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JOEL NEILSON

TitleAssistant Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular Physiology & Biophysics
AddressOne Baylor Plaza
Houston TX 77030
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    1996Phi Beta Kappa, University of Washington
    2004Postdoctoral Fellowship, Cancer Research Institute
    2004Sidney J. Raffel Award for Outstanding Accomplishment in Graduate Study, Stanford University School of Medicine Department of Microbiology and Immunology
    2007Poster Award, NE Soc. for Dev. Biol. Annual Meeting
    2007K99 Pathways to Independence Award, National Cancer Institute
    2010LC Sciences Award, AAAS Southwest Area Regional Meeting
    2010Career Development Award, BCM Leukemia/Lymphoma SPORE

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Tajhya RB, Hu X, Tanner MR, Huq R, Kongchan N, Neilson JR, Rodney GG, Horrigan FT, Timchenko LT, Beeton C. Functional KCa1.1 channels are crucial for regulating the proliferation, migration and differentiation of human primary skeletal myoblasts. Cell Death Dis. 2016 Oct 20; 7(10):e2426. PMID: 27763639.
      View in: PubMed
    2. Xu Y, Chaudhury A, Zhang M, Savoldo B, Metelitsa LS, Rodgers J, Yustein JT, Neilson JR, Dotti G. Glycolysis determines dichotomous regulation of T cell subsets in hypoxia. J Clin Invest. 2016 Jul 1; 126(7):2678-88. PMID: 27294526; PMCID: PMC4922684 [Available on 10/01/16].
    3. Domingues RG, Lago-Baldaia I, Pereira-Castro I, Fachini JM, Oliveira L, Drpic D, Lopes N, Henriques T, Neilson JR, Carmo AM, Moreira A. CD5 expression is regulated during human T-cell activation by alternative polyadenylation, PTBP1, and miR-204. Eur J Immunol. 2016 Jun; 46(6):1490-503. PMID: 27005442.
      View in: PubMed
    4. Pal R, Bajaj L, Sharma J, Palmieri M, Di Ronza A, Lotfi P, Chaudhury A, Neilson J, Sardiello M, Rodney GG. NADPH oxidase promotes Parkinsonian phenotypes by impairing autophagic flux in an mTORC1-independent fashion in a cellular model of Parkinson's disease. Sci Rep. 2016; 6:22866. PMID: 26960433; PMCID: PMC4785399.
    5. Chaudhury A, Neilson JR. Use of the pBUTR Reporter System for Scalable Analysis of 3' UTR-Mediated Gene Regulation. Methods Mol Biol. 2016; 1358:109-28. PMID: 26463380.
      View in: PubMed
    6. Hsu TY, Simon LM, Neill NJ, Marcotte R, Sayad A, Bland CS, Echeverria GV, Sun T, Kurley SJ, Tyagi S, Karlin KL, Dominguez-Vidaña R, Hartman JD, Renwick A, Scorsone K, Bernardi RJ, Skinner SO, Jain A, Orellana M, Lagisetti C, Golding I, Jung SY, Neilson JR, Zhang XH, Cooper TA, Webb TR, Neel BG, Shaw CA, Westbrook TF. The spliceosome is a therapeutic vulnerability in MYC-driven cancer. Nature. 2015 Sep 17; 525(7569):384-8. PMID: 26331541.
      View in: PubMed
    7. Tan YD, Deng J, Neilson JR. RAX2: a genome-wide detection method of condition-associated transcription variation. Nucleic Acids Res. 2015 Sep 3; 43(15):e96. PMID: 25953852.
      View in: PubMed
    8. Tan YD, Chandler AM, Chaudhury A, Neilson JR. A powerful statistical approach for large-scale differential transcription analysis. PLoS One. 2015; 10(4):e0123658. PMID: 25894390; PMCID: PMC4404056.
    9. Xia Z, Donehower LA, Cooper TA, Neilson JR, Wheeler DA, Wagner EJ, Li W. Dynamic analyses of alternative polyadenylation from RNA-seq reveal a 3'-UTR landscape across seven tumour types. Nat Commun. 2014; 5:5274. PMID: 25409906; PMCID: PMC4467577.
    10. Chiang DY, Kongchan N, Beavers DL, Alsina KM, Voigt N, Neilson JR, Jakob H, Martin JF, Dobrev D, Wehrens XH, Li N. Loss of microRNA-106b-25 cluster promotes atrial fibrillation by enhancing ryanodine receptor type-2 expression and calcium release. Circ Arrhythm Electrophysiol. 2014 Dec; 7(6):1214-22. PMID: 25389315; PMCID: PMC4270890.
