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LI XIN

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular & Cellular Biology
DivisionMolecular & Cellular Biology
AddressMolecular & Cellular Biology Department
One Baylor Plaza
Houston TX 77030
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Zhang B, Kwon OJ, Henry G, Malewska A, Wei X, Zhang L, Brinkley W, Zhang Y, Castro PD, Titus M, Chen R, Sayeeduddin M, Raj GV, Mauck R, Roehrborn C, Creighton CJ, Strand DW, Ittmann MM, Xin L. Non-Cell-Autonomous Regulation of Prostate Epithelial Homeostasis by Androgen Receptor. Mol Cell. 2016 Sep 15; 63(6):976-89. PMID: 27594448; PMCID: PMC5026614 [Available on 09/15/17].
    2. Xiao L, Feng Q, Zhang Z, Wang F, Lydon JP, Ittmann MM, Xin L, Mitsiades N, He B. The essential role of GATA transcription factors in adult murine prostate. Oncotarget. 2016 Jul 26; 7(30):47891-47903. PMID: 27374105.
      View in: PubMed
    3. Su Q, Zhang B, Zhang L, Dang T, Rowley D, Ittmann M, Xin L. Jagged1 upregulation in prostate epithelial cells promotes formation of reactive stroma in the Pten null mouse model for prostate cancer. Oncogene. 2016 Jun 27. PMID: 27345403.
      View in: PubMed
    4. Toneff MJ, Sreekumar A, Tinnirello A, Hollander PD, Habib S, Li S, Ellis MJ, Xin L, Mani SA, Rosen JM. The Z-cad dual fluorescent sensor detects dynamic changes between the epithelial and mesenchymal cellular states. BMC Biol. 2016; 14(1):47. PMID: 27317311; PMCID: PMC4912796.
    5. Welte T, Kim IS, Tian L, Gao X, Wang H, Li J, Holdman XB, Herschkowitz JI, Pond A, Xie G, Kurley S, Nguyen T, Liao L, Dobrolecki LE, Pang L, Mo Q, Edwards DP, Huang S, Xin L, Xu J, Li Y, Lewis MT, Wang T, Westbrook TF, Rosen JM, Zhang XH. Oncogenic mTOR signalling recruits myeloid-derived suppressor cells to promote tumour initiation. Nat Cell Biol. 2016 Jun; 18(6):632-44. PMID: 27183469; PMCID: PMC4884142 [Available on 12/01/16].
    6. Kwon OJ, Zhang B, Zhang L, Xin L. High fat diet promotes prostatic basal-to-luminal differentiation and accelerates initiation of prostate epithelial hyperplasia originated from basal cells. Stem Cell Res. 2016 May; 16(3):682-91. PMID: 27107344.
      View in: PubMed
    7. Wei X, Orjalo AV, Xin L. CD133 does not enrich for the stem cell activity in vivo in adult mouse prostates. Stem Cell Res. 2016 May; 16(3):597-606. PMID: 27010655.
      View in: PubMed
    8. Jiang XX, Fei XW, Zhao L, Ye XL, Xin LB, Qu Y, Xu KH, Wu RJ, Lin J. Aquaporin 5 Plays a Role in Estrogen-Induced Ectopic Implantation of Endometrial Stromal Cells in Endometriosis. PLoS One. 2015; 10(12):e0145290. PMID: 26679484.
      View in: PubMed
    9. Su Q, Xin L. Notch signaling in prostate cancer: refining a therapeutic opportunity. Histol Histopathol. 2016 Feb; 31(2):149-57. PMID: 26521657.
      View in: PubMed
    10. Kwon OJ, Zhang L, Xin L. Stem Cell Antigen-1 Identifies a Distinct Androgen-Independent Murine Prostatic Luminal Cell Lineage with Bipotent Potential. Stem Cells. 2016 Jan; 34(1):191-202. PMID: 26418304.
      View in: PubMed
    11. Shore AN, Chang CH, Kwon OJ, Weston MC, Zhang M, Xin L, Rosen JM. PTEN is required to maintain luminal epithelial homeostasis and integrity in the adult mammary gland. Dev Biol. 2016 Jan 1; 409(1):202-17. PMID: 26526198.
