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EUGENE SUNG KYUN KIM

TitleAdjunct Associate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Surgery
Address6701 Fannin, Suite 1210
Clinical Care Center
Houston TX 77030
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    Dr. Eugene S. Kim’s clinical focus has been pediatric surgical oncology, chest wall deformities, and anorectal malformations. His academic focus has been in basic science oncology research, specifically the development of novel preclinical therapies for neuroblastoma, an aggressive pediatric malignancy.

    Dr. Kim’s laboratory has two main areas of interest in the study of neuroblastoma. Dr Kim’s primary area of expertise is the study of antiangiogenic therapies in neuroblastoma. Specifically, Dr. Kim has investigated the dual role of the oncogene MDM2 in neuroblastoma. Dr. Kim has published findings which show that inhibition of MDM2 in neuroblastoma is both antitumoral, via a p53-mediated pathway, and anti-angiogenic, via a p53 independent pathway by modulating the expression of HIF-1a and downstream VEGF. Current studies with MDM2 inhibition in neuroblastoma include the use of a novel and more potent inhibitor of MDM2 (RG7388) in determining the synergy of this drug with mTOR inhibitors as well as the efficacy of this drug in p53-mutant neuroblastoma tumors. Such a discovery may expand the use of these drugs to p53 mutant tumors. We have been selected as a lab to trial this new drug in our preclinical model of neuroblastoma to provide supporting evidence of its efficacy prior to clinical trials in children.

    Dr. Kim’s second area of expertise involves the study of a novel cancer stem cell population in neuroblastoma, which is believed tobe the cause of tumor relapse. Recently, our lab in collaboration with Dr. Shohet has isolated and characterized a novel cancer stem cell population in neuroblastoma based on the expression of CD114. As the potential cause of recurrence in this aggressive pediatric malignancy, the cancer stem cell subpopulation in neuroblastoma has significant clinical implications. We are continuing our studies of this CD114+ subpopulation by studying in vitro and in vivo the effect of the ligand to the receptor. The ligand, G-CSF, is a common medication given to children with neuroblastoma as part of their therapy – therefore, there is a concern that part of the treatment for these patients may be inadvertantly leading tuo tumor recurrence. In addition, we are looking to target this subpopulation in animal models as well as examine human tissue to determine and correlate the expression levels of this receptor to clinical outcomes.

