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HIDETO KOJIMA

TitleVisiting Associate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular & Cellular Biology
Address1 Baylor Plaza
Houston TX 77030
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Urabe H, Terashima T, Kojima H, Chan L. Ablation of a small subpopulation of diabetes-specific bone marrow-derived cells in mice protects against diabetic neuropathy. Am J Physiol Endocrinol Metab. 2016 Feb 15; 310(4):E269-75. PMID: 26695138.
      View in: PubMed
    2. Buras ED, Yang L, Saha P, Kim J, Mehta P, Yang Y, Hilsenbeck S, Kojima H, Chen W, Smith CW, Chan L. Proinsulin-producing, hyperglycemia-induced adipose tissue macrophages underlie insulin resistance in high fat-fed diabetic mice. FASEB J. 2015 Aug; 29(8):3537-3548. PMID: 25953849.
      View in: PubMed
    3. Okano J, Kojima H, Katagi M, Nakae Y, Terashima T, Nakagawa T, Kurakane T, Okamoto N, Morohashi K, Maegawa H, Udagawa J. Epidermis-dermis junction as a novel location for bone marrow-derived cells to reside in response to ionizing radiation. Biochem Biophys Res Commun. 2015 Jun 12; 461(4):695-701. PMID: 25922286.
      View in: PubMed
    4. Ookubo M, Sadamatsu M, Yoshimura A, Suzuki S, Kato N, Kojima H, Yamada N, Kanai H. Aberrant Monoaminergic System in Thyroid Hormone Receptor-? Deficient Mice as a Model of Attention-Deficit/Hyperactivity Disorder. Int J Neuropsychopharmacol. 2015 May; 18(7):pyv004. PMID: 25612897; PMCID: PMC4540106.
    5. Urabe H, Terashima T, Lin F, Kojima H, Chan L. Bone marrow-derived TNF-? causes diabetic neuropathy in mice. Diabetologia. 2015 Feb; 58(2):402-10. PMID: 25399355; PMCID: PMC4289451.
    6. Terashima T, Kojima H, Urabe H, Yamakawa I, Ogawa N, Kawai H, Chan L, Maegawa H. Stem cell factor-activated bone marrow ameliorates amyotrophic lateral sclerosis by promoting protective microglial migration. J Neurosci Res. 2014 Jul; 92(7):856-69. PMID: 24936617; PMCID: PMC4061499.
    7. Zhao L, Nakae Y, Qin H, Ito T, Kimura T, Kojima H, Chan L, Komatsu N. Polyglycerol-functionalized nanodiamond as a platform for gene delivery: Derivatization, characterization, and hybridization with DNA. Beilstein J Org Chem. 2014; 10:707-13. PMID: 24778723; PMCID: PMC3999746.
    8. Ogawa N, Kawai H, Terashima T, Kojima H, Oka K, Chan L, Maegawa H. Gene therapy for neuropathic pain by silencing of TNF-? expression with lentiviral vectors targeting the dorsal root ganglion in mice. PLoS One. 2014; 9(3):e92073. PMID: 24642694; PMCID: PMC3958473.
    9. Katagi M, Terashima T, Okano J, Urabe H, Nakae Y, Ogawa N, Udagawa J, Maegawa H, Matsumura K, Chan L, Kojima H. Hyperglycemia induces abnormal gene expression in hematopoietic stem cells and their progeny in diabetic neuropathy. FEBS Lett. 2014 Mar 18; 588(6):1080-6. PMID: 24583009; PMCID: PMC4004028.
    10. Kojima H, Kim J, Chan L. Emerging roles of hematopoietic cells in the pathobiology of diabetic complications. Trends Endocrinol Metab. 2014 Apr; 25(4):178-87. PMID: 24507996; PMCID: PMC3975817.
    11. Urabe H, Kojima H, Chan L, Terashima T, Ogawa N, Katagi M, Fujino K, Kumagai A, Kawai H, Asakawa A, Inui A, Yasuda H, Eguchi Y, Oka K, Maegawa H, Kashiwagi A, Kimura H. Haematopoietic cells produce BDNF and regulate appetite upon migration to the hypothalamus. Nat Commun. 2013; 4:1526. PMID: 23443554; PMCID: PMC3640364.