      View in: PubMed
    12. Xin LB, Jiang XX, Ye XL, Wu RJ, Xu KH, Ma JY, Lin J. [AQP5 gene silencing inhibits proliferation and migration of ectopic endometrial glandular epithelial cells in endometriosis]. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2015 May; 44(3):285-92. PMID: 26350009.
      View in: PubMed
    13. Kwon OJ, Xin L. Prostate epithelial stem and progenitor cells. Am J Clin Exp Urol. 2014; 2(3):209-18. PMID: 25374923; PMCID: PMC4219311.
    14. Kwon OJ, Valdez JM, Zhang L, Zhang B, Wei X, Su Q, Ittmann MM, Creighton CJ, Xin L. Increased Notch signalling inhibits anoikis and stimulates proliferation of prostate luminal epithelial cells. Nat Commun. 2014; 5:4416. PMID: 25048699; PMCID: PMC4167399.
    15. Tsouko E, Khan AS, White MA, Han JJ, Shi Y, Merchant FA, Sharpe MA, Xin L, Frigo DE. Regulation of the pentose phosphate pathway by an androgen receptor-mTOR-mediated mechanism and its role in prostate cancer cell growth. Oncogenesis. 2014; 3:e103. PMID: 24861463; PMCID: PMC4035695.
    16. Kwon OJ, Zhang L, Ittmann MM, Xin L. Prostatic inflammation enhances basal-to-luminal differentiation and accelerates initiation of prostate cancer with a basal cell origin. Proc Natl Acad Sci U S A. 2014 Feb 4; 111(5):E592-600. PMID: 24367088; PMCID: PMC3918789.
    17. Tennakoon JB, Shi Y, Han JJ, Tsouko E, White MA, Burns AR, Zhang A, Xia X, Ilkayeva OR, Xin L, Ittmann MM, Rick FG, Schally AV, Frigo DE. Androgens regulate prostate cancer cell growth via an AMPK-PGC-1?-mediated metabolic switch. Oncogene. 2014 Nov 6; 33(45):5251-61. PMID: 24186207; PMCID: PMC4009392.
    18. Zhang B, Chen H, Zhang L, Dakhova O, Zhang Y, Lewis MT, Creighton CJ, Ittmann MM, Xin L. A dosage-dependent pleiotropic role of Dicer in prostate cancer growth and metastasis. Oncogene. 2014 Jun 12; 33(24):3099-108. PMID: 23851498; PMCID: PMC3916938.
    19. Valdez JM, Xin L. The dual nature of Notch in tissue homeostasis and carcinogenesis. Cell Cycle. 2013 Feb 15; 12(4):541. PMID: 23370389; PMCID: PMC3594250.
    20. Xin L. A developmental stage-dependent switch of the mechanisms for prostate epithelial maintenance. Asian J Androl. 2013 Jan; 15(1):85-6. PMID: 23223032; PMCID: PMC3684388.
    21. Xin L. Cells of origin for cancer: an updated view from prostate cancer. Oncogene. 2013 Aug 8; 32(32):3655-63. PMID: 23178496; PMCID: PMC3740004.
    22. Valdez JM, Zhang L, Su Q, Dakhova O, Zhang Y, Shahi P, Spencer DM, Creighton CJ, Ittmann MM, Xin L. Notch and TGF? form a reciprocal positive regulatory loop that suppresses murine prostate basal stem/progenitor cell activity. Cell Stem Cell. 2012 Nov 2; 11(5):676-88. PMID: 23122291; PMCID: PMC3490134.
    23. Rowe JH, Ertelt JM, Xin L, Way SS. Listeria monocytogenes cytoplasmic entry induces fetal wastage by disrupting maternal Foxp3+ regulatory T cell-sustained fetal tolerance. PLoS Pathog. 2012; 8(8):e1002873. PMID: 22916020; PMCID: PMC3420962.
    24. Xin L, Shelite TR, Gong B, Mendell NL, Soong L, Fang R, Walker DH. Systemic treatment with CpG-B after sublethal rickettsial infection induces mouse death through indoleamine 2,3-dioxygenase (IDO). PLoS One. 2012; 7(3):e34062. PMID: 22470514; PMCID: PMC3314704.
