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JOHN STEVEN OLSON

TitleAdjunct Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pediatrics
AddressONE BAYLOR PLAZA
HOUSTON TX 77030
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Esquerra RM, Bibi BM, Tipgunlakant P, Birukou I, Soman J, Olson JS, Kliger DS, Goldbeck RA. Role of Heme Pocket Water in Allosteric Regulation of Ligand Reactivity in Human Hemoglobin. Biochemistry. 2016 Jul 26; 55(29):4005-17. PMID: 27355904; PMCID: PMC4978812 [Available on 07/26/17].
    2. Da Q, Teruya M, Guchhait P, Teruya J, Olson JS, Cruz MA. Free hemoglobin increases von Willebrand factor-mediated platelet adhesion in vitro: implications on circulatory devices. Blood. 2015 Aug 25. PMID: 26307534.
      View in: PubMed
    3. Samuel PP, Smith LP, Phillips GN, Olson JS. Apoglobin Stability Is the Major Factor Governing both Cell-free and in Vivo Expression of Holomyoglobin. J Biol Chem. 2015 Sep 25; 290(39):23479-95. PMID: 26205820.
      View in: PubMed
    4. Strader MB, Hicks WA, Kassa T, Singleton E, Soman J, Olson JS, Weiss MJ, Mollan TL, Wilson MT, Alayash AI. Post-translational transformation of methionine to aspartate is catalyzed by heme iron and driven by peroxide: a novel subunit-specific mechanism in hemoglobin. J Biol Chem. 2014 Aug 8; 289(32):22342-57. PMID: 24939847; PMCID: PMC4862693.
    5. Mollan TL, Jia Y, Banerjee S, Wu G, Kreulen RT, Tsai AL, Olson JS, Crumbliss AL, Alayash AI. Redox properties of human hemoglobin in complex with fractionated dimeric and polymeric human haptoglobin. Free Radic Biol Med. 2014 Apr; 69:265-77. PMID: 24486321; PMCID: PMC4104362.
    6. Lukianova-Hleb EY, Campbell KM, Constantinou PE, Braam J, Olson JS, Ware RE, Sullivan DJ, Lapotko DO. Hemozoin-generated vapor nanobubbles for transdermal reagent- and needle-free detection of malaria. Proc Natl Acad Sci U S A. 2014 Jan 21; 111(3):900-5. PMID: 24379385; PMCID: PMC3903264.
    7. Dickson CF, Rich AM, D'Avigdor WM, Collins DA, Lowry JA, Mollan TL, Khandros E, Olson JS, Weiss MJ, Mackay JP, Lay PA, Gell DA. ?-Hemoglobin-stabilizing protein (AHSP) perturbs the proximal heme pocket of oxy-?-hemoglobin and weakens the iron-oxygen bond. J Biol Chem. 2013 Jul 5; 288(27):19986-20001. PMID: 23696640; PMCID: PMC3707698.
    8. Nienhaus K, Olson JS, Nienhaus GU. An engineered heme-copper center in myoglobin: CO migration and binding. Biochim Biophys Acta. 2013 Sep; 1834(9):1824-31. PMID: 23459127; PMCID: PMC3687040.
    9. Boechi L, Arrar M, Martí MA, Olson JS, Roitberg AE, Estrin DA. Hydrophobic effect drives oxygen uptake in myoglobin via histidine E7. J Biol Chem. 2013 Mar 1; 288(9):6754-62. PMID: 23297402; PMCID: PMC3585112.
    10. Mollan TL, Banerjee S, Wu G, Parker Siburt CJ, Tsai AL, Olson JS, Weiss MJ, Crumbliss AL, Alayash AI. ?-Hemoglobin stabilizing protein (AHSP) markedly decreases the redox potential and reactivity of ?-subunits of human HbA with hydrogen peroxide. J Biol Chem. 2013 Feb 8; 288(6):4288-98. PMID: 23264625; PMCID: PMC3567680.
    11. Varnado CL, Mollan TL, Birukou I, Smith BJ, Henderson DP, Olson JS. Development of recombinant hemoglobin-based oxygen carriers. Antioxid Redox Signal. 2013 Jun 10; 18(17):2314-28. PMID: 23025383; PMCID: PMC3638513.