    12. Takemura Y, Imai S, Kojima H, Katagi M, Yamakawa I, Kasahara T, Urabe H, Terashima T, Yasuda H, Chan L, Kimura H, Matsusue Y. Brain-derived neurotrophic factor from bone marrow-derived cells promotes post-injury repair of peripheral nerve. PLoS One. 2012; 7(9):e44592. PMID: 23028564; PMCID: PMC3446933.
    13. Chan L, Terashima T, Urabe H, Lin F, Kojima H. Pathogenesis of diabetic neuropathy: bad to the bone. Ann N Y Acad Sci. 2011 Dec; 1240:70-6. PMID: 22172042; PMCID: PMC3636709.
    14. Terashima T, Kojima H, Chan L. Bone marrow expression of poly(ADP-ribose) polymerase underlies diabetic neuropathy via hematopoietic-neuronal cell fusion. FASEB J. 2012 Jan; 26(1):295-308. PMID: 21978940; PMCID: PMC3250244.
    15. Yamakawa I, Kojima H, Terashima T, Katagi M, Oi J, Urabe H, Sanada M, Kawai H, Chan L, Yasuda H, Maegawa H, Kimura H. Inactivation of TNF-? ameliorates diabetic neuropathy in mice. Am J Physiol Endocrinol Metab. 2011 Nov; 301(5):E844-52. PMID: 21810933; PMCID: PMC3213998.
    16. Li Y, Kojima H, Fujino K, Matsumura K, Katagi M, Urabe H, Chan L, Eguchi Y, Zhao L, Kimura H. Homing of the bone marrow-derived interstitial cells of Cajal is decreased in diabetic mouse intestine. J Gastroenterol Hepatol. 2011 Jun; 26(6):1072-8. PMID: 21265880; PMCID: PMC3321643.
    17. Kojima H, Kimura H. [Cell fusion]. Nihon Rinsho. 2010 Nov; 68 Suppl 9:573-7. PMID: 21661192.
      View in: PubMed
    18. Brevet M, Kojima H, Asakawa A, Atsuchi K, Ushikai M, Ataka K, Inui A, Kimura H, Sevestre H, Fujimiya M. Chronic foot-shock stress potentiates the influx of bone marrow-derived microglia into hippocampus. J Neurosci Res. 2010 Jul; 88(9):1890-7. PMID: 20155811.
      View in: PubMed
    19. Kasahara T, Imai S, Kojima H, Katagi M, Kimura H, Chan L, Matsusue Y. Malfunction of bone marrow-derived osteoclasts and the delay of bone fracture healing in diabetic mice. Bone. 2010 Sep; 47(3):617-25. PMID: 20601287; PMCID: PMC2926189.
    20. Koike M, Kojima H, Fujimiya M, Matsubayashi K, Aimi Y, Kimura H, Asai T. Transfer of bone marrow progenitors prevents coronary insufficiency and systolic dysfunction in the mechanical unloaded heart in mice. J Surg Res. 2011 Nov; 171(1):47-57. PMID: 20451917.
      View in: PubMed
    21. Fujimiya T, Liu J, Kojima H, Shirafuji S, Kimura H, Fujimiya M. Pathological roles of bone marrow-derived stellate cells in a mouse model of alcohol-induced fatty liver. Am J Physiol Gastrointest Liver Physiol. 2009 Sep; 297(3):G451-60. PMID: 19608736.
      View in: PubMed
    22. Terashima T, Oka K, Kritz AB, Kojima H, Baker AH, Chan L. DRG-targeted helper-dependent adenoviruses mediate selective gene delivery for therapeutic rescue of sensory neuronopathies in mice. J Clin Invest. 2009 Jul; 119(7):2100-112. PMID: 19603551; PMCID: PMC2701884.
    23. Yechoor V, Liu V, Espiritu C, Paul A, Oka K, Kojima H, Chan L. Neurogenin3 is sufficient for transdetermination of hepatic progenitor cells into neo-islets in vivo but not transdifferentiation of hepatocytes. Dev Cell. 2009 Mar; 16(3):358-73. PMID: 19289082; PMCID: PMC2676438.
