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XIA LIN

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Surgery
AddressOne Baylor Plaza, BCM-Alkek for Biomedical Research To
HOUSTON TX 77030
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    Dr. Lin’s research interest is on cell functions under physiological and pathological conditions. Currently, they are investigating several cell functions such as cell proliferation, differentiation, and metabolism by focusing on protein phosphatase. Specifically, they are trying to identify protein phosphatases that regulate critical signal transduction pathways such as BMP, TGF-ß, insulin pathways, and gluconeogenesis. By doing this, the team hopes to better understand the signaling pathways that regulate normal cellular functions, and the deregulation of them leads to human diseases such as cancer, which is our main focus, bone disease, and diabetes. Eventually, they hope to provide the rationale for protein phosphatases as potential therapeutic targets.

    Another major focus of her research is on the functions and regulation of TGF-ß signal transduction pathway. She also investigates the crosstalk of TGF-ß signal with other signaling pathways such as oncogenic pathway and hormone receptor pathway, and the role of protein posttranslational modifications (e.g. phosphorylation, ubiquitination and sumoylation) in TGF-ß functions. By using cell-based assays and animal models, she seeks to determine the role of TGF-ß in normal cellular functions, cancer initiation, and cancer progression. Ultimately, the studies will advance our knowledge on understanding the molecular mechanisms of cancer initiation and progression, and on the identification of potential targets for cancer therapy.

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    Cancer, Cell cycle regulation, Diabetes, Mouse development, TGF-beta signaling


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Zhao Y, Xiao M, Sun B, Zhang Z, Shen T, Duan X, Yu PB, Feng XH, Lin X. C-terminal domain (CTD) small phosphatase-like 2 modulates the canonical bone morphogenetic protein (BMP) signaling and mesenchymal differentiation via Smad dephosphorylation. J Biol Chem. 2014 Sep 19; 289(38):26441-50. PMID: 25100727; PMCID: PMC4176200.
    2. Shen T, Sun C, Zhang Z, Xu N, Duan X, Feng XH, Lin X. Specific control of BMP signaling and mesenchymal differentiation by cytoplasmic phosphatase PPM1H. Cell Res. 2014 Jun; 24(6):727-41. PMID: 24732009; PMCID: PMC4042171.
    3. Chen J, Xia Y, Lin X, Feng XH, Wang Y. Smad3 signaling activates bone marrow-derived fibroblasts in renal fibrosis. Lab Invest. 2014 May; 94(5):545-56. PMID: 24614197; PMCID: PMC4006302.
    4. Qin J, Wu SP, Creighton CJ, Dai F, Xie X, Cheng CM, Frolov A, Ayala G, Lin X, Feng XH, Ittmann MM, Tsai SJ, Tsai MJ, Tsai SY. COUP-TFII inhibits TGF-?-induced growth barrier to promote prostate tumorigenesis. Nature. 2013 Jan 10; 493(7431):236-40. PMID: 23201680; PMCID: PMC4022346.
    5. Lin X, Yang X, Li Q, Ma Y, Cui S, He D, Lin X, Schwartz RJ, Chang J. Protein tyrosine phosphatase-like A regulates myoblast proliferation and differentiation through MyoG and the cell cycling signaling pathway. Mol Cell Biol. 2012 Jan; 32(2):297-308. PMID: 22106411; PMCID: PMC3255775.
    6. Dai F, Shen T, Li Z, Lin X, Feng XH. PPM1A dephosphorylates RanBP3 to enable efficient nuclear export of Smad2 and Smad3. EMBO Rep. 2011 Nov; 12(11):1175-81. PMID: 21960005; PMCID: PMC3207100.
    7. Martinez GJ, Zhang Z, Reynolds JM, Tanaka S, Chung Y, Liu T, Robertson E, Lin X, Feng XH, Dong C. Smad2 positively regulates the generation of Th17 cells. J Biol Chem. 2010 Sep 17; 285(38):29039-43. PMID: 20667820; PMCID: PMC2937933.
    8. Dai F, Duan X, Liang YY, Lin X, Feng XH. Coupling of dephosphorylation and nuclear export of Smads in TGF-beta signaling. Methods Mol Biol. 2010; 647:125-37. PMID: 20694664; PMCID: PMC3153448.
    9. Martinez GJ, Zhang Z, Chung Y, Reynolds JM, Lin X, Jetten AM, Feng XH, Dong C. Smad3 differentially regulates the induction of regulatory and inflammatory T cell differentiation. J Biol Chem. 2009 Dec 18; 284(51):35283-6. PMID: 19887374; PMCID: PMC2790957.
    10. Dai F, Lin X, Chang C, Feng XH. Nuclear export of Smad2 and Smad3 by RanBP3 facilitates termination of TGF-beta signaling. Dev Cell. 2009 Mar; 16(3):345-57. PMID: 19289081; PMCID: PMC2676691.