    12. Mollan TL, Abraham B, Strader MB, Jia Y, Lozier JN, Olson JS, Alayash AI. Familial secondary erythrocytosis due to increased oxygen affinity is caused by destabilization of the T state of hemoglobin Brigham (????(Pro100Leu)). Protein Sci. 2012 Oct; 21(10):1444-55. PMID: 22821886; PMCID: PMC3526987.
    13. Salter MD, Blouin GC, Soman J, Singleton EW, Dewilde S, Moens L, Pesce A, Nardini M, Bolognesi M, Olson JS. Determination of ligand pathways in globins: apolar tunnels versus polar gates. J Biol Chem. 2012 Sep 28; 287(40):33163-78. PMID: 22859299; PMCID: PMC3460423.
    14. Tsai AL, Martin E, Berka V, Olson JS. How do heme-protein sensors exclude oxygen? Lessons learned from cytochrome c', Nostoc puntiforme heme nitric oxide/oxygen-binding domain, and soluble guanylyl cyclase. Antioxid Redox Signal. 2012 Nov 1; 17(9):1246-63. PMID: 22356101; PMCID: PMC3430480.
    15. Ekworomadu MT, Poor CB, Owens CP, Balderas MA, Fabian M, Olson JS, Murphy F, Bakkalbasi E, Balkabasi E, Honsa ES, He C, Goulding CW, Maresso AW. Differential function of lip residues in the mechanism and biology of an anthrax hemophore. PLoS Pathog. 2012; 8(3):e1002559. PMID: 22412371; PMCID: PMC3297588.
    16. Mollan TL, Khandros E, Weiss MJ, Olson JS. Kinetics of ?-globin binding to ?-hemoglobin stabilizing protein (AHSP) indicate preferential stabilization of hemichrome folding intermediate. J Biol Chem. 2012 Mar 30; 287(14):11338-50. PMID: 22298770; PMCID: PMC3322864.
    17. Khandros E, Mollan TL, Yu X, Wang X, Yao Y, D'Souza J, Gell DA, Olson JS, Weiss MJ. Insights into hemoglobin assembly through in vivo mutagenesis of ?-hemoglobin stabilizing protein. J Biol Chem. 2012 Mar 30; 287(14):11325-37. PMID: 22287545; PMCID: PMC3322894.
    18. Tsai AL, Berka V, Martin E, Olson JS. A "sliding scale rule" for selectivity among NO, CO, and O? by heme protein sensors. Biochemistry. 2012 Jan 10; 51(1):172-86. PMID: 22111978; PMCID: PMC3254785.
    19. Birukou I, Maillett DH, Birukova A, Olson JS. Modulating distal cavities in the ? and ? subunits of human HbA reveals the primary ligand migration pathway. Biochemistry. 2011 Aug 30; 50(34):7361-74. PMID: 21793487; PMCID: PMC3160505.
    20. Honsa ES, Fabian M, Cardenas AM, Olson JS, Maresso AW. The five near-iron transporter (NEAT) domain anthrax hemophore, IsdX2, scavenges heme from hemoglobin and transfers heme to the surface protein IsdC. J Biol Chem. 2011 Sep 23; 286(38):33652-60. PMID: 21808055; PMCID: PMC3190864.
    21. Crowley MA, Mollan TL, Abdulmalik OY, Butler AD, Goodwin EF, Sarkar A, Stolle CA, Gow AJ, Olson JS, Weiss MJ. A hemoglobin variant associated with neonatal cyanosis and anemia. N Engl J Med. 2011 May 12; 364(19):1837-43. PMID: 21561349; PMCID: PMC3632254.
    22. Lukianova-Hleb EY, Oginsky AO, Olson JS, Lapotko DO. Short laser pulse-induced irreversible photothermal effects in red blood cells. Lasers Surg Med. 2011 Mar; 43(3):249-60. PMID: 21290393; PMCID: PMC3822757.
