; 110(2):199-202. PMID: 2116089.
      Citations:    Fields:    Translation:CellsPHPublic Health
    365. Pflugfelder SC, Huang AJ, Feuer W, Chuchovski PT, Pereira IC, Tseng SC. Conjunctival cytologic features of primary Sj?gren's syndrome. Ophthalmology. 1990 Aug; 97(8):985-91. PMID: 1698273.
      Citations: 51     Fields:    Translation:HumansCells
    366. Pflugfelder SC, Crouse C, Pereira I, Atherton S. Amplification of Epstein-Barr virus genomic sequences in blood cells, lacrimal glands, and tears from primary Sj?gren's syndrome patients. Ophthalmology. 1990 Aug; 97(8):976-84. PMID: 2169602.
      Citations: 12     Fields:    Translation:HumansCells
    367. Rosenwasser GO, Holland S, Pflugfelder SC, Lugo M, Heidemann DG, Culbertson WW, Kattan H. Topical anesthetic abuse. Ophthalmology. 1990 Aug; 97(8):967-72. PMID: 2402423.
      Citations: 16     Fields:    Translation:Humans
    368. Crouse CA, Pflugfelder SC, Pereira I, Cleary T, Rabinowitz S, Atherton SS. Detection of herpes viral genomes in normal and diseased corneal epithelium. Curr Eye Res. 1990 Jun; 9(6):569-81. PMID: 2167192.
      Citations: 18     Fields:    Translation:HumansCells
    369. Brod RD, Flynn HW, Clarkson JG, Pflugfelder SC, Culbertson WW, Miller D. Endogenous Candida endophthalmitis. Management without intravenous amphotericin B. Ophthalmology. 1990 May; 97(5):666-72; disc: 672-4. PMID: 2188195.
      Citations: 11     Fields:    Translation:HumansAnimals
    370. Pflugfelder SC, Tseng SC, Pepose JS, Fletcher MA, Klimas N, Feuer W. Epstein-Barr virus infection and immunologic dysfunction in patients with aqueous tear deficiency. Ophthalmology. 1990 Mar; 97(3):313-23. PMID: 2159609.
      Citations: 10     Fields:    Translation:HumansCells
    371. Rosenfeld SI, Mandelbaum S, Corrent GF, Pflugfelder SC, Culbertson WW. Granular epithelial keratopathy as an unusual manifestation of Pseudomonas keratitis associated with extended-wear soft contact lenses. Am J Ophthalmol. 1990 Jan 15; 109(1):17-22. PMID: 2105056.
      Citations: 2     Fields:    Translation:HumansCells
    372. McLeish W, Pflugfelder SC, Crouse C, Rabinowitz S, Miller D, Hill EL, Atherton S. Interferon treatment of herpetic keratitis in a patient with acquired immunodeficiency syndrome. Am J Ophthalmol. 1990 Jan 15; 109(1):93-5. PMID: 2153343.
      Citations: 2     Fields:    Translation:HumansCells
    373. Levine J, Pflugfelder SC, Yen M, Crouse CA, Atherton SS. Detection of the complement (CD21)/Epstein-Barr virus receptor in human lacrimal gland and ocular surface epithelia. Reg Immunol. 1990-1991; 3(4):164-70. PMID: 1966579.
      Citations: 5     Fields:    Translation:HumansCells
    374. Nanda M, Pflugfelder SC, Holland S. Mycobacterium tuberculosis scleritis. Am J Ophthalmol. 1989 Dec 15; 108(6):736-7. PMID: 2512813.
      Citations: 6     Fields:    Translation:HumansCells
    375. Denham D, Mandelbaum S, Parel JM, Holland S, Pflugfelder S. Shadow photogrammetric apparatus for the quantitative evaluation of corneal buttons. Ophthalmic Surg. 1989 Nov; 20(11):794-9. PMID: 2616127.
      Citations: 4     Fields:    Translation:Humans
    376. Rabinowitz SM, Pflugfelder SC, Goldberg M. Disposable extended-wear contact lens-related keratitis. Case report. Arch Ophthalmol. 1989 Aug; 107(8):1121. PMID: 2502975.
      Citations:    Fields:    Translation:HumansCells
    377. Zambrano W, Flynn HW, Pflugfelder SC, Roussel TJ, Culbertson WW, Holland S, Miller D. Management options for Propionibacterium acnes endophthalmitis. Ophthalmology. 1989 Jul; 96(7):1100-5. PMID: 2788852.