    11. Wrighton KH, Lin X, Yu PB, Feng XH. Transforming Growth Factor {beta} Can Stimulate Smad1 Phosphorylation Independently of Bone Morphogenic Protein Receptors. J Biol Chem. 2009 Apr 10; 284(15):9755-63. PMID: 19224917; PMCID: PMC2665096.
    12. Wrighton KH, Lin X, Feng XH. Phospho-control of TGF-beta superfamily signaling. Cell Res. 2009 Jan; 19(1):8-20. PMID: 19114991; PMCID: PMC2929013.
    13. Liang YY, Brunicardi FC, Lin X. Smad3 mediates immediate early induction of Id1 by TGF-beta. Cell Res. 2009 Jan; 19(1):140-8. PMID: 19079362.
      View in: PubMed
    14. Sun W, Yu Y, Dotti G, Shen T, Tan X, Savoldo B, Pass AK, Chu M, Zhang D, Lu X, Fu S, Lin X, Yang J. PPM1A and PPM1B act as IKKbeta phosphatases to terminate TNFalpha-induced IKKbeta-NF-kappaB activation. Cell Signal. 2009 Jan; 21(1):95-102. PMID: 18930133; PMCID: PMC2658596.
    15. Wang Y, Dow EC, Liang YY, Ramakrishnan R, Liu H, Sung TL, Lin X, Rice AP. Phosphatase PPM1A regulates phosphorylation of Thr-186 in the Cdk9 T-loop. J Biol Chem. 2008 Nov 28; 283(48):33578-84. PMID: 18829461; PMCID: PMC2586277.
    16. Wrighton KH, Lin X, Feng XH. Critical regulation of TGFbeta signaling by Hsp90. Proc Natl Acad Sci U S A. 2008 Jul 8; 105(27):9244-9. PMID: 18591668; PMCID: PMC2453700.
    17. Tan R, He W, Lin X, Kiss LP, Liu Y. Smad ubiquitination regulatory factor-2 in the fibrotic kidney: regulation, target specificity, and functional implication. Am J Physiol Renal Physiol. 2008 May; 294(5):F1076-83. PMID: 18353873; PMCID: PMC2703490.
    18. Wang D, Long J, Dai F, Liang M, Feng XH, Lin X. BCL6 represses Smad signaling in transforming growth factor-beta resistance. Cancer Res. 2008 Feb 1; 68(3):783-9. PMID: 18245479.
      View in: PubMed
    19. Dai F, Chang C, Lin X, Dai P, Mei L, Feng XH. Erbin inhibits transforming growth factor beta signaling through a novel Smad-interacting domain. Mol Cell Biol. 2007 Sep; 27(17):6183-94. PMID: 17591701; PMCID: PMC1952163.
    20. Wrighton KH, Liang M, Bryan B, Luo K, Liu M, Feng XH, Lin X. Transforming growth factor-beta-independent regulation of myogenesis by SnoN sumoylation. J Biol Chem. 2007 Mar 2; 282(9):6517-24. PMID: 17202138.
      View in: PubMed
    21. Lin X, Chen Y, Meng A, Feng X. Termination of TGF-beta superfamily signaling through SMAD dephosphorylation--a functional genomic view. J Genet Genomics. 2007 Jan; 34(1):1-9. PMID: 17469772.
      View in: PubMed
    22. Wu Y, Zhang X, Salmon M, Lin X, Zehner ZE. TGFbeta1 regulation of vimentin gene expression during differentiation of the C2C12 skeletal myogenic cell line requires Smads, AP-1 and Sp1 family members. Biochim Biophys Acta. 2007 Mar; 1773(3):427-39. PMID: 17270292; PMCID: PMC1855268.
    23. Wrighton KH, Willis D, Long J, Liu F, Lin X, Feng XH. Small C-terminal domain phosphatases dephosphorylate the regulatory linker regions of Smad2 and Smad3 to enhance transforming growth factor-beta signaling. J Biol Chem. 2006 Dec 15; 281(50):38365-75. PMID: 17035229.
      View in: PubMed
    24. Han G, Li AG, Liang YY, Owens P, He W, Lu S, Yoshimatsu Y, Wang D, Ten Dijke P, Lin X, Wang XJ. Smad7-induced beta-catenin degradation alters epidermal appendage development. Dev Cell. 2006 Sep; 11(3):301-12. PMID: 16950122.
      View in: PubMed
    25. Duan X, Liang YY, Feng XH, Lin X. Protein serine/threonine phosphatase PPM1A dephosphorylates Smad1 in the bone morphogenetic protein signaling pathway. J Biol Chem. 2006 Dec 1; 281(48):36526-32. PMID: 16931515.
      View in: PubMed
    26. Lin X, Duan X, Liang YY, Su Y, Wrighton KH, Long J, Hu M, Davis CM, Wang J, Brunicardi FC, Shi Y, Chen YG, Meng A, Feng XH. PPM1A functions as a Smad phosphatase to terminate TGFbeta signaling. Cell. 2006 Jun 2; 125(5):915-28. PMID: 16751101.