    23. Birukou I, Soman J, Olson JS. Blocking the gate to ligand entry in human hemoglobin. J Biol Chem. 2011 Mar 25; 286(12):10515-29. PMID: 21193395; PMCID: PMC3060505.
    24. Pesce A, Nardini M, Dewilde S, Capece L, Martí MA, Congia S, Salter MD, Blouin GC, Estrin DA, Ascenzi P, Moens L, Bolognesi M, Olson JS. Ligand migration in the apolar tunnel of Cerebratulus lacteus mini-hemoglobin. J Biol Chem. 2011 Feb 18; 286(7):5347-58. PMID: 21147768; PMCID: PMC3037647.
    25. Tsai AL, Berka V, Martin F, Ma X, van den Akker F, Fabian M, Olson JS. Is Nostoc H-NOX a NO sensor or redox switch? Biochemistry. 2010 Aug 10; 49(31):6587-99. PMID: 20572679; PMCID: PMC2914821.
    26. Esquerra RM, López-Peña I, Tipgunlakant P, Birukou I, Nguyen RL, Soman J, Olson JS, Kliger DS, Goldbeck RA. Kinetic spectroscopy of heme hydration and ligand binding in myoglobin and isolated hemoglobin chains: an optical window into heme pocket water dynamics. Phys Chem Chem Phys. 2010 Sep 21; 12(35):10270-8. PMID: 20668762; PMCID: PMC2935257.
    27. Culbertson DS, Olson JS. Role of heme in the unfolding and assembly of myoglobin. Biochemistry. 2010 Jul 27; 49(29):6052-63. PMID: 20540498; PMCID: PMC2912444.
    28. Peña MI, Davlieva M, Bennett MR, Olson JS, Shamoo Y. Evolutionary fates within a microbial population highlight an essential role for protein folding during natural selection. Mol Syst Biol. 2010 Jul 13; 6:387. PMID: 20631681; PMCID: PMC2925523.
    29. Blouin GC, Schweers RL, Olson JS. Alkyl isocyanides serve as transition state analogues for ligand entry and exit in myoglobin. Biochemistry. 2010 Jun 22; 49(24):4987-97. PMID: 20476741; PMCID: PMC4102008.
    30. Blouin GC, Olson JS. The stretching frequencies of bound alkyl isocyanides indicate two distinct ligand orientations within the distal pocket of myoglobin. Biochemistry. 2010 Jun 22; 49(24):4968-76. PMID: 20476740; PMCID: PMC4102131.
    31. Smith RD, Blouin GC, Johnson KA, Phillips GN, Olson JS. Straight-chain alkyl isocyanides open the distal histidine gate in crystal structures of myoglobin . Biochemistry. 2010 Jun 22; 49(24):4977-86. PMID: 20481504; PMCID: PMC4074459.
    32. Tarlovsky Y, Fabian M, Solomaha E, Honsa E, Olson JS, Maresso AW. A Bacillus anthracis S-layer homology protein that binds heme and mediates heme delivery to IsdC. J Bacteriol. 2010 Jul; 192(13):3503-11. PMID: 20435727; PMCID: PMC2897652.
    33. Soldatova AV, Ibrahim M, Olson JS, Czernuszewicz RS, Spiro TG. New light on NO bonding in Fe(III) heme proteins from resonance Raman spectroscopy and DFT modeling. J Am Chem Soc. 2010 Apr 7; 132(13):4614-25. PMID: 20218710; PMCID: PMC2853766.
    34. Bianchetti CM, Blouin GC, Bitto E, Olson JS, Phillips GN. The structure and NO binding properties of the nitrophorin-like heme-binding protein from Arabidopsis thaliana gene locus At1g79260.1. Proteins. 2010 Mar; 78(4):917-31. PMID: 19938152; PMCID: PMC2811769.
    35. Mollan TL, Yu X, Weiss MJ, Olson JS. The role of alpha-hemoglobin stabilizing protein in redox chemistry, denaturation, and hemoglobin assembly. Antioxid Redox Signal. 2010 Feb; 12(2):219-31. PMID: 19659437; PMCID: PMC2821148.