    11. Chaudhury A, Kongchan N, Gengler JP, Mohanty V, Christiansen AE, Fachini JM, Martin JF, Neilson JR. A piggyBac-based reporter system for scalable in vitro and in vivo analysis of 3' untranslated region-mediated gene regulation. Nucleic Acids Res. 2014 Jun; 42(10):e86. PMID: 24753411; PMCID: PMC4041432.
    12. Zhao P, Damerow MS, Stern P, Liu AH, Sweet-Cordero A, Siziopikou K, Neilson JR, Sharp PA, Cheng C. CD44 promotes Kras-dependent lung adenocarcinoma. Oncogene. 2013 Oct 24; 32(43):5186-90. PMID: 23208496; PMCID: PMC4227610.
    13. Neilson JR, Sandberg R. Heterogeneity in mammalian RNA 3' end formation. Exp Cell Res. 2010 May 1; 316(8):1357-64. PMID: 20211174; PMCID: PMC2866830.
    14. Edbauer D, Neilson JR, Foster KA, Wang CF, Seeburg DP, Batterton MN, Tada T, Dolan BM, Sharp PA, Sheng M. Regulation of synaptic structure and function by FMRP-associated microRNAs miR-125b and miR-132. Neuron. 2010 Feb 11; 65(3):373-84. PMID: 20159450.
      View in: PubMed
    15. Wu H, Neilson J, Manjunath N. MicroRNA cloning from cells of the immune system. Methods Mol Biol. 2010; 667:67-77. PMID: 20827527.
      View in: PubMed
    16. Jones MR, Quinton LJ, Blahna MT, Neilson JR, Fu S, Ivanov AR, Wolf DA, Mizgerd JP. Zcchc11-dependent uridylation of microRNA directs cytokine expression. Nat Cell Biol. 2009 Sep; 11(9):1157-63. PMID: 19701194; PMCID: PMC2759306.
    17. Neilson JR, Sharp PA. Small RNA regulators of gene expression. Cell. 2008 Sep 19; 134(6):899-902. PMID: 18805079.
      View in: PubMed
    18. Sandberg R, Neilson JR, Sarma A, Sharp PA, Burge CB. Proliferating cells express mRNAs with shortened 3' untranslated regions and fewer microRNA target sites. Science. 2008 Jun 20; 320(5883):1643-7. PMID: 18566288; PMCID: PMC2587246.
    19. Gallo EM, Winslow MM, Canté-Barrett K, Radermacher AN, Ho L, McGinnis L, Iritani B, Neilson JR, Crabtree GR. Calcineurin sets the bandwidth for discrimination of signals during thymocyte development. Nature. 2007 Nov 29; 450(7170):731-5. PMID: 18046413.
      View in: PubMed
    20. Wu H, Neilson JR, Kumar P, Manocha M, Shankar P, Sharp PA, Manjunath N. miRNA profiling of naïve, effector and memory CD8 T cells. PLoS One. 2007; 2(10):e1020. PMID: 17925868; PMCID: PMC2000354.
    21. Ebert MS, Neilson JR, Sharp PA. MicroRNA sponges: competitive inhibitors of small RNAs in mammalian cells. Nat Methods. 2007 Sep; 4(9):721-6. PMID: 17694064; PMCID: PMC3857099.
    22. Neilson JR, Zheng GX, Burge CB, Sharp PA. Dynamic regulation of miRNA expression in ordered stages of cellular development. Genes Dev. 2007 Mar 1; 21(5):578-89. PMID: 17344418; PMCID: PMC1820899.
    23. Heit JJ, Apelqvist AA, Gu X, Winslow MM, Neilson JR, Crabtree GR, Kim SK. Calcineurin/NFAT signalling regulates pancreatic beta-cell growth and function. Nature. 2006 Sep 21; 443(7109):345-9. PMID: 16988714.
      View in: PubMed
    24. Davé V, Childs T, Xu Y, Ikegami M, Besnard V, Maeda Y, Wert SE, Neilson JR, Crabtree GR, Whitsett JA. Calcineurin/Nfat signaling is required for perinatal lung maturation and function. J Clin Invest. 2006 Oct; 116(10):2597-609. PMID: 16998587; PMCID: PMC1570374.