    24. Oi J, Terashima T, Kojima H, Fujimiya M, Maeda K, Arai R, Chan L, Yasuda H, Kashiwagi A, Kimura H. Isolation of specific peptides that home to dorsal root ganglion neurons in mice. Neurosci Lett. 2008 Apr 4; 434(3):266-72. PMID: 18329804; PMCID: PMC2348187.
    25. Matsumura K, Chang BH, Fujimiya M, Chen W, Kulkarni RN, Eguchi Y, Kimura H, Kojima H, Chan L. Aquaporin 7 is a beta-cell protein and regulator of intraislet glycerol content and glycerol kinase activity, beta-cell mass, and insulin production and secretion. Mol Cell Biol. 2007 Sep; 27(17):6026-37. PMID: 17576812; PMCID: PMC1952143.
    26. Fujimiya M, Kojima H, Ichinose M, Arai R, Kimura H, Kashiwagi A, Chan L. Fusion of proinsulin-producing bone marrow-derived cells with hepatocytes in diabetes. Proc Natl Acad Sci U S A. 2007 Mar 6; 104(10):4030-5. PMID: 17360472; PMCID: PMC1820703.
    27. Kojima H, Fujimiya M, Terashima T, Kimura H, Chan L. Extrapancreatic proinsulin/insulin-expressing cells in diabetes mellitus: is history repeating itself? Endocr J. 2006 Dec; 53(6):715-22. PMID: 16960402.
      View in: PubMed
    28. Chan L, Terashima T, Fujimiya M, Kojima H. Chronic diabetic complications: the body's adaptive response to hyperglycemia gone awry? Trans Am Clin Climatol Assoc. 2006; 117:341-51; discussion 351-2. PMID: 18528485; PMCID: PMC1500919.
    29. Terashima T, Kojima H, Fujimiya M, Matsumura K, Oi J, Hara M, Kashiwagi A, Kimura H, Yasuda H, Chan L. The fusion of bone-marrow-derived proinsulin-expressing cells with nerve cells underlies diabetic neuropathy. Proc Natl Acad Sci U S A. 2005 Aug 30; 102(35):12525-30. PMID: 16116088; PMCID: PMC1194942.
    30. Saha PK, Kojima H, Martinez-Botas J, Sunehag AL, Chan L. Metabolic adaptations in the absence of perilipin: increased beta-oxidation and decreased hepatic glucose production associated with peripheral insulin resistance but normal glucose tolerance in perilipin-null mice. J Biol Chem. 2004 Aug 20; 279(34):35150-8. PMID: 15197189.
      View in: PubMed
    31. Kojima H, Fujimiya M, Matsumura K, Nakahara T, Hara M, Chan L. Extrapancreatic insulin-producing cells in multiple organs in diabetes. Proc Natl Acad Sci U S A. 2004 Feb 24; 101(8):2458-63. PMID: 14983031; PMCID: PMC356972.
    32. Chan L, Fujimiya M, Kojima H. In vivo gene therapy for diabetes mellitus. Trends Mol Med. 2003 Oct; 9(10):430-5. PMID: 14557055.
      View in: PubMed
    33. Kojima H, Fujimiya M, Matsumura K, Younan P, Imaeda H, Maeda M, Chan L. NeuroD-betacellulin gene therapy induces islet neogenesis in the liver and reverses diabetes in mice. Nat Med. 2003 May; 9(5):596-603. PMID: 12704384.
      View in: PubMed
    34. Ma K, Cabrero A, Saha PK, Kojima H, Li L, Chang BH, Paul A, Chan L. Increased beta -oxidation but no insulin resistance or glucose intolerance in mice lacking adiponectin. J Biol Chem. 2002 Sep 20; 277(38):34658-61. PMID: 12151381.
      View in: PubMed
    35. Kojima H, Nakamura T, Fujita Y, Kishi A, Fujimiya M, Yamada S, Kudo M, Nishio Y, Maegawa H, Haneda M, Yasuda H, Kojima I, Seno M, Wong NC, Kikkawa R, Kashiwagi A. Combined expression of pancreatic duodenal homeobox 1 and islet factor 1 induces immature enterocytes to produce insulin. Diabetes. 2002 May; 51(5):1398-408. PMID: 11978636.
      View in: PubMed
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