    36. Birukou I, Schweers RL, Olson JS. Distal histidine stabilizes bound O2 and acts as a gate for ligand entry in both subunits of adult human hemoglobin. J Biol Chem. 2010 Mar 19; 285(12):8840-54. PMID: 20080971; PMCID: PMC2838306.
    37. Smagghe BJ, Hoy JA, Percifield R, Kundu S, Hargrove MS, Sarath G, Hilbert JL, Watts RA, Dennis ES, Peacock WJ, Dewilde S, Moens L, Blouin GC, Olson JS, Appleby CA. Review: correlations between oxygen affinity and sequence classifications of plant hemoglobins. Biopolymers. 2009 Dec; 91(12):1083-96. PMID: 19441024.
      View in: PubMed
    38. Fabian M, Solomaha E, Olson JS, Maresso AW. Heme transfer to the bacterial cell envelope occurs via a secreted hemophore in the Gram-positive pathogen Bacillus anthracis. J Biol Chem. 2009 Nov 13; 284(46):32138-46. PMID: 19759022; PMCID: PMC2797284.
    39. Goldbeck RA, Pillsbury ML, Jensen RA, Mendoza JL, Nguyen RL, Olson JS, Soman J, Kliger DS, Esquerra RM. Optical detection of disordered water within a protein cavity. J Am Chem Soc. 2009 Sep 2; 131(34):12265-72. PMID: 19655795; PMCID: PMC2774273.
    40. Asmundson AL, Taber AM, van der Walde A, Lin DH, Olson JS, Anthony-Cahill SJ. Coexpression of human alpha- and circularly permuted beta-globins yields a hemoglobin with normal R state but modified T state properties. Biochemistry. 2009 Jun 16; 48(23):5456-65. PMID: 19397368; PMCID: PMC2725443.
    41. Yu X, Mollan TL, Butler A, Gow AJ, Olson JS, Weiss MJ. Analysis of human alpha globin gene mutations that impair binding to the alpha hemoglobin stabilizing protein. Blood. 2009 Jun 4; 113(23):5961-9. PMID: 19349619; PMCID: PMC2700329.
    42. Aranda R, Cai H, Worley CE, Levin EJ, Li R, Olson JS, Phillips GN, Richards MP. Structural analysis of fish versus mammalian hemoglobins: effect of the heme pocket environment on autooxidation and hemin loss. Proteins. 2009 Apr; 75(1):217-30. PMID: 18831041; PMCID: PMC2649966.
    43. Salter MD, Nienhaus K, Nienhaus GU, Dewilde S, Moens L, Pesce A, Nardini M, Bolognesi M, Olson JS. The apolar channel in Cerebratulus lacteus hemoglobin is the route for O2 entry and exit. J Biol Chem. 2008 Dec 19; 283(51):35689-702. PMID: 18840607; PMCID: PMC2602902.
    44. Maillett DH, Simplaceanu V, Shen TJ, Ho NT, Olson JS, Ho C. Interfacial and distal-heme pocket mutations exhibit additive effects on the structure and function of hemoglobin. Biochemistry. 2008 Oct 7; 47(40):10551-63. PMID: 18788751; PMCID: PMC2692483.
    45. Hussain F, Olson JS, Wittung-Stafshede P. Conserved residues modulate copper release in human copper chaperone Atox1. Proc Natl Acad Sci U S A. 2008 Aug 12; 105(32):11158-63. PMID: 18685091; PMCID: PMC2516206.
    46. Zhu H, Xie G, Liu M, Olson JS, Fabian M, Dooley DM, Lei B. Pathway for heme uptake from human methemoglobin by the iron-regulated surface determinants system of Staphylococcus aureus. J Biol Chem. 2008 Jun 27; 283(26):18450-60. PMID: 18467329; PMCID: PMC2440603.
    47. Graves PE, Henderson DP, Horstman MJ, Solomon BJ, Olson JS. Enhancing stability and expression of recombinant human hemoglobin in E. coli: Progress in the development of a recombinant HBOC source. Biochim Biophys Acta. 2008 Oct; 1784(10):1471-9. PMID: 18489914.