    25. Zhang L, Zhang B, Han SJ, Shore AN, Rosen JM, Demayo FJ, Xin L. Targeting CreER(T2) expression to keratin 8-expressing murine simple epithelia using bacterial artificial chromosome transgenesis. Transgenic Res. 2012 Oct; 21(5):1117-23. PMID: 22350718; PMCID: PMC3433578.
    26. Choi N, Zhang B, Zhang L, Ittmann M, Xin L. Adult murine prostate basal and luminal cells are self-sustained lineages that can both serve as targets for prostate cancer initiation. Cancer Cell. 2012 Feb 14; 21(2):253-65. PMID: 22340597; PMCID: PMC3285423.
    27. Jayaraman R, Pilla Reddy V, Pasha MK, Wang H, Sangthongpitag K, Yeo P, Hu CY, Wu X, Xin L, Goh E, New LS, Ethirajulu K. Preclinical metabolism and disposition of SB939 (Pracinostat), an orally active histone deacetylase inhibitor, and prediction of human pharmacokinetics. Drug Metab Dispos. 2011 Dec; 39(12):2219-32. PMID: 21873472.
      View in: PubMed
    28. Shahi P, Seethammagari MR, Valdez JM, Xin L, Spencer DM. Wnt and Notch pathways have interrelated opposing roles on prostate progenitor cell proliferation and differentiation. Stem Cells. 2011 Apr; 29(4):678-88. PMID: 21308863; PMCID: PMC3148789.
    29. Zhang L, Valdez JM, Zhang B, Wei L, Chang J, Xin L. ROCK inhibitor Y-27632 suppresses dissociation-induced apoptosis of murine prostate stem/progenitor cells and increases their cloning efficiency. PLoS One. 2011; 6(3):e18271. PMID: 21464902; PMCID: PMC3065488.
    30. Mullany LK, Fan HY, Liu Z, White LD, Marshall A, Gunaratne P, Anderson ML, Creighton CJ, Xin L, Deavers M, Wong KK, Richards JS. Molecular and functional characteristics of ovarian surface epithelial cells transformed by KrasG12D and loss of Pten in a mouse model in vivo. Oncogene. 2011 Aug 11; 30(32):3522-36. PMID: 21423204; PMCID: PMC3139785.
    31. Zhang L, Zhang B, Valdez JM, Wang F, Ittmann M, Xin L. Dicer ablation impairs prostate stem cell activity and causes prostate atrophy. Stem Cells. 2010 Jul; 28(7):1260-9. PMID: 20517984; PMCID: PMC3030968.
    32. Wang B, Jiao Z, Shao X, Lu L, Yang N, Zhou X, Xin L, Zhou Y, Chou KY. Phenotypic alterations of dendritic cells are involved in suppressive activity of trichosanthin-induced CD8+CD28- regulatory T cells. J Immunol. 2010 Jul 1; 185(1):79-88. PMID: 20498361.
      View in: PubMed
    33. Xin L, Vargas-Inchaustegui DA, Raimer SS, Kelly BC, Hu J, Zhu L, Sun J, Soong L. Type I IFN receptor regulates neutrophil functions and innate immunity to Leishmania parasites. J Immunol. 2010 Jun 15; 184(12):7047-56. PMID: 20483775; PMCID: PMC4159077.
    34. Zhang L, Zhao W, Valdez JM, Creighton CJ, Xin L. Low-density Taqman miRNA array reveals miRNAs differentially expressed in prostatic stem cells and luminal cells. Prostate. 2010 Feb 15; 70(3):297-304. PMID: 19827049; PMCID: PMC3031866.
    35. Bu W, Xin L, Toneff M, Li L, Li Y. Lentivirus vectors for stably introducing genes into mammary epithelial cells in vivo. J Mammary Gland Biol Neoplasia. 2009 Dec; 14(4):401-4. PMID: 19936990.
      View in: PubMed
    36. Sanabria MX, Vargas-Inchaustegui DA, Xin L, Soong L. Role of natural killer cells in modulating dendritic cell responses to Leishmania amazonensis infection. Infect Immun. 2008 Nov; 76(11):5100-9. PMID: 18794295; PMCID: PMC2573361.
    37. Xin L, Li K, Soong L. Down-regulation of dendritic cell signaling pathways by Leishmania amazonensis amastigotes. Mol Immunol. 2008 Jul; 45(12):3371-82. PMID: 18538399; PMCID: PMC2583126.
