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ANTONY RODRIGUEZ

TitleAssistant Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Medicine
DivisionMedicine-Immunology, Allergy, Rheum
AddressOne Baylor Plaza
Houston TX 77030
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    Collapse Biography 
    Collapse awards and honors
    Ruth L. Kirschstein Postdoctoral National Research Award , National Institutes of Health
    Junior Faculty Seed Award, Gillson Longebaugh Foundation
    National Scientist Development Award, American Heart Association

    Collapse Overview 
    Collapse overview
    Over the last 10 years, we have focused our research on the identification of microRNAs with important roles in mammalian immunity and cardiopulmonary disease. Our approach is multipronged as we work with genetically modified mice and human samples. During the course of our work, we have identified novel miRNAs involved in adaptive and innate immunity (i.e. miR-155), heart failure (i.e. miR-22), and emphysema (i.e. miR-22). We are currently characterizing the pathophysiology of let-7 miRNA during emphysema/COPD with novel mouse models in collaboration with Drs. Corry and Kheradmand.

    Collapse keywords
    microRNA, miRNA, let-7, lincRNA, post-transcription gene regulation, non-coding RNAs, CRISPR, mice genetics, gene targeting, gene editing, cardiovascular disease, autoimmunity


    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Rowe RG, Wang LD, Coma S, Han A, Mathieu R, Pearson DS, Ross S, Sousa P, Nguyen PT, Rodriguez A, Wagers AJ, Daley GQ. Developmental regulation of myeloerythroid progenitor function by the Lin28b-let-7-Hmga2 axis. J Exp Med. 2016 Jul 25; 213(8):1497-512. PMID: 27401346; PMCID: PMC4986532 [Available on 01/25/17].
    2. Lu W, You R, Yuan X, Yang T, Samuel EL, Marcano DC, Sikkema WK, Tour JM, Rodriguez A, Kheradmand F, Corry DB. The microRNA miR-22 inhibits the histone deacetylase HDAC4 to promote T(H)17 cell-dependent emphysema. Nat Immunol. 2015 Nov; 16(11):1185-94. PMID: 26437241.
      View in: PubMed
    3. Nam JW, Rissland OS, Koppstein D, Abreu-Goodger C, Jan CH, Agarwal V, Yildirim MA, Rodriguez A, Bartel DP. Global analyses of the effect of different cellular contexts on microRNA targeting. Mol Cell. 2014 Mar 20; 53(6):1031-43. PMID: 24631284; PMCID: PMC4062300.
    4. Long J, Badal SS, Wang Y, Chang BH, Rodriguez A, Danesh FR. MicroRNA-22 is a master regulator of bone morphogenetic protein-7/6 homeostasis in the kidney. J Biol Chem. 2013 Dec 20; 288(51):36202-14. PMID: 24163368; PMCID: PMC3868735.
    5. Gurha P, Wang T, Larimore AH, Sassi Y, Abreu-Goodger C, Ramirez MO, Reddy AK, Engelhardt S, Taffet GE, Wehrens XH, Entman ML, Rodriguez A. microRNA-22 promotes heart failure through coordinate suppression of PPAR/ERR-nuclear hormone receptor transcription. PLoS One. 2013; 8(9):e75882. PMID: 24086656; PMCID: PMC3785418.
    6. Harper AR, Mayosi BM, Rodriguez A, Rahman T, Hall D, Mamasoula C, Avery PJ, Keavney BD. Common variation neighbouring micro-RNA 22 is associated with increased left ventricular mass. PLoS One. 2013; 8(1):e55061. PMID: 23372812; PMCID: PMC3555935.
    7. Gurha P, Abreu-Goodger C, Wang T, Ramirez MO, Drumond AL, van Dongen S, Chen Y, Bartonicek N, Enright AJ, Lee B, Kelm RJ, Reddy AK, Taffet GE, Bradley A, Wehrens XH, Entman ML, Rodriguez A. Targeted deletion of microRNA-22 promotes stress-induced cardiac dilation and contractile dysfunction. Circulation. 2012 Jun 5; 125(22):2751-61. PMID: 22570371; PMCID: PMC3503489.