      View in: PubMed
    48. Aranda R, Worley CE, Liu M, Bitto E, Cates MS, Olson JS, Lei B, Phillips GN. Bis-methionyl coordination in the crystal structure of the heme-binding domain of the streptococcal cell surface protein Shp. J Mol Biol. 2007 Nov 23; 374(2):374-83. PMID: 17920629; PMCID: PMC2386982.
    49. Ran Y, Zhu H, Liu M, Fabian M, Olson JS, Aranda R, Phillips GN, Dooley DM, Lei B. Bis-methionine ligation to heme iron in the streptococcal cell surface protein Shp facilitates rapid hemin transfer to HtsA of the HtsABC transporter. J Biol Chem. 2007 Oct 26; 282(43):31380-8. PMID: 17699155; PMCID: PMC2424027.
    50. Mocny JC, Olson JS, Connell TD. Passively released heme from hemoglobin and myoglobin is a potential source of nutrient iron for Bordetella bronchiseptica. Infect Immun. 2007 Oct; 75(10):4857-66. PMID: 17664260; PMCID: PMC2044545.
    51. Deng P, Nienhaus K, Palladino P, Olson JS, Blouin G, Moens L, Dewilde S, Geuens E, Nienhaus GU. Transient ligand docking sites in Cerebratulus lacteus mini-hemoglobin. Gene. 2007 Aug 15; 398(1-2):208-23. PMID: 17531406; PMCID: PMC1986801.
    52. Zhou S, Olson JS, Fabian M, Weiss MJ, Gow AJ. Biochemical fates of alpha hemoglobin bound to alpha hemoglobin-stabilizing protein AHSP. J Biol Chem. 2006 Oct 27; 281(43):32611-8. PMID: 16901899.
      View in: PubMed
    53. Nygaard TK, Blouin GC, Liu M, Fukumura M, Olson JS, Fabian M, Dooley DM, Lei B. The mechanism of direct heme transfer from the streptococcal cell surface protein Shp to HtsA of the HtsABC transporter. J Biol Chem. 2006 Jul 28; 281(30):20761-71. PMID: 16717094; PMCID: PMC2423311.
    54. Gardner PR, Gardner AM, Brashear WT, Suzuki T, Hvitved AN, Setchell KD, Olson JS. Hemoglobins dioxygenate nitric oxide with high fidelity. J Inorg Biochem. 2006 Apr; 100(4):542-50. PMID: 16439024.
      View in: PubMed
    55. Goldbeck RA, Bhaskaran S, Ortega C, Mendoza JL, Olson JS, Soman J, Kliger DS, Esquerra RM. Water and ligand entry in myoglobin: assessing the speed and extent of heme pocket hydration after CO photodissociation. Proc Natl Acad Sci U S A. 2006 Jan 31; 103(5):1254-9. PMID: 16432219; PMCID: PMC1360539.
    56. Ionascu D, Gruia F, Ye X, Yu A, Rosca F, Beck C, Demidov A, Olson JS, Champion PM. Temperature-dependent studies of NO recombination to heme and heme proteins. J Am Chem Soc. 2005 Dec 7; 127(48):16921-34. PMID: 16316238; PMCID: PMC2553725.
    57. Dantsker D, Roche C, Samuni U, Blouin G, Olson JS, Friedman JM. The position 68(E11) side chain in myoglobin regulates ligand capture, bond formation with heme iron, and internal movement into the xenon cavities. J Biol Chem. 2005 Nov 18; 280(46):38740-55. PMID: 16155005.
      View in: PubMed
    58. Miranda JJ, Maillett DH, Soman J, Olson JS. Thermoglobin, oxygen-avid hemoglobin in a bacterial hyperthermophile. J Biol Chem. 2005 Nov 4; 280(44):36754-61. PMID: 16135523.
      View in: PubMed
    59. Zhang W, Olson JS, Phillips GN. Biophysical and kinetic characterization of HemAT, an aerotaxis receptor from Bacillus subtilis. Biophys J. 2005 Apr; 88(4):2801-14. PMID: 15653746; PMCID: PMC1305375.