    38. Vargas-Inchaustegui DA, Xin L, Soong L. Leishmania braziliensis infection induces dendritic cell activation, ISG15 transcription, and the generation of protective immune responses. J Immunol. 2008 Jun 1; 180(11):7537-45. PMID: 18490754; PMCID: PMC2641013.
    39. Vasquez RE, Xin L, Soong L. Effects of CXCL10 on dendritic cell and CD4+ T-cell functions during Leishmania amazonensis infection. Infect Immun. 2008 Jan; 76(1):161-9. PMID: 17998308; PMCID: PMC2223631.
    40. Wanasen N, Xin L, Soong L. Pathogenic role of B cells and antibodies in murine Leishmania amazonensis infection. Int J Parasitol. 2008 Mar; 38(3-4):417-29. PMID: 17959178; PMCID: PMC2276857.
    41. Xin L, Li Y, Soong L. Role of interleukin-1beta in activating the CD11c(high) CD45RB- dendritic cell subset and priming Leishmania amazonensis-specific CD4+ T cells in vitro and in vivo. Infect Immun. 2007 Oct; 75(10):5018-26. PMID: 17682041; PMCID: PMC2044509.
    42. Zhou X, Jiang Y, Lu L, Ding Q, Jiao Z, Zhou Y, Xin L, Chou KY. MHC class II transactivator represses human IL-4 gene transcription by interruption of promoter binding with CBP/p300, STAT6 and NFAT1 via histone hypoacetylation. Immunology. 2007 Dec; 122(4):476-85. PMID: 17645498; PMCID: PMC2266042.
    43. Ding Q, Lu L, Wang B, Zhou Y, Jiang Y, Zhou X, Xin L, Jiao Z, Chou KY. B7H1-Ig fusion protein activates the CD4+ IFN-gamma receptor+ type 1 T regulatory subset through IFN-gamma-secreting Th1 cells. J Immunol. 2006 Sep 15; 177(6):3606-14. PMID: 16951320.
      View in: PubMed
    44. Benamar K, Xin L, Geller EB, Adler MW. Effect of central and peripheral administration of a nitric oxide synthase inhibitor on morphine hyperthermia in rats. Brain Res. 2001 Mar 16; 894(2):266-73. PMID: 11251200.
      View in: PubMed
    45. Benamar K, Xin L, Geller EB, Adler MW. Blockade of lipopolysaccharide-induced fever by a mu-opioid receptor-selective antagonist in rats. Eur J Pharmacol. 2000 Aug 4; 401(2):161-5. PMID: 10924921.
      View in: PubMed
    46. Xin L, Geller EB, Liu-Chen LY, Chen C, Adler MW. Substance P release in the rat periaqueductal gray and preoptic anterior hypothalamus after noxious cold stimulation: effect of selective mu and kappa opioid agonists. J Pharmacol Exp Ther. 1997 Aug; 282(2):1055-63. PMID: 9262375.
      View in: PubMed
    47. Xin L, Geller EB, Adler MW. Body temperature and analgesic effects of selective mu and kappa opioid receptor agonists microdialyzed into rat brain. J Pharmacol Exp Ther. 1997 Apr; 281(1):499-507. PMID: 9103537.
      View in: PubMed
    48. Xin L, Zhao SF, Geller EB, McCafferty MR, Sterling GH, Adler MW. Involvement of beta-endorphin in the preoptic anterior hypothalamus during interleukin-1 beta-induced fever in rats. Ann N Y Acad Sci. 1997 Mar 15; 813:324-6. PMID: 9100902.
      View in: PubMed
    49. Abood LG, Michael GJ, Xin L, Knigge KM. Interaction of putative vasopressin receptor proteins of rat brain and bovine pituitary gland with an antibody against a nanopeptide encoded by the reverse message of the complementary mRNA to vasopressin. J Recept Res. 1989; 9(1):19-25. PMID: 2521669.
      View in: PubMed
    50. Abood LG, Xin L, Michael G, Knigge KM. Interaction of putative vasopressin receptors in rat brain and bovine pituitary gland with a vasopressin anti-idiotype antibody as revealed by immunoblotting. Peptides. 1988 Nov-Dec; 9(6):1407-9. PMID: 2977644.
      View in: PubMed
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