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    neuroblastoma


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Rojas Y, Jaramillo S, Lyons K, Mahmood N, Wu MF, Liu H, Vasudevan SA, Guillerman RP, Louis CU, Russell HV, Nuchtern JG, Kim ES. The optimal timing of surgical resection in high-risk neuroblastoma. J Pediatr Surg. 2016 Jun 7. PMID: 27318861.
      View in: PubMed
    2. Agarwal S, Ghosh R, Chen Z, Lakoma A, Gunaratne PH, Kim ES, Shohet JM. Transmembrane adaptor protein PAG1 is a novel tumor suppressor in neuroblastoma. Oncotarget. 2016 Mar 16. PMID: 26993602.
      View in: PubMed
    3. Abbas PI, Roehm CE, Friedman EM, Athanassaki I, Kim ES, Brandt ML, Wesson DE, Lopez ME. Successful endoscopic ablation of a pyriform sinus fistula in a child: case report and literature review. Pediatr Surg Int. 2016 Jun; 32(6):623-7. PMID: 26820515.
      View in: PubMed
    4. Mazziotti MV, Weldon CB, Lopez ME, Abbas PI, Rescorla FJ, Kim ES. Analysis of submitted abstracts for the American Academy of Pediatrics, Section on Surgery, National Conference (AAP SoSU). J Pediatr Surg. 2015 Jun; 50(6):1058-61. PMID: 25812447.
      View in: PubMed
    5. Lakoma A, Kim ES. Minimally invasive surgical management of benign breast lesions. Gland Surg. 2014 May; 3(2):142-8. PMID: 25083508; PMCID: PMC4115760.
    6. Fallon SC, Kim ME, Fernandes CJ, Vasudevan SA, Nuchtern JG, Kim ES. Identifying and reducing early complications of surgical central lines in infants and toddlers. J Surg Res. 2014 Jul; 190(1):246-50. PMID: 24811915.
      View in: PubMed
    7. Lakoma A, Kim ES. Current readings: surgical repair experience of congenital chest wall deformities. Semin Thorac Cardiovasc Surg. 2013; 25(4):317-22. PMID: 24673961.
      View in: PubMed
    8. Barbieri E, De Preter K, Capasso M, Chen Z, Hsu DM, Tonini GP, Lefever S, Hicks J, Versteeg R, Pession A, Speleman F, Kim ES, Shohet JM. Histone chaperone CHAF1A inhibits differentiation and promotes aggressive neuroblastoma. Cancer Res. 2014 Feb 1; 74(3):765-74. PMID: 24335960.
      View in: PubMed
    9. Fan Y, Cheng J, Vasudevan SA, Patel RH, Liang L, Xu X, Zhao Y, Jia W, Lu F, Zhang H, Nuchtern JG, Kim ES, Yang J. TAK1 inhibitor 5Z-7-oxozeaenol sensitizes neuroblastoma to chemotherapy. Apoptosis. 2013 Oct; 18(10):1224-34. PMID: 23700229; PMCID: PMC3778057.
    10. Nordin AB, Fallon SC, Jea A, Kim ES. The use of spinal angiography in the management of posterior mediastinal tumors: case series and review of the literature. J Pediatr Surg. 2013 Sep; 48(9):1871-7. PMID: 24074660.
      View in: PubMed
    11. Fallon SC, Larimer EL, Gwilliam NR, Nuchtern JG, Rodriguez JR, Lee TC, Lopez ME, Kim ES. Increased complication rates associated with Port-a-Cath placement in pediatric patients: location matters. J Pediatr Surg. 2013 Jun; 48(6):1263-8. PMID: 23845616.
      View in: PubMed
    12. Fallon SC, Brandt ML, Rodriguez JR, Vasudevan SA, Lopez ME, Hicks MJ, Kim ES. Cytogenetic analysis in the diagnosis and management of lipoblastomas: results from a single institution. J Surg Res. 2013 Sep; 184(1):341-6. PMID: 23751806.
      View in: PubMed
    13. Hsu DM, Agarwal S, Benham A, Coarfa C, Trahan DN, Chen Z, Stowers PN, Courtney AN, Lakoma A, Barbieri E, Metelitsa LS, Gunaratne P, Kim ES, Shohet JM. G-CSF receptor positive neuroblastoma subpopulations are enriched in chemotherapy-resistant or relapsed tumors and are highly tumorigenic. Cancer Res. 2013 Jul 1; 73(13):4134-46. PMID: 23687340; PMCID: PMC4298227.
    14. Fallon SC, Shekerdemian LS, Olutoye OO, Cass DL, Zamora IJ, Nguyen T, Kim ES, Larimer EL, Lee TC. Initial experience with single-vessel cannulation for venovenous extracorporeal membrane oxygenation in pediatric respiratory failure. Pediatr Crit Care Med. 2013 May; 14(4):366-73. PMID: 23548959.
      View in: PubMed
    15. Fallon SC, Slater BJ, Nuchtern JG, Cass DL, Kim ES, Lopez ME, Mazziotti MV. Complications related to the Nuss procedure: minimizing risk with operative technique. J Pediatr Surg. 2013 May; 48(5):1044-8. PMID: 23701780.