    60. Nienhaus K, Olson JS, Franzen S, Nienhaus GU. The origin of stark splitting in the initial photoproduct state of MbCO. J Am Chem Soc. 2005 Jan 12; 127(1):40-1. PMID: 15631438.
      View in: PubMed
    61. Schotte F, Soman J, Olson JS, Wulff M, Anfinrud PA. Picosecond time-resolved X-ray crystallography: probing protein function in real time. J Struct Biol. 2004 Sep; 147(3):235-46. PMID: 15450293.
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    62. Kundu S, Blouin GC, Premer SA, Sarath G, Olson JS, Hargrove MS. Tyrosine B10 inhibits stabilization of bound carbon monoxide and oxygen in soybean leghemoglobin. Biochemistry. 2004 May 25; 43(20):6241-52. PMID: 15147208.
      View in: PubMed
    63. Pesce A, Nardini M, Ascenzi P, Geuens E, Dewilde S, Moens L, Bolognesi M, Riggs AF, Hale A, Deng P, Nienhaus GU, Olson JS, Nienhaus K. Thr-E11 regulates O2 affinity in Cerebratulus lacteus mini-hemoglobin. J Biol Chem. 2004 Aug 6; 279(32):33662-72. PMID: 15161908.
      View in: PubMed
    64. Olson JS, Foley EW, Rogge C, Tsai AL, Doyle MP, Lemon DD. No scavenging and the hypertensive effect of hemoglobin-based blood substitutes. Free Radic Biol Med. 2004 Mar 15; 36(6):685-97. PMID: 14990349.
      View in: PubMed
    65. Puranik M, Nielsen SB, Youn H, Hvitved AN, Bourassa JL, Case MA, Tengroth C, Balakrishnan G, Thorsteinsson MV, Groves JT, McLendon GL, Roberts GP, Olson JS, Spiro TG. Dynamics of carbon monoxide binding to CooA. J Biol Chem. 2004 May 14; 279(20):21096-108. PMID: 14990568.
      View in: PubMed
    66. Unno M, Matsui T, Chu GC, Couture M, Yoshida T, Rousseau DL, Olson JS, Ikeda-Saito M. Crystal structure of the dioxygen-bound heme oxygenase from Corynebacterium diphtheriae: implications for heme oxygenase function. J Biol Chem. 2004 May 14; 279(20):21055-61. PMID: 14966119.
      View in: PubMed
    67. Nienhaus K, Deng P, Olson JS, Warren JJ, Nienhaus GU. Structural dynamics of myoglobin: ligand migration and binding in valine 68 mutants. J Biol Chem. 2003 Oct 24; 278(43):42532-44. PMID: 12907676.
      View in: PubMed
    68. Schotte F, Lim M, Jackson TA, Smirnov AV, Soman J, Olson JS, Phillips GN, Wulff M, Anfinrud PA. Watching a protein as it functions with 150-ps time-resolved x-ray crystallography. Science. 2003 Jun 20; 300(5627):1944-7. PMID: 12817148.
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    69. Coyle CM, Vogel KM, Rush TS, Kozlowski PM, Williams R, Spiro TG, Dou Y, Ikeda-Saito M, Olson JS, Zgierski MZ. FeNO structure in distal pocket mutants of myoglobin based on resonance Raman spectroscopy. Biochemistry. 2003 May 6; 42(17):4896-903. PMID: 12718530.
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    70. Olson JS, Foley EW, Maillett DH, Paster EV. Measurement of rate constants for reactions of O2, CO, and NO with hemoglobin. Methods Mol Med. 2003; 82:65-91. PMID: 12669638.
      View in: PubMed
    71. Dou Y, Maillett DH, Eich RF, Olson JS. Myoglobin as a model system for designing heme protein based blood substitutes. Biophys Chem. 2002 Jul 10; 98(1-2):127-48. PMID: 12128195.
      View in: PubMed
    72. Draghi F, Miele AE, Travaglini-Allocatelli C, Vallone B, Brunori M, Gibson QH, Olson JS. Controlling ligand binding in myoglobin by mutagenesis. J Biol Chem. 2002 Mar 1; 277(9):7509-19. PMID: 11744723.
      View in: PubMed
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