    25. Arron JR, Winslow MM, Polleri A, Chang CP, Wu H, Gao X, Neilson JR, Chen L, Heit JJ, Kim SK, Yamasaki N, Miyakawa T, Francke U, Graef IA, Crabtree GR. NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21. Nature. 2006 Jun 1; 441(7093):595-600. PMID: 16554754.
      View in: PubMed
    26. Winslow MM, Gallo EM, Neilson JR, Crabtree GR. The calcineurin phosphatase complex modulates immunogenic B cell responses. Immunity. 2006 Feb; 24(2):141-52. PMID: 16473827.
      View in: PubMed
    27. Mammucari C, Tommasi di Vignano A, Sharov AA, Neilson J, Havrda MC, Roop DR, Botchkarev VA, Crabtree GR, Dotto GP. Integration of Notch 1 and calcineurin/NFAT signaling pathways in keratinocyte growth and differentiation control. Dev Cell. 2005 May; 8(5):665-76. PMID: 15866158.
      View in: PubMed
    28. Neilson JR, Sharp PA. Herpesviruses throw a curve ball: new insights into microRNA biogenesis and evolution. Nat Methods. 2005 Apr; 2(4):252-4. PMID: 15782215.
      View in: PubMed
    29. Chang CP, Neilson JR, Bayle JH, Gestwicki JE, Kuo A, Stankunas K, Graef IA, Crabtree GR. A field of myocardial-endocardial NFAT signaling underlies heart valve morphogenesis. Cell. 2004 Sep 3; 118(5):649-63. PMID: 15339668.
      View in: PubMed
    30. Schaeffer PJ, Wende AR, Magee CJ, Neilson JR, Leone TC, Chen F, Kelly DP. Calcineurin and calcium/calmodulin-dependent protein kinase activate distinct metabolic gene regulatory programs in cardiac muscle. J Biol Chem. 2004 Sep 17; 279(38):39593-603. PMID: 15262994.
      View in: PubMed
    31. Parsons SA, Millay DP, Wilkins BJ, Bueno OF, Tsika GL, Neilson JR, Liberatore CM, Yutzey KE, Crabtree GR, Tsika RW, Molkentin JD. Genetic loss of calcineurin blocks mechanical overload-induced skeletal muscle fiber type switching but not hypertrophy. J Biol Chem. 2004 Jun 18; 279(25):26192-200. PMID: 15082723.
      View in: PubMed
    32. Chang CP, McDill BW, Neilson JR, Joist HE, Epstein JA, Crabtree GR, Chen F. Calcineurin is required in urinary tract mesenchyme for the development of the pyeloureteral peristaltic machinery. J Clin Invest. 2004 Apr; 113(7):1051-8. PMID: 15057312; PMCID: PMC379320.
    33. Winslow MM, Neilson JR, Crabtree GR. Calcium signalling in lymphocytes. Curr Opin Immunol. 2003 Jun; 15(3):299-307. PMID: 12787755.
      View in: PubMed
    34. Graef IA, Wang F, Charron F, Chen L, Neilson J, Tessier-Lavigne M, Crabtree GR. Neurotrophins and netrins require calcineurin/NFAT signaling to stimulate outgrowth of embryonic axons. Cell. 2003 May 30; 113(5):657-70. PMID: 12787506.
      View in: PubMed
    35. Graef IA, Mermelstein PG, Stankunas K, Neilson JR, Deisseroth K, Tsien RW, Crabtree GR. L-type calcium channels and GSK-3 regulate the activity of NF-ATc4 in hippocampal neurons. Nature. 1999 Oct 14; 401(6754):703-8. PMID: 10537109.
      View in: PubMed
    36. Neilson JR, John GC, Carr JK, Lewis P, Kreiss JK, Jackson S, Nduati RW, Mbori-Ngacha D, Panteleeff DD, Bodrug S, Giachetti C, Bott MA, Richardson BA, Bwayo J, Ndinya-Achola J, Overbaugh J. Subtypes of human immunodeficiency virus type 1 and disease stage among women in Nairobi, Kenya. J Virol. 1999 May; 73(5):4393-403. PMID: 10196337; PMCID: PMC104220.
    37. Stankunas K, Graef IA, Neilson JR, Park SH, Crabtree GR. Signaling through calcium, calcineurin, and NF-AT in lymphocyte activation and development. Cold Spring Harb Symp Quant Biol. 1999; 64:505-16. PMID: 11232327.
      View in: PubMed
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