      View in: PubMed
    16. Lakoma A, Fallon SC, Mathur S, Kim ES. Use of Mitomycin C for Refractory Esophageal Stricture following Tracheoesophageal Fistula Repair. European J Pediatr Surg Rep. 2013 Jun; 1(1):24-6. PMID: 25755944; PMCID: PMC4335951.
    17. Fallon SC, Kim ES, Naik-Mathuria BJ, Nuchtern JG, Cassady CI, Rodriguez JR. Needle decompression to avoid tension pneumoperitoneum and hemodynamic compromise after pneumatic reduction of pediatric intussusception. Pediatr Radiol. 2013 Jun; 43(6):662-7. PMID: 23283408.
      View in: PubMed
    18. Rojas Y, Warneke CL, Dhamne CA, Tsao K, Nuchtern JG, Lally KP, Vasudevan SA, Hayes-Jordan AA, Cass DL, Herzog CE, Hicks MJ, Kim ES, Austin MT. Primary malignant pancreatic neoplasms in children and adolescents: a 20 year experience. J Pediatr Surg. 2012 Dec; 47(12):2199-204. PMID: 23217876.
      View in: PubMed
    19. Burchhardt D, Fallon SC, Lopez ME, Kim ES, Hicks J, Brandt ML. Retroperitoneal lipoblastoma: a discussion of current management. J Pediatr Surg. 2012 Oct; 47(10):e51-4. PMID: 23084233.
      View in: PubMed
    20. Hassan SF, Mathur S, Magliaro TJ, Larimer EL, Ferrell LB, Vasudevan SA, Patterson DM, Louis CU, Russell HV, Nuchtern JG, Kim ES. Needle core vs open biopsy for diagnosis of intermediate- and high-risk neuroblastoma in children. J Pediatr Surg. 2012 Jun; 47(6):1261-6. PMID: 22703803.
      View in: PubMed
    21. Cheng PJ, Vu LT, Cass DL, Hicks MJ, Brandt ML, Kim ES. Endoscopic specimen pouch technique for removal of giant fibroadenomas of the breast. J Pediatr Surg. 2012 Apr; 47(4):803-7. PMID: 22498401.
      View in: PubMed
    22. Lazar DA, Cass DL, Olutoye OO, Kim ES, Welty SE, Fernandes CJ, Lee TC. Venovenous cannulation for extracorporeal membrane oxygenation using a bicaval dual-lumen catheter in neonates. J Pediatr Surg. 2012 Feb; 47(2):430-4. PMID: 22325408.
      View in: PubMed
    23. Hwang SW, Thomas JG, Whitehead WE, Curry DJ, Dauser RC, Kim ES, Luerssen TG, Jea A. Left thorascopic sympathectomy for refractory long QT syndrome in children. J Neurosurg Pediatr. 2011 Nov; 8(5):455-9. PMID: 22044368.
      View in: PubMed
    24. Shohet JM, Ghosh R, Coarfa C, Ludwig A, Benham AL, Chen Z, Patterson DM, Barbieri E, Mestdagh P, Sikorski DN, Milosavljevic A, Kim ES, Gunaratne PH. A genome-wide search for promoters that respond to increased MYCN reveals both new oncogenic and tumor suppressor microRNAs associated with aggressive neuroblastoma. Cancer Res. 2011 Jun 1; 71(11):3841-51. PMID: 21498633.
      View in: PubMed
    25. Patterson DM, Gao D, Trahan DN, Johnson BA, Ludwig A, Barbieri E, Chen Z, Diaz-Miron J, Vassilev L, Shohet JM, Kim ES. Effect of MDM2 and vascular endothelial growth factor inhibition on tumor angiogenesis and metastasis in neuroblastoma. Angiogenesis. 2011 Sep; 14(3):255-66. PMID: 21484514.
      View in: PubMed
    26. Mathur S, Vasudevan SA, Patterson DM, Hassan SF, Kim ES. Novel use of glycopyrrolate (Robinul) in the treatment of anastomotic leak after repair of esophageal atresia and tracheoesophageal fistula. J Pediatr Surg. 2011 Mar; 46(3):e29-32. PMID: 21376184.
      View in: PubMed
    27. Patterson DM, Shohet JM, Kim ES. Preclinical models of pediatric solid tumors (neuroblastoma) and their use in drug discovery. Curr Protoc Pharmacol. 2011 Mar; Chapter 14:Unit 14.17. PMID: 21935903.
      View in: PubMed
    28. Humphries WE, Satyan KB, Relyea K, Kim ES, Adesina AM, Chintagumpala M, Jea A. Low-grade myofibroblastic sarcoma of the sacrum. J Neurosurg Pediatr. 2010 Sep; 6(3):286-90. PMID: 20809714.
      View in: PubMed
    29. Vasudevan SA, Shang X, Shang X, Chang S, Ge N, Diaz-Miron JL, Russell HV, Hicks MJ, Ludwig AD, Wesson CL, Burlingame SM, Kim ES, Khan J, Yang J, Nuchtern JG. Neuroblastoma-derived secretory protein is a novel secreted factor overexpressed in neuroblastoma. Mol Cancer Ther. 2009 Aug; 8(8):2478-89. PMID: 19671756; PMCID: PMC3618953.
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