      View in: PubMed
    27. Lin X, Feng XH. Design and application of a versatile expression vector for RNAi in mammalian cells. J RNAi Gene Silencing. 2005; 1(1):38-43. PMID: 19771203; PMCID: PMC2737199.
    28. Maduzia LL, Roberts AF, Wang H, Lin X, Chin LJ, Zimmerman CM, Cohen S, Feng XH, Padgett RW. C. elegans serine-threonine kinase KIN-29 modulates TGFbeta signaling and regulates body size formation. BMC Dev Biol. 2005; 5:8. PMID: 15840165; PMCID: PMC1112587.
    29. Lin X, Feng XH. Abrogation of transforming growth factor-beta signaling in pancreatic cancer. World J Surg. 2005 Mar; 29(3):312-6. PMID: 15706432.
      View in: PubMed
    30. Liang M, Liang YY, Wrighton K, Ungermannova D, Wang XP, Brunicardi FC, Liu X, Feng XH, Lin X. Ubiquitination and proteolysis of cancer-derived Smad4 mutants by SCFSkp2. Mol Cell Biol. 2004 Sep; 24(17):7524-37. PMID: 15314162; PMCID: PMC506984.
    31. Liang M, Melchior F, Feng XH, Lin X. Regulation of Smad4 sumoylation and transforming growth factor-beta signaling by protein inhibitor of activated STAT1. J Biol Chem. 2004 May 28; 279(22):22857-65. PMID: 15028714.
      View in: PubMed
    32. Lin X, Liang YY, Sun B, Liang M, Shi Y, Brunicardi FC, Shi Y, Feng XH. Smad6 recruits transcription corepressor CtBP to repress bone morphogenetic protein-induced transcription. Mol Cell Biol. 2003 Dec; 23(24):9081-93. PMID: 14645520; PMCID: PMC309600.
    33. Lin X, Liang M, Liang YY, Brunicardi FC, Feng XH. SUMO-1/Ubc9 promotes nuclear accumulation and metabolic stability of tumor suppressor Smad4. J Biol Chem. 2003 Aug 15; 278(33):31043-8. PMID: 12813045.
      View in: PubMed
    34. Liang YY, Lin X, Liang M, Brunicardi FC, ten Dijke P, Chen Z, Choi KW, Feng XH. dSmurf selectively degrades decapentaplegic-activated MAD, and its overexpression disrupts imaginal disc development. J Biol Chem. 2003 Jul 18; 278(29):26307-10. PMID: 12754252.
      View in: PubMed
    35. Lin X, Sun B, Liang M, Liang YY, Gast A, Hildebrand J, Brunicardi FC, Melchior F, Feng XH. Opposed regulation of corepressor CtBP by SUMOylation and PDZ binding. Mol Cell. 2003 May; 11(5):1389-96. PMID: 12769861.
      View in: PubMed
    36. Lin X, Liang M, Liang YY, Brunicardi FC, Melchior F, Feng XH. Activation of transforming growth factor-beta signaling by SUMO-1 modification of tumor suppressor Smad4/DPC4. J Biol Chem. 2003 May 23; 278(21):18714-9. PMID: 12621041.
      View in: PubMed
    37. Berger DH, Feng XH, Yao J, Saha D, Beauchamp RD, Lin X. Resistance to transforming growth factor-beta occurs in the presence of normal Smad activation. Surgery. 2002 Aug; 132(2):310-6. PMID: 12219028.
      View in: PubMed
    38. Feng XH, Liang YY, Liang M, Zhai W, Lin X. Direct interaction of c-Myc with Smad2 and Smad3 to inhibit TGF-beta-mediated induction of the CDK inhibitor p15(Ink4B). Mol Cell. 2002 Jan; 9(1):133-43. PMID: 11804592.
      View in: PubMed
    39. Lin X, Liang M, Feng XH. Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor-beta signaling. J Biol Chem. 2000 Nov 24; 275(47):36818-22. PMID: 11016919.
      View in: PubMed
    40. Feng XH, Lin X, Derynck R. Smad2, Smad3 and Smad4 cooperate with Sp1 to induce p15(Ink4B) transcription in response to TGF-beta. EMBO J. 2000 Oct 2; 19(19):5178-93. PMID: 11013220; PMCID: PMC302105.
    41. Lin X, Sikkink RA, Rusnak F, Barber DL. Inhibition of calcineurin phosphatase activity by a calcineurin B homologous protein. J Biol Chem. 1999 Dec 17; 274(51):36125-31. PMID: 10593895.
      View in: PubMed
    42. Lin X, Barber DL. A calcineurin homologous protein inhibits GTPase-stimulated Na-H exchange. Proc Natl Acad Sci U S A. 1996 Oct 29; 93(22):12631-6. PMID: 8901634; PMCID: PMC38044.
    43. Lin X, Voyno-Yasenetskaya TA, Hooley R, Lin CY, Orlowski J, Barber DL. Galpha12 differentially regulates Na+-H+ exchanger isoforms. J Biol Chem. 1996 Sep 13; 271(37):22604-10. PMID: 8798430.
      View in: PubMed
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