      Citations: 20     Fields:    Translation:HumansCells
    378. Thompson KP, Barraquer E, Parel JM, Loertscher H, Pflugfelder S, Roussel T, Holland S, Hanna K. Potential use of lasers for penetrating keratoplasty. J Cataract Refract Surg. 1989 Jul; 15(4):397-403. PMID: 2674411.
      Citations: 1     Fields:    Translation:Humans
    379. Kattan H, Pflugfelder SC. Complications of intraocular antimicrobial agents. Int Ophthalmol Clin. 1989; 29(3):188-94. PMID: 2666333.
      Citations:    Fields:    Translation:HumansAnimals
    380. Duerksen KM, Albert DW, Saulson RM, Pflugfelder SC. Soda pop top ophthalmopathy. Am J Ophthalmol. 1988 Dec 15; 106(6):761-2. PMID: 3195669.
      Citations: 2     Fields:    Translation:Humans
    381. Davis JL, Koidou-Tsiligianni A, Pflugfelder SC, Miller D, Flynn HW, Forster RK. Coagulase-negative staphylococcal endophthalmitis. Increase in antimicrobial resistance. Ophthalmology. 1988 Oct; 95(10):1404-10. PMID: 3265776.
      Citations: 10     Fields:    Translation:HumansCells
    382. Pflugfelder SC, Suelflow J, Pflugfelder ME, Parke DW. Serum and vitreous herpes simplex antibodies in noninfected eyes. Ann Ophthalmol. 1988 Sep; 20(9):355-7. PMID: 2847623.
      Citations:    Fields:    Translation:HumansCells
    383. Heidemann DG, Pflugfelder SC, Kronish J, Alfonso EC, Dunn SP, Ullman S. Necrotizing keratitis caused by Capnocytophaga ochracea. Am J Ophthalmol. 1988 Jun 15; 105(6):655-60. PMID: 3377043.
      Citations: 4     Fields:    Translation:HumansCells
    384. Buus DR, Pflugfelder SC, Schachter J, Miller D, Forster RK. Lymphogranuloma venereum conjunctivitis with a marginal corneal perforation. Ophthalmology. 1988 Jun; 95(6):799-802. PMID: 3062531.
      Citations: 2     Fields:    Translation:HumansCells
    385. Pflugfelder SC, Parel JM, Denham D, Mandelbaum S. A suction trephine block for marking donor corneal buttons. Arch Ophthalmol. 1988 Feb; 106(2):276-81. PMID: 3277610.
      Citations: 1     Fields:    Translation:Humans
    386. Pflugfelder SC, Flynn HW, Zwickey TA, Forster RK, Tsiligianni A, Culbertson WW, Mandelbaum S. Exogenous fungal endophthalmitis. Ophthalmology. 1988 Jan; 95(1):19-30. PMID: 3257818.
      Citations: 45     Fields:    Translation:HumansCells
    387. Pflugfelder SC, Saulson R, Ullman S. Peripheral corneal ulceration in a patient with AIDS-related complex. Am J Ophthalmol. 1987 Nov 15; 104(5):542-3. PMID: 3674189.
      Citations:    Fields:    Translation:Humans
    388. Pflugfelder SC, Fliesler SJ, Alvarez J, Pflugfelder ME, Forster RK, Hern?ndez E. Intravitreal vancomycin. Retinal toxicity, clearance, and interaction with gentamicin. Arch Ophthalmol. 1987 Jun; 105(6):831-7. PMID: 3495255.
      Citations: 28     Fields:    Translation:Animals
    389. Ullman S, Pflugfelder SC. A supplemental labeling system for topical medications. Am J Ophthalmol. 1987 Mar 15; 103(3 Pt 1):335. PMID: 3826245.
      Citations: 1     Fields:    Translation:Humans
    390. Pflugfelder SC, Roussel TJ, Culbertson WW. Primary Sj?gren's syndrome after infectious mononucleosis. JAMA. 1987 Feb 27; 257(8):1049-50. PMID: 3806887.
      Citations: 2     Fields:    Translation:Humans
    391. Ullman S, Pflugfelder SC, Hughes R, Forster RK. Bacillus cereus panophthalmitis manifesting as an orbital cellulitis. Am J Ophthalmol. 1987 Jan 15; 103(1):105-6. PMID: 3099579.
      Citations: 3     Fields:    Translation:HumansCells
    392. Pflugfelder SC, Wilhelmus KR, Osato MS, Matoba AY, Font RL. The autoimmune nature of aqueous tear deficiency. Ophthalmology. 1986 Dec; 93(12):1513-7. PMID: 3808613.
      Citations: 16     Fields:    Translation:Humans
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