    8. Vigorito E, Perks KL, Abreu-Goodger C, Bunting S, Xiang Z, Kohlhaas S, Das PP, Miska EA, Rodriguez A, Bradley A, Smith KG, Rada C, Enright AJ, Toellner KM, Maclennan IC, Turner M. microRNA-155 regulates the generation of immunoglobulin class-switched plasma cells. Immunity. 2007 Dec; 27(6):847-59. PMID: 18055230; PMCID: PMC4135426.
    9. Peterson JS, Bass BP, Jue D, Rodriguez A, Abrams JM, McCall K. Noncanonical cell death pathways act during Drosophila oogenesis. Genesis. 2007 Jun; 45(6):396-404. PMID: 17506088.
      View in: PubMed
    10. Rodriguez A, Vigorito E, Clare S, Warren MV, Couttet P, Soond DR, van Dongen S, Grocock RJ, Das PP, Miska EA, Vetrie D, Okkenhaug K, Enright AJ, Dougan G, Turner M, Bradley A. Requirement of bic/microRNA-155 for normal immune function. Science. 2007 Apr 27; 316(5824):608-11. PMID: 17463290; PMCID: PMC2610435.
    11. Akdemir F, Farkas R, Chen P, Juhasz G, Medved'ová L, Sass M, Wang L, Wang X, Chittaranjan S, Gorski SM, Rodriguez A, Abrams JM. Autophagy occurs upstream or parallel to the apoptosome during histolytic cell death. Development. 2006 Apr; 133(8):1457-65. PMID: 16540507.
      View in: PubMed
    12. Sang TK, Li C, Liu W, Rodriguez A, Abrams JM, Zipursky SL, Jackson GR. Inactivation of Drosophila Apaf-1 related killer suppresses formation of polyglutamine aggregates and blocks polyglutamine pathogenesis. Hum Mol Genet. 2005 Feb 1; 14(3):357-72. PMID: 15590702.
      View in: PubMed
    13. Chew SK, Akdemir F, Chen P, Lu WJ, Mills K, Daish T, Kumar S, Rodriguez A, Abrams JM. The apical caspase dronc governs programmed and unprogrammed cell death in Drosophila. Dev Cell. 2004 Dec; 7(6):897-907. PMID: 15572131.
      View in: PubMed
    14. Rodriguez A, Griffiths-Jones S, Ashurst JL, Bradley A. Identification of mammalian microRNA host genes and transcription units. Genome Res. 2004 Oct; 14(10A):1902-10. PMID: 15364901; PMCID: PMC524413.
    15. Rodriguez A, Chen P, Oliver H, Abrams JM. Unrestrained caspase-dependent cell death caused by loss of Diap1 function requires the Drosophila Apaf-1 homolog, Dark. EMBO J. 2002 May 01; 21(9):2189-97. PMID: 11980716; PMCID: PMC125994.
    16. Zhou Z, Rodriguez A, Wu CY, Kimbrell DA. Drosophila cellular immune system: Dorothy encodes a UDP glycosyltransferase. Adv Exp Med Biol. 2001; 484:251-63. PMID: 11418991.
      View in: PubMed
    17. Leulier F, Rodriguez A, Khush RS, Abrams JM, Lemaitre B. The Drosophila caspase Dredd is required to resist gram-negative bacterial infection. EMBO Rep. 2000 Oct; 1(4):353-8. PMID: 11269502; PMCID: PMC1083747.
    18. Rodriguez A, Oliver H, Zou H, Chen P, Wang X, Abrams JM. Dark is a Drosophila homologue of Apaf-1/CED-4 and functions in an evolutionarily conserved death pathway. Nat Cell Biol. 1999 Sep; 1(5):272-9. PMID: 10559939.
      View in: PubMed
    19. Chen P, Rodriguez A, Erskine R, Thach T, Abrams JM. Dredd, a novel effector of the apoptosis activators reaper, grim, and hid in Drosophila. Dev Biol. 1998 Sep 15; 201(2):202-16. PMID: 9740659.
      View in: PubMed
    20. Rodriguez A, Chen P, Abrams JM. Molecular prophets of death in the fly. Am J Hum Genet. 1998 Mar; 62(3):514-9. PMID: 9497272; PMCID: PMC1376969.
    21. Williams MJ, Rodriguez A, Kimbrell DA, Eldon ED. The 18-wheeler mutation reveals complex antibacterial gene regulation in Drosophila host defense. EMBO J. 1997 Oct 15; 16(20):6120-30. PMID: 9321392; PMCID: PMC1326296.
    22. Rodriguez A, Zhou Z, Tang ML, Meller S, Chen J, Bellen H, Kimbrell DA. Identification of immune system and response genes, and novel mutations causing melanotic tumor formation in Drosophila melanogaster. Genetics. 1996 Jun; 143(2):929-40. PMID: 8725239; PMCID: PMC1207349.
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